Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(94 produtos)
- CDK(500 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(224 produtos)
- Cinesina(66 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(262 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(69 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(69 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3482 produtos de "Ciclo celular/Ponto de verificação"
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GKI-1
CAS:<p>GKI-1, a GWL kinase inhibitor: IC50 - 4.9 µM for hGWLFL, 2.5 µM for hGWL-KinDom, 11 µM for ROCK1; weak on PKA.</p>Fórmula:C15H12ClN3Pureza:99.96%Cor e Forma:SolidPeso molecular:269.73PLK1-IN-4
CAS:<p>PLK1-IN-4: strong PLK1 blocker (<0.508 nM IC50), inhibits cancer cell growth, triggers G2/M arrest and apoptosis.</p>Fórmula:C24H25F3N6O4SCor e Forma:SolidPeso molecular:550.55WRN inhibitor 2
CAS:<p>WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].</p>Fórmula:C15H11F3N2O5S2Pureza:98%Cor e Forma:SolidPeso molecular:420.38DHODH-IN-14
CAS:<p>DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.</p>Fórmula:C15H7F4N3O3Pureza:99.81%Cor e Forma:SolidPeso molecular:353.23Myt1-IN-2
CAS:<p>Myt1-IN-2, a highly potent Myt1 inhibitor, exhibits remarkable anticancer properties with an IC50 value below 10 nM (WO2021195782A1; compound 28) [1].</p>Fórmula:C18H16N6O2SCor e Forma:SolidPeso molecular:380.42TAS-114
CAS:<p>TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.</p>Fórmula:C21H29N3O6SPureza:99.76%Cor e Forma:SolidPeso molecular:451.54DAM-IN-1
CAS:<p>DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.</p>Fórmula:C16H17NO4Pureza:98%Cor e Forma:SolidPeso molecular:287.31CDK9-IN-2
CAS:<p>CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.</p>Fórmula:C23H25ClFN5Pureza:99%Cor e Forma:SolidPeso molecular:425.93WRN inhibitor 5
CAS:<p>WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Fórmula:C23H20N2O6SCor e Forma:SolidPeso molecular:452.48AVG-233
CAS:<p>AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.</p>Fórmula:C26H22ClN5O3Pureza:99%Cor e Forma:SolidPeso molecular:487.94Carotegrast
CAS:<p>Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.</p>Fórmula:C27H24Cl2N4O5Cor e Forma:SolidPeso molecular:555.41Cdc7-IN-7
CAS:<p>Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.</p>Fórmula:C21H22N4O5Pureza:98.78%Cor e Forma:SolidPeso molecular:410.42NTRC 0066-0
CAS:<p>NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.</p>Fórmula:C33H39N7O2Pureza:98.30%Cor e Forma:SolidPeso molecular:565.71IIIM-290
CAS:<p>IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).</p>Fórmula:C23H21Cl2NO5Pureza:98%Cor e Forma:SolidPeso molecular:462.32Balapiravir hydrochloride
CAS:<p>Balapiravir HCl, an NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Fórmula:C21H31ClN6O8Cor e Forma:SolidPeso molecular:530.96Luvixasertib hydrochloride
CAS:<p>CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].</p>Fórmula:C28H31ClN6O3Cor e Forma:SolidPeso molecular:535.04SB-743921 free base
CAS:<p>SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).</p>Fórmula:C31H33ClN2O3Pureza:98%Cor e Forma:SolidPeso molecular:517.06N-desmethyl Netupitant
CAS:<p>N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.</p>Fórmula:C29H30F6N4OPureza:98%Cor e Forma:SolidPeso molecular:564.57SB-267268
CAS:<p>SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).</p>Fórmula:C22H24F3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:451.44XL413 hydrochloride
CAS:<p>XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.</p>Fórmula:C14H13Cl2N3O2Pureza:98.81% - 99.8%Cor e Forma:SolidPeso molecular:326.18CDK7-IN-14
CAS:<p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>Fórmula:C22H24F3N6OPCor e Forma:SolidPeso molecular:476.43PLK1-IN-7
CAS:<p>PLK1-IN-7 (compound 30e) is a potent inhibitor exhibiting an IC50 value of 0.66 nM and demonstrates significant antiproliferative and antitumor activities [1].</p>Fórmula:C24H24F4N8O2Cor e Forma:SolidPeso molecular:532.49SHP2/CDK4-IN-1
CAS:<p>SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.</p>Fórmula:C33H35ClF2N10OSCor e Forma:SolidPeso molecular:693.21CDK4-IN-2
