Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(94 produtos)
- CDK(500 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(224 produtos)
- Cinesina(66 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(261 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(70 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(69 produtos)
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Foram encontrados 3477 produtos de "Ciclo celular/Ponto de verificação"
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Isocytosine
CAS:<p>Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C4H5N3OCor e Forma:White To Off-White SolidPeso molecular:111.1PAT-LM1
<p>PAT-LM1 is a human monoclonal antibody that targets NRB54/NONO. It is applicable in the study of hematological malignancies.</p>Cor e Forma:Odour LiquidMps1-IN-6
<p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>Fórmula:C35H39N9O3Cor e Forma:SolidPeso molecular:633.74RNA splicing modulator 3
CAS:<p>RNA Splicing Modulator 3 (Compound 236) is an effective RNA splicing modulator, exhibiting an AC50 value of less than 100 nM [1].</p>Fórmula:C19H20N6OSCor e Forma:SolidPeso molecular:380.47MRK-952
<p>MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.</p>Fórmula:C20H20ClF3N6Cor e Forma:SolidPeso molecular:436.861N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine
<p>N3,5-Dimethyl-2’-O-(2-methoxyethyl) uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Fórmula:C14H22N2O7Cor e Forma:SolidPeso molecular:330.33Stigmatellin
CAS:<p>Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.</p>Fórmula:C30H42O7Cor e Forma:SolidPeso molecular:514.65N1-Methyl-2'-β-C-methyl adenosine
<p>N1-Methyl-2’-beta-C-methyl adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Fórmula:C12H17N5O4Cor e Forma:SolidPeso molecular:295.29CDK5-IN-1
CAS:<p>CDK5-IN-1: Potent CDK5 inhibitor (<10 nM) used in kidney disease research.</p>Fórmula:C24H25FN6O3SCor e Forma:SolidPeso molecular:496.56Rev dC(Bz)-5'-amidite
<p>Rev dC(Bz)-5'-amidite, a purine nucleoside analog with antitumor effects, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.</p>Fórmula:C46H52N5O8PCor e Forma:SolidPeso molecular:833.916-Thioguanosine
CAS:<p>6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside and low molecular weight gel.6-Thioguanosine has immunosuppressive properties.</p>Fórmula:C10H13N5O4SPureza:97.05%Cor e Forma:Yellow-Green PowderPeso molecular:299.31Remdesivir nucleoside monophosphate
CAS:<p>Remdesivir metabolite, antiviral nucleoside analog, effective against SARS-CoV and MERS-CoV.</p>Fórmula:C12H14N5O7PCor e Forma:SolidPeso molecular:371.24Sarecycline hydrochloride
CAS:<p>Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.</p>Fórmula:C24H30ClN3O8Pureza:99.23%Cor e Forma:SolidPeso molecular:523.96Uridine triphosphate 13C9,15N2 sodium
CAS:<p>Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.</p>Fórmula:C9H1415N2NaO15P3Cor e Forma:SolidPeso molecular:517.04Rifalazil
CAS:<p>Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.</p>Fórmula:C51H64N4O13Pureza:98%Cor e Forma:SolidPeso molecular:941.07m7GpppApG
CAS:<p>M7GpppApG is a trinucleotide mRNA 5' cap analog utilized for in vitro RNA synthesis [1].</p>Fórmula:C31H41N15O24P4Cor e Forma:SolidPeso molecular:1131.64Xanthosine-5'-Triphosphate
CAS:<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>Fórmula:C10H15N4O15P3Cor e Forma:SolidPeso molecular:524.164Subquinocin
<p>Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.</p>Fórmula:C20H27N3O4SCor e Forma:SolidPeso molecular:405.172235-Methylcytidine 5′-triphosphate trisodium
<p>5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while</p>Fórmula:C10H15N3Na3O14P3Cor e Forma:SolidPeso molecular:563.13Etrolizumab
CAS:<p>MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.</p>Pureza:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Cor e Forma:LiquidPKMYT1-IN-3
<p>PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.</p>Fórmula:C24H26FN5O2Cor e Forma:SolidPeso molecular:435.49AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Fórmula:C137H215IN30O45SCor e Forma:SolidPeso molecular:3161.325'-O-DMT-N2-DMF-dG
