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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3493 produtos de "Ciclo celular/Ponto de verificação"

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  • RAD51-IN-4
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    RAD51-IN-4

    CAS:
    <p>RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.</p>
    Fórmula:C31H34FN5O5S2
    Cor e Forma:Solid
    Peso molecular:639.76

    Ref: TM-T73107

  • TNP-351
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    TNP-351

    CAS:
    <p>Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.</p>
    Fórmula:C21H24N6O5
    Cor e Forma:Solid
    Peso molecular:440.45

    Ref: TM-T26283

  • AAPK-25
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    AAPK-25

    CAS:
    <p>AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.</p>
    Fórmula:C21H13Cl2N3O2S
    Pureza:97.05%
    Cor e Forma:Solid
    Peso molecular:442.32

    Ref: TM-T10215

  • CDK9-IN-23
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    CDK9-IN-23

    CAS:
    <p>CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].</p>
    Fórmula:C22H25ClN4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:428.91

    Ref: TM-T79037

  • (S)-Cdc7-IN-18
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    (S)-Cdc7-IN-18

    CAS:
    <p>'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'</p>
    Fórmula:C19H21N5OS
    Cor e Forma:Solid
    Peso molecular:367.47

    Ref: TM-T61435

  • GSK2850163
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    GSK2850163

    CAS:
    <p>GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).</p>
    Fórmula:C24H29Cl2N3O
    Pureza:99.04%
    Cor e Forma:Solid
    Peso molecular:446.41

    Ref: TM-T11488

  • CDK4/6-IN-15
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    CDK4/6-IN-15

    CAS:
    <p>CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.</p>
    Fórmula:C21H27FN8S
    Cor e Forma:Solid
    Peso molecular:442.56

    Ref: TM-T72928

  • CCT251455
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    CCT251455

    CAS:
    <p>CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.</p>
    Fórmula:C26H26ClN7O2
    Pureza:99.1% - 99.1%
    Cor e Forma:Solid
    Peso molecular:503.98

    Ref: TM-T14906

  • SHP2/CDK4-IN-1
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    SHP2/CDK4-IN-1

    CAS:
    <p>SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.</p>
    Fórmula:C33H35ClF2N10OS
    Cor e Forma:Solid
    Peso molecular:693.21

    Ref: TM-T72836

  • DHODH-IN-14
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    DHODH-IN-14

    CAS:
    <p>DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.</p>
    Fórmula:C15H7F4N3O3
    Pureza:99.81%
    Cor e Forma:Solid
    Peso molecular:353.23

    Ref: TM-T11023

  • CCT241533
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    CCT241533

    CAS:
    <p>CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>
    Fórmula:C23H27FN4O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:442.48

    Ref: TM-T10718

  • UNC2170 maleate
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    UNC2170 maleate

    CAS:
    <p>53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.</p>
    Fórmula:C14H21BrN2OC4H4O4
    Cor e Forma:Solid
    Peso molecular:429.31

    Ref: TM-T84416

  • NU6300
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    NU6300

    CAS:
    <p>NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.</p>
    Fórmula:C20H23N5O3S
    Pureza:96.08%
    Cor e Forma:Solid
    Peso molecular:413.49

    Ref: TM-T16360

  • WRN inhibitor 1
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    WRN inhibitor 1

    CAS:
    <p>WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain.</p>
    Fórmula:C16H13FN2O4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:348.35

    Ref: TM-T79107

  • TAK 029
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    TAK 029

    CAS:
    <p>TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.</p>
    Fórmula:C19H23N5O7
    Cor e Forma:Solid
    Peso molecular:433.42

    Ref: TM-T28913

  • EHT 5372
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    EHT 5372

    CAS:
    <p>EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.</p>
    Fórmula:C17H11Cl2N5OS
    Cor e Forma:Solid
    Peso molecular:404.27

    Ref: TM-T61985

  • COH1
    Targetmol
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    COH1

    CAS:
    <p>COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1].</p>
    Fórmula:C11H10N2O3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:250.27

    Ref: TM-T78814

  • MC-Val-Cit-PAB-Ispinesib
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    MC-Val-Cit-PAB-Ispinesib

    CAS:
    <p>MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].</p>
    Fórmula:C59H71ClN10O10
    Cor e Forma:Solid
    Peso molecular:1115.71

    Ref: TM-T84703

  • IIIM-290
    Targetmol
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    IIIM-290

    CAS:
    IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).
    Fórmula:C23H21Cl2NO5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:462.32

    Ref: TM-T11632

  • UNC-2170
    Targetmol
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    UNC-2170

    CAS:
    <p>UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.</p>
    Fórmula:C14H21BrN2O
    Pureza:97.44%
    Cor e Forma:Solid
    Peso molecular:313.23

    Ref: TM-T24925