Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(100 produtos)
- CDK(520 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(43 produtos)
- DYRK(48 produtos)
- Dinamina(25 produtos)
- Ferroptose(218 produtos)
- HSP(173 produtos)
- Integrinas(248 produtos)
- Cinesina(75 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(279 produtos)
- PKC(107 produtos)
- PLK(26 produtos)
- ROCK(68 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(73 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3655 produtos de "Ciclo celular/Ponto de verificação"
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BUR1
CAS:<p>BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.</p>Fórmula:C16H17N5Pureza:90%Cor e Forma:SolidPeso molecular:279.34GSK2850163 hydrochloride
CAS:<p>GSK2850163 hydrochloride is a novel IRE1α inhibitor with IC50 of 20 nM for kinase and 200 nM for RNA enzyme.</p>Fórmula:C24H30Cl3N3OCor e Forma:SolidPeso molecular:482.87FEN1-IN-SC13
CAS:<p>FEN1-IN-SC13 is a potent inhibitor of DNA fragmentation endonuclease 1 (FEN1)</p>Fórmula:C24H23N3O3SPureza:98.02%Cor e Forma:SolidPeso molecular:433.52Madrasin
CAS:<p>Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.</p>Fórmula:C16H17N5O2Pureza:99.06% - 99.61%Cor e Forma:SolidPeso molecular:311.34MTOB
CAS:MTOB, a CtBP substrate, inhibits CtBP-linked cancer activity in cells/mice and regulates TCF-4, affecting CSC proliferation.Fórmula:C5H7NaO3SPureza:98.23%Cor e Forma:SolidPeso molecular:170.16TAK-960 monohydrochloride
CAS:<p>TAK-960 monohydrochloride, an oral compound, inhibits PLK1 (IC50=0.8 nM), PLK2, PLK3, stunts cancer cell growth, and is effective in tumor models.</p>Fórmula:C27H35ClF3N7O3Cor e Forma:SolidPeso molecular:598.07XMD8-92
CAS:XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).Fórmula:C26H30N6O3Pureza:98.21%Cor e Forma:SolidPeso molecular:474.55FUBP1-IN-1
CAS:<p>FUBP1-in-1: Potent FUBP1 inhibitor with 11.0 M IC50, disrupts FUBP1-DNA binding.</p>Fórmula:C19H14F3N3O2SPureza:99.7%Cor e Forma:SolidPeso molecular:405.39Dimethylenastron
CAS:Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Fórmula:C16H18N2O2SPureza:98.07%Cor e Forma:SolidPeso molecular:302.39Piritrexim isethionate
CAS:Piritrexim isethionate, a fat-soluble DHFR inhibitor, shows efficacy in metastatic urothelial cancer with a 5-day oral regimen.Fórmula:C19H25N5O6SCor e Forma:SolidPeso molecular:451.49SBC-115076
CAS:<p>SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.</p>Fórmula:C31H33N3O5Pureza:97.07% - 99.89%Cor e Forma:SolidPeso molecular:527.61Garenoxacin mesylate hydrate
CAS:Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strainsFórmula:C23H20F2N2O4·CH4O3S·H2OPureza:99.56%Cor e Forma:SolidPeso molecular:540.53Besifloxacin Hydrochloride
CAS:Besifloxacin Hydrochloride (BOL-303224-A) is a fourth-generation fluoroquinolone antibiotic.Fórmula:C19H21ClFN3O3·HClPureza:99.20%Cor e Forma:Pale Yellow SolidPeso molecular:430.3Nemorubicin
CAS:<p>Nemorubicin (PNU 152243) is a unique doxorubicin variant with varied antitumor action, metabolism, and toxicity, effective against resistant tumors.</p>Fórmula:C32H37NO13Pureza:97.4%Cor e Forma:SolidPeso molecular:643.64roxifiban