CAS:<p>5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, finds application in deoxyribonucleic acid (DNA) or nucleic acid synthesis.</p>Fórmula:C34H36N6O6Cor e Forma:SolidPeso molecular:624.698SD49-7
CAS:<p>SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.</p>Fórmula:C18H14N2O3Pureza:99.91%Cor e Forma:SoildPeso molecular:306.322-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Fórmula:C12H24ClNO4Cor e Forma:SolidPeso molecular:281.78N4-(3,3,3-Trifluoropropanoyl)cytidine
<p>N4-(3,3,3-Trifluoropropanoyl)cytidine, a cytidine analog, inhibits DNA methyltransferases, possibly anti-metabolic and anti-cancer.</p>Fórmula:C12H14F3N3O6Cor e Forma:SolidPeso molecular:353.25AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Fórmula:C28H32FN9O2Cor e Forma:SolidPeso molecular:545.61Emicoron
CAS:<p>Importazole is an inhibitor of the transport receptor importin-β. It specifically inhibits importin-β likely by altering its interaction with RanGTP.</p>Fórmula:C52H58N6O4Pureza:98%Cor e Forma:SolidPeso molecular:831.05Pseudouridimycin
CAS:<p>Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.</p>Fórmula:C17H26N8O9Pureza:98%Cor e Forma:SolidPeso molecular:486.44HEMTAC WEE1 degrader-1
CAS:<p>HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.</p>Fórmula:C57H71N15O6Cor e Forma:SolidPeso molecular:1062.27Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Fórmula:C25H41N11O8SCor e Forma:SolidPeso molecular:655.727DSPE-PEG1000-cRGD
<p>DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.</p>Cor e Forma:Odour Solid2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS:<p>dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.</p>Fórmula:C10H14N5Na2O8PCor e Forma:SolidPeso molecular:409.202RNA splicing modulator 2
CAS:<p>RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .</p>Fórmula:C20H21N5OSCor e Forma:SolidPeso molecular:379.48c(phg-isoDGR-(NMe)k) TFA
<p>C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].</p>Fórmula:C29H42F3N9O9Cor e Forma:SolidPeso molecular:717.691-(β-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine
<p>1-(β-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine is an adenosine analog.</p>Fórmula:C18H18F3N5O4Cor e Forma:SolidPeso molecular:425.363,5'-Bis(O-t-butyldimethylsilyl)-2'-O-methyl-5-methyl cytidine
<p>3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine, a cytidine analog, inhibits DNA methyltransferases (e.g., Zebularine), exhibiting potential anti</p>Fórmula:C23H45N3O5Si2Cor e Forma:SolidPeso molecular:499.79CDK7-IN-2 hydrochloride hydrate
CAS:<p>CDK7-IN-2 HCl hydrate is a potent, specific CDK7 enzyme inhibitor with significant anti-cancer effects.</p>Fórmula:C26H42ClN7O4Cor e Forma:SolidPeso molecular:552.12αVβ8-IN-1
CAS:<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Fórmula:C25H32ClN5O4Cor e Forma:SolidPeso molecular:502.01WAY-230563
CAS:<p>WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cells</p>Fórmula:C17H12N2O2SPureza:98.40%Cor e Forma:SolidPeso molecular:308.35CDK2/PIM1-IN-1
<p>CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.</p>Cor e Forma:Odour SolidCy5-dATP
<p>Cy5-dATP is a Cy5 -labeled dATP . Cy5-dATP can be incorporated into a DNA primer [1] [2] .</p>Fórmula:C47H58N7O19P3S2Cor e Forma:SolidPeso molecular:1182.05JH-XVI-178
CAS:<p>JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.</p>Fórmula:C22H22ClN7OCor e Forma:SolidPeso molecular:435.92huATN-658
<p>huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.</p>Cor e Forma:Odour LiquidEesperamicin A1
CAS:<p>Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.</p>Fórmula:C59H80N4O22S4Cor e Forma:SolidPeso molecular:1325.54Tirandamycin A
<p>Tirandamycin A is a useful organic compound for research related to life sciences and the catalog number is T124996.</p>Fórmula:C22H27NO7Cor e Forma:SolidPeso molecular:417.458Erythromycin A dihydrate
CAS:<p>Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.</p>Fórmula:C37H69NO14Cor e Forma:SolidPeso molecular:751.94Psammaplin A
CAS:<p>Psammaplin A: marine-derived, inhibits HDAC/DNA methyltransferases, strong DAC1 blocker (IC50=0.9nM), antimicrobial against Gram-positive bacteria, anticancer.</p>Fórmula:C22H24Br2N4O6S2Cor e Forma:SolidPeso molecular:664.38Chk1-IN-6
