Enzimas Inibidoras
Inibidores enzimáticos são compostos que diminuem ou interrompem a atividade das enzimas, ligando-se a elas de forma específica. Esses inibidores desempenham um papel crucial na regulação dos processos biológicos e são amplamente utilizados na pesquisa médica e no desenvolvimento de medicamentos. Ao bloquear a ação das enzimas, permitem o estudo da função enzimática e o desenvolvimento de tratamentos para diversas doenças. Na CymitQuimica, oferecemos uma ampla gama de inibidores enzimáticos de alta qualidade para apoiar suas pesquisas em biologia e farmacologia.
Foram encontrados 123 produtos de "Enzimas Inibidoras"
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Argatroban
CAS:Fórmula:C23H38N6O6SPureza:(HPLC) ≥ 98%Cor e Forma:White to off-white powderPeso molecular:526.65IU1
CAS:Fórmula:C18H21FN2OPureza:(TLC) ≥ 98%Cor e Forma:Off-white to pale brown solidPeso molecular:300.37Fumagillin
CAS:Fórmula:C26H34O7Pureza:≥ 95.0%Cor e Forma:White, off-white or pale yellow to tan powderPeso molecular:458.54Vildagliptin
CAS:Fórmula:C17H25N3O2Pureza:≥ 98.0%Cor e Forma:White to off-white powderPeso molecular:303.40Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride
CAS:Fórmula:C14H21ClN2O3S·HClPureza:(HPLC) ≥ 98.0%Cor e Forma:White powderPeso molecular:369.31Nafamostat
CAS:Fórmula:C19H17N5O2Pureza:≥ 98.0%Cor e Forma:White to off-white powderPeso molecular:347.37Lactacystin
CAS:Fórmula:C15H24N2O7SPureza:≥ 95.0%Cor e Forma:White solid or powderPeso molecular:376.43E-64 protease inhibitor
CAS:Fórmula:C15H27N5O5Pureza:(HPLC) ≥ 98.0%Cor e Forma:White crystalline powderPeso molecular:357.40Bestatin hydrochloride
CAS:Fórmula:C16H24N2O4·HClPureza:≥ 98.0% (dried basis)Cor e Forma:White to almost white powderPeso molecular:344.87Bortezomib
CAS:Fórmula:C19H25BN4O4Pureza:≥ 98.0%Cor e Forma:White to off-white powder or solidPeso molecular:384.24Suramin sodium salt
CAS:Fórmula:C51H34N6Na6O23S6Pureza:≥ 98%Cor e Forma:White to off-white powderPeso molecular:1429.16Phosphoramidon disodium salt
CAS:Fórmula:C23H32N3Na2O10PPureza:≥ 97.0%Cor e Forma:Colourless, transparent crystals or white to light yellow crystalline powderPeso molecular:587.47Nafamostat mesylate
CAS:Fórmula:C19H17N5O2Pureza:≥ 99.0%Cor e Forma:White to off-white or beige crystalline powderPeso molecular:347.37Z-Leu-Leu-Leu-al
CAS:Fórmula:C26H41N3O5Pureza:≥ 97.0%Cor e Forma:White to off-white powder or solidPeso molecular:475.63Carfilzomib
CAS:Fórmula:C40H57N5O7Pureza:(HPLC) ≥ 98.0%Cor e Forma:White to off-white crystalline powder or crystalsPeso molecular:719.91DAPT
CAS:Fórmula:C23H26F2N2O4Pureza:(NMR) ≥ 98.0%Cor e Forma:White to off-white solidPeso molecular:432.50N-p-Tosyl-L-phenylalanine chloromethyl ketone
CAS:Fórmula:C17H18ClNO3SPureza:(TLC) ≥ 98.0%Cor e Forma:White to off-white powderPeso molecular:351.85Leupeptin hemisulfate
CAS:Fórmula:C20H38N6O4·5H2SO4Pureza:≥ 95%Cor e Forma:White to off-white powderPeso molecular:475.59Pepstatin A
CAS:Fórmula:C34H63N5O9Pureza:≥ 98.0%Cor e Forma:White to off-white powderPeso molecular:685.90E-64d protease inhibitor
CAS:Fórmula:C17H30N2O5Pureza:≥ 95.0%Cor e Forma:White powderPeso molecular:342.43Elastatinal microbial
CAS:Fórmula:C21H36N8O7Pureza:~0.64μg/ml (IC50, pH8.8, 37°C)Cor e Forma:White to light-yellow or tan powderPeso molecular:512.60Z-VAD-FMK, cell permeable
