Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(94 produtos)
- CDK(500 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(224 produtos)
- Cinesina(66 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(262 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(69 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(69 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3482 produtos de "Ciclo celular/Ponto de verificação"
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USP7-IN-12
CAS:<p>USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].</p>Fórmula:C29H28ClFN4O2SCor e Forma:SolidPeso molecular:551.07Solitomab
CAS:<p>Solitomab (AMG 110) is a bispecific antibody targeting CD3 and EpCAM, used in uterine/ovarian carcinosarcoma research.</p>Cor e Forma:LiquidNε-(1-Carboxyethyl)-L-lysine
CAS:<p>Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.</p>Fórmula:C9H18N2O4Cor e Forma:SolidPeso molecular:218.25CDK4/6-IN-15
CAS:<p>CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.</p>Fórmula:C21H27FN8SCor e Forma:SolidPeso molecular:442.56GSK2646264
CAS:<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Fórmula:C24H26N2O2Cor e Forma:SolidPeso molecular:374.48PD-1/PD-L1-IN-26
CAS:<p>PD-1/PD-L1-IN-26 is a strong inhibitor with IC50 of 0.0380 μM that may boost immune response in cancer by aiding CD4+ T cell entry to tumors.</p>Fórmula:C43H52N4O8Pureza:98%Cor e Forma:SolidPeso molecular:752.89CDK-IN-11
CAS:<p>CDK-IN-11, a heterocyclic compound, promotes cardiomyocyte maturation [1].</p>Fórmula:C25H21BrN4O2Cor e Forma:SolidPeso molecular:489.36WRN inhibitor 3
CAS:<p>WRN Inhibitor 3 (example 110), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Fórmula:C20H20N2O5SCor e Forma:SolidPeso molecular:400.45WRN inhibitor 4
CAS:<p>WRN Inhibitor 4 (Example 107), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Fórmula:C16H14N2O5SCor e Forma:SolidPeso molecular:346.36Tirofiban HCl
CAS:<p>Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.</p>Fórmula:C22H37ClN2O5SPureza:98%Cor e Forma:SolidPeso molecular:477.06Senexin A hydrochloride
CAS:<p>Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].</p>Fórmula:C17H15ClN4Cor e Forma:SolidPeso molecular:310.78CDK9-IN-29
CAS:<p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>Fórmula:C29H33F2N5O4Pureza:98%Cor e Forma:SolidPeso molecular:553.6CDK9-IN-8
CAS:<p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>Fórmula:C31H32FN7O3Pureza:99.54%Cor e Forma:SolidPeso molecular:569.63Cdc7-IN-12
CAS:<p>Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).</p>Fórmula:C16H14N2O2SCor e Forma:SolidPeso molecular:298.36ML 315 hydrochloride
CAS:<p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>Fórmula:C18H14Cl3N3O2Cor e Forma:SolidPeso molecular:410.6829-Deazaguanine
CAS:<p>9-Deazaguanine is a nucleoside analogue exhibiting inhibitory activity against bovine purine nucleoside phosphorylase (PNP).</p>Fórmula:C6H6N4OPureza:98%Cor e Forma:SolidPeso molecular:150.14PVZB1194
CAS:<p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>Fórmula:C13H9F4NO2SPureza:98%Cor e Forma:SolidPeso molecular:319.28BIO-7662
CAS:<p>BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.</p>Fórmula:C38H48N6O8SPureza:98%Cor e Forma:SolidPeso molecular:748.89GGTI 2147
CAS:<p>GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.</p>Fórmula:C28H30N4O3Pureza:98.69%Cor e Forma:SolidPeso molecular:470.56Integrin Antagonists 27
CAS:<p>Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.</p>Fórmula:C24H20N4O5Cor e Forma:SolidPeso molecular:444.44c-Myc inhibitor 8
CAS:<p>c-Myc inhibitor 8 suppresses cell growth in various cancers and is used in research.</p>Fórmula:C19H12BrClF3NO3S2Cor e Forma:SolidPeso molecular:538.79αvβ1 integrin-IN-2
CAS:<p>αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.</p>Fórmula:C29H38N4O4Pureza:98%Cor e Forma:SolidPeso molecular:506.64Bisindolylmaleimide X hydrochloride
CAS:<p>Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).</p>Fórmula:C26H25ClN4O2Pureza:99.23%Cor e Forma:SolidPeso molecular:460.96(2S,3R)-Voruciclib
