CymitQuimica logo
Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

Exibir 10 mais subcategorias

Foram encontrados 3480 produtos de "Ciclo celular/Ponto de verificação"

Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
produtos por página.
  • Logotipo do CymitQuimica
    Targetmol
    + Info

    Mps1-IN-6

    <p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>
    Fórmula:C35H39N9O3
    Cor e Forma:Solid
    Peso molecular:633.74

    Ref: TM-T78965

  • 5-Methylcytidine 5′-triphosphate
    Targetmol
    + Info

    5-Methylcytidine 5′-triphosphate

    CAS:
    <p>5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innate</p>
    Fórmula:C10H18N3O14P3
    Cor e Forma:Solid
    Peso molecular:497.18

    Ref: TM-T74584

  • PDI-IN-4
    Targetmol
    + Info

    PDI-IN-4

    <p>PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.</p>
    Fórmula:C17H12F3NO2
    Cor e Forma:Solid
    Peso molecular:319.278

    Ref: TM-T204195

  • CDK4/6-IN-23
    Targetmol
    + Info

    CDK4/6-IN-23

    <p>CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.</p>
    Fórmula:C32H34FN7O4
    Cor e Forma:Solid
    Peso molecular:599.655

    Ref: TM-T204550

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    Anti-MRSA agent 7

    <p>Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.</p>
    Fórmula:C22H20BrF2N3O4
    Cor e Forma:Solid
    Peso molecular:508.31

    Ref: TM-T74810

  • HSDVHK-NH2
    Targetmol
    + Info

    HSDVHK-NH2

    CAS:
    <p>Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.</p>
    Fórmula:C30H48N12O9
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:720.78

    Ref: TM-TP1879

  • Censavudine
    Targetmol
    + Info

    Censavudine

    CAS:
    <p>Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.</p>
    Fórmula:C12H12N2O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:248.23

    Ref: TM-T30791

  • Filanesib TFA
    Targetmol
    + Info

    Filanesib TFA

    CAS:
    <p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>
    Fórmula:C22H23F5N4O4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:534.5

    Ref: TM-T25418

  • dCeMM3 
    Targetmol
    + Info

    dCeMM3 

    CAS:
    <p>dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.</p>
    Fórmula:C14H11ClN4OS
    Pureza:98.48% - 99.41%
    Cor e Forma:Solid
    Peso molecular:318.78

    Ref: TM-T9758

  • α2β1 Integrin Ligand Peptide
    Targetmol
    + Info

    α2β1 Integrin Ligand Peptide

    CAS:
    <p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>
    Fórmula:C14H22N4O9
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:390.35

    Ref: TM-TP1484

  • 5'-O-DMT-N4-Bz-2'-F-dC
    Targetmol
    + Info

    5'-O-DMT-N4-Bz-2'-F-dC

    CAS:
    <p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>
    Fórmula:C37H34FN3O7
    Cor e Forma:Solid
    Peso molecular:651.68

    Ref: TM-T37137

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    RNA polymerase II-IN-2

    <p>RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.</p>
    Fórmula:C41H58N10O12S
    Cor e Forma:Solid
    Peso molecular:915.02

    Ref: TM-T74631

  • Fuzapladib
    Targetmol
    + Info

    Fuzapladib

    CAS:
    <p>Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.</p>
    Fórmula:C15H20F3N3O3S
    Pureza:99.87%
    Cor e Forma:Soild
    Peso molecular:379.4

    Ref: TM-T67749

  • Adenosine Dialdehyde (ADOX)
    Targetmol
    + Info

    Adenosine Dialdehyde (ADOX)

    CAS:
    <p>Adenosine Dialdehyde, a purine analogue, inhibits SAHH (Ki=3.3 nM), and shows strong anti-tumor effects in vivo.</p>
    Fórmula:C10H11N5O4
    Pureza:95%
    Cor e Forma:Solid
    Peso molecular:265.23

    Ref: TM-T22231

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    GK13S

    <p>G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.</p>
    Fórmula:C21H22N6O2
    Cor e Forma:Solid
    Peso molecular:390.44

    Ref: TM-T75182

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    UnyLinker 12 TEA

    <p>UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.</p>
    Fórmula:C39H35NO10C6H15N
    Cor e Forma:Solid
    Peso molecular:778.34655

    Ref: TM-TSW-00947

  • CDK7-IN-5
    Targetmol
    + Info

    CDK7-IN-5

    CAS:
    <p>CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).</p>
    Fórmula:C34H45N9O2
    Cor e Forma:Solid
    Peso molecular:611.795

    Ref: TM-T39247

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    DHFR-IN-11

    <p>DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.</p>
    Cor e Forma:Odour Solid

    Ref: TM-T82570

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    PD-1/PD-L1-IN-52

    <p>PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.</p>
    Cor e Forma:Odour Solid

    Ref: TM-T200724

  • Mumefural
    Targetmol
    + Info

    Mumefural

    CAS:
    <p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>
    Fórmula:C12H12O9
    Cor e Forma:Solid
    Peso molecular:300.22

    Ref: TM-T75689