CAS:Fórmula:C22H30FN3O7Pureza:≥ 95.0%Cor e Forma:White to off-white solidPeso molecular:467.5AEBSF hydrochloride
CAS:Fórmula:C8H10FNO2S·HClPureza:≥ 98.0%Cor e Forma:White to off-white powder or solidPeso molecular:239.69Apricoxib
CAS:Produto Controlado<p>Applications Apricoxib, is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also has anticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy.<br>References Kirane, A, et al.: Clinical Cancer Res., 18, 5031 (2012); Rohatagi, Sh., et al.: British J. Clin. Pharmaco., 66, 60 (2008);<br></p>Fórmula:C19H20N2O3SCor e Forma:NeatPeso molecular:356.44Vitamin B12 e-Monocarboxylic Acid
CAS:<p>Stability Hygroscopic<br>Applications Vitamin B12 Monocarboxylic Acid is an impurity of Vitamin B12 (V676005) which is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.<br>References Rickes, et al.: Science, 107, 396 (1948); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 10, 183 (1981); Grasbeck, R., et al.: Clin. Biochem., 17, 99 (1984)<br></p>Fórmula:C63H87CoN13O15PCor e Forma:Dark Red SolidPeso molecular:1356.35(3S,4S,3’S)-Ezetimibe
CAS:<p>Applications (3S,4S,3’S)-Ezetimbe is a 3-epimer impurity of Ezetimibe (E975000), a cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Fórmula:C24H21F2NO3Cor e Forma:Off-WhitePeso molecular:409.43(3S,5S)-Atorvastatin Calcium Salt
CAS:Produto Controlado<p>Impurity Atorvastatin Related Compound E<br>Applications Impuritiy of Atorvaststin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Atorvastatin Related Compound E<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),<br></p>Fórmula:C33H34FN2O5·CaCor e Forma:NeatPeso molecular:1155.34N-(2-Hydroxyethyl)-1-deoxy-L-altronojirimycin Hydrochloride Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997), Hassan, A., et al.: Carbohydr. Res., 339, 1565 (2004),<br></p>Fórmula:C8H18ClNO5Cor e Forma:NeatPeso molecular:243.68522,5-Dideoxy-2,5-imino-D-mannitol
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A glucosidase inhibitor.<br>References Fellows, L.E.: Pestic. Sci., 17, 602 (1986)<br></p>Fórmula:C6H13NO4Cor e Forma:Off White SolidPeso molecular:163.17Nitromifene Citrate (E/Z mixture)
CAS:Produto Controlado<p>Applications Nitromifene citrate is a non-steroidal estrogen antagonist. It is structurally similar to Tamoxifen (T006000) which is a selective estrogen response modifier (SERM).<br>References Rudick, C., et al.: Endorcrinol., 144, 179 (2003); Sutherland, R., et al.: Nature, 267, 434 (1977)<br></p>Fórmula:C33H36N2O11Cor e Forma:Yellow To OrangePeso molecular:636.65N-(2-Hydroxyethyl)-1-deoxy-L-idonojirimycin Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References van de Water, F., et al.: Drug Metab. Rev., 37, 443 (2005), Koepsell, H., et al.: Pharm. Res., 24, 1227 (2007), Jappar, D., et al.: Pharm. Res., 26, 172 (2009),<br></p>Fórmula:C8H18ClNO5Cor e Forma:NeatPeso molecular:243.69Daidzein Diglucuronide
CAS:Produto ControladoFórmula:C27H26O16Cor e Forma:White To Off-WhitePeso molecular:606.49Teneligliptin Hydrobromide (2:5)
CAS:Produto Controlado<p>Applications Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.<br>References Goda, M. & Kadowaki, T.: Drugs Today, 49, 615 (2013); Kishimoto, M.: Diabetes Metab. Syndr. Obes., 6, 187 (2012)<br></p>Fórmula:C22H32·5Br2·5N6OSCor e Forma:NeatPeso molecular:628.862-(Hydroxyamino)acetic Acid
