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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3480 produtos de "Ciclo celular/Ponto de verificação"

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  • LNA-GDP
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    LNA-GDP

    CAS:
    <p>LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C11H15N5O11P2
    Cor e Forma:Solid
    Peso molecular:455.21

    Ref: TM-TSW-00961

  • MtTMPK-IN-2
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    MtTMPK-IN-2

    CAS:
    <p>MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).</p>
    Fórmula:C23H24ClN3O3
    Cor e Forma:Solid
    Peso molecular:425.91

    Ref: TM-T62305

  • Logotipo do CymitQuimica
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    MtTMPK-IN-7

    <p>MtTMPK-IN-7 inhibits MtbTMPK (IC50: 47 μM), active against M. brevis (MIC: 2.3-4.7 μM), useful for tuberculosis research.</p>
    Fórmula:C27H29ClN6O3
    Cor e Forma:Solid
    Peso molecular:521.01

    Ref: TM-T63639

  • Cdc7-IN-10
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    Cdc7-IN-10

    CAS:
    <p>Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.</p>
    Fórmula:C20H22F2N4O2S
    Cor e Forma:Solid
    Peso molecular:420.48

    Ref: TM-T62230

  • DHX9-IN-19
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    DHX9-IN-19

    CAS:
    <p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>
    Fórmula:C20H21ClN4O4S2
    Cor e Forma:Solid
    Peso molecular:480.988

    Ref: TM-T204732

  • SR121566A
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    SR121566A

    CAS:
    <p>SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).</p>
    Fórmula:C20H25N5O4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:431.51

    Ref: TM-T12999

  • 3'-Deoxy-GTP
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    3'-Deoxy-GTP

    CAS:
    <p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.</p>
    Fórmula:C10H16N5O13P3
    Cor e Forma:Solid
    Peso molecular:507.181

    Ref: TM-T206927

  • Metesind Glucuronate
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    Metesind Glucuronate

    CAS:
    <p>Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.</p>
    Fórmula:C29H34N4O10S
    Cor e Forma:Solid
    Peso molecular:630.67

    Ref: TM-T24454

  • AB25583
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    AB25583

    CAS:
    <p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>
    Fórmula:C22H17ClN4O3S
    Cor e Forma:Solid
    Peso molecular:452.91

    Ref: TM-T200101

  • 2′-O-MOE-CMP
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    2′-O-MOE-CMP

    CAS:
    <p>2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C12H20N3O9P
    Cor e Forma:Solid
    Peso molecular:381.28

    Ref: TM-TSW-00960

  • Cdc7-IN-19
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    Cdc7-IN-19

    CAS:
    <p>Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1].</p>
    Fórmula:C19H21N5O2
    Cor e Forma:Solid
    Peso molecular:351.40

    Ref: TM-T61223

  • PPA-037
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    PPA-037

    CAS:
    <p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>
    Fórmula:C25H27N7
    Cor e Forma:Solid
    Peso molecular:425.53

    Ref: TM-T207610

  • Polθ-IN-7
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    Polθ-IN-7

    CAS:
    <p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>
    Fórmula:C28H35F3N6O2
    Cor e Forma:Solid
    Peso molecular:544.612

    Ref: TM-T204135

  • Cdc7-IN-18
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    Cdc7-IN-18

    CAS:
    <p>Cdc7-IN-18 (1-2) inhibits CDC7 enzyme (IC50: 1.29 nM) and COLO205 cell proliferation (IC50: 53.62 nM).</p>
    Fórmula:C19H21N5OS
    Cor e Forma:Solid
    Peso molecular:367.47

    Ref: TM-T61436

  • CDK4/6-IN-3
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    CDK4/6-IN-3

    CAS:
    <p>CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: &lt;0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.</p>
    Fórmula:C25H31FN8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:462.57

    Ref: TM-T10737

  • CDK8-IN-14
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    CDK8-IN-14

    CAS:
    <p>CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01μM in MOLM-13 cells and 0.03±0.01μM in MV4-11 cells [1].</p>
    Fórmula:C18H13N3O2
    Cor e Forma:Solid
    Peso molecular:303.31

    Ref: TM-T86031

  • WRN inhibitor 12
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    WRN inhibitor 12

    CAS:
    WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.
    Fórmula:C33H33ClF3N9O5
    Cor e Forma:Solid
    Peso molecular:728.12

    Ref: TM-T201316

  • Logotipo do CymitQuimica
    Targetmol
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    MtTMPK-IN-8

    <p>MtTMPK-IN-8 inhibits MtbTMPK, has low cytotoxicity, shows 0.78-9.4 μM activity against Mycobacterium, useful for tuberculosis research.</p>
    Fórmula:C24H24N6O7
    Cor e Forma:Solid
    Peso molecular:508.48

    Ref: TM-T63491

  • WRN inhibitor 13
    Targetmol
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    WRN inhibitor 13

    CAS:
    <p>WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.</p>
    Fórmula:C16H20N2O5S
    Cor e Forma:Solid
    Peso molecular:352.405

    Ref: TM-T204389

  • Logotipo do CymitQuimica
    Targetmol
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    14α-Demethylase/DNA Gyrase-IN-1

    <p>14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.</p>
    Fórmula:C26H22N4O4
    Cor e Forma:Solid
    Peso molecular:454.48

    Ref: TM-T62792