Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(102 produtos)
- CDK(520 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(45 produtos)
- DYRK(48 produtos)
- Dinamina(25 produtos)
- Ferroptose(218 produtos)
- HSP(174 produtos)
- Integrinas(249 produtos)
- Cinesina(77 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(281 produtos)
- PKC(107 produtos)
- PLK(26 produtos)
- ROCK(67 produtos)
- Rho(2 produtos)
- Wee1(14 produtos)
- c-Myc(73 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3675 produtos de "Ciclo celular/Ponto de verificação"
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Favipiravir
CAS:<p>Favipiravir is a potent and selective RNA-dependent RNA polymerase inhibitor for the treatment of influenza virus infections.Cost-effective and quality-assured.</p>Fórmula:C5H4FN3O2Pureza:97.32% - 99.90%Cor e Forma:SolidPeso molecular:157.1CVT-313
CAS:<p>CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.</p>Fórmula:C20H28N6O3Pureza:97.46% - 97.97%Cor e Forma:SolidPeso molecular:400.47PTC-209 hydrobromide
CAS:<p>PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in</p>Fórmula:C17H13Br2N5OS·HBrPureza:99.91%Cor e Forma:SolidPeso molecular:576.1GW779439X
CAS:GW779439X is an inhibitor of CDK.Fórmula:C22H21F3N8Pureza:97.87%Cor e Forma:SolidPeso molecular:454.45SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Fórmula:C18H15ClN6OS2·CH4O3SPureza:99.44% - 99.92%Cor e Forma:SolidPeso molecular:527.046-Mercaptopurine hydrate
CAS:6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.Fórmula:C5H6N4OSPureza:97.54% - 99.14%Cor e Forma:Light Yellow Crystalline PowderPeso molecular:170.19Verosudil hydrochloride
CAS:Verosudil (AR-12286) is a selective Rho kinase inhibitor, reducing IOP in XFS & OHT/XFG, offering a new treatment option.Fórmula:C17H18ClN3O2SCor e Forma:SolidPeso molecular:363.86BRD32048
CAS:<p>BRD32048 is a top candidate ETV1 perturbagen. BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation.</p>Fórmula:C16H22N6OPureza:99.87%Cor e Forma:SolidPeso molecular:314.39CKI-7 free base
CAS:CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Fórmula:C11H12ClN3O2SCor e Forma:SolidPeso molecular:285.75Orbofiban
CAS:<p>Orbofiban, an orally administered antagonist of the platelet GPIIb/IIIa receptor, effectively inhibits platelet aggregation.</p>Fórmula:C17H23N5O4Cor e Forma:SolidPeso molecular:361.4Apcin
CAS:Apcin: potent APC/C(Cdc20) E3 ligase inhibitor, blocks substrate recognition & mitosis, synergizes with Ts-Arg-OMe.Fórmula:C13H14Cl3N7O4Pureza:96.74%Cor e Forma:SolidPeso molecular:438.65NU2058
CAS:NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.Fórmula:C12H17N5OPureza:99.34% - 99.92%Cor e Forma:SolidPeso molecular:247.3CHR-6494
CAS:<p>CHR-6494 is a haspin inhibitor that inhibits histone H3T3 phosphorylation (IC50: 2 nM).</p>Fórmula:C16H16N6Pureza:98.78%Cor e Forma:SolidPeso molecular:292.34Raltitrexed
CAS:Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.Fórmula:C21H22N4O6SPureza:98.99% - 99.29%Cor e Forma:Yellow Crystalline PowderPeso molecular:458.49Brr2-IN-3
CAS:Brr2-IN-3 (Brr2 Inhibitor C9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa.Fórmula:C24H20N4O3SPureza:99.26%Cor e Forma:SolidPeso molecular:444.51DHFR-IN-3
CAS:<p>DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.</p>Fórmula:C8H7BrN4Pureza:99.521% - 99.65%Cor e Forma:SolidPeso molecular:239.07Palbociclib dihydrochloride
<p>Palbociclib, oral CDK4/6 inhibitor (IC50: 11/16 nM), targets HR+/HER2- breast cancer and hepatocellular carcinoma.</p>Fórmula:C24H31Cl2N7O2Cor e Forma:SolidPeso molecular:520.45Brequinar
CAS:Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.Fórmula:C23H15F2NO2Pureza:99.1% - 99.57%Cor e Forma:SolidPeso molecular:375.37AMG 900
CAS:<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Fórmula:C28H21N7OSPureza:98.4% - 99.51%Cor e Forma:SolidPeso molecular:503.58MKC3946
CAS:MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.Fórmula:C21H20N2O3SPureza:99.65%Cor e Forma:SolidPeso molecular:380.46BSJ-03-123
CAS:BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.Fórmula:C47H56N10O11Pureza:97.78% - 99.38%Cor e Forma:SolidPeso molecular:937.01NSAH
CAS:NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-Fórmula:C18H14N2O3Pureza:99.27%Cor e Forma:SolidPeso molecular:306.322′-O-Methylcytidine