CAS:Produto Controlado<p>Applications 2-(Hydroxyamino)acetic Acid is a novel lactase inhibitor.<br>References Hattori, M., et al.: J. Insect Physiol., 51, 1359 (2005); Murao, S., et al.: Biosci. Biotech. Biochem., 56, 987 (1992)<br></p>Fórmula:C2H5NO3Cor e Forma:NeatPeso molecular:91.07Galacto-PUGNAc (>90%)
CAS:Produto Controlado<p>Stability Moisture and Temperature Sensitive<br>Applications Galacto-PUGNAc is a highly selective inhibitor for β-hexosaminidases HEXA and HEXB is cell-permeable. Galacto-PUGNAc is able to modulate the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels in neuroblastoma cells<br>References Stubbs, K.A. et al.: Angew. Chem. Int. Ed., 48, 1300 (2009);<br></p>Fórmula:C15H19N3O7Pureza:>90%Cor e Forma:NeatPeso molecular:353.33Aprotinin Hydrochloride
CAS:<p>Applications Aprotinin is used in cardiac surgery to minimize bleeding and reduce exposure to blood products.<br>References Mangano, D. et al.: New Eng. J. Med., 354, 353 (2006); Fergusson, D. et al.: New. Eng. J. Med., 358, 2319 (2008);<br></p>Fórmula:C284H432N84O79S7·x(ClH)Cor e Forma:White SolidPeso molecular:6511.51(free amine)tert-Butyl (2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-[(1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate
CAS:Produto Controlado<p>Applications tert-Butyl (2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-[(1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate is an orally anti-diabetic agent as a inhibitors of dipeptidylpeptidase IV (DPP-4).<br>References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705-5719 (2012);<br></p>Fórmula:C27H38N6O3SCor e Forma:NeatPeso molecular:526.69LCZ696
CAS:<p>Applications LCZ696 is a novel dual-acting inhibitor of angiotensin II receptor and neprilysin, which can be used for blood pressure reduction.<br>References Ruilope, L.M.; et al.: Lancet, 375, 1255 (2010)<br></p>Fórmula:C24H28NO5·C24H27N5O3·3Na·x(H2O)Cor e Forma:MixturePeso molecular:479.48 + (433.47) + x(18.02)Abamine
CAS:Produto Controlado<p>Applications Abamine is an inhibitor of 9-Cis-Epoxycarotenoid dioxygenase (NCED), the key regulatory enzyme in the plant hormone abscisic acid (ABA) biosynthesis pathway.<br>References Kitahata, N., et al.: Bioorg. Med. Chem., 14, 5555 (2006); Han, S., et al.: Bioorg. Med. Chem. Lett., 14, 3033 (2004)<br></p>Fórmula:C21H24FNO4Cor e Forma:NeatPeso molecular:373.42CP-10447
CAS:<p>Applications CP-10447 is an inhibitor apolipoprotein B (apoB) and triglyceride secretion in human hepatoma cells (HepG2) by inhibiting MTP activity and stimulating the early ER degradation of apoB. It is useful tool for further study of the mechanisms of apoB secretion and triglyceride-rich lipoprotein assembly.<br>References Haghpassand, M. et al.: J. Lipid. Res., 37, 1468 (1996); Pan, M. et al.: J. Biol. chem., 275, 27399 (2000);<br></p>Fórmula:C16H13BrN2OCor e Forma:NeatPeso molecular:329.193'-Deoxyadenosine 5’-Diphosphate Triethylamine Salt (>90%)