CAS:<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Fórmula:C16H18F3N7Cor e Forma:SolidPeso molecular:365.364m7Gpppm6AmpG
CAS:<p>m7Gpppm6AmpG, a trinucleotide mRNA 5’ cap analog, facilitates RNA synthesis in vitro [1].</p>Fórmula:C33H45N15O24P4Cor e Forma:SolidPeso molecular:1159.69SP27
<p>SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].</p>Fórmula:C40H40F2N12O5Pureza:98%Cor e Forma:SolidPeso molecular:806.826-O-Methyl-2'-O-methylinosine
<p>6-O-Methyl-2’-O-methylinosine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Fórmula:C12H16N4O5Cor e Forma:SolidPeso molecular:296.28Heliquinomycin
CAS:<p>Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.</p>Fórmula:C33H30O17Cor e Forma:SolidPeso molecular:698.586N6-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl) adenosine
<p>N6-Benzoyl-3'-O-DMT-adenosine is a purine analog with antitumor effects by hindering DNA synthesis and inducing apoptosis.</p>Fórmula:C41H41N5O8Cor e Forma:SolidPeso molecular:731.79(1S,3R,5R)-PIM447 dihydrochloride
<p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>Fórmula:C24H25Cl2F3N4OPureza:98%Cor e Forma:SolidPeso molecular:513.3812R-LOX-IN-2
CAS:<p>12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.</p>Fórmula:C19H13NOPureza:99.84%Cor e Forma:SolidPeso molecular:271.31Mulnitorsen
CAS:<p>Mulnitorsen acts as an inhibitor of antisense non-coding mitochondrial RNA (ASncmtRNA) synthesis and serves as an antitumor agent [1].</p>Fórmula:C172H217N74O82P17S17Cor e Forma:SolidPeso molecular:5704.662'-Deoxy-2'-fluorouridine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits extensive antitumor effects against indolent lymphoid</p>Fórmula:C21H42FN4O7PCor e Forma:SolidPeso molecular:512.553'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
<p>3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolent lymphoid</p>Fórmula:C38H43N5O9Cor e Forma:SolidPeso molecular:713.785'-O-DMT-N4-Ac-2'-F-dC
CAS:<p>5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Fórmula:C32H32FN3O7Cor e Forma:SolidPeso molecular:589.61Chrysomycin A
CAS:<p>Chrysomycin A is an antibiotic that can be derived from Streptomyces.</p>Fórmula:C28H28O9Cor e Forma:SolidPeso molecular:508.52Deoxythymidine-5'-triphosphate sodium hydrate
<p>dTTP sodium hydrate, a DNA synthesis component, is a nucleoside triphosphate.</p>Fórmula:C10H17N2O14P3·xNa·xH2OCor e Forma:SolidPeso molecular:C10H17N2O14P3.xNa.xH2ODG1
<p>DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressing</p>Fórmula:C19H17N5O5SCor e Forma:SolidPeso molecular:427.43Mumefural
CAS:<p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>Fórmula:C12H12O9Cor e Forma:SolidPeso molecular:300.22m7GpppCpG
CAS:<p>m7GpppCpG, a trinucleotide cap analogue, is used for synthesizing RNA with cap 0 or cap 1 structures.</p>Fórmula:C30H41N13O25P4Cor e Forma:SolidPeso molecular:1107.61CDK2-IN-7
CAS:<p>CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).</p>Fórmula:C24H30N6O4SCor e Forma:SolidPeso molecular:498.6CW-2
<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>Fórmula:C43H42Cl2FN11O10PtCor e Forma:SolidPeso molecular:1156.212515-(2-Hydroxyethyl)-2',3'-di-O-toluoyl-2'-deoxyuridine
<p>5-(2-Hydroxyethyl)-2',3'-di-O-toluoyl-2'-deoxyuridine, a purine nucleoside analog, exhibits widespread antitumor activity specifically against indolent lymphoid</p>Fórmula:C27H28N2O8Cor e Forma:SolidPeso molecular:508.52JB300
CAS:<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Fórmula:C43H45ClFN7O10SCor e Forma:SolidPeso molecular:906.3755-Iminodaunorubicin
CAS:<p>5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.</p>Fórmula:C27H30N2O9Cor e Forma:SolidPeso molecular:526.54TTK/PLK1-IN-1
CAS:<p>TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.</p>Fórmula:C30H33N7O2Pureza:97.39%Cor e Forma:SolidPeso molecular:523.63Nogalamycin
CAS:<p>Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.</p>Fórmula:C39H49NO16Pureza:98%Cor e Forma:SolidPeso molecular:787.8125'-O-TBDMS-dA
CAS:<p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Fórmula:C16H27N5O3SiCor e Forma:SolidPeso molecular:365.5095'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
<p>5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.</p>Fórmula:C44H49F2N4O7PCor e Forma:SolidPeso molecular:814.85WAY-647802
