Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(548 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(49 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(278 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(275 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3943 produtos de "Ciclo celular/Ponto de verificação"
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ERCC1-XPF-IN-2
CAS:ERCC1-XPF-IN-2: Nucleotide repair active, boosts cisplatin, inhibits ERCC1-XPF (IC50: 0.6 μM).
Fórmula:C15H13Cl2NO3Pureza:98.21%Cor e Forma:SolidPeso molecular:326.17Ref: TM-T60904
2mg40,00€5mg60,00€10mg96,00€25mg187,00€50mg311,00€100mg472,00€200mg658,00€500mg1.026,00€Caracemide
CAS:Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.Fórmula:C6H11N3O4Pureza:99.8%Cor e Forma:SolidPeso molecular:189.17L82
CAS:L82: A selective, non-competitive DNA Lig1 inhibitor with anti-proliferative effects on breast cancer cells. IC50=12 μM.Fórmula:C11H8ClN5O4Pureza:98.06% - 98.91%Cor e Forma:SolidPeso molecular:309.67Ref: TM-T60753
5mg66,00€1mL*10mM (DMSO)73,00€10mg98,00€25mg177,00€50mg281,00€100mg447,00€500mg973,00€116-9e
CAS:116-9e (MAL2-11B) is an Hsp70 chaperone DNAJA1 inhibitor with antiviral properties, inhibits SV40 replication, and can be used to study cancer drug resistance.Fórmula:C31H32N2O5Pureza:99.55%Cor e Forma:SolidPeso molecular:512.6Ref: TM-T25770
1mL*10mM (DMSO)34,00€1mg50,00€5mg105,00€10mg170,00€25mg355,00€50mg595,00€100mg862,00€200mg1.153,00€Poloxin-2
CAS:Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.Fórmula:C16H15NO3Pureza:99.67%Cor e Forma:SolidPeso molecular:269.3CLK-IN-T3
CAS:CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.Fórmula:C28H30N6O2Pureza:99.61%Cor e Forma:SolidPeso molecular:482.58Ref: TM-T14980
1mg47,00€2mg62,00€5mg92,00€10mg160,00€25mg289,00€50mg505,00€100mg787,00€200mg1.063,00€9-Isopropylolomoucine
CAS:9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.Fórmula:C17H22N6OPureza:99.82%Cor e Forma:SolidPeso molecular:326.4Ref: TM-T23589
1mg315,00€1mL*10mM (DMSO)607,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€CDK-IN-2
CAS:CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Fórmula:C18H19ClFN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:363.81Ref: TM-TQ0078
1mg38,00€2mg51,00€1mL*10mM (DMSO)92,00€5mg96,00€10mg138,00€25mg258,00€50mg376,00€100mg532,00€500mg1.063,00€ML 315
CAS:ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.Fórmula:C18H13Cl2N3O2Pureza:99.08%Cor e Forma:SolidPeso molecular:374.22ProINDY
CAS:ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.Fórmula:C14H15NO3SPureza:97.19%Cor e Forma:SolidPeso molecular:277.34USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Fórmula:C17H16N6O2SPureza:98.84% - 99.59%Cor e Forma:SolidPeso molecular:368.41P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Fórmula:C12H9NO3S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:279.33Ref: TM-T28284
1mg137,00€1mL*10mM (DMSO)239,00€5mg314,00€10mg427,00€25mg600,00€50mg798,00€100mg1.099,00€200mg1.468,00€SMN-C2
CAS:SMN-C2, a SMN2 gene splicing regulator, is an RNA-binding ligand that regulates pre-mRNA splicing and has potential for studying spinal muscular atrophy.Fórmula:C24H27N5O2Pureza:99.14%Cor e Forma:SolidPeso molecular:417.5Ref: TM-T73475
1mg105,00€5mg250,00€1mL*10mM (DMSO)268,00€10mg401,00€25mg795,00€50mg982,00€100mg1.324,00€UMK57
CAS:UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,Fórmula:C17H17N3SPureza:99.86%Cor e Forma:SolidPeso molecular:295.4CRT-0105950
CAS:CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C21H16ClN3OSPureza:99.78% - 99.86%Cor e Forma:SolidPeso molecular:393.89Ref: TM-T23917
1mg62,00€5mg133,00€1mL*10mM (DMSO)147,00€10mg205,00€25mg416,00€50mg670,00€100mg1.071,00€GRK6-IN-1