CAS:<p>Stability Hygroscopic<br>Applications 3'-Deoxyadenosine 5’-Diphosphate Triethylamine Salt, is a nucleotide and was proposed to be a possible inhibitor of DNA synthesis.<br>References Frederiksen, Sune.: Biochimica et Biophysica Acta, 76(3), 366-71 (1963)<br></p>Fórmula:C10H15N5O9P2•xC6H15NPureza:>90%Cor e Forma:NeatPeso molecular:411.20 + x(101.19)Bis(2-butoxyethyl) 2-(3-Hydroxybutoxy)ethyl Phosphate Triester
CAS:Produto Controlado<p>Applications Bis(2-butoxyethyl) 2-(3-Hydroxybutoxy)ethyl Phosphate Triester is derived from 2-Butoxyethanol (B692895), which is a reagent in the synthesis of 4-butoxyethoxy-N-octadecyl-1,8-naphthalimide as a new fluorescent probe for the determination of proteins. Also used as a reagent in the synthesis of 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.<br>References Sun, Y., et al.: Bioorg. Med. Chem. Lett., 21, 3798 (2011); Yi, W., et al.: Eur. J. Med. Chem., 45, 639 (2010)<br></p>Fórmula:C18H39O8PCor e Forma:Colourless To Light YellowPeso molecular:414.47Nicotelline
CAS:Produto Controlado<p>Applications Nicotelline is a Nicotine (N412420) related metabolite with potential as an inhibitor of human cytochrome P-450 2A6.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Denton, T. et al.: Biochem. Pharm., 67, 751 (2004); Gorrod, J. et al.: Anal. Det. Nic. Rel. Comp. Metab., 69, (1999);<br></p>Fórmula:C15H11N3Cor e Forma:NeatPeso molecular:233.27N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride
CAS:Produto Controlado<p>Applications Naphthalenesulfonamides derivatives are neoplasm inhibitors.<br>References Hidaka, H., et al.: Proc. Nat. Acad. Sci. USA, 78, 4354 (1981)<br></p>Fórmula:C20H29ClN2O2S·ClHCor e Forma:NeatPeso molecular:433.44Avelestat
CAS:Produto Controlado<p>Applications Avelstat inhibits plasma neutrophil elastase (NE) activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.<br>References Stevens, T., et al.: J. Pharmacol. Exp. Ther., 339, 313 (2011)<br></p>Fórmula:C25H22F3N5O4SCor e Forma:NeatPeso molecular:545.53Enviroxime
CAS:Produto Controlado<p>Applications Enviroxime is a benzimidazole derivative that inhibits rhinovirus multiplication.<br>References De Long, D.C., et al.: J. Infect. Dis., 141, 87 (1980), Wikel, J.H., et al.: J. Med. Chem., 23, 368 (1980), Phillpotts, R.J., et al.: Lancet, 1, 1342 (1981), Haden, F.G., et al.: Antimicrob. Agents Chemother., 21, 892 (1982),<br></p>Fórmula:C17H18N4O3SCor e Forma:NeatPeso molecular:358.41Benzyl Methyl Carbonate
CAS:Produto Controlado<p>Applications Benzyl Methyl Carbonate is used in designing of inhibitors for serine and thiol proteases.<br></p>Fórmula:C9H10O3Cor e Forma:NeatPeso molecular:166.174,5,6,7-Tetrabromo-1H-benzotriazole
CAS:Produto Controlado<p>Applications TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.<br>References Boehning, D., et al.: Neuron, 40, 129 (2993)<br></p>Fórmula:C6HBr4N3Cor e Forma:NeatPeso molecular:434.71Chelerythrine Chloride
CAS:<p>Stability Hygroscopic<br>Applications Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.<br>References Song, L., et. al.: Brain Res., 1564, 52 (2014)<br></p>Fórmula:C21H18NO4·ClCor e Forma:YellowPeso molecular:383.82(R)-Pinocembrin
