Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(114 produtos)
- CDK(546 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(47 produtos)
- Dinamina(27 produtos)
- Ferroptose(227 produtos)
- HSP(180 produtos)
- Integrinas(269 produtos)
- Cinesina(87 produtos)
- LIM Quinase(20 produtos)
- Microtúbulo associado(274 produtos)
- PKC(126 produtos)
- PLK(25 produtos)
- ROCK(62 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(76 produtos)
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Foram encontrados 3904 produtos de "Ciclo celular/Ponto de verificação"
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3'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolent lymphoidFórmula:C38H43N5O9Cor e Forma:SolidPeso molecular:713.785'-O-DMT-N4-Ac-2'-F-dC
CAS:5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.Fórmula:C32H32FN3O7Cor e Forma:SolidPeso molecular:589.615'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.Fórmula:C44H49F2N4O7PCor e Forma:SolidPeso molecular:814.85α2β1 Integrin Ligand Peptide TFA
α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is aFórmula:C16H23F3N4O11Pureza:98%Cor e Forma:SolidPeso molecular:504.37Lorutengitide
CAS:Lorutengitide is a transcription-regulating peptide with antiproliferative activity.Fórmula:C30H50N8O12Cor e Forma:SolidPeso molecular:714.764Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Fórmula:C21H25FN4O2Cor e Forma:SolidPeso molecular:384.45CDK2-IN-43
CDK2-IN-43 (Compound 3a) is a CDK2-cyclin E2 inhibitor with an IC50 value of 6.0 nM. It is applicable to cancer research.Fórmula:C19H27N7OCor e Forma:SolidPeso molecular:369.464[pThr3]-CDK5 Substrate
CAS:[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.[pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM[1].Fórmula:C53H100N15O15PPureza:98%Cor e Forma:SolidPeso molecular:1218.4313-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.Fórmula:C12H19F2N6O12P3Cor e Forma:SolidPeso molecular:570.23(1S,3R,5R)-PIM447 dihydrochloride
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).Fórmula:C24H25Cl2F3N4OPureza:98%Cor e Forma:SolidPeso molecular:513.38CDK7-IN-21
CAS:CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor [1] .Fórmula:C33H36FN9O2Cor e Forma:SolidPeso molecular:609.7Trimethoprim hydrochloride
CAS:Trimethoprim hydrochloride: oral, broad-spectrum antibiotic, DHFR inhibitor, treats UTIs, shigellosis, pneumocystis pneumonia, may block Influenza A with zinc.Fórmula:C14H19ClN4O3Cor e Forma:SolidPeso molecular:326.78Obtustatin
Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.Fórmula:C184H284N52O57S8Pureza:98%Cor e Forma:SolidPeso molecular:4393.07CDK4/6-IN-5
CAS:CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) & 4.4 nM (CDK6/D3). (WO2019207463A1, A93)Fórmula:C22H28ClFN6O4SCor e Forma:SolidPeso molecular:527.01Gly-Arg-Gly-Asp-Ser
CAS:Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.Fórmula:C17H30N8O9Pureza:98%Cor e Forma:SolidPeso molecular:490.47Solidagonic acid
CAS:Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.Fórmula:C22H34O4Cor e Forma:SolidPeso molecular:362.5Rev 2'-O-MOE-A(Bz)-5'-amidite
'Rev 2’-O-MOE-A(Bz)-5’-amidite is a nucleoside analog specifically categorized within the purine subset, renowned for its wide-ranging antitumor efficacyFórmula:C50H58N7O9PCor e Forma:SolidPeso molecular:932.01MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Cor e Forma:Odour SolidMYC-IN-2
CAS:MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.Fórmula:C25H17N3O2SCor e Forma:SolidPeso molecular:423.49Pseudorabies virus-IN-1
Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.Fórmula:C27H23ClF2N4O2Cor e Forma:SolidPeso molecular:508.947ONX 0801 trisodium
CAS:ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Fórmula:C32H30N5Na3O10Cor e Forma:SolidPeso molecular:713.58DHFR-IN-11
DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.Cor e Forma:Odour SolidHDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Fórmula:C24H27FN4O5Cor e Forma:SolidPeso molecular:470.49BIO5192 hydrate
BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.Cor e Forma:SolidN4-(n-Palmitoyl)-4'-azido-2'-deoxy-2'-fluoro-arabinocytidine
N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a cytidine nucleoside analog.Fórmula:C25H41FN6O5Cor e Forma:SolidPeso molecular:524.63WAY-322243
