Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(114 produtos)
- CDK(545 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(47 produtos)
- Dinamina(27 produtos)
- Ferroptose(226 produtos)
- HSP(179 produtos)
- Integrinas(249 produtos)
- Cinesina(87 produtos)
- LIM Quinase(20 produtos)
- Microtúbulo associado(274 produtos)
- PKC(124 produtos)
- PLK(25 produtos)
- ROCK(62 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(76 produtos)
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Foram encontrados 3860 produtos de "Ciclo celular/Ponto de verificação"
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DIDS
CAS:DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.Fórmula:C16H10N2O6S4Pureza:98%Cor e Forma:SolidPeso molecular:454.52DB18
CAS:DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].Fórmula:C24H18ClN7O3Cor e Forma:SolidPeso molecular:487.9Dyrk1A/B-IN-1
Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.Fórmula:C21H17N3O2S2Cor e Forma:SolidPeso molecular:407.51TY-011
CAS:TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Fórmula:C18H16ClN5Cor e Forma:SolidPeso molecular:337.81GSK3-IN-10
CAS:GSK3-IN-10 (Compound 4) is a multi-target inhibitor primarily affecting GSK3α and GSK3β with IC50 values of 1.0 nM and 2.0 nM, respectively. It inhibits the activation of β-catenin, enhances neuronal survival, and provides protective effects against endoplasmic reticulum stress.Fórmula:C17H18F2N4O3Cor e Forma:SolidPeso molecular:364.347Aurora A inhibitor 4
CAS:Aurora A inhibitor4 (compound C9) is a potent inhibitor of Aurora A, with GI50 values of 4.26 μM in DU 145 cells and 7.08 μM in HT-29 cells.Fórmula:C22H23N5O3Cor e Forma:SolidPeso molecular:405.45Werner syndrome RecQ helicase-IN-2
CAS:Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Fórmula:C32H34F3N9O5Pureza:99.02%Cor e Forma:SolidPeso molecular:681.673-deoxy-3-fluoro-β-D-Ribofuranose 25
CAS:Compound 25, β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate), exhibits strong activity in inhibiting the growth of tumor cells [1].Fórmula:C17H19FO7Cor e Forma:SolidPeso molecular:354.33Dyrk1A-IN-2
Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.Fórmula:C27H32N6O4Cor e Forma:SolidPeso molecular:504.582′-OMe-ADP
CAS:2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.Fórmula:C11H17N5O10P2Cor e Forma:SolidPeso molecular:441.23(Rac)-Plevitrexed
CAS:(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).Fórmula:C26H25FN8O4Pureza:98%Cor e Forma:SolidPeso molecular:532.53CDK/HDAC-IN-1
CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.Fórmula:C20H18N4O4Cor e Forma:SolidPeso molecular:378.38WEE1-IN-10
CAS:WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.Fórmula:C28H30Cl2N8OPureza:98.18%Cor e Forma:SolidPeso molecular:565.5YKL-1-116
CAS:YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.Fórmula:C34H38N8O3Pureza:98%Cor e Forma:SolidPeso molecular:606.72OSI-7904L free acid
CAS:OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.Fórmula:C27H24N4O6Pureza:98%Cor e Forma:SolidPeso molecular:500.5T-2513 hydrochloride
CAS:T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.Fórmula:C25H28ClN3O5Cor e Forma:SolidPeso molecular:485.9612(S)-HETE
CAS:Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.
Fórmula:C20H32O3Cor e Forma:SolidPeso molecular:320.47c-Myc inhibitor 4
Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.Fórmula:C26H33FN6O3Cor e Forma:SolidPeso molecular:496.58CDK4-IN-1
CAS:CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Fórmula:C22H29ClN8Pureza:98%Cor e Forma:SolidPeso molecular:440.97Z4P
CAS:Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB), inhibited glioblastoma growth and recurrence in combination with Temozolomide.Fórmula:C19H24N2O2Pureza:98.99%Cor e Forma:SolidPeso molecular:312.41Ref: TM-T87658
1mg77,00€5mg167,00€10mg268,00€25mg537,00€50mg858,00€100mg1.333,00€200mg1.783,00€1mL*10mM (DMSO)178,00€Tripolin B
CAS:Tripolin B is an ATP-competitive inhibitor of Aurora kinases, with IC50 values of 2.5 µM and 6 µM for Aurora A and Aurora B kinases, respectively. However, it exhibits no inhibitory effect within cells.Fórmula:C12H9N3OPeso molecular:211.22Cdc7-IN-8
CAS:Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)Fórmula:C19H21N5O2Cor e Forma:SolidPeso molecular:351.40DDO-6079
CAS:DDO-6079 is an efficient CDC37 inhibitor. It suppresses the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes by binding to an allosteric site on CDC37. Additionally, DDO-6079 reduces the thermal stability of CDK6.Fórmula:C18H13ClN2O3Cor e Forma:SolidPeso molecular:340.76Aurora B inhibitor 1
CAS:Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Fórmula:C25H26ClF2N7O2Pureza:98.37%Cor e Forma:SolidPeso molecular:529.972-CEES
CAS:2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.Fórmula:C4H9ClSCor e Forma:SolidPeso molecular:124.632LNA-GDP
CAS:LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.Fórmula:C11H15N5O11P2Cor e Forma:SolidPeso molecular:455.21Dyrk1A/α-synuclein-IN-2
Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).Fórmula:C21H16N4O4SCor e Forma:SolidPeso molecular:420.44Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Fórmula:C29H33ClN4O3SCor e Forma:SolidPeso molecular:553.12RAD51-IN-7
CAS:RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)Fórmula:C25H31N5O4S2Cor e Forma:SolidPeso molecular:529.67BRD-7880
CAS:BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.Fórmula:C32H38N4O7Cor e Forma:SolidPeso molecular:590.67PCNA-IN-1
CAS:PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.Fórmula:C19H18I3NO3Cor e Forma:SolidPeso molecular:689.065WEE1/PKMYT1-IN-1
CAS:WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.
