Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(95 produtos)
- CDK(502 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(226 produtos)
- Cinesina(68 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(261 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(69 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(68 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3493 produtos de "Ciclo celular/Ponto de verificação"
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BPKDi
CAS:<p>BPKDi is a potent and selective inhibitor of PKD (protein kinase D).</p>Fórmula:C21H28N6OPureza:98%Cor e Forma:SolidPeso molecular:380.49(S)-LY3177833 hydrate
CAS:<p>(S)-LY3177833 ((S)-Example 2) hydrate, an orally active CDC7 kinase inhibitor, exhibits extensive in vitro anticancer efficacy.</p>Fórmula:C16H14FN5O2Cor e Forma:SolidPeso molecular:327.31Bofumustine
CAS:<p>Bofumustine is a chloroethyl nitrosourea with anti tumor properties.</p>Fórmula:C18H21ClN4O9Cor e Forma:SolidPeso molecular:472.83Metioprim
CAS:<p>Metioprim is a competitive bacterial dihydrofolate reductases inhibitor.</p>Fórmula:C14H18N4O2SPureza:98%Cor e Forma:SolidPeso molecular:306.38Levoleucovorin disodium
CAS:<p>Levoleucovorin disodium is the sodium salt of the enantiomerically active form of Folinic Acid.</p>Fórmula:C20H21N7Na2O7Pureza:98%Cor e Forma:SolidPeso molecular:517.41Nitracrine
CAS:<p>Nitracrine: a 1-nitroacridine, hypoxia-selective, anti-tumor agent; inhibits RNA synthesis, binds DNA reversibly and forms covalent adducts.</p>Fórmula:C18H20N4O2Pureza:98%Cor e Forma:SolidPeso molecular:324.38Aloisine A
CAS:Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.Fórmula:C16H17N3OPureza:98%Cor e Forma:SolidPeso molecular:267.33ProTAME
CAS:<p>ProTAME inhibits APC/CFzr & APC/CCdc20, enhances cell death with doxorubicin/etoposide in primary/MM cells, especially after TOPIIα upregulation.</p>Fórmula:C34H38N4O12SPureza:98%Cor e Forma:SolidPeso molecular:726.75TC-Mps1-12
CAS:<p>TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .</p>Fórmula:C17H20N6OPureza:98%Cor e Forma:SolidPeso molecular:324.38L-Cytidine
CAS:<p>L-Cytidine, pyrimidine nucleoside in RNA, regulates glial glutamate, brain lipids, catecholamines, and mitochondria.</p>Fórmula:C9H13N3O5Cor e Forma:SolidPeso molecular:243.22TP1287
CAS:<p>TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.</p>Fórmula:C21H21ClNO8PCor e Forma:SolidPeso molecular:481.82DDD100097
CAS:<p>DDD100097 is a N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.</p>Fórmula:C22H30Cl2F2N4O2SPureza:98.89%Cor e Forma:SolidPeso molecular:523.47CDK5 inhibitor 20-223
CAS:<p>CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.</p>Fórmula:C19H19N3OCor e Forma:SolidPeso molecular:305.37DHODH-IN-8
CAS:<p>DHODH-IN-8 is a DHODH inhibitor with antimalarial properties, IC50: 0.13 μM (human), 47.4 μM (P. falciparum); Ki: 0.016 μM (human), 5.6 μM (P. falciparum).</p>Fórmula:C17H13ClN2O2Pureza:99.78%Cor e Forma:SolidPeso molecular:312.75LY 222306
CAS:LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.Fórmula:C19H23N5O7Pureza:98%Cor e Forma:SolidPeso molecular:433.42Ipivivint
CAS:<p>Ipivivint: orally active, potent CLK inhibitor; hinders CLK1, CLK2, & CLK3; curbs Wnt signaling & SRSF phosphorylation for cancer research.</p>Fórmula:C26H21FN8Cor e Forma:SolidPeso molecular:464.5Braco-19 trihydrochloride
CAS:<p>BRACO19 3HCl inhibits telomerase, blocking its capping function, and prevents HAdV viral replication.</p>Fórmula:C35H46Cl3N7O2Pureza:98.74%Cor e Forma:SolidPeso molecular:703.14CDK8-IN-6
CAS:<p>CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers.</p>Fórmula:C26H37ClN2Cor e Forma:SolidPeso molecular:413.04OM-137
CAS:<p>OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.</p>Fórmula:C13H14N4O3SCor e Forma:SolidPeso molecular:306.34KH-CB19
CAS:KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).Fórmula:C15H13Cl2N3O2Cor e Forma:SolidPeso molecular:338.19VRX-0466617
CAS:<p>VRX-0466617 is a novel selective Chk2 inhibitor.</p>Fórmula:C19H20BrN5O2SCor e Forma:SolidPeso molecular:462.36CDK2-IN-12
CAS:<p>CDK2-IN-12 (10b), potent CDK2 inhibitor, IC50: 11.6 μM; inhibits hCA I/II/IX/XII, KI: 3534/638.4/44.3/48.8 nM; anti-cancer properties.</p>Fórmula:C20H17N9O2SCor e Forma:SolidPeso molecular:447.47Litronesib Racemate
CAS:<p>Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.</p>Fórmula:C23H37N5O4S2Cor e Forma:SolidPeso molecular:511.72-Fluoroadenine