CAS:GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Fórmula:C22H23ClN6O2Pureza:99.37%Cor e Forma:SolidPeso molecular:438.91Ref: TM-T62518
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg178,00€25mg409,00€50mg708,00€100mg1.153,00€Setrobuvir
CAS:Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension withFórmula:C25H25FN4O6S2Pureza:99.95% - 99.97%Cor e Forma:SolidPeso molecular:560.62Ref: TM-T28762
1mg216,00€5mg540,00€1mL*10mM (DMSO)698,00€10mg770,00€25mg1.153,00€50mg1.575,00€100mg2.125,00€500mg4.258,00€ZIM
CAS:ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.Fórmula:C20H19N3O3Pureza:99.85%Cor e Forma:SolidPeso molecular:349.38DDRI-18
CAS:DDRI-18 is an inhibitor that regulates the DNA damage response, has anticancer activity, and inhibits non-homologous end-joining (NHEJ) DNA repair.Fórmula:C26H20N6Pureza:98%Cor e Forma:SolidPeso molecular:416.48GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Fórmula:C17H12FN3Pureza:97.09%Cor e Forma:SolidPeso molecular:277.3Ref: TM-T11485
1mg39,00€2mg50,00€5mg82,00€1mL*10mM (DMSO)90,00€10mg120,00€25mg236,00€50mg356,00€100mg537,00€200mg762,00€IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Fórmula:C23H21Cl2NO5Pureza:98%Cor e Forma:SolidPeso molecular:462.32L-739758
CAS:L-739758 is a glycoprotein IIb/IIIa inhibitor.Fórmula:C22H26N4O5S3Cor e Forma:SolidPeso molecular:522.66Anti-hepatic fibrosis agent 2
CAS:Compound 6k, also known as Anti-hepatic fibrosis agent 2, is an orally active inhibitor of the COL1A1 enzyme and exerts anti-fibrogenic effects by targeting theFórmula:C26H41N3OCor e Forma:SolidPeso molecular:411.62Pelitrexol
CAS:Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, block the cell cycle in the s-phase, with antiproliferative activity,NSCLC .Fórmula:C20H25N5O6SPureza:98.03%Cor e Forma:SolidPeso molecular:463.51CCT239065
CAS:CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600EBRAF and LCK inhibitor.Fórmula:C29H29N7O3SCor e Forma:SolidPeso molecular:555.65Cytidine 3'-monophosphate
CAS:Cytidine 3'-monophosphate, a ribonucleotide, results from the hydrolysis of cytidine 2',3'-cyclic monophosphate via RNase—a process that cytidine 3'-monophosphate itself inhibits. Additionally, it can be dephosphorylated to cytidine by 3'-nucleotidase.Fórmula:C9H14N3O8PCor e Forma:SolidPeso molecular:323.2Lerociclib
CAS:Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.Fórmula:C26H34N8OPureza:99%Cor e Forma:SolidPeso molecular:474.6Netropsin dihydrochloride
CAS:Netropsin dihydrochloride, a small MGB, blocks topoisomerase I/II, hindering cleavable complex stabilization.Fórmula:C18H28Cl2N10O3Pureza:98%Cor e Forma:SolidPeso molecular:503.39Myt1-IN-3
CAS:Myt1-IN-3 is a potent inhibitor of Myt1 (IC50 <10 nM) [1].Fórmula:C18H19N5O2Cor e Forma:SolidPeso molecular:337.38Integrin Antagonists 27
CAS:Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.Fórmula:C24H20N4O5Cor e Forma:SolidPeso molecular:444.44TC-I 15
CAS:α2β1 integrin inhibitorFórmula:C23H28N4O6S2Pureza:98%Cor e Forma:SolidPeso molecular:520.62MU-380
CAS:MU-380 is an effective and selective inhibitor of CHK1.Fórmula:C15H15BrF3N7Cor e Forma:SolidPeso molecular:430.23CCT-251921
CAS:CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Fórmula:C21H23ClN6OPureza:99.07%Cor e Forma:SolidPeso molecular:410.9Ref: TM-T14901
1mg90,00€1mL*10mM (DMSO)192,00€5mg210,00€10mg308,00€25mg520,00€50mg745,00€100mg1.018,00€SB-743921 free base
CAS:SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).Fórmula:C31H33ClN2O3Pureza:98%Cor e Forma:SolidPeso molecular:517.06DYRKs-IN-2
CAS:DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.Fórmula:C32H38ClN9O3Pureza:98%Cor e Forma:SolidPeso molecular:632.16AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Fórmula:C21H13Cl2N3O2SPureza:97.05%Cor e Forma:SolidPeso molecular:442.32Ref: TM-T10215
