Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(100 produtos)
- CDK(520 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(43 produtos)
- DYRK(48 produtos)
- Dinamina(25 produtos)
- Ferroptose(218 produtos)
- HSP(173 produtos)
- Integrinas(248 produtos)
- Cinesina(75 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(279 produtos)
- PKC(107 produtos)
- PLK(26 produtos)
- ROCK(68 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(73 produtos)
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Foram encontrados 3655 produtos de "Ciclo celular/Ponto de verificação"
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IIP0943
CAS:<p>IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.</p>Fórmula:C26H28N6O3SCor e Forma:SolidPeso molecular:504.604L-I-OddU
CAS:<p>L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).</p>Fórmula:C8H9IN2O5Cor e Forma:SolidPeso molecular:340.07SF0166
CAS:SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Fórmula:C23H27F2N5O4Cor e Forma:SolidPeso molecular:475.49Ladirubicin
CAS:<p>Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.</p>Fórmula:C29H31NO11SCor e Forma:SolidPeso molecular:601.62PPA-037
CAS:<p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>Fórmula:C25H27N7Cor e Forma:SolidPeso molecular:425.53(R)-Atuveciclib
CAS:Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].Fórmula:C18H18FN5O2SPureza:98%Cor e Forma:SolidPeso molecular:387.43RMS-07
CAS:RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Fórmula:C35H40N8O2Cor e Forma:SolidPeso molecular:604.745-Iminodaunorubicin hydrochloride
CAS:<p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>Fórmula:C27H31ClN2O9Cor e Forma:SolidPeso molecular:563.00VPC-80051
CAS:<p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>Fórmula:C16H13F2N3OCor e Forma:SolidPeso molecular:301.2912'-(2-Nitrobenzyl)-ATP
CAS:<p>2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.</p>Fórmula:C17H21N6O15P3Cor e Forma:SolidPeso molecular:642.30RAD51-IN-7
CAS:RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)Fórmula:C25H31N5O4S2Cor e Forma:SolidPeso molecular:529.67CDK1-IN-7
CAS:<p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>Fórmula:C23H19ClN4O3Cor e Forma:SolidPeso molecular:434.88CDK6-IN-1
CAS:<p>CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.</p>Fórmula:C30H23N5Cor e Forma:SolidPeso molecular:453.54CDK7-IN-31
CAS:CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.Fórmula:C27H32F5N6O2PCor e Forma:SolidPeso molecular:598.55β-catenin-IN-8
CAS:<p>β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.</p>Fórmula:C15H12ClN3O2SCor e Forma:SolidPeso molecular:333.79CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Fórmula:C21H22N4OCor e Forma:SolidPeso molecular:346.432,5-Di-tert-butyl-1,4-benzoquinone
CAS:<p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>Fórmula:C14H20O2Cor e Forma:SolidPeso molecular:220.31T-2513 hydrochloride
CAS:T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.Fórmula:C25H28ClN3O5Cor e Forma:SolidPeso molecular:485.96α5β1 integrin agonist-1
CAS:α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Fórmula:C24H26FN5O9Cor e Forma:SolidPeso molecular:547.49Dyrk1A-IN-2
<p>Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.</p>Fórmula:C27H32N6O4Cor e Forma:SolidPeso molecular:504.58TMX-3013
CAS:TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Fórmula:C17H14BrFN6O3SCor e Forma:SolidPeso molecular:481.3FT709
CAS:<p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>Fórmula:C23H22N4O7SCor e Forma:SolidPeso molecular:498.51DNA polymerase-IN-6
CAS:DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.Fórmula:C26H28ClFN8O4Cor e Forma:SolidPeso molecular:571.003Antifolate agent 1
CAS:Antifolateagent 1 (Compound 1) is an antifolate agent featuring a single-carbon bridge. It lacks RFC transport, shows no affinity for FRα and FRβ, and exhibits no GARFTase inhibition activity. Antifolateagent 1 serves as a negative control in the development of folate receptor-targeted antifolate agents.Fórmula:C19H19N5O6Cor e Forma:SolidPeso molecular:413.38Antiangiogenic agent 2
<p>Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.</p>Fórmula:C26H26FN3O4Cor e Forma:SolidPeso molecular:463.53'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