CAS:<p>WAY-647802 is a CDK inhibitor.</p>Fórmula:C11H14N4O3Pureza:99.53%Cor e Forma:SolidPeso molecular:250.25Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Fórmula:C21H25FN4O2Cor e Forma:SolidPeso molecular:384.45Anticancer agent 263
<p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>Fórmula:C13H20N2O6Cor e Forma:SolidPeso molecular:300.3086-Methoxypurine-9-β-D-5'(R)-C-methylriboside
<p>6-Methoxypurine-9-β-D-5’(R)-C-methylriboside, an analog of hypoxanthine—a purine base predominantly found in muscle tissue and a metabolite generated when</p>Fórmula:C12H16N4O5Cor e Forma:SolidPeso molecular:296.28Obtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Fórmula:C184H284N52O57S8Pureza:98%Cor e Forma:SolidPeso molecular:4393.0713-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Fórmula:C12H19F2N6O12P3Cor e Forma:SolidPeso molecular:570.23Rachelmycin
CAS:<p>Rachelmycin, a potent antibiotic and antitumor agent from Streptomyces zelensis, binds to DNA's minor groove.</p>Fórmula:C37H33N7O8Cor e Forma:SolidPeso molecular:703.712wrwycr-NH2 TFA
<p>wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.</p>Cor e Forma:Odour SolidBz-rC Phosphoramidite
CAS:<p>Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>Fórmula:C52H66N5O9PSiCor e Forma:SolidPeso molecular:964.185DNA Gyrase-IN-6
<p>Agent 138: soluble benzothiazole, inhibits DNA gyrase/topoisomerase IV, targets Gram+ & Gram- bacteria, binds plasma proteins.</p>Fórmula:C18H16Cl2N4O4SCor e Forma:SolidPeso molecular:455.32EC0488
CAS:<p>EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity.</p>Fórmula:C65H98N16O34SPureza:98%Cor e Forma:SolidPeso molecular:1679.63Biotin-PEG8-Vidarabine
<p>Biotin-PEG8-Vidarabine is an antiviral PEG linker targeting herpes and varicella zoster with adenosine analog Vidarabine.</p>Fórmula:C36H60N8O13SCor e Forma:SolidPeso molecular:844.973,6-DMAD hydrochloride
<p>3,6-DMAD hydrochloride functions as an inhibitor for the IRE1α-XBP1 pathway within the unfolded protein response mechanism.</p>Fórmula:C22H31N5xHClPureza:98%Cor e Forma:SolidPeso molecular:365.525-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS:<p>5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.</p>Fórmula:C22H31N3O5SiCor e Forma:SolidPeso molecular:445.585'-O-DMT-2'-O-TBDMS-Ac-rC
CAS:<p>5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Fórmula:C38H47N3O8SiCor e Forma:SolidPeso molecular:701.892N4-(n-Palmitoyl)-4'-azido-2'-deoxy-2'-fluoro-arabinocytidine
<p>N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a cytidine nucleoside analog.</p>Fórmula:C25H41FN6O5Cor e Forma:SolidPeso molecular:524.63Pseudorabies virus-IN-1
<p>Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.</p>Fórmula:C27H23ClF2N4O2Cor e Forma:SolidPeso molecular:508.947ONX 0801 trisodium
CAS:<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>Fórmula:C32H30N5Na3O10Cor e Forma:SolidPeso molecular:713.58Ficellomycin
CAS:<p>Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.</p>Fórmula:C13H24N6O3Cor e Forma:SolidPeso molecular:312.37Ganodermaones B
<p>Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .</p>Fórmula:C21H26O5Cor e Forma:SolidPeso molecular:358.43Nitrosofolic acid
CAS:<p>Nitrosofolic acid is a folic acid derivaive.</p>Fórmula:C19H18N8O7Cor e Forma:SolidPeso molecular:470.405'-O-DMT-2'-O-TBDMS-Bz-rC
CAS:<p>5'-O-DMT-2'-O-TBDMS-Bz-rC, a modified nucleoside, is utilized in the synthesis of DNA or RNA.</p>Fórmula:C43H49N3O8SiCor e Forma:SolidPeso molecular:763.95R-BC154 acetate
<p>R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.</p>Fórmula:C56H65N9O14S3Cor e Forma:SolidPeso molecular:1184.36L-5-Methyluridine
CAS:<p>L-5-Methyluridine, an L-configuration of 5-Methyluridine, is an endogenous methylated nucleoside present in human fluids.</p>Fórmula:C10H14N2O6Cor e Forma:SolidPeso molecular:258.23EFdA-TP tetraammonium
<p>EFdA-TP tetraammonium is a potent HIV-1 RT inhibitor and DNA synthesis blocker, acting as an ICT or DCT.</p>Fórmula:C12H27N9O12P3Cor e Forma:SolidPeso molecular:601.312'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolent</p>Fórmula:C22H43FN7O7PCor e Forma:SolidPeso molecular:567.59
