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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3495 produtos de "Ciclo celular/Ponto de verificação"

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  • PVZB1194
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    PVZB1194

    CAS:
    <p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>
    Fórmula:C13H9F4NO2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:319.28

    Ref: TM-T78125

  • αvβ6 integrin inhibitor 2
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    αvβ6 integrin inhibitor 2

    CAS:
    <p>αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.</p>
    Fórmula:C21H30N4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:386.49

    Ref: TM-T79140

  • CDK9-IN-2
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    CDK9-IN-2

    CAS:
    CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.
    Fórmula:C23H25ClFN5
    Pureza:99%
    Cor e Forma:Solid
    Peso molecular:425.93

    Ref: TM-T14918

  • ON 108600
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    ON 108600

    CAS:
    <p>ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.</p>
    Fórmula:C22H14Cl2N2O6S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:537.39

    Ref: TM-T79908

  • Kif15-IN-2
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    Kif15-IN-2

    CAS:
    <p>Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.</p>
    Fórmula:C20H20N6O4S
    Pureza:98.17%
    Cor e Forma:Solid
    Peso molecular:440.48

    Ref: TM-T11759

  • CT1113
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    CT1113

    CAS:
    <p>CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDX</p>
    Fórmula:C25H29N5O2S
    Cor e Forma:Solid
    Peso molecular:463.6

    Ref: TM-T79187

  • Trovafloxacin mesylate
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    Trovafloxacin mesylate

    CAS:
    <p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>
    Fórmula:C21H19F3N4O6S
    Pureza:99.18%
    Cor e Forma:Solid
    Peso molecular:512.46

    Ref: TM-T13231L

  • Luvixasertib hydrochloride
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    Luvixasertib hydrochloride

    CAS:
    <p>CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].</p>
    Fórmula:C28H31ClN6O3
    Cor e Forma:Solid
    Peso molecular:535.04

    Ref: TM-T84711

  • LDC3140
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    LDC3140

    CAS:
    <p>LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).</p>
    Fórmula:C23H33N7O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:423.55

    Ref: TM-T27805

  • USP1-IN-3
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    USP1-IN-3

    CAS:
    <p>USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50&lt;30 nM). USP1-IN-3 can be used to study cancer.</p>
    Fórmula:C27H24F3N7O
    Cor e Forma:Solid
    Peso molecular:519.52

    Ref: TM-T63625

  • Lerociclib
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    Lerociclib

    CAS:
    <p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>
    Fórmula:C26H34N8O
    Pureza:99%
    Cor e Forma:Solid
    Peso molecular:474.6

    Ref: TM-T11345

  • WRN inhibitor 5
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    WRN inhibitor 5

    CAS:
    <p>WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>
    Fórmula:C23H20N2O6S
    Cor e Forma:Solid
    Peso molecular:452.48

    Ref: TM-T80772

  • WEE1-IN-4
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    WEE1-IN-4

    CAS:
    <p>Wee1 Inhibitor I is an ATP-binding site-targeting Wee1 inhibitor.</p>
    Fórmula:C20H11ClN2O3
    Cor e Forma:Solid
    Peso molecular:362.77

    Ref: TM-T23869

  • Palmitoyl 3-carbacyclic phosphatidic acid
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    Palmitoyl 3-carbacyclic phosphatidic acid

    CAS:
    <p>Palmitoyl 3-carbacyclic phosphatidic acid, a palmitoylated Carba-like cyclophosphatidic acid and LPA (lysophosphatidic acid) analog, possesses distinct biological activities compared to LPA, including the inhibition of RhoA activation and melanoma cell migration. This compound has demonstrated efficacy in inhibiting experimental lung metastasis and reducing tumor nodule counts in a B16-F0 xenograft mouse model [1].</p>
    Fórmula:C20H39O5P
    Cor e Forma:Solid
    Peso molecular:390.49

    Ref: TM-T84483

  • KY386
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    KY386

    CAS:
    <p>KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM.</p>
    Fórmula:C21H19N5O2S
    Cor e Forma:Solid
    Peso molecular:405.47

    Ref: TM-T81967

  • Mevociclib
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    Mevociclib

    CAS:
    Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
    Fórmula:C31H35ClN8O2
    Pureza:98.02% - 98.02%
    Cor e Forma:Solid
    Peso molecular:587.11

    Ref: TM-T13044

  • L-739758
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    L-739758

    CAS:
    <p>L-739758 is a glycoprotein IIb/IIIa inhibitor.</p>
    Fórmula:C22H26N4O5S3
    Cor e Forma:Solid
    Peso molecular:522.66

    Ref: TM-T70281

  • TNP-351
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    TNP-351

    CAS:
    <p>Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.</p>
    Fórmula:C21H24N6O5
    Cor e Forma:Solid
    Peso molecular:440.45

    Ref: TM-T26283

  • 8-NH2-ATP tetrasodium
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    8-NH2-ATP tetrasodium

    CAS:
    <p>8-NH2-ATP tetrasodium, an inactive ATP variant, originates from 8-NH2-Ado tetrasodium, which triggers the apoptosis-associated cleavage of poly (ADP-ribose) polymerase [1] [2].</p>
    Fórmula:C10H13N6Na4O13P3
    Cor e Forma:Solid
    Peso molecular:610.12

    Ref: TM-T84731

  • (2S,3R)-Voruciclib
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    (2S,3R)-Voruciclib

    CAS:
    <p>(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.</p>
    Fórmula:C22H19ClF3NO5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:469.84

    Ref: TM-T10096