Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(95 produtos)
- CDK(502 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(226 produtos)
- Cinesina(68 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(261 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(69 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(68 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3493 produtos de "Ciclo celular/Ponto de verificação"
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A 65281
CAS:<p>A 65281: antibacterial isothiazoloquinolone, inhibits P4-unknotting, induces DNA breakage via topoisomerase II.</p>Fórmula:C17H16F2N4O2SPureza:98%Cor e Forma:SolidPeso molecular:378.4MFH290
CAS:<p>MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.</p>Fórmula:C26H31N5O3S2Cor e Forma:SolidPeso molecular:525.69KIF18A-IN-4
CAS:KIF18A-IN-4: Non-competitive KIF18A inhibitor, IC50 6.16 μM, targets mitotic kinesins/kinases, anti-tumor.Fórmula:C22H27N3O3SCor e Forma:SolidPeso molecular:413.53RHI002-Me
CAS:<p>RHI002-Me is a methylated derivative of RHI002, a selective inhibitor of human RNaseH2.</p>Fórmula:C18H19N3O2S2Pureza:98%Cor e Forma:SolidPeso molecular:373.49KIRA-7
CAS:KIRA-7: imidazopyrazine, anti-fibrotic, inhibits IRE1α RNase (IC50: 110 nM) allosterically.Fórmula:C27H23FN6OCor e Forma:SolidPeso molecular:466.51ROCK-IN-D2
CAS:<p>ROCK-IN-D2 is an effective and selective inhibitor of ROCK.</p>Fórmula:C22H28N6OPureza:98%Cor e Forma:SolidPeso molecular:392.5CRT5
CAS:<p>CRT5, a selective PKD inhibitor, blocks VEGF effects on histone deacetylase 5, CREB, HSP27, and endothelial functions. IC50s: 1-2 nM for PKD1-3.</p>Fórmula:C28H30N4O2Cor e Forma:SolidPeso molecular:454.56Apricitabine
CAS:<p>Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-</p>Fórmula:C8H11N3O3SPureza:99.45%Cor e Forma:SolidPeso molecular:229.26PD 130883
CAS:<p>PD 130883 is a potent lipophilic quinazoline antifolate.</p>Fórmula:C18H15N5O3Pureza:98%Cor e Forma:SolidPeso molecular:349.34RP-106
CAS:<p>RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.</p>Fórmula:C17H19N3OPureza:98%Cor e Forma:SolidPeso molecular:281.35A 65282
CAS:<p>A 65282: antibacterial isothiazoloquinolone, inhibits P4-unknotting, causes DNA breaks via topoisomerase II.</p>Fórmula:C17H16F2N4O2SPureza:98%Cor e Forma:SolidPeso molecular:378.4CDK8-IN-10
CAS:<p>CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.</p>Fórmula:C25H15ClF3N5O3Cor e Forma:SolidPeso molecular:525.87DHFR-IN-2
CAS:<p>DHFR-IN-2 (4e) is a potent MtDHFR uncompetitive inhibitor with a 7 μM IC50, promising for TB research.</p>Fórmula:C14H13NO2Cor e Forma:SolidPeso molecular:227.26Chrysotobibenzyl
CAS:<p>Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.</p>Fórmula:C19H24O5Cor e Forma:SolidPeso molecular:332.39RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Fórmula:C28H28N6O4SCor e Forma:SolidPeso molecular:544.62(R)-Filanesib
CAS:<p>(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).</p>Fórmula:C20H22F2N4O2SCor e Forma:SolidPeso molecular:420.48AnnH31
CAS:AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm theFórmula:C15H13N3OPureza:99.99%Cor e Forma:SolidPeso molecular:251.28hDHODH-IN-4
CAS:<p>hDHODH-IN-4, a potent DHODH inhibitor, has a pIC50 of 7.8 and blocks measles virus replication with a pMIC50 of 8.8.</p>Fórmula:C21H24N4O2Pureza:99.87%Cor e Forma:SolidPeso molecular:364.44SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Fórmula:C15H13N5O2Pureza:98%Cor e Forma:SolidPeso molecular:295.3TDRL-551
CAS:TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 µM) with potential anticancer activity.TDRL-551 inhibits RPA-DNA interaction andFórmula:C25H23ClIN3O4Pureza:98.09%Cor e Forma:SolidPeso molecular:591.83Kira8 Hydrochloride
CAS:<p>Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.</p>Fórmula:C31H30Cl2N6O3SPureza:98%Cor e Forma:SolidPeso molecular:637.58HBV-IN-15
CAS:<p>HBV-IN-15, a flavone derivative, is a potent cccDNA inhibitor, potentially aiding HBV research.</p>Fórmula:C24H23ClO6Cor e Forma:SolidPeso molecular:442.89CDK4/6-IN-12
CAS:<p>CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.</p>Fórmula:C12H10N6Cor e Forma:SolidPeso molecular:238.25CDK4/6-IN-8
