Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(111 produtos)
- CDK(525 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(46 produtos)
- DYRK(49 produtos)
- Dinamina(26 produtos)
- Ferroptose(225 produtos)
- HSP(180 produtos)
- Integrinas(256 produtos)
- Cinesina(87 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(283 produtos)
- PKC(111 produtos)
- PLK(25 produtos)
- ROCK(66 produtos)
- Rho(2 produtos)
- Wee1(14 produtos)
- c-Myc(75 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3749 produtos de "Ciclo celular/Ponto de verificação"
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GW406108X(Z/E)
CAS:GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .Fórmula:C20H11Cl2NO4Pureza:98.23%Cor e Forma:SolidPeso molecular:400.21Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Fórmula:C21H18F3N5OPureza:98.91%Cor e Forma:SolidPeso molecular:413.4TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Fórmula:C24H21Cl2NO5Pureza:98.98%Cor e Forma:SolidPeso molecular:474.33LDC-4297 HCl (1453834-21-3(free base))
<p>LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.</p>Fórmula:C23H29ClN8OPureza:100%Cor e Forma:SolidPeso molecular:469.022′-Deoxy-2′-fluoroguanosine
CAS:2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that potently inhibits influenza virus A and B strains(EC90 <0.35 μM).Fórmula:C10H12FN5O4Pureza:99.89%Cor e Forma:SolidPeso molecular:285.23BMS-5
CAS:BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H14Cl2F2N4OSPureza:98.01% - 99.88%Cor e Forma:SolidPeso molecular:431.29BMS-1001
CAS:BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay).Fórmula:C35H34N2O7Pureza:98.43%Cor e Forma:SolidPeso molecular:594.7Fosifloxuridine nafalbenamide
CAS:<p>Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.</p>Fórmula:C29H29FN3O9PPureza:95.87%Cor e Forma:SolidPeso molecular:613.53Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Fórmula:C18H18FN5O2SPureza:98.8%Cor e Forma:SolidPeso molecular:387.43Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Fórmula:C27H40N8O7Pureza:98% - 99.8%Cor e Forma:SolidPeso molecular:588.66Danusertib
CAS:<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Fórmula:C26H30N6O3Pureza:97.88% - 98.79%Cor e Forma:White PowderPeso molecular:474.55KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Fórmula:C20H20N4OPureza:98.43% - 99.69%Cor e Forma:SolidPeso molecular:332.4Silver sulfadiazine
CAS:Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.Fórmula:C10H9AgN4O2SPureza:99.04% - 99.58%Cor e Forma:SolidPeso molecular:357.14Arginine-glycine-aspartic acid
CAS:RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.Fórmula:C12H22N6O6Pureza:99.11%Cor e Forma:SolidPeso molecular:346.34YKL-5-124
CAS:YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displaysFórmula:C28H33N7O3Pureza:99.36%Cor e Forma:SolidPeso molecular:515.61PTC-209 hydrobromide
CAS:<p>PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in</p>Fórmula:C17H13Br2N5OS·HBrPureza:99.91%Cor e Forma:SolidPeso molecular:576.1Bredinin aglycone
CAS:Bredinin aglycone (SM-108) is a purine nucleotide analog.Fórmula:C4H5N3O2Pureza:99.06%Cor e Forma:SolidPeso molecular:127.1WEE1-IN-3
CAS:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Fórmula:C28H31N7O2Pureza:98.33%Cor e Forma:SolidPeso molecular:497.59HALOFUGINONE LACTATE
CAS:HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.Fórmula:C19H23BrClN3O6Pureza:99.70% - 99.96%Cor e Forma:SolidPeso molecular:504.8dGTP
CAS:dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, andFórmula:C10H16N5O13P3Pureza:99.64%Cor e Forma:SolidPeso molecular:507.182'-Fluoro-2'-Deoxyadenosine
CAS:2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).Fórmula:C10H12FN5O3Pureza:99.95%Cor e Forma:SolidPeso molecular:269.23Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Fórmula:C28H26Cl2N4O5Pureza:99.26% - 99.72%Cor e Forma:SolidPeso molecular:569.44Levomefolate calcium
