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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3477 produtos de "Ciclo celular/Ponto de verificação"

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  • Kolavenic acid analog
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    Kolavenic acid analog

    CAS:
    <p>KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.</p>
    Fórmula:C25H38O4
    Cor e Forma:Solid
    Peso molecular:402.57

    Ref: TM-T61970

  • Logotipo do CymitQuimica
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    Zalunfiban dihydrochloride

    <p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>
    Fórmula:C16H20Cl2N8O2S
    Cor e Forma:Solid
    Peso molecular:459.35

    Ref: TM-T62878

  • Logotipo do CymitQuimica
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    MtTMPK-IN-9

    <p>MtTMPK-IN-9 moderately inhibits MtbTMPK (IC50: 48 μM), has submicromolar Mycobacterium activity, and is non-toxic, aiding tuberculosis research.</p>
    Fórmula:C25H26N6O7
    Cor e Forma:Solid
    Peso molecular:522.51

    Ref: TM-T63657

  • (R)-CSN5i-3
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    (R)-CSN5i-3

    CAS:
    <p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>
    Fórmula:C28H29F2N5O2
    Pureza:99.76% - 99.97%
    Cor e Forma:Solid
    Peso molecular:505.56

    Ref: TM-T12620

  • WRN inhibitor 11
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    WRN inhibitor 11

    CAS:
    <p>WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.</p>
    Fórmula:C34H35ClF3N9O5
    Cor e Forma:Solid
    Peso molecular:742.15

    Ref: TM-T201262

  • LY 254155
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    LY 254155

    CAS:
    <p>LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.</p>
    Fórmula:C19H23N5O6S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:449.48

    Ref: TM-T11922

  • LNA-GTP
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    LNA-GTP

    CAS:
    <p>LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.</p>
    Fórmula:C11H16N5O14P3
    Cor e Forma:Solid
    Peso molecular:535.19

    Ref: TM-TSW-00969

  • Logotipo do CymitQuimica
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    4,5'-Dimethylangelicin-NHS

    <p>NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity &amp; photosensitivity.</p>
    Fórmula:C21H19NO7S
    Cor e Forma:Solid
    Peso molecular:429.44

    Ref: TM-T62365

  • DYRKs-IN-1 hydrochloride
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    DYRKs-IN-1 hydrochloride

    CAS:
    <p>DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) &amp; DYRK1B (8 nM IC50) with antitumor properties.</p>
    Fórmula:C30H31Cl2N7O4
    Cor e Forma:Solid
    Peso molecular:624.52

    Ref: TM-T72242

  • Logotipo do CymitQuimica
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    DNA gyrase B-IN-1

    <p>DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.</p>
    Fórmula:C23H18ClF3N6O4S
    Cor e Forma:Solid
    Peso molecular:566.94

    Ref: TM-T64012

  • Logotipo do CymitQuimica
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    α5β1 integrin agonist-1

    CAS:
    <p>α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.</p>
    Fórmula:C24H26FN5O9
    Cor e Forma:Solid
    Peso molecular:547.49

    Ref: TM-T63868

  • (R)-Atuveciclib
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    (R)-Atuveciclib

    CAS:
    <p>Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].</p>
    Fórmula:C18H18FN5O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:387.43

    Ref: TM-T10464

  • RAD51-IN-7
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    RAD51-IN-7

    CAS:
    <p>RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)</p>
    Fórmula:C25H31N5O4S2
    Cor e Forma:Solid
    Peso molecular:529.67

    Ref: TM-T63728

  • DNA ligase-IN-2
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    DNA ligase-IN-2

    CAS:
    <p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is &gt;64 μg/mL.</p>
    Fórmula:C13H8FN3O3
    Cor e Forma:Solid
    Peso molecular:273.219

    Ref: TM-T204415

  • AR-13324 M1 metabolite
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    AR-13324 M1 metabolite

    CAS:
    <p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>
    Fórmula:C19H19N3O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:321.37

    Ref: TM-T10358L

  • Methyl 3-oxodecanoate
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    Methyl 3-oxodecanoate

    CAS:
    <p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>
    Fórmula:C11H20O3
    Cor e Forma:Solid
    Peso molecular:200.275

    Ref: TM-T206384

  • DS96432529
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    DS96432529

    <p>DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.</p>
    Fórmula:C18H26N4O3S
    Cor e Forma:Soild
    Peso molecular:378.49

    Ref: TM-T61590

  • Logotipo do CymitQuimica
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    CDK9-IN-13

    <p>CDK9-IN-13 is a potent and selective CDK inhibitor (IC50&lt;3 nM). CDK9-IN-13 has a very short half-life in rodents.</p>
    Fórmula:C27H35N5O2
    Cor e Forma:Solid
    Peso molecular:461.6

    Ref: TM-T62919

  • 2'-O-MOE-GMP
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    2'-O-MOE-GMP

    CAS:
    <p>2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C13H20N5O9P
    Cor e Forma:Solid
    Peso molecular:421.30

    Ref: TM-TSW-00967

  • Chk1-IN-5
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    Chk1-IN-5

    CAS:
    <p>Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.</p>
    Fórmula:C18H18FN7O2
    Cor e Forma:Solid
    Peso molecular:383.38

    Ref: TM-T37098