1mg54,00€5mg118,00€1mL*10mM (DMSO)131,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€BMT-090605 hydrochloride
CAS:BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.Fórmula:C21H25ClN4O2Cor e Forma:SolidPeso molecular:400.91KIF18A-IN-7
CAS:KIF18A-IN-7 is an orally active inhibitor targeting KIF18A, demonstrating potent inhibition with an IC50 value of 9.4 nM against the microtubule-dependentFórmula:C27H35N3O5S2Cor e Forma:SoildPeso molecular:545.71αvβ6 integrin inhibitor 2
CAS:αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.Fórmula:C21H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:386.49USP1-IN-3
CAS:USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Fórmula:C27H24F3N7OCor e Forma:SolidPeso molecular:519.52WRN inhibitor 1
CAS:WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain.Fórmula:C16H13FN2O4SPureza:98%Cor e Forma:SolidPeso molecular:348.35PLK1/p38γ-IN-1
CAS:PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellularFórmula:C21H26ClN3O2Pureza:98%Cor e Forma:SolidPeso molecular:387.9CDK4/6-IN-15
CAS:CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.Fórmula:C21H27FN8SCor e Forma:SolidPeso molecular:442.56RAD51-IN-4
CAS:RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.Fórmula:C31H34FN5O5S2Cor e Forma:SolidPeso molecular:639.76VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Fórmula:C31H34N6O3Pureza:98%Cor e Forma:SolidPeso molecular:538.64DNA polymerase-IN-3
CAS:DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications inFórmula:C13H12O4Pureza:98%Cor e Forma:SolidPeso molecular:232.23Carotegrast
CAS:Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.Fórmula:C27H24Cl2N4O5Cor e Forma:SolidPeso molecular:555.41ON 108600
CAS:ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.Fórmula:C22H14Cl2N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:537.39KY386
CAS:KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM.Fórmula:C21H19N5O2SCor e Forma:SolidPeso molecular:405.47NSC15520
CAS:NSC15520 is an RPA inhibitor that inhibits helical destabilization of double-stranded DNA oligonucleotides and can be used to study DNA damage repair.Fórmula:C24H34O6Cor e Forma:SolidPeso molecular:418.52Votoplam
CAS:Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1].Fórmula:C21H25N9OPureza:98%Cor e Forma:SolidPeso molecular:419.48BMT-090605
CAS:BMT-090605: AAK1 inhibitor (IC50=0.6 nM), also affects BIKE (45 nM) and GAK (60 nM), has antinociceptive properties.Fórmula:C21H24N4O2Pureza:98%Cor e Forma:SolidPeso molecular:364.44CDK7-IN-14
CAS:CDK7-IN-14 (compound 3) is a pyrimidine-derived CDK7 inhibitor applicable for studying cancers associated with transcriptional dysregulation.Fórmula:C22H24F3N6OPPureza:99.24% - 99.48%Cor e Forma:SolidPeso molecular:476.43PD 121373
CAS:PD 121373, a Benzothiopyrano-indazole, inhibits nucleic acid synthesis, equally affecting DNA/RNA.Fórmula:C21H27N5OSCor e Forma:SolidPeso molecular:397.54SZ-015268
CAS:SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.Fórmula:C25H38N8O3Cor e Forma:SolidPeso molecular:498.62CDK/HDAC-IN-3
CAS:CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,Fórmula:C24H18Cl2N6O3Pureza:98%Cor e Forma:SolidPeso molecular:509.34c-Myc inhibitor 8
CAS:c-Myc inhibitor 8 suppresses cell growth in various cancers and is used in research.Fórmula:C19H12BrClF3NO3S2Cor e Forma:SolidPeso molecular:538.79Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Pureza:95%Cor e Forma:LiquidPeso molecular:143.64 kDaDNA Gyrase-IN-8
CAS:DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Fórmula:C19H14BrN5OPureza:98%Cor e Forma:SolidPeso molecular:408.255'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
CAS:5'-ODMT cEt N-Bzm5 C Phosphoramidite is a strong modified nucleic acid analog for antisense oligos.Fórmula:C49H56N5O9PCor e Forma:SolidPeso molecular:889.97Litronesib