CAS:<p>2-Fluoroadenine (NSC-27364) has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.</p>Fórmula:C5H4FN5Pureza:98.84% - 99.62%Cor e Forma:White To Light Yellow Crystal PowderPeso molecular:153.12Dyrk1A-IN-3
CAS:<p>Dyrk1A-IN-3 is a selective DYRK1A inhibitor with an IC50 of 76 nM, useful for neurodegenerative disease research.</p>Fórmula:C18H16N6Cor e Forma:SolidPeso molecular:316.363,6-DMAD dihydrochloride
CAS:<p>3,6-DMAD dihydrochloride: Potent IRE1α-XBP1s inhibitor, affects IL-6 secretion and RNase activity, used in cancer research.</p>Fórmula:C22H33Cl2N5Cor e Forma:SolidPeso molecular:438.44XMD-17-51
CAS:<p>XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.</p>Fórmula:C21H24N8OPureza:99.04%Cor e Forma:SoildPeso molecular:404.47GP29
CAS:<p>GP29 is a Type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.</p>Fórmula:C33H28F3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:599.6Sibrafiban
CAS:<p>Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.</p>Fórmula:C20H28N4O6Cor e Forma:SolidPeso molecular:420.46Datelliptium chloride
CAS:<p>Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.</p>Fórmula:C23H28ClN3OPureza:98%Cor e Forma:SolidPeso molecular:397.94BMVC2
CAS:<p>BMVC2 (o-BMVC), a carbazole derivative of BMVC, is a G-quadruplex (G4) stabilizer.</p>Fórmula:C28H25I2N3Cor e Forma:SolidPeso molecular:657.33Synucleozid
CAS:<p>Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.</p>Fórmula:C22H20N6Pureza:98%Cor e Forma:SolidPeso molecular:368.43BMH-22
CAS:<p>BMH-22 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types.</p>Fórmula:C16H17N3Cor e Forma:SolidPeso molecular:251.33IACS-4759
CAS:<p>IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.</p>Fórmula:C10H17N3O2Cor e Forma:SolidPeso molecular:211.262-Keto-D-galactose
CAS:<p>2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.</p>Fórmula:C6H10O6Pureza:98%Cor e Forma:SolidPeso molecular:178.14MSC-1186
CAS:<p>MSC-1186 selectively inhibits SRPKs—IC50: 2.7nM (SRPK1), 81nM (SRPK2), 0.6nM (SRPK3)—for cancer research.</p>Fórmula:C19H17ClFN7O2SCor e Forma:SolidPeso molecular:461.9PF-4950834
CAS:PF-4950834, a ATP-competitive, selective Rho kinase inhibitor, provides therapeutic benefits in chronic inflammatory diseases.Fórmula:C21H19N3O2Pureza:98%Cor e Forma:SolidPeso molecular:345.395,10-Dideazafolic acid
CAS:<p>5,10-Dideazafolic acid is an antileukemic drug.</p>Fórmula:C21H21N5O6Cor e Forma:SolidPeso molecular:439.42CAP-53194
CAS:CAP-53194 is a selective Plk1 inhibitor.Fórmula:C21H14N6O5Pureza:98%Cor e Forma:SolidPeso molecular:430.37PV-1115
CAS:<p>PV-1115 is an effective and highly selective inhibitor of the Chk2.</p>Fórmula:C20H19N7O3Pureza:98%Cor e Forma:SolidPeso molecular:405.41GSK-3008348
CAS:<p>GSK-3008348 is an antagonist of integrin alpha(v)beta6.</p>Fórmula:C29H37N5O2Pureza:99.547%Cor e Forma:SolidPeso molecular:487.64Bis-Pro-5FU
CAS:<p>Bis-Pro-5FU enhances oral uptake and safety of 5-FU, an anti-cancer drug for colorectal and pancreatic tumors.</p>Fórmula:C10H7FN2O2Cor e Forma:SolidPeso molecular:206.17Mivobulin Isethionate
CAS:<p>Mivobulin, a tubulin inhibitor (CI-980), may treat glioma, melanoma, prostate, and ovarian cancer, targeting colchicine-binding site.</p>Fórmula:C19H25N5O6SPureza:98%Cor e Forma:SolidPeso molecular:451.5Picoplatin
CAS:<p>Picoplatin, an anti-cancer agent overcoming platinum resistance, alkylates DNA to block replication, transcription, and induce apoptosis.</p>Fórmula:C6H10Cl2N2PtPureza:98%Cor e Forma:SolidPeso molecular:376.14HHL-6
CAS:<p>HHL-6 is a c-Fos and BDNF protein expression modulator.</p>Fórmula:C19H26N2O3Cor e Forma:SolidPeso molecular:330.42FINDY
CAS:<p>FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.</p>Fórmula:C16H17NO2S2SiCor e Forma:SolidPeso molecular:347.53Fozivudine tidoxil
CAS:<p>Fozivudine tidoxil, a reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.</p>Fórmula:C35H64N5O8PSCor e Forma:SolidPeso molecular:745.95HIV-1 inhibitor-43
CAS:<p>HIV-1 Inhibitor-43 suppresses HIV-1, with EC50: 21.3 nM (Y188L), 6.2 nM (K103N-Y181C), <0.7 nM (K103N/Y181C), and lowers HIV RNA/p24 protein.</p>Fórmula:C24H21ClN2O4SCor e Forma:SolidPeso molecular:468.95Metralindole HCl
CAS:Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.Fórmula:C15H18ClN3OPureza:98%Cor e Forma:SolidPeso molecular:291.78HR22C16
CAS:<p>HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.</p>Fórmula:C23H23N3O3Cor e Forma:SolidPeso molecular:389.45
