Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(94 produtos)
- CDK(500 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(224 produtos)
- Cinesina(66 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(261 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(70 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(69 produtos)
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Foram encontrados 3477 produtos de "Ciclo celular/Ponto de verificação"
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5-Iodo-indirubin-3'-monoxime
CAS:<p>5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s</p>Fórmula:C16H10IN3O2Cor e Forma:SolidPeso molecular:403.17Galidesivir hydrochloride
CAS:<p>Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.</p>Fórmula:C11H16ClN5O3Pureza:98%Cor e Forma:SolidPeso molecular:301.73Zaurategrast
CAS:<p>Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.</p>Fórmula:C26H25BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:521.41Riviciclib
CAS:<p>Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.</p>Fórmula:C21H20ClNO5Pureza:98%Cor e Forma:SolidPeso molecular:401.84Kif15-IN-2
CAS:<p>Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.</p>Fórmula:C20H20N6O4SPureza:98.17%Cor e Forma:SolidPeso molecular:440.48KY386
CAS:<p>KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM.</p>Fórmula:C21H19N5O2SCor e Forma:SolidPeso molecular:405.47Xylocydine
CAS:<p>Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.</p>Fórmula:C12H14BrN5O5Cor e Forma:SolidPeso molecular:388.175,6,7,8-Tetrahydro-8-deazahomofolic acid
CAS:<p>5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.</p>Fórmula:C21H26N6O6Cor e Forma:SolidPeso molecular:458.47UNC-2170
CAS:<p>UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.</p>Fórmula:C14H21BrN2OPureza:97.44%Cor e Forma:SolidPeso molecular:313.23USP7-IN-13
CAS:<p>USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].</p>Fórmula:C24H28N4O3Cor e Forma:SolidPeso molecular:420.5AAPK-25
CAS:<p>AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.</p>Fórmula:C21H13Cl2N3O2SPureza:97.05%Cor e Forma:SolidPeso molecular:442.32Cdc7-IN-12
CAS:<p>Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).</p>Fórmula:C16H14N2O2SCor e Forma:SolidPeso molecular:298.36BMT-090605
CAS:<p>BMT-090605: AAK1 inhibitor (IC50=0.6 nM), also affects BIKE (45 nM) and GAK (60 nM), has antinociceptive properties.</p>Fórmula:C21H24N4O2Pureza:98%Cor e Forma:SolidPeso molecular:364.44hDHODH-IN-1
CAS:<p>hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.</p>Fórmula:C17H14N2O2Pureza:99.97%Cor e Forma:SolidPeso molecular:278.31EHT 5372
CAS:<p>EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.</p>Fórmula:C17H11Cl2N5OSCor e Forma:SolidPeso molecular:404.27Butylparaben sodium
CAS:<p>Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and/or RNA and protein synthesis [1</p>Fórmula:C11H13NaO3Pureza:98%Cor e Forma:SolidPeso molecular:216.21PDD00031705
CAS:<p>PDD00031705 is a benzimidazolone core cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor.</p>Fórmula:C20H22N6O3S3Pureza:98%Cor e Forma:SolidPeso molecular:490.62T521
CAS:<p>T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.</p>Fórmula:C17H14FNO5S2Pureza:99.67%Cor e Forma:SolidPeso molecular:395.43WRN inhibitor 1
CAS:<p>WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain.</p>Fórmula:C16H13FN2O4SPureza:98%Cor e Forma:SolidPeso molecular:348.35ROCK-IN-10
CAS:<p>ROCK-IN-10 (compound 50) serves as a powerful inhibitor of ROCK, exhibiting IC50 values of 6 nM for ROCK1 and 4 nM for ROCK2, respectively. It demonstrates over 100-fold selectivity towards ROCK1 and ROCK2 when compared to other kinases [1].</p>Fórmula:C25H25N5O3Cor e Forma:SolidPeso molecular:443.507PD-L1-IN-2
CAS:<p>PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity.</p>Fórmula:C33H38N4O6Pureza:98%Cor e Forma:SolidPeso molecular:586.68JNJ-26076713
