Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(94 produtos)
- CDK(500 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(224 produtos)
- Cinesina(66 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(261 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(70 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(69 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3477 produtos de "Ciclo celular/Ponto de verificação"
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Isocytosine
CAS:<p>Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C4H5N3OCor e Forma:White To Off-White SolidPeso molecular:111.1PAT-LM1
<p>PAT-LM1 is a human monoclonal antibody that targets NRB54/NONO. It is applicable in the study of hematological malignancies.</p>Cor e Forma:Odour LiquidUridine triphosphate 13C9,15N2 sodium
CAS:<p>Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.</p>Fórmula:C9H1415N2NaO15P3Cor e Forma:SolidPeso molecular:517.04Etrolizumab
CAS:<p>MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.</p>Pureza:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Cor e Forma:LiquidMRK-952
<p>MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.</p>Fórmula:C20H20ClF3N6Cor e Forma:SolidPeso molecular:436.861N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine
<p>N3,5-Dimethyl-2’-O-(2-methoxyethyl) uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Fórmula:C14H22N2O7Cor e Forma:SolidPeso molecular:330.33Stigmatellin
CAS:<p>Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.</p>Fórmula:C30H42O7Cor e Forma:SolidPeso molecular:514.65CDK12-IN-4
CAS:<p>CDK12-IN-4 is a pyrazolotriazine that inhibits CDK12 (IC50: 0.641 μM) with high ATP (2 mM) and spares CDK2/Cyclin E and CDK9/Cyclin T1 (IC50: >20 μM).</p>Fórmula:C20H20F2N8OCor e Forma:SolidPeso molecular:426.432CDK5-IN-1
CAS:<p>CDK5-IN-1: Potent CDK5 inhibitor (<10 nM) used in kidney disease research.</p>Fórmula:C24H25FN6O3SCor e Forma:SolidPeso molecular:496.5613-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Fórmula:C12H19F2N6O12P3Cor e Forma:SolidPeso molecular:570.235'-O-DMT-N2-DMF-dG
CAS:<p>5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, finds application in deoxyribonucleic acid (DNA) or nucleic acid synthesis.</p>Fórmula:C34H36N6O6Cor e Forma:SolidPeso molecular:624.698TMX-2138
CAS:<p>TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.</p>Fórmula:C40H43BrFN9O11SCor e Forma:SolidPeso molecular:956.791Sarecycline hydrochloride
CAS:<p>Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.</p>Fórmula:C24H30ClN3O8Pureza:99.23%Cor e Forma:SolidPeso molecular:523.963'-Deoxy-N6-(m-methoxy benzyl)adenosine
<p>3’-Deoxy-N6-(m-methoxy benzyl)adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Fórmula:C18H21N5O4Cor e Forma:SolidPeso molecular:371.39Rifalazil
CAS:<p>Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.</p>Fórmula:C51H64N4O13Pureza:98%Cor e Forma:SolidPeso molecular:941.07LEB-03-146
CAS:<p>LEB-03-146: WEE1 DUBTAC linking AZD1775 to OTUB1 via PEG2; stabilizes WEE1 in HEP3B cells.</p>Fórmula:C46H57N11O8Cor e Forma:SolidPeso molecular:892.01Cimpuciclib
CAS:<p>Cimpuciclib is a cyclin-dependent kinase(CDK) inhibitor and antineoplastic.</p>Fórmula:C30H35FN8OCor e Forma:SolidPeso molecular:542.6635'-O-TBDMS-dU
CAS:<p>5'-O-TBDMS-dU can be used in the synthesis of oligoribonucleotides.</p>Fórmula:C15H26N2O5SiCor e Forma:SolidPeso molecular:342.4675-Methylcytidine 5′-triphosphate trisodium
<p>5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while</p>Fórmula:C10H15N3Na3O14P3Cor e Forma:SolidPeso molecular:563.13m7GpppGmpG
CAS:<p>m7GpppGmpG, a trinucleotide 5′ cap analog, exhibits capping efficiencies of 86% for the RNAs obtained [1].</p>Fórmula:C32H43N15O25P4Cor e Forma:SolidPeso molecular:1161.66PKMYT1-IN-3
<p>PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.</p>Fórmula:C24H26FN5O2Cor e Forma:SolidPeso molecular:435.49AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Fórmula:C137H215IN30O45SCor e Forma:SolidPeso molecular:3161.325-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS:<p>5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.</p>Fórmula:C22H31N3O5SiCor e Forma:SolidPeso molecular:445.58Ficellomycin
CAS:<p>Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.</p>Fórmula:C13H24N6O3Cor e Forma:SolidPeso molecular:312.372-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Fórmula:C12H24ClNO4Cor e Forma:SolidPeso molecular:281.78LL-K8-22
