Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(94 produtos)
- CDK(500 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(224 produtos)
- Cinesina(66 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(262 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(69 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(69 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3482 produtos de "Ciclo celular/Ponto de verificação"
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HBV-IN-15
CAS:<p>HBV-IN-15, a flavone derivative, is a potent cccDNA inhibitor, potentially aiding HBV research.</p>Fórmula:C24H23ClO6Cor e Forma:SolidPeso molecular:442.89LIMK1 inhibitor BMS-4
CAS:<p>BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.</p>Fórmula:C23H23N7O2SCor e Forma:SolidPeso molecular:461.54PD-1-IN-22
CAS:<p>PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).</p>Fórmula:C25H25N5O4Pureza:99.51%Cor e Forma:SolidPeso molecular:459.5TC-Mps1-12
CAS:<p>TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .</p>Fórmula:C17H20N6OPureza:98%Cor e Forma:SolidPeso molecular:324.38CB 3717
CAS:<p>CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist.</p>Fórmula:C24H23N5O6Cor e Forma:SolidPeso molecular:477.47Pyrazofurin
CAS:<p>Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).</p>Fórmula:C9H13N3O6Pureza:98%Cor e Forma:SolidPeso molecular:259.22IPR-803
CAS:<p>IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity.</p>Fórmula:C27H23N3O4Pureza:95%Cor e Forma:SolidPeso molecular:453.49Datelliptium chloride
CAS:<p>Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.</p>Fórmula:C23H28ClN3OPureza:98%Cor e Forma:SolidPeso molecular:397.94Sibrafiban
CAS:<p>Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.</p>Fórmula:C20H28N4O6Cor e Forma:SolidPeso molecular:420.46CFI-400437
CAS:<p>CFI-400437 is an ATP-competitive PLK4 inhibitor (IC50: 0.6 nM) and is an indolequinone derivative.</p>Fórmula:C29H28N6O2Cor e Forma:SolidPeso molecular:492.57IACS-4759
CAS:<p>IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.</p>Fórmula:C10H17N3O2Cor e Forma:SolidPeso molecular:211.26FINDY
CAS:<p>FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.</p>Fórmula:C16H17NO2S2SiCor e Forma:SolidPeso molecular:347.53CDK-IN-10
CAS:<p>CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.</p>Fórmula:C18H18N4O2Pureza:97.07%Cor e Forma:SolidPeso molecular:322.36MtTMPK-IN-6
CAS:<p>MtTMPK-IN-6 inhibits M. tuberculosis thymidylate kinase with IC50 of 29 μM, promising for TB research.</p>Fórmula:C23H25N3O3Cor e Forma:SolidPeso molecular:391.46SR7826
CAS:<p>SR7826 is a selective LIMK inhibitor.</p>Fórmula:C22H21N5O2Pureza:98%Cor e Forma:SolidPeso molecular:387.43ERCC1-XPF-IN-1
CAS:<p>ERCC1-XPF-IN-1: potent ERCC1-XPF inhibitor (IC50: 0.49 μM), hampers CPD removal, boosts UV toxicity, hinders DNA repair.</p>Fórmula:C28H32ClN5O2Cor e Forma:SolidPeso molecular:506.04CLT-28643
CAS:<p>CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.</p>Fórmula:C19H17N3O4Pureza:99.89%Cor e Forma:SolidPeso molecular:351.36ML372
CAS:<p>ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration.</p>Fórmula:C18H20N2O4SCor e Forma:SolidPeso molecular:360.43BMS-587101
CAS:<p>BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.</p>Fórmula:C26H20Cl2N4O4SCor e Forma:SolidPeso molecular:555.43PFM03
CAS:<p>PFM03 is a endonuclease inhibitor that specifically blocks Mre11,reduce MRN endonuclease activity, blocking hMRN-mediated endonucleotomy and nuclear exocytosis.</p>Fórmula:C14H15NO2S2Pureza:99.81% - 99.98%Cor e Forma:SolidPeso molecular:293.4c-Myc inhibitor 9
CAS:<p>c-Myc inhibitor 9 (compound 332) with logEC50 ≥6, suppresses tumors in mice, useful for cancer research.</p>Fórmula:C27H31N5OSCor e Forma:SolidPeso molecular:473.63CDK7-IN-20
<p>CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.</p>Fórmula:C30H26N6O3Cor e Forma:SolidPeso molecular:518.57Integrin modulator 1
CAS:<p>Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.</p>Fórmula:C13H14N2O4Pureza:99.61%Cor e Forma:SolidPeso molecular:262.26EMD534085
CAS:<p>EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).</p>Fórmula:C25H31F3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:476.53Chrysotobibenzyl
CAS:<p>Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.</p>Fórmula:C19H24O5Cor e Forma:SolidPeso molecular:332.398RK64