CAS:<p>JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.</p>Fórmula:C29H38N4O3Pureza:98%Cor e Forma:SolidPeso molecular:490.64Myt1-IN-2
CAS:<p>Myt1-IN-2, a highly potent Myt1 inhibitor, exhibits remarkable anticancer properties with an IC50 value below 10 nM (WO2021195782A1; compound 28) [1].</p>Fórmula:C18H16N6O2SCor e Forma:SolidPeso molecular:380.42Synstatin (92-119)
CAS:<p>Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and</p>Fórmula:C133H207N35O46Pureza:98%Cor e Forma:SolidPeso molecular:3032.27Cdk4 Inhibitor
CAS:<p>PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.</p>Fórmula:C20H10BrN3O2Cor e Forma:SolidPeso molecular:404.2CCT241533
CAS:<p>CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Fórmula:C23H27FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:442.48PVZB1194
CAS:<p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>Fórmula:C13H9F4NO2SPureza:98%Cor e Forma:SolidPeso molecular:319.28PF-6808472
CAS:<p>PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.</p>Fórmula:C25H27FN8O3SPureza:99.02%Cor e Forma:SolidPeso molecular:538.6USP1-IN-6
CAS:<p>USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.</p>Fórmula:C29H27F3N8OCor e Forma:SolidPeso molecular:560.57PLK4-IN-4
CAS:<p>PLK4-IN-4 (compound 22), a potent inhibitor of PLK4, exhibits an IC50 value of 7.9 nM, suggesting its potential use in cancer research [1].</p>Fórmula:C21H23F2N9Cor e Forma:SolidPeso molecular:439.46SB-267268
CAS:<p>SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).</p>Fórmula:C22H24F3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:451.44CCT-251921
CAS:<p>CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).</p>Fórmula:C21H23ClN6OPureza:99.07%Cor e Forma:SolidPeso molecular:410.9Inixaciclib
CAS:<p>Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.</p>Fórmula:C26H30F2N6OCor e Forma:SolidPeso molecular:480.55DNA Gyrase-IN-8
CAS:<p>DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].</p>Fórmula:C19H14BrN5OPureza:98%Cor e Forma:SolidPeso molecular:408.25Integrin Antagonists 27
CAS:<p>Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.</p>Fórmula:C24H20N4O5Cor e Forma:SolidPeso molecular:444.44Litronesib
CAS:<p>Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.</p>Fórmula:C23H37N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:511.7Tirofiban HCl
CAS:<p>Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.</p>Fórmula:C22H37ClN2O5SPureza:98%Cor e Forma:SolidPeso molecular:477.06ML 315 hydrochloride
CAS:<p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>Fórmula:C18H14Cl3N3O2Cor e Forma:SolidPeso molecular:410.682CDK4-IN-2
CAS:<p>CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].</p>Fórmula:C22H26F2N6O4SPureza:98%Cor e Forma:SolidPeso molecular:508.54Bisindolylmaleimide X hydrochloride
CAS:<p>Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).</p>Fórmula:C26H25ClN4O2Pureza:99.23%Cor e Forma:SolidPeso molecular:460.96BMT-090605 hydrochloride
CAS:<p>BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.</p>Fórmula:C21H25ClN4O2Cor e Forma:SolidPeso molecular:400.91αvβ6 integrin inhibitor 2
CAS:<p>αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.</p>Fórmula:C21H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:386.49USP7-IN-12
CAS:<p>USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].</p>Fórmula:C29H28ClFN4O2SCor e Forma:SolidPeso molecular:551.07NTRC 0066-0
CAS:<p>NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.</p>Fórmula:C33H39N7O2Pureza:98.30%Cor e Forma:SolidPeso molecular:565.71Trovafloxacin mesylate
CAS:<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Fórmula:C21H19F3N4O6SPureza:99.18%Cor e Forma:SolidPeso molecular:512.46Thymectacin
CAS:<p>Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.</p>Fórmula:C21H25BrN3O9PPureza:97.05% - 99.49%Cor e Forma:SolidPeso molecular:574.32CF53
CAS:<p>CF53: potent, selective oral BET inhibitor; Ki <1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.</p>Fórmula:C24H25N7O2Pureza:99.72%Cor e Forma:SolidPeso molecular:443.5LNA-Adenosine