CAS:<p>Roxifiban, a prodrug of XV459, is an antiplatelet agent with high affinity and specificity for platelet glycoprotein IIb/IIIa complex(GPIIb/IIIa) receptors.</p>Fórmula:C21H29N5O6Pureza:98%Cor e Forma:SolidPeso molecular:447.48SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Fórmula:C15H18BrN7Pureza:99.88%Cor e Forma:SolidPeso molecular:376.25Methotrexate metabolite
CAS:<p>DAMPA, active metabolite of Methotrexate, is a chemotherapeutic and immunosuppressive folic acid antagonist.</p>Fórmula:C15H15N7O2Pureza:95.60% - 97.59%Cor e Forma:SolidPeso molecular:325.33THZ531
CAS:<p>THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).</p>Fórmula:C30H32ClN7O2Pureza:97.17% - 99.86%Cor e Forma:SolidPeso molecular:558.07TAK-632
CAS:<p>TAK-632 is a potent pan-Raf inhibitor.</p>Fórmula:C27H18F4N4O3SPureza:98% - 99.5%Cor e Forma:SolidPeso molecular:554.52Eptifibatide acetate (148031-34-9 free base)
CAS:Eptifibatide acetate (148031-34-9), a cyclic heptapeptide GP IIb/IIIa inhibitor antiplatelet drug.Fórmula:C35H49N11O9S2·xC2H4O2Pureza:99.7% - 99.87%Cor e Forma:SolidPeso molecular:831.96 (free base)PFM01
CAS:PFM01 inhibits MRE11 enzyme, steering DSBR towards NHEJ over HR.Fórmula:C14H15NO2S2Pureza:98.68%Cor e Forma:SolidPeso molecular:293.4CX-5461 dihydrochloride
CX-5461 dihydrochloride: Oral Pol I inhibitor, HCT-116 (IC50: 142 nM), A375 (IC50: 113 nM), MIA PaCa-2 (IC50: 54 nM), weak on Pol II (IC50 ≥ 25 μM).Fórmula:C27H29Cl2N7O2SCor e Forma:SolidPeso molecular:586.54CAN508
CAS:CAN508: potent CDK9/T1 inhibitor; IC50 0.35 μM, Cdk2/E; Ki 13.3 μM, IC50 20 μM; 38x selective; antitumor.Fórmula:C9H10N6OPureza:98.65%Cor e Forma:SolidPeso molecular:218.222-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Fórmula:C4H3ClN2Pureza:98.98% - 99.89%Cor e Forma:Clear Colorless To Yellowish LiquidPeso molecular:114.53CB-6644
CAS:<p>CB-6644 is a small molecule inhibitor of the ATPase activity of the RUVBL1/2 complex.Cost-effective and quality-assured.</p>Fórmula:C29H34ClFN4O5Pureza:96.33% - 99.85%Cor e Forma:SolidPeso molecular:573.06LJI308
CAS:LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.Fórmula:C21H18F2N2O2Pureza:99.73% - 99.87%Cor e Forma:SolidPeso molecular:368.38N1-Methylpseudouridine
CAS:N1-Methylpseudouridine (1-Methylpseudouridine) is a methylpseudouridine and enhances translation through eIF2α-dependent and independent mechanisms byFórmula:C10H14N2O6Pureza:98.95% - 99.88%Cor e Forma:SolidPeso molecular:258.23PHA-767491
CAS:PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Fórmula:C12H11N3OPureza:99.49% - >99.99%Cor e Forma:SolidPeso molecular:213.24Tiazofurin
CAS:Tiazofurin, a synthetic nucleoside, has anti-cancer effects and inhibits IMPDH as TAD after metabolism.Fórmula:C9H12N2O5SPureza:99.91%Cor e Forma:SolidPeso molecular:260.27VPC-80051 racemate
CAS:<p>VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach.</p>Fórmula:C16H13F2N3OPureza:97.36%Cor e Forma:SolidPeso molecular:301.29C/EBPα inducer 1
CAS:<p>C/EBPα inducer 1 (4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-) is a potential inducer of myeloid differentiation via</p>Fórmula:C20H12FN3O4Pureza:98.99%Cor e Forma:SolidPeso molecular:377.33MK-8745
CAS:<p>MK-8745 is a potent and selective Aurora A inhibitor.</p>Fórmula:C20H19ClFN5OSPureza:99.09% - 99.79%Cor e Forma:SolidPeso molecular:431.91TC-E 5003
