Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(94 produtos)
- CDK(500 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(224 produtos)
- Cinesina(66 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(262 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(69 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(69 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3482 produtos de "Ciclo celular/Ponto de verificação"
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AM-TS23
CAS:<p>AM-TS23 is used as a DNA polymerase lambda and beta inhibitor.</p>Fórmula:C17H12N2O3S3Pureza:98%Cor e Forma:SolidPeso molecular:388.48JTK-101
CAS:<p>JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.</p>Fórmula:C25H23N3O3Cor e Forma:SolidPeso molecular:413.47LDN-209929 dihydrochloride
CAS:<p>LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.</p>Fórmula:C17H19Cl3N2OSCor e Forma:SolidPeso molecular:405.77D-Xylofuranose, 1,2,3,5-tetraacetate
CAS:<p>1,2,3,5-Tetra-O-acetyl-D-xylofuranose is a starting material for the synthesis of nucleosides.</p>Fórmula:C13H18O9Cor e Forma:SolidPeso molecular:318.28LSN 3213128
CAS:<p>LSN 3213128: a potent oral antifolate targeting AICARFT with IC50s of 16 nM (enzyme) and 19 nM (cells), offers anti-tumor effects.</p>Fórmula:C17H16FN3O4S2Cor e Forma:SolidPeso molecular:409.45ML366
CAS:<p>ML366 is a Vibrio cholerae Quorum Sensing inhibitor Acting via the LuxO response regulator.</p>Fórmula:C17H19N3O4Pureza:98%Cor e Forma:SolidPeso molecular:329.35HBX28258
CAS:<p>HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.</p>Fórmula:C26H30ClN3OPureza:98%Cor e Forma:SolidPeso molecular:435.99JNJ-9676
CAS:<p>JNJ-9676 is an orally active inhibitor of the coronavirus membrane protein, thereby blocking viral assembly and release.coronavirus and SARS-CoV.</p>Fórmula:C28H21F2N5O2Pureza:99.83%Cor e Forma:SoildPeso molecular:497.5Myt1-IN-1
CAS:<p>Myt1-IN-1 has anticancer effects that is a potent inhibitor of Myt1 with an IC 50 of <10 nM [1].</p>Fórmula:C16H15ClN4O2Cor e Forma:SolidPeso molecular:330.77DHODH-IN-3
CAS:<p>DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.</p>Fórmula:C17H13ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:312.75OXA-06 Dihydrochloride
CAS:<p>OXA-06 Dihydrochloride is a PANC-1 cell migration and MYPT1 phosphorylation inhibitor.</p>Fórmula:C21H18FN3Pureza:98%Cor e Forma:SolidPeso molecular:331.39Lysine-methotrexate
CAS:<p>Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase.</p>Fórmula:C21H27N9O3Pureza:98%Cor e Forma:SolidPeso molecular:453.5LY 207702
CAS:<p>LY 207702, a difluorinated purine nucleoside, exhibits antitumor activity in preclinical models.</p>Fórmula:C10H12F2N6O3Pureza:98%Cor e Forma:SolidPeso molecular:302.24Codon readthrough inducer 1
CAS:<p>Codon readthrough inducer 1 contains pyrimidine bases and shows good readthrough activity.</p>Fórmula:C15H11N3O5Pureza:98%Cor e Forma:SolidPeso molecular:313.26Type II topoisomerase inhibitor 1
CAS:<p>Potent E. coli DNA gyrase inhibitor (IC50: 1.7 nM), targets Asp73; weak topoisomerase IV inhibitor (IC50: 0.98 μM).</p>Fórmula:C18H15N3O4Cor e Forma:SolidPeso molecular:337.33MS0017509
CAS:<p>MS0017509 is a DNA damage repair inhibitor.</p>Fórmula:C11H10N4Pureza:98%Cor e Forma:SolidPeso molecular:198.22Ulecaciclib
CAS:<p>Ulecaciclib: oral, BBB-permeable CDK inhibitor; favorable pharmacokinetics; ki: 0.62 μM (CDK2/A), 3 nM (CDK6/D3), 0.2 nM (CDK4/D1), 0.63 μM (CDK7/H).</p>Fórmula:C25H33FN8SCor e Forma:SolidPeso molecular:496.652'-Fluorothymidine
CAS:<p>2'-Fluorothymidine is a selective substrate for TK2, related to thymidine and methyluridine.</p>Fórmula:C10H13FN2O5Pureza:99.67%Cor e Forma:SolidPeso molecular:260.22Cdc7-IN-13
CAS:<p>Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1].</p>Fórmula:C18H20N4O2SCor e Forma:SolidPeso molecular:356.44GR 144053 trihydrochloride
CAS:<p>platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist</p>Fórmula:C18H30Cl3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:454.82AZD7762 HCl
CAS:<p>AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.</p>Fórmula:C17H20ClFN4O2SPureza:98%Cor e Forma:SolidPeso molecular:398.88VPC-70619
CAS:<p>VPC-70619: Oral, selective N-Myc inhibitor; blocks cancer growth by hindering N-Myc-Max/DNA binding; well-absorbed.</p>Fórmula:C16H8ClF3N4OCor e Forma:SolidPeso molecular:364.71Tetrahydrouridine
CAS:<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Fórmula:C9H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:248.23Cdc7-IN-9