CAS:<p>LNA-Adenosine (LNA-A) is a nucleoside analogue that acts as a ligand for adenosine A3 receptors.</p>Fórmula:C11H13N5O4Pureza:99.15%Cor e Forma:SolidPeso molecular:279.25SMN-C3
CAS:<p>SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).</p>Fórmula:C24H28N6OPureza:99.01% - 99.05%Cor e Forma:SolidPeso molecular:416.52AZD4573
CAS:<p>AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.</p>Fórmula:C22H28ClN5O2Pureza:99% - 99.51%Cor e Forma:SolidPeso molecular:429.94LY3295668
CAS:<p>LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.</p>Fórmula:C24H26ClF2N5O2Pureza:99.68%Cor e Forma:SolidPeso molecular:489.95DHX9-IN-2
CAS:<p>DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.</p>Fórmula:C18H16ClN3O3S2Pureza:98%Cor e Forma:SolidPeso molecular:421.92BDP9066
CAS:<p>BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.</p>Fórmula:C20H24N6Pureza:98.18%Cor e Forma:SolidPeso molecular:348.44Cdk1/2 Inhibitor III
CAS:<p>Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.</p>Fórmula:C15H13F2N7O2S2Pureza:99.07%Cor e Forma:SolidPeso molecular:425.44αvβ1 integrin-IN-1
CAS:<p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>Fórmula:C26H34N6O6SPureza:99.74% - >99.99%Cor e Forma:SolidPeso molecular:558.65Roxifiban acetate
CAS:<p>Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used in</p>Fórmula:C23H33N5O8Pureza:97.91% - 98.36%Cor e Forma:SolidPeso molecular:507.54CFI-402257
CAS:<p>CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.</p>Fórmula:C28H30N6O3Pureza:96.66% - 99.51%Cor e Forma:SolidPeso molecular:498.58Debio-0123
CAS:<p>Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.</p>Fórmula:C26H28Cl2N6OPureza:99.93%Cor e Forma:SolidPeso molecular:511.45Plogosertib
CAS:<p>Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.</p>Fórmula:C34H48N8O3Pureza:99.22% - 99.85%Cor e Forma:SolidPeso molecular:616.797PD-L1-IN-3
CAS:<p>PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.</p>Fórmula:C19H15ClFN2OSPureza:99.47%Cor e Forma:SoildPeso molecular:373.85CCT129202
CAS:<p>CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.</p>Fórmula:C23H25ClN8OSPureza:98.14%Cor e Forma:SolidPeso molecular:497.02B I09
CAS:<p>B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.</p>Fórmula:C16H17NO5Pureza:98.80%Cor e Forma:SolidPeso molecular:303.31(R)-Simurosertib
CAS:<p>(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.</p>Fórmula:C17H19N5OSPureza:99.89%Cor e Forma:SolidPeso molecular:341.43Sorivudine
CAS:<p>Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.</p>Fórmula:C11H13BrN2O6Pureza:99.74%Cor e Forma:SolidPeso molecular:349.13Lomibuvir
CAS:<p>Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.</p>Fórmula:C25H35NO4SPureza:99.83%Cor e Forma:SolidPeso molecular:445.61CLK1/4-IN-1
<p>CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.</p>Fórmula:C18H14ClNO4SCor e Forma:SolidPeso molecular:375.83PAIR2
CAS:<p>PAIR2 is a selective IRE1α RNase partial antagonist, blocking its ATP site and preventing KIRA from hindering XBP1 splicing.</p>Fórmula:C27H26F4N6O3SCor e Forma:SolidPeso molecular:590.592-Amino-2'-fluoro-2'-deoxyadenosine
CAS:<p>2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.</p>Fórmula:C10H13FN6O3Cor e Forma:SolidPeso molecular:284.25CTX-712
CAS:<p>CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.</p>Fórmula:C19H17FN8O2Cor e Forma:SolidPeso molecular:408.392'-Deoxycytidine hydrate
CAS:<p>2'-Deoxycytidine (Deoxycytidine) hydrate is a component of nucleic acids.</p>Fórmula:C9H15N3O5Cor e Forma:SolidPeso molecular:245.23KWR095
CAS:<p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>Fórmula:C33H31ClF3N9O4Cor e Forma:SolidPeso molecular:710.105Terpendole E
CAS:<p>Terpendole E is an atypical L5 site inhibitor.</p>Fórmula:C28H39NO3Cor e Forma:SolidPeso molecular:437.61ATIC-IN-2
CAS:<p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>Fórmula:C4H4N4O3SCor e Forma:SolidPeso molecular:188.165DENV-IN-6
