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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

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Foram encontrados 3756 produtos de "Ciclo celular/Ponto de verificação"

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  • LNA-GDP
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    LNA-GDP

    CAS:
    LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.
    Fórmula:C11H15N5O11P2
    Cor e Forma:Solid
    Peso molecular:455.21

    Ref: TM-TSW-00961

  • 5-Methylcytosine hydrochloride
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    5-Methylcytosine hydrochloride

    CAS:
    5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.
    Fórmula:C5H8ClN3O
    Cor e Forma:Solid
    Peso molecular:161.59

    Ref: TM-T201054

  • LIMK-IN-2
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    LIMK-IN-2

    CAS:
    <p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>
    Fórmula:C28H27N5O2
    Cor e Forma:Solid
    Peso molecular:465.55

    Ref: TM-T86811

  • D-G23
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    D-G23

    CAS:
    <p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>
    Fórmula:C19H22N4O3
    Cor e Forma:Solid
    Peso molecular:354.403

    Ref: TM-T206763

  • Logotipo do CymitQuimica
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    Antibacterial agent 110

    Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).
    Fórmula:C22H21N5O4S
    Cor e Forma:Solid
    Peso molecular:451.5

    Ref: TM-T62740

  • LIMK1 inhibitor 2
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    LIMK1 inhibitor 2

    CAS:
    LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.
    Fórmula:C10H11N3OS
    Cor e Forma:Solid
    Peso molecular:221.279

    Ref: TM-T204765

  • Pseudouridine 5'-OTBDPS
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    Pseudouridine 5'-OTBDPS

    CAS:
    <p>Pseudouridine5'-OTBDPS [5-(5-O-TBDPS-β-D-ribofuranosyl)uracil] is an intermediate of Pseudouridine.</p>
    Fórmula:C25H30N2O6Si
    Cor e Forma:Solid
    Peso molecular:482.60

    Ref: TM-TSW-00962

  • CDK7-IN-31
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    CDK7-IN-31

    CAS:
    CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.
    Fórmula:C27H32F5N6O2P
    Cor e Forma:Solid
    Peso molecular:598.55

    Ref: TM-T201665

  • AB25583
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    AB25583

    CAS:
    AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.
    Fórmula:C22H17ClN4O3S
    Cor e Forma:Solid
    Peso molecular:452.91

    Ref: TM-T200101

  • DYRK1-IN-1
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    DYRK1-IN-1

    CAS:
    DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.
    Fórmula:C12H12N6
    Cor e Forma:Solid
    Peso molecular:240.26

    Ref: TM-T60334

  • KL-50
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    KL-50

    CAS:
    KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.
    Fórmula:C7H7FN6O2
    Cor e Forma:Solid
    Peso molecular:226.17

    Ref: TM-T200136

  • GR 83895
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    GR 83895

    CAS:
    GR 83895 is an antagonist of prototype fibrinogen receptor.
    Fórmula:C29H39N9O8S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:673.74

    Ref: TM-T25460

  • Zorubicin
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    Zorubicin

    CAS:
    <p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>
    Fórmula:C34H35N3O10
    Cor e Forma:Solid
    Peso molecular:645.66

    Ref: TM-T69130

  • Galidesivir
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    Galidesivir

    CAS:
    Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.
    Fórmula:C11H15N5O3
    Pureza:96.73% - 99.13%
    Cor e Forma:Solid
    Peso molecular:265.27

    Ref: TM-T10491

  • PLK1-IN-11
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    PLK1-IN-11

    CAS:
    PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.
    Fórmula:C12H11N5O
    Cor e Forma:Solid
    Peso molecular:241.249

    Ref: TM-T205548

  • 6-B345TTQ
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    6-B345TTQ

    CAS:
    6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.
    Fórmula:C22H20BrNO4
    Cor e Forma:Solid
    Peso molecular:442.303

    Ref: TM-T204244

  • And1 degrader 1
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    And1 degrader 1

    CAS:
    And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.
    Fórmula:C26H27Cl2N3O
    Cor e Forma:Solid
    Peso molecular:468.42

    Ref: TM-T200443

  • Cdc7-IN-11
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    Cdc7-IN-11

    CAS:
    Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.
    Fórmula:C20H22F2N4O2S
    Cor e Forma:Solid
    Peso molecular:420.48

    Ref: TM-T62231

  • LN-439A
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    LN-439A

    CAS:
    LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.
    Fórmula:C24H26FN3O4
    Cor e Forma:Solid
    Peso molecular:439.48

    Ref: TM-T200435

  • LNA-GMP
    Targetmol
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    LNA-GMP

    CAS:
    LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.
    Fórmula:C11H14N5O8P
    Cor e Forma:Solid
    Peso molecular:375.23

    Ref: TM-TSW-00965