<p>LL-K8-22: potent CDK8/cyclin C degrader; DC50 ~2.5μM; hinders STAT1 phosphorylation; curbs E2F/MYC cancer pathways; for TNBC study.</p>Fórmula:C37H43N5OCor e Forma:SolidPeso molecular:573.77AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Fórmula:C28H32FN9O2Cor e Forma:SolidPeso molecular:545.616-Amino-4-methoxy-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
<p>6-Amino-4-methoxy-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits widespread antitumor efficacy, particularly against</p>Fórmula:C11H17N5O5Cor e Forma:SolidPeso molecular:299.28Pseudouridimycin
CAS:<p>Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.</p>Fórmula:C17H26N8O9Pureza:98%Cor e Forma:SolidPeso molecular:486.44CDK9-IN-25
<p>CDK9-IN-25 (compound 4a), an imidazopyrazine derivative, functions as a CDK9 inhibitor with an IC50 of 0.24 μM.</p>Fórmula:C15H16FN5Pureza:98%Cor e Forma:SolidPeso molecular:285.32Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Fórmula:C25H41N11O8SCor e Forma:SolidPeso molecular:655.727ONX 0801 trisodium
CAS:<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>Fórmula:C32H30N5Na3O10Cor e Forma:SolidPeso molecular:713.58Pseudorabies virus-IN-1
<p>Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.</p>Fórmula:C27H23ClF2N4O2Cor e Forma:SolidPeso molecular:508.9479-(5(R)-C-Methyl-2,3,5-tri-O-benzoyl-D-ribofuranosyl)-6-chloropurine
<p>9-(5(R)-C-Methyl-2,3,5-tri-O-benzoyl-D-ribofuranosyl)-6-chloropurine: A purine analog with antitumor effects, inhibiting DNA synthesis and inducing apoptosis.</p>Fórmula:C32H25ClN4O7Cor e Forma:SolidPeso molecular:613.02EFdA-TP
CAS:<p>EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.</p>Fórmula:C12H15FN5O12P3Cor e Forma:SolidPeso molecular:533.1952'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS:<p>dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.</p>Fórmula:C10H14N5Na2O8PCor e Forma:SolidPeso molecular:409.202DSPE-PEG1000-cRGD
<p>DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.</p>Cor e Forma:Odour Solidm7GpppApG
CAS:<p>M7GpppApG is a trinucleotide mRNA 5' cap analog utilized for in vitro RNA synthesis [1].</p>Fórmula:C31H41N15O24P4Cor e Forma:SolidPeso molecular:1131.642'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolent</p>Fórmula:C22H43FN7O7PCor e Forma:SolidPeso molecular:567.59Orbofiban acetate
CAS:<p>Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administered</p>Fórmula:C19H27N5O6Cor e Forma:SolidPeso molecular:421.45N4-(3,3,3-Trifluoropropanoyl)cytidine
<p>N4-(3,3,3-Trifluoropropanoyl)cytidine, a cytidine analog, inhibits DNA methyltransferases, possibly anti-metabolic and anti-cancer.</p>Fórmula:C12H14F3N3O6Cor e Forma:SolidPeso molecular:353.25Rev 2'-O-MOE-5MeC(Bz)-5'-amidite
<p>Rev 2’-O-MOE-5MeC(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Fórmula:C50H60N5O10PCor e Forma:SolidPeso molecular:922.01DNA Gyrase-IN-17
<p>DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.</p>Fórmula:C18H15ClFN5OCor e Forma:SolidPeso molecular:371.094926-Amino-4-hydrozino-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
<p>6-Amino-4-hydrozino-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, boasts a broad spectrum of biochemical and</p>Fórmula:C10H17N7O3Cor e Forma:SolidPeso molecular:283.29Eesperamicin A1
CAS:<p>Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.</p>Fórmula:C59H80N4O22S4Cor e Forma:SolidPeso molecular:1325.54RNA splicing modulator 2
CAS:<p>RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .</p>Fórmula:C20H21N5OSCor e Forma:SolidPeso molecular:379.48Biotin-PEG8-Vidarabine
<p>Biotin-PEG8-Vidarabine is an antiviral PEG linker targeting herpes and varicella zoster with adenosine analog Vidarabine.</p>Fórmula:C36H60N8O13SCor e Forma:SolidPeso molecular:844.97RNA polymerase II-IN-2
<p>RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.</p>Fórmula:C41H58N10O12SCor e Forma:SolidPeso molecular:915.025'-O-DMT-rI
CAS:<p>5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1].</p>Fórmula:C31H30N4O7Cor e Forma:SolidPeso molecular:570.59GSK299423
CAS:<p>GSK299423: Antibiotic possibly effective against bacteria with New Delhi metal-β-lactamase, targeting topoisomerases.</p>Fórmula:C25H27N5O2SPureza:97.34%Cor e Forma:SolidPeso molecular:461.58