CAS:Produto Controlado<p>Applications (2R)-Pinocembrin is the (R)-enantiomer of Pinocembrin, a flavanoid with antioxidant activity found in damiana, honey, and propolis. (2R)-Pinocembrin is a potential inhibitor of PIM1 kinase, an oncogene that has been implicated in the development of leukemias, lymphomas, and prostate cancer.<br>References Zhao, J. et al.: J. Ethnopharmacol., 120, 387 (2008); Holder, S. et al.: Mol. Cancer Ther., 6, 163 (2007); Holder, S. et al.: Bioorg. Med. Chem., 15, 6463 (2007);<br></p>Fórmula:C15H12O4Cor e Forma:WhitePeso molecular:256.25O,O-Dimethyl Dithiophosphate
CAS:Produto ControladoFórmula:C2H7O2PS2Cor e Forma:ColourlessPeso molecular:158.18Morusin
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications Morusin is an inhibitor of human cervical cancer stem cell growth, attenuating NF-kB activity, and initiating apoptosis.<br>References Wang, L. et al.: Mol. Cell. Biochem., 379, 7 (2013);<br></p>Fórmula:C25H24O6Cor e Forma:NeatPeso molecular:420.45GDC 0152
CAS:Produto Controlado<p>Applications GDC 0152 is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity.<br>References Yue, Q., et. al.: Drug Metab. Dispos., 41, 508 (2013)<br></p>Fórmula:C25H34N6O3SCor e Forma:NeatPeso molecular:498.643a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-methyl-(3aR,5R,6S,7R,7aR)-5H-pyrano[3,2-d]thiazole-6,7-diol
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications 3a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-methyl-(3aR,5R,6S,7R,7aR)-5H-pyrano[3,2-d]thiazole-6,7-diol, can be used in the synthesis of Hexosaminidase inhibitors, which are the new drug candidates for the therapy of osteoarthritis.<br>References Liu, J. et al.: Chem. Bio., 8, 701 (2001);<br></p>Fórmula:C8H13NO4SCor e Forma:White To Light BeigePeso molecular:219.26Bisindolylmaleimide VIII Acetic Acid Salt
CAS:Produto Controlado<p>Applications It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.<br>References Emery, J., et al.: J. Biol. Chem., 273, 14363 (1998), Wiley, S., et al.: Immunity, 3, 673 (1995), MacFarlane, M., et al.: Biochem. J., 348, 93 (2000),<br></p>Fórmula:C26H26N4O4Cor e Forma:NeatPeso molecular:458.511-(5-Isoquinolinesulfonyl)-2-methylpiperazine Dihydrochloride
CAS:Produto Controlado<p>Applications A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases.<br>References Hidaka, H. and Kawamoto, S.: Biochem. and Biophys. Res. Comm., 125, 1, 258 (1984)<br></p>Fórmula:C14H17N3O2S·2ClHCor e Forma:NeatPeso molecular:364.29O,S-Diethyl Methylphosphonothioate
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications An inhibitor of cholinesterase.<br>References Berman, H., et al.: J. Biol. Chem., 264, 3951 (1989), Millard, C., et al.: Biochemistry, 37, 237 (1998), Koellner, G., et al.: J. Mol. Biol., 296, 713 (2000),<br></p>Fórmula:C5H13O2PSCor e Forma:NeatPeso molecular:168.193-Acetyl-11-keto-β-boswellic Acid
CAS:Produto ControladoFórmula:C32H48O5Cor e Forma:WhitePeso molecular:512.721-Propan-1,1,2,2,3,3,3-d7-amine
CAS:Produto ControladoFórmula:C3H2D7NCor e Forma:NeatPeso molecular:66.15O-(2,4-Dinitrophenyl)hydroxylamine
CAS:<p>Applications O-(2,4-Dinitrophenyl)hydroxylamine is a rapid active-site-directed inhibitor of D-amino acid oxidase; modification results in specific incorporation of an amine group into an accessible nucleophilic residue with concomitant release of 2,4-dinitrophenol.<br>References D'Silva, C., et al.: Biochemi., 25, 5602 (1986),<br></p>Fórmula:C6H5N3O5Cor e Forma:Brown SolidPeso molecular:199.12N-Acetyl-Lys-Octreotide Trifluoroacetic Acid Salt
