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<p>NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC (antibody-drug conjugate) linker characterized by a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on PAB facilitates conjugation with reactive groups like PNP, enabling attachment to drug payloads. The primary amine readily participates in various reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, and other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular proteases, allowing efficient payload delivery through an elimination mechanism within the PAB structure.</p>

Boc-Gly-Gly-Gly-Gly-Gly is a protease-cleavable ADC linker with a Boc group at the N-terminus, utilized in the development of antibody-drug conjugates (ADC). The Boc group can be deprotected under mild acidic conditions, resulting in a free amine.

<p>Thalidomide-CH2NH2 hydrochloride is an analog of Thalidomide, characterized by a primary amine group. This primary amine is a versatile functional group that can participate in numerous reactions.</p>

<p>Mal-amido-PEG8-Val-Gly is an ADC linker containing a maleimide moiety.</p>

Boc-PEG2-Val-Cit-PAB-OH is an enzymatically cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized for attachment to reactive groups (such as PNP) to connect with a drug payload. The Boc protecting group can be removed with acid, revealing a primary amine that serves for coupling reactions to form an amide. The Val-Cit-PAB segment is cleaved by cellular proteases, facilitating the effective release of the payload inside the cell.

<p>PD-224378 is the lactam form of glycamine (β-isomer), produced through a Maillard reaction between pregabalin and lactose.</p>

<p>t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker, featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is susceptible to cleavage by cellular proteases and contains a free carboxylic acid that can couple with amines to form amides. The Boc group can be removed under acidic conditions to reveal a free primary amine, which is useful for various reactions, such as conjugation or reductive amination.</p>

Rivaroxabandiol is a metabolite of Rivaroxaban, which is a potent and selective direct inhibitor of coagulation factor Xa (FXa) with an IC50 of 0.7 nM and a Ki of 0.4 nM.

PSI-7410 is a metabolite of PSI-7851. PSI-7851 acts as an inhibitor of the HCV non-structural protein 5B (NS5B) and exhibits antiviral properties.

<p>4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO), produced through the N-dealkylation of BRO.</p>

(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1.

<p>DOSPA hydrochloride is a cationic lipid utilized in the formation of lipid nanoparticles.</p>

Benzyl N1-[PEG1-NHS]-N6-(t-Boc)-L-lysinate is a versatile ADC linker composed of a terminal benzyl group, a PEG unit, an NHS ester, and L-lysine protected with a t-Boc group. It is frequently utilized in research and development for bioconjugation and chemical modification.

NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker that features a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on the PAB component is suitable for attaching reactive groups (such as PNP) to facilitate binding with drug payloads. The primary amine is versatile for reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, or other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular cathepsins, allowing efficient payload delivery via an elimination mechanism through the PAB structure.

<p>11-Mercaptoundecanoate-NHS is a lipid utilized in the synthesis of Linkers.</p>

MC-Val-Ala-NHS ester is a cleavable ADC linker featuring maleimide and NHS ester groups. The Val-Ala linker is susceptible to cleavage by cathepsin B. The maleimide group can react with thiol groups, as can the MC component. The NHS ester reacts specifically and efficiently with amines (such as lysine residue side chains or aminosilane-coated surfaces) under neutral or mildly alkaline conditions, forming covalent bonds. Reagent grade, intended for research use only.

(S)-MCOPPB is the S-enantiomer of MCOPPB, an orally active selective agonist for the Nociceptin/Orphanin FQ-Receptor. It inhibits signal transduction in mouse brain NOP receptors and is utilized in anxiety disorder research.

<p>3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.</p>

<p>7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.</p>

<p>BrAc-Val-Ala is an ADC linker, utilized for synthesizing antibody-drug conjugates (ADC) such as ABBV-969.</p>