CAS:Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.Fórmula:C23H37N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:511.7WRN inhibitor 2
CAS:WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].Fórmula:C15H11F3N2O5S2Pureza:98%Cor e Forma:SolidPeso molecular:420.38(2S,3R)-Voruciclib
CAS:(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.Fórmula:C22H19ClF3NO5Pureza:98%Cor e Forma:SolidPeso molecular:469.84Diazoketone methotrexate
CAS:Diazoketone methotrexate is an analog of methotrexate with potential antitumor activity.Fórmula:C21H22N10O4Cor e Forma:SolidPeso molecular:478.46Gly-Arg-Gly-Asp-Ser TFA
CAS:Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.Fórmula:C19H31F3N8O11Cor e Forma:SolidPeso molecular:604.49Xylocydine
CAS:Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.Fórmula:C12H14BrN5O5Cor e Forma:SolidPeso molecular:388.17Mevociclib
CAS:Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Fórmula:C31H35ClN8O2Pureza:98.02% - 98.02%Cor e Forma:SolidPeso molecular:587.11Amotosalen free base
CAS:Amotosalen is a Dermatologic Agent.Fórmula:C17H19NO4Cor e Forma:SolidPeso molecular:301.34L-Methioninamide hydrochloride
CAS:L-Methioninamide hydrochloride is a potent inhibitor of methionyl-tRNA synthetase that reduces the toxicity of CDDP.Fórmula:C5H13ClN2OSPureza:99.93%Cor e Forma:SolidPeso molecular:184.69Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.18%Cor e Forma:SolidPeso molecular:512.46GSK2850163
CAS:GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).Fórmula:C24H29Cl2N3OPureza:99.04%Cor e Forma:SolidPeso molecular:446.41N-desmethyl Netupitant
CAS:N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.Fórmula:C29H30F6N4OPureza:98%Cor e Forma:SolidPeso molecular:564.57Palbociclib orotate
CAS:Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.Fórmula:C29H33N9O6Pureza:98%Cor e Forma:SolidPeso molecular:603.63ROCK-IN-9
CAS:ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Fórmula:C20H20FN5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.45'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
CAS:5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].Fórmula:C49H54N7O8PCor e Forma:SolidPeso molecular:899.97H3B-968
CAS:H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonucleaseFórmula:C22H18F6N4O4SPureza:98%Cor e Forma:SolidPeso molecular:548.46PF-6808472
CAS:PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.Fórmula:C25H27FN8O3SPureza:99.02%Cor e Forma:SolidPeso molecular:538.6Cdc7-IN-12
CAS:Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).Fórmula:C16H14N2O2SCor e Forma:SolidPeso molecular:298.36USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Fórmula:C23H24ClN3O3Pureza:99.82%Cor e Forma:SolidPeso molecular:425.91Ref: TM-T13268
1mg92,00€5mg178,00€1mL*10mM (DMSO)207,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€Spirofylline
CAS:Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.Fórmula:C24H28N6O5Pureza:98%Cor e Forma:SolidPeso molecular:480.52Mefenidil
CAS:Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.Fórmula:C12H11N3Pureza:98.27%Cor e Forma:SolidPeso molecular:197.24DHX9-IN-6
CAS:DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.Fórmula:C23H18ClFN4O4S2Pureza:99.71%Cor e Forma:SolidPeso molecular:533ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Fórmula:C26H22ClF2N7OPureza:98%Cor e Forma:SolidPeso molecular:521.95TC-A 2317 hydrochloride
CAS:TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Fórmula:C19H29ClN6OPureza:98%Cor e Forma:SolidPeso molecular:392.93TAS-114
CAS:TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.Fórmula:C21H29N3O6SPureza:99.76%Cor e Forma:SolidPeso molecular:451.54JNJ-26076713
