Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(94 produtos)
- CDK(500 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(224 produtos)
- Cinesina(66 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(261 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(70 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(69 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3477 produtos de "Ciclo celular/Ponto de verificação"
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SP27
<p>SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].</p>Fórmula:C40H40F2N12O5Pureza:98%Cor e Forma:SolidPeso molecular:806.826-O-Methyl-2'-O-methylinosine
<p>6-O-Methyl-2’-O-methylinosine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Fórmula:C12H16N4O5Cor e Forma:SolidPeso molecular:296.28Heliquinomycin
CAS:<p>Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.</p>Fórmula:C33H30O17Cor e Forma:SolidPeso molecular:698.586N6-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl) adenosine
<p>N6-Benzoyl-3'-O-DMT-adenosine is a purine analog with antitumor effects by hindering DNA synthesis and inducing apoptosis.</p>Fórmula:C41H41N5O8Cor e Forma:SolidPeso molecular:731.79(1S,3R,5R)-PIM447 dihydrochloride
<p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>Fórmula:C24H25Cl2F3N4OPureza:98%Cor e Forma:SolidPeso molecular:513.3812R-LOX-IN-2
CAS:<p>12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.</p>Fórmula:C19H13NOPureza:99.84%Cor e Forma:SolidPeso molecular:271.31Mulnitorsen
CAS:<p>Mulnitorsen acts as an inhibitor of antisense non-coding mitochondrial RNA (ASncmtRNA) synthesis and serves as an antitumor agent [1].</p>Fórmula:C172H217N74O82P17S17Cor e Forma:SolidPeso molecular:5704.662'-Deoxy-2'-fluorouridine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits extensive antitumor effects against indolent lymphoid</p>Fórmula:C21H42FN4O7PCor e Forma:SolidPeso molecular:512.553'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
<p>3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolent lymphoid</p>Fórmula:C38H43N5O9Cor e Forma:SolidPeso molecular:713.785'-O-DMT-N4-Ac-2'-F-dC
CAS:<p>5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Fórmula:C32H32FN3O7Cor e Forma:SolidPeso molecular:589.61Chrysomycin A
CAS:<p>Chrysomycin A is an antibiotic that can be derived from Streptomyces.</p>Fórmula:C28H28O9Cor e Forma:SolidPeso molecular:508.52Deoxythymidine-5'-triphosphate sodium hydrate
<p>dTTP sodium hydrate, a DNA synthesis component, is a nucleoside triphosphate.</p>Fórmula:C10H17N2O14P3·xNa·xH2OCor e Forma:SolidPeso molecular:C10H17N2O14P3.xNa.xH2ODG1
<p>DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressing</p>Fórmula:C19H17N5O5SCor e Forma:SolidPeso molecular:427.43Mumefural
CAS:<p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>Fórmula:C12H12O9Cor e Forma:SolidPeso molecular:300.22m7GpppCpG
CAS:<p>m7GpppCpG, a trinucleotide cap analogue, is used for synthesizing RNA with cap 0 or cap 1 structures.</p>Fórmula:C30H41N13O25P4Cor e Forma:SolidPeso molecular:1107.61CDK2-IN-7
CAS:<p>CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).</p>Fórmula:C24H30N6O4SCor e Forma:SolidPeso molecular:498.6CW-2
<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>Fórmula:C43H42Cl2FN11O10PtCor e Forma:SolidPeso molecular:1156.212515-(2-Hydroxyethyl)-2',3'-di-O-toluoyl-2'-deoxyuridine
<p>5-(2-Hydroxyethyl)-2',3'-di-O-toluoyl-2'-deoxyuridine, a purine nucleoside analog, exhibits widespread antitumor activity specifically against indolent lymphoid</p>Fórmula:C27H28N2O8Cor e Forma:SolidPeso molecular:508.52JB300
CAS:<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Fórmula:C43H45ClFN7O10SCor e Forma:SolidPeso molecular:906.3755-Iminodaunorubicin
CAS:<p>5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.</p>Fórmula:C27H30N2O9Cor e Forma:SolidPeso molecular:526.54TTK/PLK1-IN-1
CAS:<p>TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.</p>Fórmula:C30H33N7O2Pureza:97.39%Cor e Forma:SolidPeso molecular:523.63Nogalamycin
CAS:<p>Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.</p>Fórmula:C39H49NO16Pureza:98%Cor e Forma:SolidPeso molecular:787.8125'-O-TBDMS-dA
CAS:<p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Fórmula:C16H27N5O3SiCor e Forma:SolidPeso molecular:365.5095'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