CAS:<p>Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.</p>Fórmula:C20H23CaN7O6Pureza:97.35%Cor e Forma:Off-White To Pale Yellow SolidPeso molecular:497.52AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Fórmula:C17H19FN4O2SPureza:98.96% - 99.19%Cor e Forma:SolidPeso molecular:362.42CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Fórmula:C21H17ClF6N2O2Pureza:99.58%Cor e Forma:SolidPeso molecular:478.82Abemaciclib
CAS:Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Fórmula:C27H32F2N8Pureza:99.43% - 99.87%Cor e Forma:SolidPeso molecular:506.59NY2267
CAS:NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFórmula:C38H43N3O6Pureza:99.16% - 99.27%Cor e Forma:SolidPeso molecular:637.76NSC23005 Sodium
CAS:<p>NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.</p>Fórmula:C13H16NNaO4SPureza:99.64%Cor e Forma:SolidPeso molecular:305.32BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Fórmula:C22H32N6·HClPureza:99.21%Cor e Forma:SolidPeso molecular:416.99Triazavirin
CAS:Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.Fórmula:C5H7N6NaO5SPureza:99.55%Cor e Forma:SolidPeso molecular:286.2NSC 617145
CAS:NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependentFórmula:C13H10Cl4N2O4Pureza:99.78%Cor e Forma:SolidPeso molecular:400.04Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Pureza:97.15% (SDS-PAGE); 97.2% (SEC-HPLC) - 98.00%Cor e Forma:LiquidPeso molecular:N/AJNJ-7706621
CAS:<p>JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.</p>Fórmula:C15H12F2N6O3SPureza:99.1% - 99.85%Cor e Forma:SolidPeso molecular:394.366-Bromo-2-hydroxy-3-methoxybenzaldehyde
CAS:6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) is an inhibitor of IRE-1α (IC50 : 0.08 μM).Fórmula:C8H7BrO3Pureza:99.82%Cor e Forma:SolidPeso molecular:231.04Empesertib
CAS:Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Fórmula:C29H26FN5O4SPureza:97.45% - 99.4%Cor e Forma:SolidPeso molecular:559.614μ8C
CAS:4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Fórmula:C11H8O4Pureza:97.48% - 98.45%Cor e Forma:SolidPeso molecular:204.18Isoindigotin
CAS:<p>Isoindigotin is used in the therapy of Y.</p>Fórmula:C16H10N2O2Pureza:98.14% - ≥95%Cor e Forma:SolidPeso molecular:262.26Pyridostatin Trihydrochloride
CAS:Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.Fórmula:C31H35Cl3N8O5Pureza:99.69%Cor e Forma:SolidPeso molecular:706.026-Thioinosine
CAS:6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Fórmula:C10H12N4O4SPureza:97.74%Cor e Forma:SolidPeso molecular:284.29CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Fórmula:C23H21ClN2O3Pureza:98.82% - 99.50%Cor e Forma:SolidPeso molecular:408.88RI-1
CAS:RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).Fórmula:C14H11Cl3N2O3Pureza:99.3% - 99.62%Cor e Forma:SolidPeso molecular:361.61TMPyP4 tosylate
CAS:<p>TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.</p>Fórmula:C72H66N8O12S4Pureza:98.61% - 99.85%Cor e Forma:SolidPeso molecular:1363.6Pyridostatin
CAS:Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFórmula:C31H32N8O5Pureza:98%Cor e Forma:SolidPeso molecular:596.64Adavosertib
CAS:Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Fórmula:C27H32N8O2Pureza:98.65% - 99.86%Cor e Forma:SolidPeso molecular:500.6CK7
CAS:CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Fórmula:C14H12N6O2SPureza:99.54%Cor e Forma:SolidPeso molecular:328.35Indisulam
CAS:Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.Fórmula:C14H12ClN3O4S2Pureza:98.68% - 99.77%Cor e Forma:SolidPeso molecular:385.85Risdiplam
CAS:Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier.Cost-effective and quality-assured.Fórmula:C22H23N7OPureza:98.68% - 99.64%Cor e Forma:SolidPeso molecular:401.46Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Fórmula:C27H35F2N7O3Pureza:97.1% - >99.99%Cor e Forma:SolidPeso molecular:543.61HAMNO
CAS:HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).Fórmula:C17H13NO2Pureza:99.96%Cor e Forma:SolidPeso molecular:263.29IMT1B
CAS:<p>IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.</p>Fórmula:C24H21ClFNO6Pureza:98.26% - 99.83%Cor e Forma:SolidPeso molecular:473.88