CAS:<p>CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].</p>Fórmula:C22H26F2N6O4SPureza:98%Cor e Forma:SolidPeso molecular:508.54FT206
CAS:<p>FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].</p>Fórmula:C25H29N5OSCor e Forma:SolidPeso molecular:447.6Butylparaben sodium
CAS:<p>Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and/or RNA and protein synthesis [1</p>Fórmula:C11H13NaO3Pureza:98%Cor e Forma:SolidPeso molecular:216.21CCT251455
CAS:<p>CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.</p>Fórmula:C26H26ClN7O2Pureza:99.1% - 99.1%Cor e Forma:SolidPeso molecular:503.98Pelitrexol
CAS:<p>Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, block the cell cycle in the s-phase, with antiproliferative activity,NSCLC .</p>Fórmula:C20H25N5O6SPureza:98.03%Cor e Forma:SolidPeso molecular:463.51BI-1950
CAS:<p>BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.</p>Fórmula:C32H26Cl2FN7O3Pureza:98%Cor e Forma:SolidPeso molecular:646.5Teclistamab
CAS:<p>Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.</p>Pureza:95%Cor e Forma:LiquidSynstatin (92-119)
CAS:<p>Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and</p>Fórmula:C133H207N35O46Pureza:98%Cor e Forma:SolidPeso molecular:3032.27Votoplam
CAS:<p>Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1].</p>Fórmula:C21H25N9OPureza:98%Cor e Forma:SolidPeso molecular:419.48Raluridine
CAS:<p>Raluridine is an HIV treatment inhibiting RNA-directed DNA polymerase with IC50 of 1.8 microM, compared to FLT, AZT, ddI, and ddC.</p>Fórmula:C9H10ClFN2O4Pureza:98%Cor e Forma:SolidPeso molecular:264.64MU-380
CAS:<p>MU-380 is an effective and selective inhibitor of CHK1.</p>Fórmula:C15H15BrF3N7Cor e Forma:SolidPeso molecular:430.23PD-1/PD-L1-IN-27
CAS:<p>PD-1/PD-L1-IN-27: potent anti-cancer, IC50 134nM, minimal T cell harm, boosts CD8+ T cells, reduces fatigue.</p>Fórmula:C44H35NO6Pureza:98%Cor e Forma:SolidPeso molecular:673.75USP1-IN-3
CAS:<p>USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.</p>Fórmula:C27H24F3N7OCor e Forma:SolidPeso molecular:519.52Litronesib
CAS:<p>Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.</p>Fórmula:C23H37N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:511.7DHX9-IN-4
CAS:<p>DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.</p>Fórmula:C21H22ClN5O4S2Pureza:98.12%Cor e Forma:SolidPeso molecular:508.01SC-52012
CAS:<p>SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.</p>Fórmula:C25H30N4O6Pureza:97.20%Cor e Forma:SolidPeso molecular:482.53Emzadirib
CAS:<p>Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.</p>Fórmula:C27H40N4O6S2Pureza:99.79% - 99.9%Cor e Forma:SolidPeso molecular:580.76Senexin C
CAS:<p>Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.</p>Fórmula:C28H27N5OPureza:98.06%Cor e Forma:SolidPeso molecular:449.55DHX9-IN-6
CAS:<p>DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.</p>Fórmula:C23H18ClFN4O4S2Pureza:99.71%Cor e Forma:SolidPeso molecular:533Netropsin dihydrochloride
CAS:<p>Netropsin dihydrochloride, a small MGB, blocks topoisomerase I/II, hindering cleavable complex stabilization.</p>Fórmula:C18H28Cl2N10O3Pureza:98%Cor e Forma:SolidPeso molecular:503.39Spirofylline
CAS:<p>Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.</p>Fórmula:C24H28N6O5Pureza:98%Cor e Forma:SolidPeso molecular:480.52DUB-IN-7
CAS:<p>DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].</p>Fórmula:C17H19N5OCor e Forma:SolidPeso molecular:309.37Fosfluridine tidoxil
CAS:<p>Fosfluridine tidoxil, a thymidylate synthase inhibitor, is used potentially for the treatment of colorectal cancer, and breast cancer.</p>Fórmula:C34H62FN2O10PSCor e Forma:SolidPeso molecular:740.9Trovafloxacin mesylate
CAS:<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Fórmula:C21H19F3N4O6SPureza:99.18%Cor e Forma:SolidPeso molecular:512.46DNA polymerase-IN-3
CAS:<p>DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications in</p>Fórmula:C13H12O4Pureza:98%Cor e Forma:SolidPeso molecular:232.23LDC3140
CAS:<p>LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).</p>Fórmula:C23H33N7OPureza:98%Cor e Forma:SolidPeso molecular:423.55NVS-SM2
CAS:<p>NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.</p>Fórmula:C23H30N6OCor e Forma:SolidPeso molecular:406.52