CAS:TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.Fórmula:C16H14Cl2N2O4SPureza:97.01%Cor e Forma:SolidPeso molecular:401.26LY3177833
CAS:LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Fórmula:C16H12FN5OPureza:99.87%Cor e Forma:SolidPeso molecular:309.3TCS7010
CAS:TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.Fórmula:C31H31ClFN7O2Pureza:98.49% - 99.62%Cor e Forma:SolidPeso molecular:588.07MSC2530818
CAS:<p>MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).</p>Fórmula:C18H17ClN4OPureza:98.93%Cor e Forma:SolidPeso molecular:340.81Ribociclib succinate hydrate
CAS:<p>Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively).</p>Fórmula:C27H38N8O6Pureza:98%Cor e Forma:SolidPeso molecular:570.651TAK-960 dihydrochloride
<p>TAK-960 dihydrochloride: oral PLK1 inhibitor, IC50 0.8 nM; also Hinders PLK2 and PLK3 (IC50s 16.9/50.2 nM); curbs cancer cell growth.</p>Fórmula:C27H36Cl2F3N7O3Cor e Forma:SolidPeso molecular:634.52Antitumor agent-152
CAS:<p>Organic compound, potential dCK inhibitor, with 2-ethyl-3-methoxyphenyl-1,3-thiazole and pyrimidine units.</p>Fórmula:C17H19N5O2S2Pureza:95.00%Cor e Forma:SolidPeso molecular:389.5MLN8054 sodium
CAS:MLN8054 sodium is an Aurora A inhibitor.Fórmula:C25H14ClF2N4NaO2Cor e Forma:SolidPeso molecular:498.84PNU112455A hydrochloride
CAS:<p>PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.</p>Fórmula:C10H12ClN5O2SPureza:98.58% - 99.22%Cor e Forma:SolidPeso molecular:301.75Myoseverin
CAS:<p>Myoseverin triggers myotube fission into single cells, influencing genes for growth, immunity, matrix remodeling, and stress, aiding healing and regeneration.</p>Fórmula:C24H28N6O2Pureza:99.25%Cor e Forma:SolidPeso molecular:432.52AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Fórmula:C18H18Cl2F3N5O4Cor e Forma:SolidPeso molecular:496.272-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS:2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.Fórmula:C6H6N4OPureza:99.21% - 99.42%Cor e Forma:SolidPeso molecular:150.14LP-935509
CAS:<p>LP-935509 is a selective, brain-permeable, small molecule competitive inhibitor of articulin-2-associated kinase 1 (AAK1).Cost-effective and quality-assured.</p>Fórmula:C20H24N6O3Pureza:98.78% - 99.64%Cor e Forma:SolidPeso molecular:396.44Pipobroman
CAS:Pipobroman (Vercyte) is an alkylating anti-cancer drug effective in PV and ET with low toxicity and thrombosis risk.Fórmula:C10H16Br2N2O2Pureza:97.08%Cor e Forma:SolidPeso molecular:356.05Talotrexin
CAS:Talotrexin (PT523), a nonpolyglutamatable antifolate analog of Aminopterin, inhibits DHFR and RFC, targeting tumor growth.Fórmula:C27H27N9O6Cor e Forma:SolidPeso molecular:573.569-Ethylguanine
CAS:<p>9-Ethylguanine is a model nucleobase commonly used in the studies of DNA interactions with organometallic complexes.</p>Fórmula:C7H9N5OPureza:98.6%Cor e Forma:SolidPeso molecular:179.18CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Fórmula:C21H17ClF6N2O2Pureza:99.58%Cor e Forma:SolidPeso molecular:478.82Spermine tetrahydrochloride
CAS:<p>Spermine tetrahydrochloride, a polyamine in all eukaryotic cells, protects DNA from free radicals.</p>Fórmula:C10H26N4·4HClPureza:99.75% - 99.82%Cor e Forma:SolidPeso molecular:348.18
![2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT5445.webp&w=3840&q=75)
