a-Tocopheryl Succinate

CAS: 4345-03-3

Ref. TR-T539950

Product Information

• Name: a-Tocopheryl Succinate
• Synonyms: RRR-alpha-Tocopheryl hydrogen succinate, (2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl hydrogen succinate, Vitamin E succinate, D-alpha-Tocopheryl Hydrogen Succinate, Butanedioic acid, 1-[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester (ACI), 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, hydrogen succinate, (+)- (8CI), Butanedioic acid, mono[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester (9CI), Butanedioic acid, mono[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl] ester, [2R-[2R*(4R*,8R*)]]- (ZCI), Succinic acid, mono[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl] ester, (+)- (8CI), α-Tocopherol, succinate (6CI), Covitol 1210, CV 104, d-α-Tocopherol acid succinate, d-α-Tocopheryl acid succinate, d-α-Tocopheryl hemisuccinate, NSC 173849, Tocopherol succinate, Vitamin E acid succinate, Vitamin E d-α-tocosuccinate, Vitamin E hemisuccinate, α-Tocopherol acid succinate, α-Tocopherol hemisuccinate, α-Tocopheryl acid succinate, α-Tocopheryl hemisuccinate, α-TOS
• Brand: TRC
• Description: Applications A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.References Weber, T. et al.: Clin. Can Res., 8, 863 (2002);Staphelberg, M. et al.: Biochem. Biophys. Res. Comm., 318, 636 (2004); Ramathapuram, L.V. et al.: Cancer Immunol. Immununother., 55, 166 (2005)

Chemical properties

• Molecular weight: 530.78
• Formula: C₃₃H₅₄O₅
• Color/Form: Neat
• InChI: InChI=1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1
• InChI key: InChIKey=IELOKBJPULMYRW-NJQVLOCASA-N
• SMILES: Cc1c(C)c2c(c(C)c1OC(=O)CCC(=O)O)CC[C@@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O2