CAS:<p>CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).</p>Fórmula:C18H18N6O5Cor e Forma:SolidPeso molecular:398.37IMB-10
CAS:<p>IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.</p>Fórmula:C19H15NOS2Cor e Forma:SolidPeso molecular:337.46Levofloxacin sodium
CAS:<p>Levofloxacin sodium: synthetic antibacterial, stops DNA replication by inhibiting bacterial DNA gyrase.</p>Fórmula:C18H20FN3NaO4Pureza:98%Cor e Forma:SolidPeso molecular:384.363Clociguanil
CAS:<p>Clociguanil has antimalarial activity.</p>Fórmula:C12H15Cl2N5OCor e Forma:SolidPeso molecular:316.19LIMK1 inhibitor BMS-4
CAS:<p>BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.</p>Fórmula:C23H23N7O2SCor e Forma:SolidPeso molecular:461.54BSJ-01-175
CAS:<p>BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.</p>Fórmula:C30H33ClN6O2Cor e Forma:SolidPeso molecular:545.08Eg5 Inhibitor V, trans-24
CAS:<p>Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.</p>Fórmula:C26H21N3O3Pureza:99.75%Cor e Forma:SolidPeso molecular:423.46XL-188
CAS:<p>XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.</p>Fórmula:C32H42N6O4Cor e Forma:SolidPeso molecular:574.71EMD534085
CAS:<p>EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).</p>Fórmula:C25H31F3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:476.53Nucleoside-Analog-1
CAS:Nucleoside-Analog-1 is a 4′-Azidocytidine analogue, used to against Hepatitis C virus replication.Fórmula:C9H9N5O5Pureza:98%Cor e Forma:SolidPeso molecular:267.2FRα-IN-1
CAS:<p>FRα-IN-1 (Compound 4) is a tumour targeting agent. FRα-IN-1 exhibits selective anti-cancer effects on FRα and FRβ expressing cells.</p>Fórmula:C21H24N6O6Cor e Forma:SolidPeso molecular:456.45L-Fd4A
CAS:<p>L-Fd4A (compound 36) is an adenine derivative with anti-HIV (EC50=1.5μM) and anti-HBV (EC50=1.7μM) effects, low cytotoxicity.</p>Fórmula:C10H10FN5O2Cor e Forma:SolidPeso molecular:251.22Tenofovir exalidex
CAS:<p>Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant</p>Fórmula:C28H52N5O5PPureza:99.83%Cor e Forma:SolidPeso molecular:569.72BPIC
CAS:<p>BPIC is an agent of anti-tumor that acts by inhibiting inflammation and scavenging free radicals.</p>Fórmula:C27H20N2O5Cor e Forma:SolidPeso molecular:452.468RK64
CAS:<p>8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .</p>Fórmula:C14H16N8O2SCor e Forma:SolidPeso molecular:360.4PD-1-IN-22
CAS:<p>PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).</p>Fórmula:C25H25N5O4Pureza:99.51%Cor e Forma:SolidPeso molecular:459.5CCT068127
CAS:<p>CCT068127 is a potent CDK2 and CDK9 inhibitor.</p>Fórmula:C19H27N7OCor e Forma:SolidPeso molecular:369.46AS-136A
CAS:<p>AS-136A is an orally active MV RdRp inhibitor with antiviral activity that inhibits measles virus and blocks viral RNA synthesis.</p>Fórmula:C17H19F3N4O3SPureza:98.52%Cor e Forma:SolidPeso molecular:416.42hDHODH-IN-5
CAS:<p>hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).</p>Fórmula:C21H21F3N2O2Pureza:99.55%Cor e Forma:SolidPeso molecular:390.4DHODH-IN-13
CAS:<p>DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.</p>Fórmula:C10H6F3N3O3Pureza:99.66%Cor e Forma:SolidPeso molecular:273.17(S)-CR8
CAS:<p>(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.</p>Fórmula:C24H29N7OCor e Forma:SolidPeso molecular:431.53hDHODH-IN-3
CAS:<p>hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.</p>Fórmula:C18H19BrN4O2Pureza:99.871%Cor e Forma:SolidPeso molecular:403.27CLK1-IN-2
<p>CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.</p>Fórmula:C16H12Cl2N2O2SCor e Forma:SolidPeso molecular:367.25BMVC
CAS:<p>BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities.</p>Fórmula:C28H25I2N3Cor e Forma:SolidPeso molecular:657.33TDRL-X80
CAS:<p>TDRL-X80 inhibits XPA DNA binding; effective on single, double, and cisplatin-damaged DNA; IC50: 18-29 μM (FP), 21-39 μM (ELISA).</p>Fórmula:C23H15ClN2O6Cor e Forma:SolidPeso molecular:450.83CB 3717
CAS:<p>CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist.</p>Fórmula:C24H23N5O6Cor e Forma:SolidPeso molecular:477.47CDK2-IN-11
CAS:<p>CDK2-IN-11 inhibits CDK2 (IC50: 6.4 μM) and targets hCA II, IX, XII (Ki: 23.4-56.3 nM); suited for cancer research.</p>Fórmula:C18H14ClN7O2SCor e Forma:SolidPeso molecular:427.87
