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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3482 produtos de "Ciclo celular/Ponto de verificação"

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  • αvβ1 integrin-IN-1
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    αvβ1 integrin-IN-1

    CAS:
    <p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>
    Fórmula:C26H34N6O6S
    Pureza:99.74% - >99.99%
    Cor e Forma:Solid
    Peso molecular:558.65

    Ref: TM-T13473

  • Debio-0123
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    Debio-0123

    CAS:
    Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.
    Fórmula:C26H28Cl2N6O
    Pureza:99.93%
    Cor e Forma:Solid
    Peso molecular:511.45

    Ref: TM-T9864

  • PD-L1-IN-3
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    PD-L1-IN-3

    CAS:
    <p>PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.</p>
    Fórmula:C19H15ClFN2OS
    Pureza:99.47%
    Cor e Forma:Soild
    Peso molecular:373.85

    Ref: TM-T79314

  • CCT129202
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    CCT129202

    CAS:
    <p>CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.</p>
    Fórmula:C23H25ClN8OS
    Pureza:98.14%
    Cor e Forma:Solid
    Peso molecular:497.02

    Ref: TM-T6435

  • Cdk1/2 Inhibitor III
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    Cdk1/2 Inhibitor III

    CAS:
    <p>Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.</p>
    Fórmula:C15H13F2N7O2S2
    Pureza:99.07%
    Cor e Forma:Solid
    Peso molecular:425.44

    Ref: TM-T14914

  • (R)-Simurosertib
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    (R)-Simurosertib

    CAS:
    <p>(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.</p>
    Fórmula:C17H19N5OS
    Pureza:99.89%
    Cor e Forma:Solid
    Peso molecular:341.43

    Ref: TM-T12642

  • B I09
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    B I09

    CAS:
    <p>B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.</p>
    Fórmula:C16H17NO5
    Pureza:98.80%
    Cor e Forma:Solid
    Peso molecular:303.31

    Ref: TM-T14847

  • Sorivudine
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    Sorivudine

    CAS:
    <p>Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.</p>
    Fórmula:C11H13BrN2O6
    Pureza:99.74%
    Cor e Forma:Solid
    Peso molecular:349.13

    Ref: TM-T16911

  • Lomibuvir
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    Lomibuvir

    CAS:
    <p>Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.</p>
    Fórmula:C25H35NO4S
    Pureza:99.83%
    Cor e Forma:Solid
    Peso molecular:445.61

    Ref: TM-T6729

  • MTH1 activator-1
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    MTH1 activator-1

    CAS:
    <p>MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.</p>
    Fórmula:C29H23F3N4O2
    Cor e Forma:Solid
    Peso molecular:516.514

    Ref: TM-T204503

  • PAIR2
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    PAIR2

    CAS:
    <p>PAIR2 is a selective IRE1α RNase partial antagonist, blocking its ATP site and preventing KIRA from hindering XBP1 splicing.</p>
    Fórmula:C27H26F4N6O3S
    Cor e Forma:Solid
    Peso molecular:590.59

    Ref: TM-T64183

  • Terpendole E
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    Terpendole E

    CAS:
    <p>Terpendole E is an atypical L5 site inhibitor.</p>
    Fórmula:C28H39NO3
    Cor e Forma:Solid
    Peso molecular:437.61

    Ref: TM-T70289

  • CTX-712
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    CTX-712

    CAS:
    <p>CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.</p>
    Fórmula:C19H17FN8O2
    Cor e Forma:Solid
    Peso molecular:408.39

    Ref: TM-T62049

  • Logotipo do CymitQuimica
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    CLK1/4-IN-1

    <p>CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.</p>
    Fórmula:C18H14ClNO4S
    Cor e Forma:Solid
    Peso molecular:375.83

    Ref: TM-T61543

  • LY309887
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    LY309887

    CAS:
    <p>LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.</p>
    Fórmula:C19H23N5O6S
    Cor e Forma:Solid
    Peso molecular:449.48

    Ref: TM-T15813

  • CDK4-IN-1
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    CDK4-IN-1

    CAS:
    <p>CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50&gt;15 uM) and CDK2/Cyclin A (IC50</p>
    Fórmula:C22H29ClN8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:440.97

    Ref: TM-T2082

  • CDK4/6-IN-24
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    CDK4/6-IN-24

    CAS:
    <p>CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.</p>
    Fórmula:C32H41N7O3
    Cor e Forma:Solid
    Peso molecular:571.713

    Ref: TM-T205628

  • ATIC-IN-2
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    ATIC-IN-2

    CAS:
    <p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>
    Fórmula:C4H4N4O3S
    Cor e Forma:Solid
    Peso molecular:188.165

    Ref: TM-T204433

  • Logotipo do CymitQuimica
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    MtTMPK-IN-1

    <p>MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.</p>
    Fórmula:C22H24N4O3
    Cor e Forma:Solid
    Peso molecular:392.45

    Ref: TM-T61796

  • CDK7-IN-18
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    CDK7-IN-18

    CAS:
    <p>CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.</p>
    Fórmula:C22H24F3N7OS
    Cor e Forma:Solid
    Peso molecular:491.53

    Ref: TM-T63301