Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(547 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(276 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(273 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
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Foram encontrados 3934 produtos de "Ciclo celular/Ponto de verificação"
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N6-Methyl-2'-β-C-ethynyl adenosine
N6-Methyl-2’-beta-C-ethynyl adenosine is a purine nucleoside analog.Fórmula:C13H15N5O4Cor e Forma:SolidPeso molecular:305.29CDK2-IN-7
CAS:CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).Fórmula:C24H30N6O4SCor e Forma:SolidPeso molecular:498.65'-O-DMT-rU
CAS:5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.Fórmula:C30H30N2O8Cor e Forma:SolidPeso molecular:546.57CDK7-IN-21
CAS:CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor [1] .Fórmula:C33H36FN9O2Cor e Forma:SolidPeso molecular:609.7Clofarabine-5'-diphosphate trisodium
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Fórmula:C10H10ClFN5Na3O9P2Cor e Forma:SolidPeso molecular:529.58Cyclothialidine
CAS:Cyclothialidine is an inhibitor of DNA gyrase.Fórmula:C26H35N5O12SCor e Forma:SolidPeso molecular:641.655'-DMTr-3'dA(Bz)-methylphosphonami dite
5’-DMTr-3’dA(Bz)-methylphosphonamidite, a purine nucleoside analog, exhibits wide-ranging antitumor activity, specifically targeting indolent lymphoidFórmula:C45H51N6O6PCor e Forma:SolidPeso molecular:802.9NUAK1-IN-2
NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Fórmula:C24H30N6OCor e Forma:SolidPeso molecular:418.535N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine
N4-Benzoyl-3'-O-DMT cytidine analog inhibits DNA methyltransferases like Zebularine.Fórmula:C41H43N3O9Cor e Forma:SolidPeso molecular:721.79AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Fórmula:C28H32FN9O2Cor e Forma:SolidPeso molecular:545.61Erythromycin thiocyanate
CAS:Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.Fórmula:C38H68N2O13SPureza:98%Cor e Forma:SolidPeso molecular:793.02ONX 0801 trisodium
CAS:ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Fórmula:C32H30N5Na3O10Cor e Forma:SolidPeso molecular:713.58Rev 2'-O-MOE-A(Bz)-5'-amidite
'Rev 2’-O-MOE-A(Bz)-5’-amidite is a nucleoside analog specifically categorized within the purine subset, renowned for its wide-ranging antitumor efficacyFórmula:C50H58N7O9PCor e Forma:SolidPeso molecular:932.01MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Cor e Forma:Odour SolidRA-V
RA-V is a natural product that can be used as a reference standard.Fórmula:C160H202N24O41Cor e Forma:SolidPeso molecular:3117.5DNA Gyrase-IN-6
Agent 138: soluble benzothiazole, inhibits DNA gyrase/topoisomerase IV, targets Gram+ & Gram- bacteria, binds plasma proteins.Fórmula:C18H16Cl2N4O4SCor e Forma:SolidPeso molecular:455.32CDK6/9-IN-1
CAS:CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).Fórmula:C22H25ClN8OCor e Forma:SolidPeso molecular:452.95N7-Methyl-2'-O-(2-methoxyethyl) guanosine
N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C14H21N5O6Cor e Forma:SolidPeso molecular:355.35CDK9-IN-25
CDK9-IN-25 (compound 4a), an imidazopyrazine derivative, functions as a CDK9 inhibitor with an IC50 of 0.24 μM.Fórmula:C15H16FN5Pureza:98%Cor e Forma:SolidPeso molecular:285.32PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Fórmula:C24H26FN5O2Cor e Forma:SolidPeso molecular:435.49