CAS:<p>(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.</p>Fórmula:C22H19ClF3NO5Pureza:98%Cor e Forma:SolidPeso molecular:469.84TAK 029
CAS:<p>TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.</p>Fórmula:C19H23N5O7Cor e Forma:SolidPeso molecular:433.42Kif15-IN-2
CAS:<p>Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.</p>Fórmula:C20H20N6O4SPureza:98.17%Cor e Forma:SolidPeso molecular:440.48BVDU 5′-Triphosphate
CAS:<p>BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.</p>Fórmula:C11H16BrN2O14P3Pureza:98%Cor e Forma:SolidPeso molecular:573.08BMT-090605 hydrochloride
CAS:<p>BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.</p>Fórmula:C21H25ClN4O2Cor e Forma:SolidPeso molecular:400.91ATN-161
CAS:<p>ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.</p>Fórmula:C23H35N9O8SPureza:98%Cor e Forma:SolidPeso molecular:597.64Aurora Kinases-IN-4
CAS:<p>Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.</p>Fórmula:C26H28N8OPureza:98%Cor e Forma:SolidPeso molecular:468.55ASC-69
CAS:<p>ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].</p>Fórmula:C19H19N7Pureza:98%Cor e Forma:SolidPeso molecular:345.4G4/HDAC-IN-1
<p>G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.</p>Fórmula:C36H49ClFN7O4Cor e Forma:SolidPeso molecular:698.27UNC-2170
CAS:<p>UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.</p>Fórmula:C14H21BrN2OPureza:97.44%Cor e Forma:SolidPeso molecular:313.23ROCK2-IN-7
CAS:<p>ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.</p>Fórmula:C26H28FN5OPureza:98%Cor e Forma:SolidPeso molecular:445.53Inixaciclib
CAS:<p>Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.</p>Fórmula:C26H30F2N6OCor e Forma:SolidPeso molecular:480.558-NH2-ATP tetrasodium
CAS:<p>8-NH2-ATP tetrasodium, an inactive ATP variant, originates from 8-NH2-Ado tetrasodium, which triggers the apoptosis-associated cleavage of poly (ADP-ribose) polymerase [1] [2].</p>Fórmula:C10H13N6Na4O13P3Cor e Forma:SolidPeso molecular:610.12Zaurategrast
CAS:<p>Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.</p>Fórmula:C26H25BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:521.41CDK/HDAC-IN-3
CAS:<p>CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,</p>Fórmula:C24H18Cl2N6O3Pureza:98%Cor e Forma:SolidPeso molecular:509.34PD-1/PD-L1-IN-34
CAS:<p>PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1</p>Fórmula:C35H33ClN2O3Pureza:98%Cor e Forma:SolidPeso molecular:565.1NITD008
CAS:<p>NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.</p>Fórmula:C13H14N4O4Pureza:98.04%Cor e Forma:SolidPeso molecular:290.27Xylocydine
CAS:<p>Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.</p>Fórmula:C12H14BrN5O5Cor e Forma:SolidPeso molecular:388.17Aurora kinase inhibitor-8
CAS:<p>Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.</p>Fórmula:C30H29N7O3Cor e Forma:SolidPeso molecular:535.6GSK2163632A
CAS:<p>GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.</p>Fórmula:C27H32N8O3SCor e Forma:SolidPeso molecular:548.662'-Deoxypseudoisocytidine
CAS:<p>2'-Deoxypseudoisocytidine is a nucleoside analogue.</p>Fórmula:C9H13N3O4Pureza:98%Cor e Forma:SolidPeso molecular:227.22TC-I 15
CAS:<p>α2β1 integrin inhibitor</p>Fórmula:C23H28N4O6S2Pureza:98%Cor e Forma:SolidPeso molecular:520.62CT1113
CAS:<p>CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDX</p>Fórmula:C25H29N5O2SCor e Forma:SolidPeso molecular:463.6CCT-271850
CAS:<p>CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.</p>Fórmula:C24H29N7OPureza:98%Cor e Forma:SolidPeso molecular:431.53SZ-015268
CAS:<p>SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.</p>Fórmula:C25H38N8O3Cor e Forma:SolidPeso molecular:498.62G-5758
CAS:<p>G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.</p>Fórmula:C27H24F4N6O3SCor e Forma:SolidPeso molecular:588.58L-739758
CAS:<p>L-739758 is a glycoprotein IIb/IIIa inhibitor.</p>Fórmula:C22H26N4O5S3Cor e Forma:SolidPeso molecular:522.66
