Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(111 produtos)
- CDK(525 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(46 produtos)
- DYRK(49 produtos)
- Dinamina(26 produtos)
- Ferroptose(225 produtos)
- HSP(180 produtos)
- Integrinas(256 produtos)
- Cinesina(87 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(283 produtos)
- PKC(111 produtos)
- PLK(25 produtos)
- ROCK(66 produtos)
- Rho(2 produtos)
- Wee1(14 produtos)
- c-Myc(75 produtos)
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Foram encontrados 3749 produtos de "Ciclo celular/Ponto de verificação"
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Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Cor e Forma:Odour SolidLIN28-IN-2
LIN28-IN-2 (Compound Ln268) blocks the interaction between the zinc finger domain (ZKD) of Lin28 and RNA substrates, inhibiting both Lin28a and Lin28b. It also suppresses the proliferation of Lin28-positive cancer cells and the growth of 3D spheroids.Fórmula:C9H7FN2O2SCor e Forma:SolidPeso molecular:226.227Tilatamig samrotecan
Tilatamig samrotecan (AZD9592) is an antibody-drug conjugate (ADC) designed to deliver a topoisomerase I inhibitor (TOP1i). It targets epidermal growth factor receptor (EGFR) and c-MET and demonstrates antitumor activity. The compound induces DNA double-strand breaks, elevates pRAD50 and γH2AX expression, and inhibits the growth of non-small cell lung cancer.Cor e Forma:Odour SolidRNase L ligand 1
<p>RNase L ligand 1 (Compound F1-COOH) serves as a ligand for RNase L and is utilized in the synthesis of F1-RIBOTAC.</p>Fórmula:C21H21Cl2NO3Cor e Forma:SolidPeso molecular:406.3026-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits broad antitumor activity byFórmula:C15H17N5O6Cor e Forma:SolidPeso molecular:363.33Diopterin
CAS:Diopterin is a folic acid analog.Fórmula:C24H26N8O9Cor e Forma:SolidPeso molecular:570.51Farletuzumab
CAS:Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Pureza:> 95%Cor e Forma:LiquidPeso molecular:145.36 kDa3'-Deoxy-GTP trisodium
<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.</p>Cor e Forma:Odour SolidCDK9 ligand 3
CAS:<p>CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.</p>Fórmula:C18H18BrCl2N5O3Cor e Forma:SolidPeso molecular:503.177KIF18A-IN-11
KIF18A-IN-11 (Compound 13) is an effective inhibitor of KIF18A, exhibiting IC50 values below 100 nM in OVCAR3 and MDA-MB-157 cells. It is applicable for cancer research.Fórmula:C28H38F2N6O4SPeso molecular:592.26433CTP Synthetase-IN-1 Ammonium salt
CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infectionsFórmula:C20H22F3N7O3S2Pureza:99.97%Cor e Forma:SolidPeso molecular:529.56TLK1-IN-1
TLK1-IN-1 (Compound 5n) is a TLK1 inhibitor with an IC50 of 7.2 μM for TLK1B and a GI50 of 2.7 μM for LNCaP cells. It induces DNA damage and apoptosis (Apoptosis) in cancer cells and is applicable in prostate cancer research.Fórmula:C24H23BrClN5O3Peso molecular:544.83c-Myc inhibitor 10
CAS:c-Myc inhibitor 10 enhances cell potency with improved permeability from methylated morpholine nitrogen.Fórmula:C28H38N6O3Cor e Forma:SolidPeso molecular:506.64Fibronectin Active Fragment Control
CAS:Fibronectin: a ~440kDa glycoprotein, binds integrins, collagen, fibrin, and heparan sulfate in the extracellular matrix.Fórmula:C18H32N8O9Pureza:98%Cor e Forma:SolidPeso molecular:504.49KWR137
<p>KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.</p>Fórmula:C33H31ClF3N9O4Cor e Forma:SolidPeso molecular:710.105TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Fórmula:C23H22Cl2FN5O3Pureza:99.65%Cor e Forma:SolidPeso molecular:506.362-Amino-3',5'-di-O-acetyl-N6,N6-dimethyl-2'-O-methyladenosine
2-Amino-3’,5’-di-O-acetyl-N6,N6-dimethyl-2’-O-methyladenosine is an adenosine analog.Fórmula:C17H24N6O6Cor e Forma:SolidPeso molecular:408.412'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium
2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate is a fluorinated analog of ATP, the pivotal energy substrate for cellular metabolism, and acts as an inhibitor ofFórmula:C10H11FN5O12P3·4NaCor e Forma:SolidPeso molecular:597.10LSN3106729 hydrochloride
CAS:LSN3106729 hydrochloride, an Abemaciclib metabolite, is a CDK-inhibiting antitumor PROTAC CDK4/6 degrader.Fórmula:C25H29ClF2N8OCor e Forma:SoildPeso molecular:531.00WRN inhibitor 10
WRN inhibitor 10 (Compound P24) is an inhibitor of the Werner helicase WRN, with an IC50 of 1.1 nM. It effectively inhibits the proliferation of SW48 cancer cells, with an IC50 of 39 nM. WRN inhibitor 10 exhibits favorable liver microsomal stability and membrane permeability, and demonstrates good pharmacokinetic properties in CD-1 mice.Fórmula:C31H29BrClN9O5SPeso molecular:753.08843
