Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(114 produtos)
- CDK(546 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(47 produtos)
- Dinamina(27 produtos)
- Ferroptose(227 produtos)
- HSP(180 produtos)
- Integrinas(269 produtos)
- Cinesina(87 produtos)
- LIM Quinase(20 produtos)
- Microtúbulo associado(274 produtos)
- PKC(126 produtos)
- PLK(25 produtos)
- ROCK(62 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(76 produtos)
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Foram encontrados 3904 produtos de "Ciclo celular/Ponto de verificação"
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Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Fórmula:C21H25FN4O2Cor e Forma:SolidPeso molecular:384.45α-Methyl-DL-aspartic acid
CAS:α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.Fórmula:C5H9NO4Pureza:99.91%Cor e Forma:SolidPeso molecular:147.1313-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.Fórmula:C12H19F2N6O12P3Cor e Forma:SolidPeso molecular:570.23DSPE-PEG3000-iRGD
DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.Cor e Forma:Odour Solidc-Myc inhibitor 7
CAS:c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.Fórmula:C35H30N6O5Cor e Forma:SoildPeso molecular:614.65Pseudorabies virus-IN-1
Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.Fórmula:C27H23ClF2N4O2Cor e Forma:SolidPeso molecular:508.947CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Fórmula:C24H22FN7O2Cor e Forma:SolidPeso molecular:459.48DSPE-PEG1000-cRGD
DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.Cor e Forma:Odour SolidIRE1-IN-2
IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.Fórmula:C16H20O6Cor e Forma:SolidPeso molecular:308.12599Clofarabine-5'-diphosphate
CAS:Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Fórmula:C10H13ClFN5O9P2Cor e Forma:SolidPeso molecular:463.64Echistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Fórmula:C217H341N71O74S9Pureza:98%Cor e Forma:SolidPeso molecular:5417.1Eesperamicin A1
CAS:Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.Fórmula:C59H80N4O22S4Cor e Forma:SolidPeso molecular:1325.54Mumefural
CAS:Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.
Fórmula:C12H12O9Cor e Forma:SolidPeso molecular:300.225'-O-TBDMS-dA
CAS:5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
Fórmula:C16H27N5O3SiCor e Forma:SolidPeso molecular:365.509TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Fórmula:C23H22Cl2FN5O3Pureza:99.65%Cor e Forma:SolidPeso molecular:506.36Ref: TM-T34787
1mg97,00€5mg235,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€1mL*10mM (DMSO)261,00€Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Fórmula:C13H20N2O6Cor e Forma:SolidPeso molecular:300.308SMS 121
CAS:SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Fórmula:C20H21NO5Pureza:98.29%Cor e Forma:SoildPeso molecular:355.38JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Fórmula:C43H45ClFN7O10SCor e Forma:SolidPeso molecular:906.375EFdA-TP
CAS:EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.Fórmula:C12H15FN5O12P3Cor e Forma:SolidPeso molecular:533.1955-Iminodaunorubicin
CAS:5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.Fórmula:C27H30N2O9Cor e Forma:SolidPeso molecular:526.54