CAS:<p>Cdc7-IN-9 can be used for the research of cancer which is a potent inhibitor of Cdc7 [1].</p>Fórmula:C15H17N5OSCor e Forma:SolidPeso molecular:315.39DAP-81
CAS:<p>DAP-81, a diaminopyrimidine, inhibits Plk1 (IC50: 0.9 nM), disrupts microtubules, causes monopolar spindles; in preclinical studies.</p>Fórmula:C25H20N6O4Cor e Forma:SolidPeso molecular:468.46CDK4/6-IN-9
CAS:<p>CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.</p>Fórmula:C22H23FN8Cor e Forma:SolidPeso molecular:418.47HBV-IN-16
CAS:<p>HBV-IN-16, a quinoline derivative, inhibits HBV cccDNA, key for viral replication (from patent WO2019121357A1).</p>Fórmula:C22H20ClNO4Cor e Forma:SolidPeso molecular:397.85Phelorphan
CAS:<p>Phelorphan is an inhibitor of enkephalinase.</p>Fórmula:C20H22N2O4SPureza:98%Cor e Forma:SolidPeso molecular:386.46CDK7-IN-12
CAS:<p>CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.</p>Fórmula:C20H19F3N6Cor e Forma:SolidPeso molecular:400.4Crisnatol mesylate
CAS:<p>Crisnatol, a potent and selective DNA intercalator, has potential anticancer activity.</p>Fórmula:C24H27NO5SCor e Forma:SolidPeso molecular:441.54CID 5951923
CAS:<p>CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.</p>Fórmula:C16H18N2O7SPureza:99.95%Cor e Forma:SolidPeso molecular:382.39CFM-1
CAS:<p>CFM-1 is an antagonist of the anaphase-promoting complex (APC)-2. It also is a cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonist.</p>Fórmula:C12H7BrN2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:355.23BAY-958
CAS:<p>BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.</p>Fórmula:C17H16FN5O3SPureza:98%Cor e Forma:SolidPeso molecular:389.4Werner syndrome RecQ helicase-IN-3
CAS:<p>Potent WRN inhibitor, Werner syndrome RecQ helicase-IN-3, is orally active with 0.06 µM IC50; exhibits antiproliferative and anticancer effects.</p>Fórmula:C31H30ClF3N8O5Cor e Forma:SolidPeso molecular:687.07Mps-BAY2b
CAS:<p>Mps-BAY2b is a novel MPS1 inhibitor.</p>Fórmula:C20H23N5OCor e Forma:SolidPeso molecular:349.43Indirubin-5-sulfonate
CAS:<p>Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.</p>Fórmula:C16H10N2O5SPureza:98%Cor e Forma:SolidPeso molecular:342.33RUC-1
CAS:<p>RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor.</p>Fórmula:C11H15N5OSPureza:98%Cor e Forma:SolidPeso molecular:265.33Homocarbonyltopsentin
CAS:<p>Homocarbonyltopsentin: Small molecule, binds TSL2 pentaloops, enhances SMN2 E7 splicing, EC50 16 μM.</p>Fórmula:C21H14N4O3Pureza:98%Cor e Forma:SolidPeso molecular:370.36Guanoctine hydrochloride
CAS:<p>Guanoctine hydrochloride has antihypertensive activity.</p>Fórmula:C9H22ClN3Cor e Forma:SolidPeso molecular:207.74NSC 109555 ditosylate
CAS:<p>Chk2 inhibitor,ATP-competitive</p>Fórmula:C26H32N10O4SPureza:98%Cor e Forma:SolidPeso molecular:580.6614α-Demethylase/DNA Gyrase-IN-2
CAS:<p>14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.</p>Fórmula:C24H22N4O4Cor e Forma:SolidPeso molecular:430.46BDM44768
CAS:<p>BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.</p>Fórmula:C24H22FN5O3Cor e Forma:SolidPeso molecular:447.46IRE1α kinase-IN-3
CAS:<p>IRE1α kinase-IN-3 is a potent, ATP-competitive inhibitor of IRE1α (Ki: 480 nM).</p>Fórmula:C29H32N6O3SCor e Forma:SolidPeso molecular:544.67Mps1-IN-4
CAS:<p>Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.</p>Fórmula:C26H31F3N6O2Cor e Forma:SolidPeso molecular:516.56CDK7-IN-8
CAS:<p>CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.</p>Fórmula:C25H38N8O3Cor e Forma:SolidPeso molecular:498.62Nucleoside-Analog-2
CAS:<p>Nucleoside-Analog-2 is a 4'-Azidocytidine analogue, used to against Hepatitis C virus (HCV) replication.</p>Fórmula:C9H11N5O6Pureza:98%Cor e Forma:SolidPeso molecular:285.212'-Deoxy-L-guanosine
CAS:<p>2'-Deoxy-L-guanosine is a nucleoside that shows antibiotic properties by inhibiting protein synthesis, leading to cell death.</p>Fórmula:C10H13N5O4Cor e Forma:SolidPeso molecular:267.24VE-465
CAS:<p>VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.</p>Fórmula:C22H28N8OSCor e Forma:SolidPeso molecular:452.58Antitumor agent-85
<p>Antitumor agent-85 stabilizes G4-DNA with potent anti-tumor effects.</p>Fórmula:C24H33N7Cor e Forma:SolidPeso molecular:419.57XU1
CAS:<p>XU1（Benzo[c][1,8]naphthyridin-6(5h)-One） is an Aurora protein kinase inhibitor used for the treatment of diseases suitable for inhibition, regulation or</p>Fórmula:C12H8N2OPureza:98.58% - 99.59%Cor e Forma:SolidPeso molecular:196.2