CAS:JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.Fórmula:C29H38N4O3Pureza:98%Cor e Forma:SolidPeso molecular:490.64CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Fórmula:C23H25ClFN5Pureza:99%Cor e Forma:SolidPeso molecular:425.93Ref: TM-T14918
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg266,00€25mg460,00€50mg668,00€100mg945,00€Abetimus
CAS:Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cellFórmula:C11H18N4O7Cor e Forma:SolidPeso molecular:318.28Butylparaben sodium
CAS:Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and/or RNA and protein synthesis [1Fórmula:C11H13NaO3Pureza:98%Cor e Forma:SolidPeso molecular:216.21(±)9(10)-DiHOME
CAS:(±)9(10)-DiHOME, the diol derivative of (±)9(10)-EpOME—a cytochrome P450-derived epoxide of linoleic acid also known as leukotoxin—is formed through the action of soluble epoxide hydrolase (sEH) in neutrophils. It exhibits toxicity towards Sf21 cells expressing sEH as well as tolacZ-expressing control cells, differing from leukotoxin which only harms sEH-containing cells. Furthermore, combined exposure to 9(10)- and 12(13)-DiHOME leads to cell death in rabbit renal proximal tubule cells by disrupting mitochondrial respiration, and causes lung injury, respiratory distress, and mortality in mice, highlighting its role as a toxic lipid mediator. Specifically, 9(10)-DiHOME has been associated with acute respiratory distress syndrome (ARDS), a severe and often deadly complication in patients with major burns. Elevated levels of this compound have been detected in the bronchoalveolar lavage fluid (BALF) of women, but not men, with chronic obstructive pulmonary disease (COPD), and its levels are also increased in patients with allergic asthma, indicating its significance in respiratory conditions.Fórmula:C18H34O4Cor e Forma:SolidPeso molecular:314.5CDK9-IN-8
CAS:CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).Fórmula:C31H32FN7O3Pureza:99.54%Cor e Forma:SolidPeso molecular:569.638-NH2-ATP tetrasodium
CAS:8-NH2-ATP tetrasodium, an inactive ATP variant, originates from 8-NH2-Ado tetrasodium, which triggers the apoptosis-associated cleavage of poly (ADP-ribose) polymerase [1] [2].Fórmula:C10H13N6Na4O13P3Cor e Forma:SolidPeso molecular:610.12RIOK2-IN-1
CAS:RIOK2-IN-1 (com 4) is a selective RIOK2 inhibitor with a Kd of 150 nM, though it demonstrates low cellular activity with an IC50 of 14,600 nM.Fórmula:C18H16N2OCor e Forma:SolidPeso molecular:276.33Tirofiban HCl
CAS:Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.
Fórmula:C22H37ClN2O5SPureza:98%Cor e Forma:SolidPeso molecular:477.06CI 972 anhydrous
CAS:CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.Fórmula:C11H12ClN5OSPureza:98%Cor e Forma:SolidPeso molecular:297.76Bexotegrast HCl
CAS:Bexotegrast (PLN-74809) inhibits αVβ1/αVβ6 integrins, preventing TGF-β1 activation to treat IPF and PSC.Fórmula:C27H38Cl2N6O3Cor e Forma:SolidPeso molecular:565.54Thymidine-5'-O-(α,β-methylene)diphosphate sodium
CAS:Thymidine-5’-O-(α,β-methylene)diphosphate (TMP-CP), a hydrolytically stable derivative of TDP, functions as an inhibitor of thymidine kinase (Ki = 23 µM).Fórmula:C11H15N2O10P2·3NaCor e Forma:SolidPeso molecular:466.16WRN inhibitor 5
CAS:WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).Fórmula:C23H20N2O6SCor e Forma:SolidPeso molecular:452.48SJ26
CAS:SJ26 is a Wnt1 inhibitor known for its anticancer activity. It inhibits the expression of WNT1 and the downstream signaling pathways mediated by WNT1 in a G-quadruplex structure-dependent manner, thereby suppressing the migratory activity of cancer cells.Fórmula:C29H32ClN3OCor e Forma:SolidPeso molecular:474.04GSK2163632A
CAS:GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.Fórmula:C27H32N8O3SCor e Forma:SolidPeso molecular:548.66
