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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3485 produtos de "Ciclo celular/Ponto de verificação"

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  • 3-Cyanovinylcarbazole phosphoramidite
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    3-Cyanovinylcarbazole phosphoramidite

    CAS:
    <p>3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.</p>
    Fórmula:C50H53N4O6P
    Cor e Forma:Solid
    Peso molecular:836.95

    Ref: TM-T74188

  • DNA polymerase-IN-3
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    DNA polymerase-IN-3

    CAS:
    <p>DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications in</p>
    Fórmula:C13H12O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:232.23

    Ref: TM-T79308

  • TAS-114
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    TAS-114

    CAS:
    <p>TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.</p>
    Fórmula:C21H29N3O6S
    Pureza:99.76%
    Cor e Forma:Solid
    Peso molecular:451.54

    Ref: TM-T13089

  • CDK7-IN-14
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    CDK7-IN-14

    CAS:
    <p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>
    Fórmula:C22H24F3N6OP
    Cor e Forma:Solid
    Peso molecular:476.43

    Ref: TM-T63108

  • BI-1950
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    BI-1950

    CAS:
    <p>BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.</p>
    Fórmula:C32H26Cl2FN7O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:646.5

    Ref: TM-T14558

  • DUB-IN-7
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    DUB-IN-7

    CAS:
    <p>DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].</p>
    Fórmula:C17H19N5O
    Cor e Forma:Solid
    Peso molecular:309.37

    Ref: TM-T79672

  • PLK1-IN-4
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    PLK1-IN-4

    CAS:
    <p>PLK1-IN-4: strong PLK1 blocker (&lt;0.508 nM IC50), inhibits cancer cell growth, triggers G2/M arrest and apoptosis.</p>
    Fórmula:C24H25F3N6O4S
    Cor e Forma:Solid
    Peso molecular:550.55

    Ref: TM-T63886

  • CDK9-IN-2
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    CDK9-IN-2

    CAS:
    <p>CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.</p>
    Fórmula:C23H25ClFN5
    Pureza:99%
    Cor e Forma:Solid
    Peso molecular:425.93

    Ref: TM-T14918

  • H3B-968
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    H3B-968

    CAS:
    <p>H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonuclease</p>
    Fórmula:C22H18F6N4O4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:548.46

    Ref: TM-T78938

  • BVDU 5′-Triphosphate
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    BVDU 5′-Triphosphate

    CAS:
    <p>BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.</p>
    Fórmula:C11H16BrN2O14P3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:573.08

    Ref: TM-T80655

  • DAM-IN-1
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    DAM-IN-1

    CAS:
    <p>DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.</p>
    Fórmula:C16H17NO4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:287.31

    Ref: TM-T82614

  • SB-743921 free base
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    SB-743921 free base

    CAS:
    <p>SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).</p>
    Fórmula:C31H33ClN2O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:517.06

    Ref: TM-T28694

  • Emzadirib
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    Emzadirib

    CAS:
    <p>Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.</p>
    Fórmula:C27H40N4O6S2
    Pureza:99.79% - 99.9%
    Cor e Forma:Solid
    Peso molecular:580.76

    Ref: TM-T12682

  • MU-380
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    MU-380

    CAS:
    <p>MU-380 is an effective and selective inhibitor of CHK1.</p>
    Fórmula:C15H15BrF3N7
    Cor e Forma:Solid
    Peso molecular:430.23

    Ref: TM-T24506

  • N-desmethyl Netupitant
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    N-desmethyl Netupitant

    CAS:
    <p>N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.</p>
    Fórmula:C29H30F6N4O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:564.57

    Ref: TM-T12212

  • USP1-IN-3
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    USP1-IN-3

    CAS:
    <p>USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50&lt;30 nM). USP1-IN-3 can be used to study cancer.</p>
    Fórmula:C27H24F3N7O
    Cor e Forma:Solid
    Peso molecular:519.52

    Ref: TM-T63625

  • αvβ1 integrin-IN-2
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    αvβ1 integrin-IN-2

    CAS:
    <p>αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.</p>
    Fórmula:C29H38N4O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:506.64

    Ref: TM-T79792

  • Pelitrexol
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    Pelitrexol

    CAS:
    <p>Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, block the cell cycle in the s-phase, with antiproliferative activity,NSCLC .</p>
    Fórmula:C20H25N5O6S
    Pureza:98.03%
    Cor e Forma:Solid
    Peso molecular:463.51

    Ref: TM-T14147

  • Cdk4 Inhibitor
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    Cdk4 Inhibitor

    CAS:
    <p>PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 &lt; 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.</p>
    Fórmula:C20H10BrN3O2
    Cor e Forma:Solid
    Peso molecular:404.2

    Ref: TM-T84413

  • Logotipo do CymitQuimica
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    Teclistamab

    CAS:
    <p>Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.</p>
    Pureza:95%
    Cor e Forma:Liquid

    Ref: TM-T76881