CAS:<p>Stability Hygroscopic<br>Applications N-Acetyl-Phe-Octreotide is used as reactant/reagent in inhibition of octreotide acylation inside PLGA microspheres by derivatization of amines of peptide with self-immolative protecting group.<br>References Shirangi, M., et al.: Bioconjugate Chem., 27, 576-585 (2016)<br></p>Fórmula:C51H68N10O11S2·xC2HF3O2Cor e Forma:NeatPeso molecular:1061.284Resolvin E1 Sodium Salt
CAS:Produto ControladoFórmula:C20H29NaO5Cor e Forma:NeatPeso molecular:372.431(5E)-6-(4-Hydroxy-3-methoxyphenyl)-5-hexene-2,4-dione
CAS:Produto Controlado<p>Applications Curcumin (C838500) and gingerdione derivative. A possible human glyoxalase I inhibitor. Flavor modifier.<br>References Yuan, M. et al.; Bioorg. Med. Chem. 19, 1189 (2011); Ley, J. et al.; J. Agr. Food Chem. 56, 6656 (2008)<br></p>Fórmula:C13H14O4Cor e Forma:NeatPeso molecular:234.25(±)-Procinolol Hydrochloride
CAS:Produto Controlado<p>Applications (±)-Procinolol is a beta adrenergic receptor antagonist.<br>References Singh, K.: Indian J. Phsiol. Pharmacol., 27, 311 (1983)<br></p>Fórmula:C15H24ClNO2Cor e Forma:NeatPeso molecular:285.81Baohuoside I
CAS:Produto Controlado<p>Applications Baohuoside I is an inhibitor of cell growth and also is a down-regulator of durvivin and cyclin D1 expression. Used in the treatment of esophageal cancer. Anti-cancer agent.<br>References Lifang, W. et al.: Oncology Rep., 26, 1149 (2011); Jin, X. et al.: Drug Dev. Ind. Pharm., 39, 1421 (2013);<br></p>Fórmula:C27H30O10Cor e Forma:NeatPeso molecular:514.52Raloxifene 4’-β-D-Glucuronide Lithium Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Raloxifene 4’-Glucuronide Lithium Salt is a metabolite of Raloxifene (R099995), a nonsteroidal estrogen receptor mixed agonist/antagonist.<br>References Dodge, J., et al.: Bioorg. Med. Chem. Lett., 7, 993 (1997); Jeong, E., et al.: Drug Metab. Dispos., 33, 785 (2005); Trontelj, J., et al.: Pharmacol. Res., 52, 334 (2005); Oswald, S., et al.: Clin. Pharmacol. Ther., 79 206 (2006)<br></p>Fórmula:C34H34LiNO10SCor e Forma:NeatPeso molecular:655.644-Amino-5-(bromomethyl)-2-methylpyrimidine Dihydrobromide
CAS:Produto Controlado<p>Applications A pyrimidine derivative as G protein-coupled receptor kinase (GRK) inhibitor.<br>References Bigham, E., et al.: J. Med. Chem., 35, 1399 (1992), Jansen, M., et al.: Biochem. Pharmacol., 47, 1067 (1994), Hasbi, A., et al.: J. Neurochem., 70, 2129 (1998),<br></p>Fórmula:C17H17N3O2SCor e Forma:NeatPeso molecular:327.40N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
CAS:Produto Controlado<p>Applications Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hidaka, H., et al.: J. of Biol. Chem., 264, 9, 4924 (1989)<br></p>Fórmula:C11H12ClN3O2S·2ClHCor e Forma:NeatPeso molecular:358.67Retorphan
CAS:Produto Controlado<p>Applications Retorphan is a powerful and selective inhibitors of neprilysin and is being developed as a therapeutic agent. Retorphan behave as the prodrug of the enantiomers of Thiorphan (T369500).<br>References Monteil, T., et al.: Mini. Rev. Med. Chem., 2, 209 (2002); Roques, B.P., et al.: Nature, 288, 286 (1980); Tiraboschi, G., et al.: Protein Engineering, 12, 2, 141 (1999)<br></p>Fórmula:C21H23NO4SCor e Forma:NeatPeso molecular:385.48(1R,2R)-2-Fluorocyclopentanamine Hydrochloride