CAS:<p>2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.</p>Fórmula:C10H15N3O5Pureza:99.72%Cor e Forma:SolidPeso molecular:257.24Palbociclib Isethionate
CAS:<p>Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。</p>Fórmula:C24H29N7O2·C2H6O4SPureza:99.01% - 99.27%Cor e Forma:SolidPeso molecular:573.66Ilorasertib
CAS:Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).Fórmula:C25H21FN6O2SPureza:96.17% - 97.49%Cor e Forma:SolidPeso molecular:488.54Dasabuvir sodium
CAS:<p>Dasabuvir sodium (ABT-333) inhibits HCV NS5B polymerase, targeting genotypes 1a (EC50: 7.7 nM) and 1b (EC50: 1.8 nM).</p>Fórmula:C26H26N3NaO5SCor e Forma:SolidPeso molecular:515.56Bonafton
CAS:<p>Bonafton (Bonaphthone) is an antiviral agent.</p>Fórmula:C10H5BrO2Pureza:97.16%Cor e Forma:SolidPeso molecular:237.05YKL-5-124
CAS:<p>YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays</p>Fórmula:C28H33N7O3Pureza:99.36%Cor e Forma:SolidPeso molecular:515.613-Deazauridine
CAS:3-Deazauridine (NSC-126849), a uridine analog, blocks CTP synthesis by competing with CTP synthetase.Fórmula:C10H13NO6Pureza:99.86%Cor e Forma:SolidPeso molecular:243.21S-trityl-L-Cysteine
CAS:<p>S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5</p>Fórmula:C22H21NO2SPureza:97.02%Cor e Forma:Almost White To Light Yellow Granular PowderPeso molecular:363.47WNK463
CAS:<p>WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4).</p>Fórmula:C21H24F3N7O2Pureza:>99.99% - ≥95%Cor e Forma:SolidPeso molecular:463.46ML264
CAS:<p>ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.</p>Fórmula:C17H21ClN2O4SPureza:99.33% - 99.45%Cor e Forma:SolidPeso molecular:384.88Arginine-glycine-aspartic acid
CAS:RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.Fórmula:C12H22N6O6Pureza:99.11%Cor e Forma:SolidPeso molecular:346.34kb-NB77-78
CAS:<p>kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).</p>Fórmula:C18H25NO3SiPureza:99.54%Cor e Forma:SolidPeso molecular:331.48EHT 1864 2HCl
CAS:EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Fórmula:C25H29Cl2F3N2O4SPureza:98.39% - 99.42%Cor e Forma:SolidPeso molecular:581.47CCT241736
CAS:CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Fórmula:C22H23Cl2N7Pureza:96.2% - 99.81%Cor e Forma:SolidPeso molecular:456.37Sarecycline free base
CAS:Sarecycline free base (P005672) is a tetracycline-derived, narrow-spectrum antibiotic.Fórmula:C24H29N3O8Pureza:98%Cor e Forma:SolidPeso molecular:487.5Pyridostatin hydrochloride
CAS:Pyridostatin hydrochloride stabilizes G-quadruplex DNA (Kd=490nM), inhibits cancer cell growth, and reduces SRC in breast cancer.Fórmula:C31H37Cl5N8O5Cor e Forma:SolidPeso molecular:778.94Mps1-IN-1 dihydrochloride
CAS:Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM.Fórmula:C28H35Cl2N5O4SCor e Forma:SolidPeso molecular:608.58Fanotaprim
CAS:<p>Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.</p>Fórmula:C19H22N8OPureza:98.1%Cor e Forma:SolidPeso molecular:378.43LY3405105
CAS:LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Fórmula:C26H39N7O3Pureza:99.66%Cor e Forma:SolidPeso molecular:497.63HA-100
CAS:<p>HA-100 is an inhibitor of protein kinase</p>Fórmula:C13H15N3O2SPureza:99.44%Cor e Forma:Pale Yellow Crystalline SolidPeso molecular:277.34APY29
CAS:APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.Fórmula:C17H16N8Pureza:96.51% - 98.46%Cor e Forma:SolidPeso molecular:332.36URMC-099
CAS:URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Fórmula:C27H27N5Pureza:99.32% - 99.98%Cor e Forma:SolidPeso molecular:421.54MNS
CAS:MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.Fórmula:C9H7NO4Pureza:98.53%Cor e Forma:Yellow PowderPeso molecular:193.16Silver sulfadiazine
CAS:Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.Fórmula:C10H9AgN4O2SPureza:99.04% - 99.58%Cor e Forma:SolidPeso molecular:357.14CID-797718
CAS:<p>CID-797718 is a protein kinase D1 (PKD1) inhibitor.</p>Fórmula:C12H11NO3Pureza:98.91% - 99.21%Cor e Forma:SolidPeso molecular:217.22AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Fórmula:C18H18Cl2F3N5O4Cor e Forma:SolidPeso molecular:496.27FDI-6
CAS:FDI-6 is an effective and selective inhibitor of FOXM1 that blocks DNA binding. FDI-6 binds to the FOXM1 protein and downregulates FOXM1-activated genes.Fórmula:C19H11F4N3OS2Pureza:98.92% - >99.99%Cor e Forma:SolidPeso molecular:437.43Voruciclib
CAS:Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Fórmula:C22H19ClF3NO5Pureza:99.89% - 99.99%Cor e Forma:SolidPeso molecular:469.84