CAS:WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.Fórmula:C18H18N2O2SPureza:99.88%Cor e Forma:SoildPeso molecular:326.41Ganodermaones B
Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .Fórmula:C21H26O5Cor e Forma:SolidPeso molecular:358.433'-β-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine
3’-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine is an adenosine analog.Fórmula:C20H18F3N5O4Cor e Forma:SolidPeso molecular:449.38L-5-Methyluridine
CAS:L-5-Methyluridine, an L-configuration of 5-Methyluridine, is an endogenous methylated nucleoside present in human fluids.Fórmula:C10H14N2O6Cor e Forma:SolidPeso molecular:258.23S-MGB-234
CAS:S-MGB-234 treats AAT, effective against T. congolense and T. vivax, no cross-resistance or shared transport with diamidines.Fórmula:C30H32N8O4Cor e Forma:SolidPeso molecular:568.638EFdA-TP tetraammonium
EFdA-TP tetraammonium is a potent HIV-1 RT inhibitor and DNA synthesis blocker, acting as an ICT or DCT.Fórmula:C12H27N9O12P3Cor e Forma:SolidPeso molecular:601.31Evybactin
Evybactin: a selective DNA gyrase inhibitor for Mycobacterium tuberculosis (MIC 0.25 µg/mL), first of its kind.Fórmula:C64H89N21O21Cor e Forma:SolidPeso molecular:1488.52DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Cor e Forma:Odour SolidFF-10502
CAS:FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.Fórmula:C9H12FN3O3SCor e Forma:SolidPeso molecular:261.27N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Fórmula:C21H35N12O17P3Cor e Forma:SolidPeso molecular:820.49STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Pureza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Cor e Forma:Odour LiquidPeso molecular:145.12 kDaRNA splicing modulator 1
CAS:RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].Fórmula:C19H20N6OSCor e Forma:SolidPeso molecular:380.47R-1479
CAS:R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.Fórmula:C9H12N6O5Pureza:98.11% - 99.95%Cor e Forma:SolidPeso molecular:284.23Ref: TM-TQ0162
1mg104,00€5mg258,00€10mg358,00€25mg595,00€50mg842,00€100mg1.134,00€200mg1.521,00€1mL*10mM (DMSO)318,00€AD16
CAS:AD16 (Acetamide) acts as an inhibitor of LINE-1 retrotransposon endonuclease, exhibiting an IC50 value of 4.7 μM. It decreases LINE-1 retrotransposition in senescent cells and mitigates the resulting DNA damage and inflammation.Fórmula:C24H20N14O3S2Cor e Forma:SolidPeso molecular:616.64CBP501 Affinity Peptide
CAS:CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].Fórmula:C68H119N21O25SCor e Forma:SolidPeso molecular:1662.86Apcin A HCL
CAS:Apcin A HCL is an Apcin-derived APC inhibitor that binds Cdc20 and hinders ubiquitination, useful for synthesizing PROTAC CP5V.
Fórmula:C10H15Cl4N5O2Pureza:99.59%Cor e Forma:SolidPeso molecular:379.07Bimosiamose disodium
CAS:Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Fórmula:C46H52Na2O16Pureza:98%Cor e Forma:SolidPeso molecular:906.88RP-1664
CAS:RP-1664,PLK4 inhibitor (IC50=3 nM). Disrupts centriole biogenesis. Antitumor activity in breast cancer, neuroblastoma.Fórmula:C23H24F2N8O2SPureza:99.04%Cor e Forma:SoildPeso molecular:514.55dCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.
Fórmula:C14H11ClN4OSPureza:98.48% - 99.41%Cor e Forma:SolidPeso molecular:318.785'-O-TBDMS-Bz-dA
CAS:5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.Fórmula:C23H31N5O4SiCor e Forma:SolidPeso molecular:469.617(S)-DI-87
CAS:(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor，reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.Fórmula:C23H30N6O3S2Pureza:99.42%Cor e Forma:SoildPeso molecular:502.655'(R)-C-Methyl-5-fluorouridine
5’(R)-C-Methyl-5-fluorouridine, a uridine analogue, possesses potential antiepileptic properties.Fórmula:C10H13FN2O6Cor e Forma:SolidPeso molecular:276.22ROCK-IN-32
CAS:ROCK-IN-32 is an effective Rho-kinase inhibitor.Fórmula:C20H17Cl2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:402.27Aclacinomycin A
CAS:Aclacinomycin A has a wide range of applications in life science related research.Fórmula:C42H53NO15Pureza:99.43%Cor e Forma:SolidPeso molecular:811.87CPS2
CAS:CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.Fórmula:C38H42N12O10S2Cor e Forma:SolidPeso molecular:890.94
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