CAS:Produto Controlado<p>Applications A cyclopentanamine used in the preparation of heterocyclic and aromatic ureas and amides as CEPT inhibitors.<br></p>Fórmula:C5H11ClFNCor e Forma:NeatPeso molecular:139.61-Deoxy-L-altronojirimycin Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997), Hassan, A., et al.: Carbohydr. Res., 339, 1565 (2004),<br></p>Fórmula:C6H13NO4·ClHPureza:>90%Cor e Forma:NeatPeso molecular:199.634-Fluorobenzoic Acid-d4
CAS:Produto Controlado<p>Applications 4-Fluorobenzoic Acid-d4 is used as a reagent in the synthesis of Flurofamide-d4 (F596687); the isotope labelled analog of Fluorofamide (F596685) which is a compound that acts as a urease inhibitor, useful in the treatment of gastritis and irregular urease activity in the urinary tract.<br>References Loes, A. et al.: Lett. App. Microbiol., 58, 31 (2014); Ohta, T.et al.: Biochem. Biophys, Res. Comm., 285, 728 (2001)<br></p>Fórmula:C7HD4FO2Cor e Forma:NeatPeso molecular:144.14tert-Butyl (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)carbamate
CAS:Produto ControladoFórmula:C17H30BNO4Cor e Forma:NeatPeso molecular:323.24n-Pentyl-d11 chloroformate
CAS:Produto Controlado<p>Applications n-Pentyl-d11 chloroformate is labelled n-Pentyl chloroformate which can be used to synthesize 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase.<br>References Kim, I., et al.: J. Med. Chem., 47, 2110 (2004); Hammock, B., et al.: PCT Int. Appl. (2006), WO 2006045119 A2 20060427.<br></p>Fórmula:C6D11ClO2Cor e Forma:NeatPeso molecular:161.674-Pyridin-2,3,5,6-d4-ol-d
CAS:Produto Controlado<p>Applications 4-Pyridin-2,3,5,6-d4-ol-d is one of the azepanone derivatives studies as CGRP receptor antagonists.<br>References Liu, J.: PCT Int. Appl. (2010), WO 2010108103 A1 20100923.<br></p>Fórmula:C5D5NOCor e Forma:NeatPeso molecular:100.13n-Propyl-2,2,3,3,3-d5-amine Hydrochloride
CAS:Produto Controlado<p>Applications n-Propyl-2,2,3,3,3-d5-amine Hydrochloride is the hydrochloride salt of 1-Propyl-d5-amine (P833702); the isotope labelled analog of 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.<br>References Goto, T. et al.: Bioorg. Med. Chem., 21, 7025 (2013); Lee, C. et al.: Bioorg. Med. Chem. 21, 7125, (2013)<br></p>Fórmula:C3H5D5ClNCor e Forma:NeatPeso molecular:100.6tert-Butyl 4-Bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate
CAS:Produto ControladoFórmula:C18H17BrN2O3Cor e Forma:NeatPeso molecular:389.24GW4869 TFA Salt (~90%, ~10% inorganics)
CAS:Produto Controlado<p>Applications GW4869 is a selective inhibitor of N-SMase.<br>References Lallemand, T., et al.: Arterioscler. Thromb. Vasc. Biol., 38, 1479 (2018); Figuera-Losada, M., et al.: PLoS One, 10, 0124481 (2015)<br></p>Fórmula:C30H28N6O2·xC2HF3O2Cor e Forma:NeatPeso molecular:504.58 + x(114.02)N-Fmoc-glycine-d2
CAS:Produto Controlado<p>Applications Isotope labelled N-Fmoc-glycine is an N-Fmoc-protected form of Glycine (G615990). Glycine is a nonessential amino acid that acts as an inhibitory neyrotransmitter in the vertebrate central nervous system. Glycine also posesses cytoprotective against oxidant damage in the kidney.<br>References Eulenberg, V., et al.: Trend. Biochem. Sci., 30, 325 (2005); Gundersen, R., et al.: Acta Anaesth. Scand., 49, 1108 (2005); Lockart, R. & Eagle, H.: Science, 129, 252 (1959); Sogabe, K., et al.: Kidn. Int., 50, 845 (1996)<br></p>Fórmula:C17H13D2NO4Cor e Forma:NeatPeso molecular:299.32Ethyl Palmitate-d31