Fórmula:C16H16N4O3Cor e Forma:SolidPeso molecular:312.323Elacytarabine
CAS:Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.Fórmula:C27H45N3O6Pureza:97.69%Cor e Forma:SolidPeso molecular:507.66VCPIP1-IN-1
CAS:VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Fórmula:C13H15ClN2O2Pureza:99.3%Cor e Forma:SolidPeso molecular:266.72Ref: TM-T88664
1mg47,00€5mg92,00€10mg145,00€25mg281,00€50mg447,00€100mg715,00€200mg964,00€1mL*10mM (DMSO)101,00€HRO761
CAS:HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Fórmula:C31H31ClF3N9O5Pureza:98.74% - 99.62%Cor e Forma:SolidPeso molecular:702.08Ref: TM-T72107
1mg57,00€5mg118,00€10mg167,00€25mg280,00€50mg475,00€100mg708,00€1mL*10mM (DMSO)778,00€GFB-12811
CAS:GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Fórmula:C22H23F4N5OPureza:98.88%Cor e Forma:SolidPeso molecular:449.44USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Fórmula:C22H23N3O3Pureza:99.509% - 99.81%Cor e Forma:SolidPeso molecular:377.44CTPS1-IN-1
CAS:CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Fórmula:C21H22N6O4S2Pureza:99.46%Cor e Forma:SolidPeso molecular:486.57SR 11302
CAS:SR 11302 is an inhibitor of activator protein-1 (AP-1).Fórmula:C26H32O2Pureza:98.65%Cor e Forma:SolidPeso molecular:376.53Ref: TM-T23384
1mg93,00€5mg137,00€10mg205,00€25mg356,00€50mg587,00€100mg888,00€1mL*10mM (DMSO)150,00€LY3143921 hydrate
CAS:LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Fórmula:C16H14FN5O2Pureza:98.43%Cor e Forma:SolidPeso molecular:327.31INCB086550
CAS:INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Fórmula:C41H39N7O4Pureza:98.49%Cor e Forma:SolidPeso molecular:693.79Bicyclomycin benzoate
CAS:Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.Fórmula:C19H22N2O8Cor e Forma:SolidPeso molecular:406.39Troxacitabine
CAS:Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.Fórmula:C8H11N3O4Pureza:98%Cor e Forma:SolidPeso molecular:213.192'-Deoxy-2'-fluoro-5-iodouridine
CAS:2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.Fórmula:C9H10FIN2O5Cor e Forma:SolidPeso molecular:372.095'-DMT-3'-TBDMS-ibu-rG
CAS:5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Fórmula:C41H51N5O8SiCor e Forma:SolidPeso molecular:769.96N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS:N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.Fórmula:C38H35N5O6Cor e Forma:SolidPeso molecular:657.7273BrB-PP1
CAS:3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase, particularly effective against protein kinases with mutations in the ATP-binding pocket, such as the Thr97 mutation within Sty1's ATP-binding pocket.Fórmula:C16H18BrN5Cor e Forma:SolidPeso molecular:360.2595'-O-DMT-N6-ibu-dA
CAS:5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Fórmula:C35H37N5O6Cor e Forma:SolidPeso molecular:623.71Tanuxiciclib
CAS:Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.Fórmula:C15H13FN6OCor e Forma:SolidPeso molecular:312.308PLK1-IN-6
PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.
Fórmula:C28H37N9O3Cor e Forma:SolidPeso molecular:547.65Formycin A
CAS:Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.Fórmula:C10H13N5O4Pureza:98%Cor e Forma:SolidPeso molecular:267.24Ethynylcytidine
CAS:Ethynylcytidine is a nucleoside antimetabolite.Fórmula:C11H13N3O5Pureza:98%Cor e Forma:SolidPeso molecular:267.24GSK-3/CDK5/CDK2-IN-1
CAS:GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].Fórmula:C21H22N4O2Cor e Forma:SolidPeso molecular:362.433NSC639828
CAS:NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Fórmula:C18H13BrClN5O3Cor e Forma:SolidPeso molecular:462.696-Amino-5-nitropyridin-2-one
CAS:6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.Fórmula:C5H5N3O3Pureza:98%Cor e Forma:SolidPeso molecular:155.11Ribocil-C
CAS:Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.Fórmula:C21H21N7OSPureza:98%Cor e Forma:SolidPeso molecular:419.5MitoE10
CAS:MitoE10 is an effective mitochondrial targeting antioxidant.Fórmula:C42H55O5PSCor e Forma:SolidPeso molecular:702.92Tibremciclib
CAS:Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].
Fórmula:C28H32F2N8Pureza:98%Cor e Forma:SolidPeso molecular:518.6PHI-101
CAS:PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.
Fórmula:C19H19FN4O2SPureza:99.4%Cor e Forma:SolidPeso molecular:386.44YK-2168
CAS:YK-2168 is a differentiated selective inhibitor of CDK9.
Fórmula:C16H18ClN5Cor e Forma:SolidPeso molecular:315.80Ref: TM-T200769
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