CAS:3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite is a nucleoside phosphoramidite monomer featuring protective group modifications, suitable for RNA oligonucleotide synthesis.Fórmula:C42H51N8O5PCor e Forma:SolidPeso molecular:778.88Deoxythymidine-5'-triphosphate-d15
CAS:Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.Fórmula:C10H15Li2N2O14P3Cor e Forma:SolidPeso molecular:509.13CLK1/2-IN-1
CAS:CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.Fórmula:C21H20F3N7OPureza:98%Cor e Forma:SolidPeso molecular:443.42Morpholino U subunit
CAS:Morpholino U subunit is one of the fundamental components of morpholino oligonucleotides, capable of pairing with adenine in target RNA.Fórmula:C30H32ClN4O5PCor e Forma:SolidPeso molecular:595.03GFB-12811
CAS:<p>GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.</p>Fórmula:C22H23F4N5OPureza:98.88%Cor e Forma:SolidPeso molecular:449.44CTPS1-IN-1
CAS:CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Fórmula:C21H22N6O4S2Pureza:99.46%Cor e Forma:SolidPeso molecular:486.57HRO761
CAS:HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Fórmula:C31H31ClF3N9O5Pureza:98.74% - 99.62%Cor e Forma:SolidPeso molecular:702.08Elacytarabine
CAS:<p>Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.</p>Fórmula:C27H45N3O6Pureza:97.69%Cor e Forma:SolidPeso molecular:507.66SR 11302
CAS:<p>SR 11302 is an inhibitor of activator protein-1 (AP-1).</p>Fórmula:C26H32O2Pureza:98.65%Cor e Forma:SolidPeso molecular:376.53LY3143921 hydrate
CAS:<p>LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].</p>Fórmula:C16H14FN5O2Pureza:98.43%Cor e Forma:SolidPeso molecular:327.31INCB086550
CAS:<p>INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.</p>Fórmula:C41H39N7O4Pureza:98.49%Cor e Forma:SolidPeso molecular:693.79Troxacitabine
CAS:Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.Fórmula:C8H11N3O4Pureza:98%Cor e Forma:SolidPeso molecular:213.19Deoxypseudouridine
CAS:<p>Deoxypseudouridine is a nucleotide analog.</p>Fórmula:C9H12N2O5Cor e Forma:SolidPeso molecular:228.2Bicyclomycin benzoate
CAS:Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.Fórmula:C19H22N2O8Cor e Forma:SolidPeso molecular:406.39N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS:N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.Fórmula:C38H35N5O6Cor e Forma:SolidPeso molecular:657.7275'-O-DMT-N6-ibu-dA
CAS:5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Fórmula:C35H37N5O6Cor e Forma:SolidPeso molecular:623.71Tanuxiciclib
CAS:Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.Fórmula:C15H13FN6OCor e Forma:SolidPeso molecular:312.308Formycin A
CAS:Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.Fórmula:C10H13N5O4Pureza:98%Cor e Forma:SolidPeso molecular:267.24NSC639828
CAS:NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Fórmula:C18H13BrClN5O3Cor e Forma:SolidPeso molecular:462.69Ethynylcytidine
CAS:<p>Ethynylcytidine is a nucleoside antimetabolite.</p>Fórmula:C11H13N3O5Pureza:98%Cor e Forma:SolidPeso molecular:267.242'-Deoxy-2'-fluoro-5-iodouridine
CAS:2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.Fórmula:C9H10FIN2O5Cor e Forma:SolidPeso molecular:372.095'-DMT-3'-TBDMS-ibu-rG
CAS:<p>5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.</p>Fórmula:C41H51N5O8SiCor e Forma:SolidPeso molecular:769.96PLK1-IN-6
<p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>Fórmula:C28H37N9O3Cor e Forma:SolidPeso molecular:547.65GSK-3/CDK5/CDK2-IN-1
CAS:GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].Fórmula:C21H22N4O2Cor e Forma:SolidPeso molecular:362.433Ribocil-C
CAS:Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.Fórmula:C21H21N7OSPureza:98%Cor e Forma:SolidPeso molecular:419.56-Amino-5-nitropyridin-2-one
CAS:<p>6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.</p>Fórmula:C5H5N3O3Pureza:98%Cor e Forma:SolidPeso molecular:155.11MitoE10
CAS:<p>MitoE10 is an effective mitochondrial targeting antioxidant.</p>Fórmula:C42H55O5PSCor e Forma:SolidPeso molecular:702.92Tibremciclib
CAS:<p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>Fórmula:C28H32F2N8Pureza:98%Cor e Forma:SolidPeso molecular:518.6PHI-101
CAS:<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Fórmula:C19H19FN4O2SPureza:99.4%Cor e Forma:SolidPeso molecular:386.44YK-2168
CAS:<p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>Fórmula:C16H18ClN5Cor e Forma:SolidPeso molecular:315.80Ref: TM-T200769
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