CAS:<p>8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .</p>Fórmula:C14H16N8O2SCor e Forma:SolidPeso molecular:360.4XMD-17-51
CAS:<p>XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.</p>Fórmula:C21H24N8OPureza:99.04%Cor e Forma:SoildPeso molecular:404.475,10-Dideazafolic acid
CAS:<p>5,10-Dideazafolic acid is an antileukemic drug.</p>Fórmula:C21H21N5O6Cor e Forma:SolidPeso molecular:439.42CDK7-IN-13
CAS:<p>CDK7-IN-13: A potent pyrimidine-based CDK7 inhibitor, potential for various cancers. See CN114249712A.</p>Fórmula:C20H23F3N6OSPureza:99.22%Cor e Forma:SolidPeso molecular:452.5Indirubin-3'-monoxime-5-sulphonic acid
CAS:<p>Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.</p>Fórmula:C16H11N3O5SPureza:98%Cor e Forma:SolidPeso molecular:357.3410-Deazaaminopterin
CAS:<p>10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor.</p>Fórmula:C20H21N7O5Cor e Forma:SolidPeso molecular:439.42Antibacterial agent 89
CAS:<p>Antibacterial agent 89 blocks bacterial transcription and clostridial cytotoxins, inhibiting β'CH-σ interactions.</p>Fórmula:C21H10Cl2F3NO5SCor e Forma:SolidPeso molecular:516.27P1788
CAS:<p>P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor that can induce DNA damage [1].</p>Fórmula:C15H17NO3Cor e Forma:SolidPeso molecular:259.3SEL120-34A
CAS:<p>SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.</p>Fórmula:C15H18Br2N4Pureza:99.764% - 99.84%Cor e Forma:SolidPeso molecular:414.14DDRI-18
CAS:<p>DDRI-18 is an inhibitor that regulates the DNA damage response, has anticancer activity, and inhibits non-homologous end-joining (NHEJ) DNA repair.</p>Fórmula:C26H20N6Pureza:98%Cor e Forma:SolidPeso molecular:416.48116-9e
CAS:<p>116-9e (MAL2-11B) is an Hsp70 chaperone DNAJA1 inhibitor with antiviral properties, inhibits SV40 replication, and can be used to study cancer drug resistance.</p>Fórmula:C31H32N2O5Pureza:99.55%Cor e Forma:SolidPeso molecular:512.6ITX3
CAS:<p>ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM.</p>Fórmula:C22H17N3OSPureza:99.02%Cor e Forma:SolidPeso molecular:371.45Cdk2 Inhibitor II
CAS:<p>Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.</p>Fórmula:C14H11BrN4O3SPureza:97.07%Cor e Forma:SolidPeso molecular:395.23SMN-C2
CAS:<p>SMN-C2, a SMN2 gene splicing regulator, is an RNA-binding ligand that regulates pre-mRNA splicing and has potential for studying spinal muscular atrophy.</p>Fórmula:C24H27N5O2Pureza:99.14%Cor e Forma:SolidPeso molecular:417.5RP-6306
CAS:<p>Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.</p>Fórmula:C18H20N4O2Pureza:98.41% - 99.28%Cor e Forma:SolidPeso molecular:324.38Abemaciclib metabolite M20
CAS:<p>Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。</p>Fórmula:C27H32F2N8OPureza:98.1% - 99.08%Cor e Forma:SolidPeso molecular:522.59Netivudine
CAS:<p>Netivudine, a potent NRTI with anti-varicella activity, treats HIV by inhibiting reverse transcriptase, reducing viral load.</p>Fórmula:C12H14N2O6Pureza:99.78%Cor e Forma:SolidPeso molecular:282.25ZIM
CAS:<p>ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.</p>Fórmula:C20H19N3O3Pureza:99.85%Cor e Forma:SolidPeso molecular:349.38TC-S 7005
CAS:<p>TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).</p>Fórmula:C21H17N3O3Pureza:99.516%Cor e Forma:SolidPeso molecular:359.38Haspin-IN-3
CAS:<p>Haspin-IN-3 is a potent haspin inhibitor with an IC50 of 14 nM.Haspin-IN-3 has anticancer activity.</p>Fórmula:C16H10N2O3Pureza:98.78%Cor e Forma:SolidPeso molecular:278.26NR2F6 modulator-1
CAS:<p>NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.</p>Fórmula:C23H17NO5SPureza:98.31%Cor e Forma:SolidPeso molecular:419.45CHD1Li 6.11
CAS:<p>CHD1Li 6.11 inhibits CHD1L protein (IC50: 3.3 µM), shrinks CRC tumors in vivo, and is orally active.</p>Fórmula:C21H22BrN5OSPureza:99.04%Cor e Forma:SolidPeso molecular:472.4dCeMM2
CAS:<p>dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.</p>Fórmula:C16H11ClN6OSPureza:99.68%Cor e Forma:SolidPeso molecular:370.82DS18561882
CAS:<p>DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.</p>Fórmula:C28H31F3N4O6SPureza:98.19% - >99.99%Cor e Forma:SolidPeso molecular:608.63(S)-PF-06873600
CAS:<p>(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.</p>Fórmula:C20H27F2N5O4SPureza:98.59%Cor e Forma:SolidPeso molecular:471.52
