Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(96 produtos)
- CDK(505 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(170 produtos)
- Integrinas(227 produtos)
- Cinesina(68 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(261 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(68 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(68 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3495 produtos de "Ciclo celular/Ponto de verificação"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Zaurategrast ethyl ester sulfate
CAS:Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.Fórmula:C56H60Br2N8O10SPureza:98%Cor e Forma:SolidPeso molecular:1197.01NSC 693868
CAS:<p>CDKs and GSK-3 inhibitor</p>Fórmula:C9H7N5Pureza:98%Cor e Forma:SolidPeso molecular:185.19MLAF50
CAS:<p>MLAF50 is an inhibitor of the REV1 UBM2-Ubiquitin interaction.</p>Fórmula:C15H12I2O4Cor e Forma:SolidPeso molecular:510.06Cdc7-IN-15
CAS:<p>Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].</p>Fórmula:C12H14N4OSCor e Forma:SolidPeso molecular:262.33Y-9738
CAS:<p>Y-9738 is an agent of hypolipidemic.</p>Fórmula:C15H16ClNO4Pureza:98%Cor e Forma:SolidPeso molecular:309.74CP681301
CAS:<p>CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.</p>Fórmula:C17H22N4OCor e Forma:SolidPeso molecular:298.38DNA Gyrase-IN-2
CAS:<p>DNA Gyrase-IN-2 inhibits E. coli (IC50: 3.29-10.49 μM) and M. tuberculosis (IC50: 4.41-5.61 μM) COX, has antibacterial properties.</p>Fórmula:C24H24N8OS2Cor e Forma:SolidPeso molecular:504.63Flurocitabine
CAS:<p>Flurocitabine is a therapeutic agent with antineoplastic activity.</p>Fórmula:C9H10FN3O4Pureza:98%Cor e Forma:SolidPeso molecular:243.19LCAHA
CAS:<p>LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.</p>Fórmula:C24H41NO3Cor e Forma:SolidPeso molecular:391.59DHFR-IN-5
CAS:<p>DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.</p>Fórmula:C18H24N4O4Cor e Forma:SolidPeso molecular:360.41CDK7-IN-15
CAS:<p>CDK7-IN-15, a pyrimidine-based potent CDK7 inhibitor, shows promise for various cancers with defective transcription.</p>Fórmula:C21H24F4N6OSCor e Forma:SolidPeso molecular:484.51HBV-IN-22
CAS:<p>HBV-IN-22 (Compound LC5f) is an HBV DNA replication inhibitor that acts on both wild-type HBV (IC50: 0.71 μM) and drug-resistant HBV (IC50: 0.84 μM).</p>Fórmula:C26H29N3O2S2Cor e Forma:SolidPeso molecular:479.66ROCK2-IN-5
<p>ROCK2-IN-5, a compound blending fasudil, caffeic, and ferulic acids, shows promise for ALS research involving SOD1 mutations.</p>Fórmula:C23H25N3O5SCor e Forma:SolidPeso molecular:455.53KIRA-7
CAS:KIRA-7: imidazopyrazine, anti-fibrotic, inhibits IRE1α RNase (IC50: 110 nM) allosterically.Fórmula:C27H23FN6OCor e Forma:SolidPeso molecular:466.51Beaucage reagent
CAS:Beaucage reagent, which is found to be effective in causing DNA cleavage.Fórmula:C7H4O3S2Pureza:98.50%Cor e Forma:White To Off-White PowderPeso molecular:200.23DHFR-IN-2
CAS:<p>DHFR-IN-2 (4e) is a potent MtDHFR uncompetitive inhibitor with a 7 μM IC50, promising for TB research.</p>Fórmula:C14H13NO2Cor e Forma:SolidPeso molecular:227.26RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Fórmula:C28H28N6O4SCor e Forma:SolidPeso molecular:544.62(R)-Filanesib
CAS:<p>(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).</p>Fórmula:C20H22F2N4O2SCor e Forma:SolidPeso molecular:420.48CDK4/6-IN-8
CAS:<p>CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).</p>Fórmula:C18H18N6O5Cor e Forma:SolidPeso molecular:398.37IMB-10
CAS:<p>IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.</p>Fórmula:C19H15NOS2Cor e Forma:SolidPeso molecular:337.46Tenofovir exalidex
CAS:<p>Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant</p>Fórmula:C28H52N5O5PPureza:99.83%Cor e Forma:SolidPeso molecular:569.72BPIC
CAS:<p>BPIC is an agent of anti-tumor that acts by inhibiting inflammation and scavenging free radicals.</p>Fórmula:C27H20N2O5Cor e Forma:SolidPeso molecular:452.46CH-1504
CAS:<p>CH-1504, dihydrofolate reductase (DHFR) inhibitor, is used potentially for the treatment of rheumatoid arthritis.</p>Fórmula:C23H23N5O5Cor e Forma:SolidPeso molecular:449.46CLK1-IN-2
<p>CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.</p>Fórmula:C16H12Cl2N2O2SCor e Forma:SolidPeso molecular:367.25MMV688844