CAS:<p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>Fórmula:C23H26ClFN4OSCor e Forma:SolidPeso molecular:461MtTMPK-IN-3
CAS:<p>MtTMPK-IN-3 inhibits Mycobacterium tuberculosis kinase with IC50 0.12μM, MIC 12.5μM on Mtb, cytotoxic EC50 12.5μM on MRC-5 cells.</p>Fórmula:C23H23Cl2N3O3Cor e Forma:SolidPeso molecular:460.35MtTMPK-IN-1
<p>MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.</p>Fórmula:C22H24N4O3Cor e Forma:SolidPeso molecular:392.45CDK7-IN-18
CAS:<p>CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.</p>Fórmula:C22H24F3N7OSCor e Forma:SolidPeso molecular:491.53LY309887
CAS:<p>LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.</p>Fórmula:C19H23N5O6SCor e Forma:SolidPeso molecular:449.48IRE1α kinase-IN-4
CAS:<p>IRE1α kinase-IN-4 (compound 6) is a potent inhibitor of IRE1α, exhibiting a Ki value of 140 nM. It acts as an ATP-competitive ligand for IRE1α [1].</p>Fórmula:C29H31N7O2Cor e Forma:SolidPeso molecular:509.6Polθ-IN-5
CAS:<p>Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.</p>Fórmula:C23H18ClF2N7O3SCor e Forma:SolidPeso molecular:545.95GSK_WRN4
CAS:<p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>Fórmula:C16H20N2O4SPureza:99.95%Cor e Forma:SolidPeso molecular:336.41GHP-88309
CAS:<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Fórmula:C16H11FN2OCor e Forma:SolidPeso molecular:266.27CDK4/6-IN-24
CAS:<p>CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.</p>Fórmula:C32H41N7O3Cor e Forma:SolidPeso molecular:571.713Valopicitabine
CAS:<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Fórmula:C15H24N4O6Pureza:98%Cor e Forma:SolidPeso molecular:356.37Pol I-IN-1
<p>Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition</p>Fórmula:C23H22N4O2Cor e Forma:SolidPeso molecular:386.45L-2'-Fd4C
CAS:<p>L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].</p>Fórmula:C9H10FN3O3Cor e Forma:SolidPeso molecular:227.196K465
CAS:<p>6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.</p>Fórmula:C26H33ClFN9OPureza:99.78%Cor e Forma:SolidPeso molecular:542.05EFdA-TP tetrasodium
CAS:<p>EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.</p>Fórmula:C12H11FN5Na4O12P3Pureza:98%Cor e Forma:SolidPeso molecular:621.1214α-Demethylase/DNA Gyrase-IN-1
<p>14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.</p>Fórmula:C26H22N4O4Cor e Forma:SolidPeso molecular:454.48PKMYT1-IN-9
CAS:<p>PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.</p>Fórmula:C17H14FN5OCor e Forma:SolidPeso molecular:323.324MtTMPK-IN-5
<p>MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.</p>Fórmula:C21H23N5O2Cor e Forma:SolidPeso molecular:377.44CHK1-IN-2
CAS:<p>CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).</p>Fórmula:C20H22N4OSPureza:98%Cor e Forma:SolidPeso molecular:366.48CDK9/PARP-IN-1
CAS:<p>CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.</p>Fórmula:C38H34F2N8O3Cor e Forma:SolidPeso molecular:688.725Aurora A inhibitor 1
CAS:<p>Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)</p>Fórmula:C25H28ClF2N5O2Cor e Forma:SolidPeso molecular:503.97Werner syndrome RecQ helicase-IN-2
CAS:<p>Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.</p>Fórmula:C32H34F3N9O5Pureza:99.02%Cor e Forma:SolidPeso molecular:681.67RAD51-IN-5
CAS:<p>RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)</p>Fórmula:C26H38N4O5S2Cor e Forma:SolidPeso molecular:550.73Mazethramycin
CAS:<p>Mazethramycin is an antitumor antibiotic that exerts its effects by disrupting DNA replication and RNA synthesis within cells. It is utilized in cancer research.</p>Fórmula:C17H19N3O4Peso molecular:329.35Zorubicin
CAS:<p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>Fórmula:C34H35N3O10Cor e Forma:SolidPeso molecular:645.66TASIN-30
CAS:<p>TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.</p>Fórmula:C18H30N2O3SCor e Forma:SolidPeso molecular:354.512′-OMe-ADP
CAS:<p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>Fórmula:C11H17N5O10P2Cor e Forma:SolidPeso molecular:441.23
