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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3493 produtos de "Ciclo celular/Ponto de verificação"

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  • FAICAR
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    FAICAR

    CAS:
    <p>FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.</p>
    Fórmula:C10H15N4O9P
    Cor e Forma:Solid
    Peso molecular:366.22

    Ref: TM-T84746

  • Carotegrast
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    Carotegrast

    CAS:
    Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.
    Fórmula:C27H24Cl2N4O5
    Cor e Forma:Solid
    Peso molecular:555.41

    Ref: TM-T14876

  • ROCK2-IN-7
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    ROCK2-IN-7

    CAS:
    <p>ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.</p>
    Fórmula:C26H28FN5O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:445.53

    Ref: TM-T81261

  • 12R-LOX-IN-1
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    12R-LOX-IN-1

    CAS:
    <p>12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX.</p>
    Fórmula:C15H11NO2
    Cor e Forma:Solid
    Peso molecular:237.25

    Ref: TM-T83457

  • Logotipo do CymitQuimica
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    CDK7-IN-25

    CAS:
    <p>CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].</p>
    Fórmula:C33H32N6O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:560.65

    Ref: TM-T79881

  • 5-Iodo-indirubin-3'-monoxime
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    5-Iodo-indirubin-3'-monoxime

    CAS:
    5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s
    Fórmula:C16H10IN3O2
    Cor e Forma:Solid
    Peso molecular:403.17

    Ref: TM-T10172

  • Trovafloxacin mesylate
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    Trovafloxacin mesylate

    CAS:
    <p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>
    Fórmula:C21H19F3N4O6S
    Pureza:99.18%
    Cor e Forma:Solid
    Peso molecular:512.46

    Ref: TM-T13231L

  • Homouridine
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    Homouridine

    CAS:
    <p>Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).</p>
    Fórmula:C10H14N2O6
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:258.23

    Ref: TM-T79190

  • Litronesib
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    Litronesib

    CAS:
    <p>Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.</p>
    Fórmula:C23H37N5O4S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:511.7

    Ref: TM-T11859L

  • CDK4/6-IN-17
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    CDK4/6-IN-17

    CAS:
    <p>CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.</p>
    Fórmula:C27H28F4N8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:540.56

    Ref: TM-T79112

  • ON 108600
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    ON 108600

    CAS:
    <p>ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.</p>
    Fórmula:C22H14Cl2N2O6S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:537.39

    Ref: TM-T79908

  • Cdk4 Inhibitor
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    Cdk4 Inhibitor

    CAS:
    <p>PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 &lt; 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.</p>
    Fórmula:C20H10BrN3O2
    Cor e Forma:Solid
    Peso molecular:404.2

    Ref: TM-T84413

  • KSP-IA
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    KSP-IA

    CAS:
    <p>KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.</p>
    Fórmula:C21H22F2N2O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:356.41

    Ref: TM-T24271

  • Lotrafiban hydrochloride
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    Lotrafiban hydrochloride

    CAS:
    <p>Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.</p>
    Fórmula:C23H33ClN4O4
    Cor e Forma:Solid
    Peso molecular:464.99

    Ref: TM-T27846

  • NITD008
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    NITD008

    CAS:
    <p>NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.</p>
    Fórmula:C13H14N4O4
    Pureza:98.04%
    Cor e Forma:Solid
    Peso molecular:290.27

    Ref: TM-T16325

  • TAS-114
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    TAS-114

    CAS:
    <p>TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.</p>
    Fórmula:C21H29N3O6S
    Pureza:99.76%
    Cor e Forma:Solid
    Peso molecular:451.54

    Ref: TM-T13089

  • Lotrafiban
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    Lotrafiban

    CAS:
    <p>Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.</p>
    Fórmula:C23H32N4O4
    Cor e Forma:Solid
    Peso molecular:428.52

    Ref: TM-T62351

  • USP1-IN-6
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    USP1-IN-6

    CAS:
    <p>USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.</p>
    Fórmula:C29H27F3N8O
    Cor e Forma:Solid
    Peso molecular:560.57

    Ref: TM-T79796

  • G-5758
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    G-5758

    CAS:
    <p>G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.</p>
    Fórmula:C27H24F4N6O3S
    Cor e Forma:Solid
    Peso molecular:588.58

    Ref: TM-T87983

  • Balapiravir hydrochloride
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    Balapiravir hydrochloride

    CAS:
    <p>Balapiravir HCl, an NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>
    Fórmula:C21H31ClN6O8
    Cor e Forma:Solid
    Peso molecular:530.96

    Ref: TM-T26736