CAS:<p>MMV688844 inhibits M. abscessus DNA cyclooxygenase (IC50: 2μM) and has MIC50 of 12μM on strain bamboo; useful in antimicrobial studies.</p>Fórmula:C23H25ClN4O2Cor e Forma:SolidPeso molecular:424.92TDRL-X80
CAS:<p>TDRL-X80 inhibits XPA DNA binding; effective on single, double, and cisplatin-damaged DNA; IC50: 18-29 μM (FP), 21-39 μM (ELISA).</p>Fórmula:C23H15ClN2O6Cor e Forma:SolidPeso molecular:450.83BPKDi
CAS:<p>BPKDi is a potent and selective inhibitor of PKD (protein kinase D).</p>Fórmula:C21H28N6OPureza:98%Cor e Forma:SolidPeso molecular:380.49Aloisine A
CAS:Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.Fórmula:C16H17N3OPureza:98%Cor e Forma:SolidPeso molecular:267.33CDK7-IN-10
CAS:<p>CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)</p>Fórmula:C29H35N7O3Cor e Forma:SolidPeso molecular:529.63TP1287
CAS:<p>TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.</p>Fórmula:C21H21ClNO8PCor e Forma:SolidPeso molecular:481.82CDK7-IN-16
CAS:<p>CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.</p>Fórmula:C19H21F3N6O2SCor e Forma:SolidPeso molecular:454.47DHX9-IN-1
CAS:<p>DHX9-IN-1 is a potent ATP-dependent RNA helicase A (DHX9) inhibitor, exhibiting an IC50 of 9.45 nM and demonstrating antitumor activity [1].</p>Fórmula:C21H21F2N5O3SCor e Forma:SolidPeso molecular:461.49Braco-19 trihydrochloride
CAS:<p>BRACO19 3HCl inhibits telomerase, blocking its capping function, and prevents HAdV viral replication.</p>Fórmula:C35H46Cl3N7O2Pureza:98.74%Cor e Forma:SolidPeso molecular:703.14Synucleozid
CAS:<p>Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.</p>Fórmula:C22H20N6Pureza:98%Cor e Forma:SolidPeso molecular:368.43DENV-IN-4
CAS:<p>DENV-IN-4: Effective DENV inhibitor (EC50=4.79 μM), low toxicity (CC50>100 μM), and strong selectivity (SI>20.9); suppresses DENV2 and RdRp.</p>Fórmula:C28H32N4O4SiCor e Forma:SolidPeso molecular:516.66PF-4950834
CAS:PF-4950834, a ATP-competitive, selective Rho kinase inhibitor, provides therapeutic benefits in chronic inflammatory diseases.Fórmula:C21H19N3O2Pureza:98%Cor e Forma:SolidPeso molecular:345.39PV-1115
CAS:<p>PV-1115 is an effective and highly selective inhibitor of the Chk2.</p>Fórmula:C20H19N7O3Pureza:98%Cor e Forma:SolidPeso molecular:405.41HIV-1 inhibitor-43
CAS:<p>HIV-1 Inhibitor-43 suppresses HIV-1, with EC50: 21.3 nM (Y188L), 6.2 nM (K103N-Y181C), <0.7 nM (K103N/Y181C), and lowers HIV RNA/p24 protein.</p>Fórmula:C24H21ClN2O4SCor e Forma:SolidPeso molecular:468.95CDK9-IN-14
CAS:<p>CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.</p>Fórmula:C21H23F2N3O4Cor e Forma:SolidPeso molecular:419.42(Rac)-Managlinat dialanetil
CAS:<p>Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.</p>Fórmula:C21H33N4O6PSPureza:98.52%Cor e Forma:SolidPeso molecular:500.55DHODH-IN-12
CAS:<p>DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.</p>Fórmula:C10H9N3O2Pureza:99.53%Cor e Forma:SolidPeso molecular:203.2CGP 53353
CAS:<p>CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.</p>Fórmula:C20H13F2N3O2Pureza:98.11%Cor e Forma:SolidPeso molecular:365.33JFN05510
CAS:<p>Compound: 3'-O-tert-BDMS-5'-O-DMT-N2-IBG 2'-CE phosphoramidite; has anticancer properties and activates enzymes.</p>Fórmula:C50H68N7O9PSiCor e Forma:SolidPeso molecular:970.18Fosteabine
CAS:<p>Fosteabine is an oral and prodrug analog of cytarabine. It is resistant to deoxycytidine deaminase.</p>Fórmula:C27H50N3O8PPureza:98%Cor e Forma:SolidPeso molecular:575.67FAK/aurora kinase-IN-1
CAS:<p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>Fórmula:C23H24ClN7O3Cor e Forma:SolidPeso molecular:481.93P18IN003
CAS:<p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>Fórmula:C17H16N2O3Pureza:98.77%Cor e Forma:SolidPeso molecular:296.32Aurora Kinases-IN-2
CAS:<p>Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.</p>Fórmula:C22H18ClN5O3Cor e Forma:SolidPeso molecular:435.86LSN 3213128
CAS:LSN 3213128: a potent oral antifolate targeting AICARFT with IC50s of 16 nM (enzyme) and 19 nM (cells), offers anti-tumor effects.Fórmula:C17H16FN3O4S2Cor e Forma:SolidPeso molecular:409.45Lysine-methotrexate
CAS:<p>Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase.</p>Fórmula:C21H27N9O3Pureza:98%Cor e Forma:SolidPeso molecular:453.5Myt1-IN-1
CAS:<p>Myt1-IN-1 has anticancer effects that is a potent inhibitor of Myt1 with an IC 50 of <10 nM [1].</p>Fórmula:C16H15ClN4O2Cor e Forma:SolidPeso molecular:330.77