<p>5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.</p>Fórmula:C44H49F2N4O7PCor e Forma:SolidPeso molecular:814.85WAY-647802
CAS:<p>WAY-647802 is a CDK inhibitor.</p>Fórmula:C11H14N4O3Pureza:99.53%Cor e Forma:SolidPeso molecular:250.25Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Fórmula:C21H25FN4O2Cor e Forma:SolidPeso molecular:384.45Anticancer agent 263
<p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>Fórmula:C13H20N2O6Cor e Forma:SolidPeso molecular:300.3086-Methoxypurine-9-β-D-5'(R)-C-methylriboside
<p>6-Methoxypurine-9-β-D-5’(R)-C-methylriboside, an analog of hypoxanthine—a purine base predominantly found in muscle tissue and a metabolite generated when</p>Fórmula:C12H16N4O5Cor e Forma:SolidPeso molecular:296.28Obtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Fórmula:C184H284N52O57S8Pureza:98%Cor e Forma:SolidPeso molecular:4393.0713-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Fórmula:C12H19F2N6O12P3Cor e Forma:SolidPeso molecular:570.23Rachelmycin
CAS:<p>Rachelmycin, a potent antibiotic and antitumor agent from Streptomyces zelensis, binds to DNA's minor groove.</p>Fórmula:C37H33N7O8Cor e Forma:SolidPeso molecular:703.712wrwycr-NH2 TFA
<p>wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.</p>Cor e Forma:Odour SolidBz-rC Phosphoramidite
CAS:<p>Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>Fórmula:C52H66N5O9PSiCor e Forma:SolidPeso molecular:964.185DNA Gyrase-IN-6
<p>Agent 138: soluble benzothiazole, inhibits DNA gyrase/topoisomerase IV, targets Gram+ & Gram- bacteria, binds plasma proteins.</p>Fórmula:C18H16Cl2N4O4SCor e Forma:SolidPeso molecular:455.32EC0488
CAS:<p>EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity.</p>Fórmula:C65H98N16O34SPureza:98%Cor e Forma:SolidPeso molecular:1679.63Biotin-PEG8-Vidarabine
<p>Biotin-PEG8-Vidarabine is an antiviral PEG linker targeting herpes and varicella zoster with adenosine analog Vidarabine.</p>Fórmula:C36H60N8O13SCor e Forma:SolidPeso molecular:844.973,6-DMAD hydrochloride
<p>3,6-DMAD hydrochloride functions as an inhibitor for the IRE1α-XBP1 pathway within the unfolded protein response mechanism.</p>Fórmula:C22H31N5xHClPureza:98%Cor e Forma:SolidPeso molecular:365.525-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS:<p>5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.</p>Fórmula:C22H31N3O5SiCor e Forma:SolidPeso molecular:445.585'-O-DMT-2'-O-TBDMS-Ac-rC
CAS:<p>5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Fórmula:C38H47N3O8SiCor e Forma:SolidPeso molecular:701.892N4-(n-Palmitoyl)-4'-azido-2'-deoxy-2'-fluoro-arabinocytidine
<p>N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a cytidine nucleoside analog.</p>Fórmula:C25H41FN6O5Cor e Forma:SolidPeso molecular:524.63Pseudorabies virus-IN-1
<p>Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.</p>Fórmula:C27H23ClF2N4O2Cor e Forma:SolidPeso molecular:508.947ONX 0801 trisodium
CAS:<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>Fórmula:C32H30N5Na3O10Cor e Forma:SolidPeso molecular:713.58Ficellomycin
CAS:<p>Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.</p>Fórmula:C13H24N6O3Cor e Forma:SolidPeso molecular:312.37Ganodermaones B
<p>Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .</p>Fórmula:C21H26O5Cor e Forma:SolidPeso molecular:358.43Nitrosofolic acid
CAS:<p>Nitrosofolic acid is a folic acid derivaive.</p>Fórmula:C19H18N8O7Cor e Forma:SolidPeso molecular:470.405'-O-DMT-2'-O-TBDMS-Bz-rC
CAS:<p>5'-O-DMT-2'-O-TBDMS-Bz-rC, a modified nucleoside, is utilized in the synthesis of DNA or RNA.</p>Fórmula:C43H49N3O8SiCor e Forma:SolidPeso molecular:763.95R-BC154 acetate
<p>R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.</p>Fórmula:C56H65N9O14S3Cor e Forma:SolidPeso molecular:1184.36L-5-Methyluridine
CAS:<p>L-5-Methyluridine, an L-configuration of 5-Methyluridine, is an endogenous methylated nucleoside present in human fluids.</p>Fórmula:C10H14N2O6Cor e Forma:SolidPeso molecular:258.23EFdA-TP tetraammonium
<p>EFdA-TP tetraammonium is a potent HIV-1 RT inhibitor and DNA synthesis blocker, acting as an ICT or DCT.</p>Fórmula:C12H27N9O12P3Cor e Forma:SolidPeso molecular:601.312'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolent</p>Fórmula:C22H43FN7O7PCor e Forma:SolidPeso molecular:567.59
