Yangonin

CAS: 500-62-9

Ref. TR-Y100550

Product Information

• Name: Yangonin
• Synonyms: 4-methoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]pyran-2-one, (E)-4-Methoxy-6-[2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one, 2H-Pyran-2-one, 4-methoxy-6-(p-methoxystyryl)-, 2H-Pyran-2-one, 4-methoxy-6-[(1E)-2-(4-methoxyphenyl)ethenyl]-, 2H-Pyran-2-one, 4-methoxy-6-[2-(4-methoxyphenyl)ethenyl]-, (E)-, 2H-pyran-2-one, 4-methoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]-, 4-Methoxy-6-[(1E)-2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one, 4-Methoxy-6-[(E)-2-(4-methoxyphenyl)vinyl]-2H-pyran-2-on, 4-Methoxy-6-[(E)-2-(4-methoxyphenyl)vinyl]-2H-pyran-2-one, 4-Methoxy-6-[b-(p-anisyl)vinyl]-a-pyrone, 4-Méthoxy-6-[(E)-2-(4-méthoxyphényl)éthènyl]-2H-pyran-2-one, 5-Hydroxy-3-methoxy-7-(p-methoxyphenyl)-2,4,6-heptatrienoic Acid d-Lactone, 6-(p-Methoxystyryl)-4-methoxy-a-pyrone

Description

Applications A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements.
References Keledjian, J., et al.: J. Pharm. Sci., 77, 1003 (1988), Clouatre, D., et al.: Toxicol. Lett., 150, 85 (2004), Mathews, J., et al.: Drug Metab. Dispos., 33, 1555 (2005), Clayton, N., et al.: Exp. Toxicol. Pathol., 58, 223 (2007),

• Brand: TRC

Chemical properties

• Molecular weight: 258.27
• Formula: C₁₅H₁₄O₄
• Color/Form: Neat
• InChI: InChI=1S/C15H14O4/c1-17-12-6-3-11(4-7-12)5-8-13-9-14(18-2)10-15(16)19-13/h3-10H,1-2H3/b8-5+
• InChI key: InChIKey=XLHIYUYCSMZCCC-VMPITWQZSA-N
• SMILES: COc1ccc(/C=C/c2cc(OC)cc(=O)o2)cc1