CAS:Produto Controlado<p>Applications A labelled fatty acid found in Amaranth oil; it shows inhibitory activity.<br>References Fidler, N., et al.: J. Lipid Res., 41, 1376 (2000), Yang, T., et al.: Food Chem., 80, 473 (2003), Gamel, T., et al.: J. Food Lipids, 14, 323 (2007),<br></p>Fórmula:C18H5D31O2Cor e Forma:NeatPeso molecular:315.671-Propyl-d5-amine
CAS:Produto Controlado<p>Applications 1-Propyl-d5-amine is labelled 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C3H4D5NCor e Forma:NeatPeso molecular:64.14(3R,5S,6E)-7-(2-Cyclopropyl-4-phenyl-3-quinolinyl)-3,5-dihydroxy-6-heptenoic Acid Sodium Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications (3R,5S,6E)-7-(2-cyclopropyl-4-phenyl-3-quinolinyl)-3,5-dihydroxy-6-heptenoic Acid Sodium Salt is an impurity of Pitavastatin (P531000), a HMG CoA reductase inhibitor and an antilipemic agent.<br>References Suzukim M., et al.: Bioorg. Med. Chem., 9, 2977 (1999); Yen, H., et al.: J. Clin. Invest., 98, 1253 (1996); Zou, Y., et al.: J. Biol. Chem., 274, 9760 (1999); Sun, X., et al.: Cancer Res., et al.: 61, 3382 (2001); Ladas, E.J., et al.: Clin. Oncol., 22, 517 (2004);<br></p>Fórmula:C25H24NNaO4Cor e Forma:NeatPeso molecular:425.45rac-1,2-Dioctanoyl-3-Chloropropanediol
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications rac-1,2-Dioctanoyl-3-Chloropropanediol was studied for its ability to act as an inhibitor of protein kinase C.<br>References Briggs, Josie C., et al.: Carbohydrate Res., 234, 23-35 (1992)<br></p>Fórmula:C19H35ClO4Cor e Forma:NeatPeso molecular:362.93N-(n-Butyl)phosphoric Triamide
CAS:<p>Applications N-Alkyl phosphoric triamide useful as urease inhibitors.<br></p>Fórmula:C4H14N3OPCor e Forma:White SolidPeso molecular:151.153-Amino-N-(Tertbutylbenzenesulfonamide
CAS:Produto Controlado<p>Applications 3-Amino-N-(Tert-Butyl)Benzenesulfonamide (cas# 608523-94-0) is a useful research chemical.<br></p>Fórmula:C10H16N2O2SCor e Forma:NeatPeso molecular:228.31(E)-a-Hydroxy Tamoxifen
CAS:Produto Controlado<p>Applications A metabolite of the chemotherapeutic drug Tamoxifen (T006000). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation.<br>References Kupfer, D., et al.: Cancer Res., 54, 3140 (1994), Custodio, J.B.A., et al.: Biochem. Pharmacol., 47, 1989 (1994),<br></p>Fórmula:C26H29NO2Cor e Forma:NeatPeso molecular:387.51Valtrate
CAS:Produto Controlado<p>Applications Valtrate is a Rev-transport inhibitor with anti-HIV activity from Valerianae Radix.<br>References Murakami, N., et al.: Bioorg. Med. Chem. Lett., 12, 2807 (2002); Watanabe, K., et al.: Drug Discoveries Ther., 5, 26 92011)<br></p>Fórmula:C22H30O8Cor e Forma:Light Brown To Dark YellowPeso molecular:422.47A 83-01
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications A 83-01 is a selective inhibitor of TGF-β type I receptor. A 83-01 treatment increases tumor permeability.<br>References Minowa, T. et al.: British. J. Canc., 101, 1884 (2009)<br></p>Fórmula:C25H19N5SCor e Forma:Off-WhitePeso molecular:421.52
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