Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(548 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(49 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(278 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(274 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3939 produtos de "Ciclo celular/Ponto de verificação"
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Antitumor agent-85
Antitumor agent-85 stabilizes G4-DNA with potent anti-tumor effects.Fórmula:C24H33N7Cor e Forma:SolidPeso molecular:419.57DHFR-IN-5
CAS:DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.Fórmula:C18H24N4O4Cor e Forma:SolidPeso molecular:360.41Remdesivir maleate
CAS:Remdesivir (GS-5734) is a broad-spectrum antiviral prodrug effective against SARS-CoV-2 and Ebola, used for research, not human treatment.Fórmula:C31H39N6O12PCor e Forma:SolidPeso molecular:718.656Olomoucine II
CAS:Olomoucine II, a CDK inhibitor effective on Cdk1/2/4/7/9, also inhibits ERK2, ABCB1, and various virus replications, not effective on measles/influenza.Fórmula:C19H26N6O2Pureza:99.94%Cor e Forma:SolidPeso molecular:370.45HBV-IN-15
CAS:HBV-IN-15, a flavone derivative, is a potent cccDNA inhibitor, potentially aiding HBV research.Fórmula:C24H23ClO6Cor e Forma:SolidPeso molecular:442.89HBV-IN-22
CAS:HBV-IN-22 (Compound LC5f) is an HBV DNA replication inhibitor that acts on both wild-type HBV (IC50: 0.71 μM) and drug-resistant HBV (IC50: 0.84 μM).Fórmula:C26H29N3O2S2Cor e Forma:SolidPeso molecular:479.66ROCK2-IN-5
ROCK2-IN-5, a compound blending fasudil, caffeic, and ferulic acids, shows promise for ALS research involving SOD1 mutations.Fórmula:C23H25N3O5SCor e Forma:SolidPeso molecular:455.53MK-0668 Mesylate
CAS:MK-0668 Mesylate is the mesylate form of MK-0668 that is a very potent and orally active very late antigen-4 antagonist.Fórmula:C32H34Cl2N6O9S2Cor e Forma:SolidPeso molecular:781.68LIMK1 inhibitor BMS-4
CAS:BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Fórmula:C23H23N7O2SCor e Forma:SolidPeso molecular:461.54M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Fórmula:C31H30F3N7O2Pureza:98.95%Cor e Forma:SolidPeso molecular:589.61Lysine-methotrexate
CAS:Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase.Fórmula:C21H27N9O3Pureza:98%Cor e Forma:SolidPeso molecular:453.5CM03
CAS:CM03 is a cell-selective G-quadruplex ligand with anti-cancer activity, stabilizing G4 genes, useful in pancreatic cancer research.Fórmula:C34H44N6O6Pureza:98.65%Cor e Forma:SolidPeso molecular:632.752-Keto-D-galactose
CAS:2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.Fórmula:C6H10O6Pureza:98%Cor e Forma:SolidPeso molecular:178.14BzDANP
CAS:BzDANP is a modulator of pre-miR-29a maturation by Dicer.Fórmula:C18H24N6Cor e Forma:SolidPeso molecular:324.42KIRA-7
CAS:KIRA-7: imidazopyrazine, anti-fibrotic, inhibits IRE1α RNase (IC50: 110 nM) allosterically.Fórmula:C27H23FN6OCor e Forma:SolidPeso molecular:466.51CDK9-IN-14
CAS:CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.Fórmula:C21H23F2N3O4Cor e Forma:SolidPeso molecular:419.42SLM6
CAS:SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.Fórmula:C12H17N7O4Cor e Forma:SolidPeso molecular:323.31POLA1 inhibitor 1
CAS:POLA1 inhibitor 1: oral, antitumor, effective on various cancers and Adaroten-resistant cells.Fórmula:C26H27NO4Cor e Forma:SolidPeso molecular:417.5CB 3717
CAS:CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist.Fórmula:C24H23N5O6Cor e Forma:SolidPeso molecular:477.47Sibrafiban
CAS:Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.Fórmula:C20H28N4O6Cor e Forma:SolidPeso molecular:420.46IACS-4759
CAS:IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.Fórmula:C10H17N3O2Cor e Forma:SolidPeso molecular:211.26DENV-IN-4
CAS:DENV-IN-4: Effective DENV inhibitor (EC50=4.79 μM), low toxicity (CC50>100 μM), and strong selectivity (SI>20.9); suppresses DENV2 and RdRp.Fórmula:C28H32N4O4SiCor e Forma:SolidPeso molecular:516.66FINDY
CAS:FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.Fórmula:C16H17NO2S2SiCor e Forma:SolidPeso molecular:347.53DHFR-IN-2
CAS:DHFR-IN-2 (4e) is a potent MtDHFR uncompetitive inhibitor with a 7 μM IC50, promising for TB research.Fórmula:C14H13NO2Cor e Forma:SolidPeso molecular:227.26CDK9/10/GSK3β-IN-1
CAS:CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50Fórmula:C29H24ClN3O4SCor e Forma:SolidPeso molecular:546.04Alsterpaullone, 2-Cyanoethyl
CAS:Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β.Fórmula:C19H14N4O3Cor e Forma:SolidPeso molecular:346.34CK0106023
CAS:CK0106023, a KSP inhibitor, shows strong antitumor effects in mice, outperforming paclitaxel, and induces monopolar spindles.Fórmula:C30H32BrClN4O2Cor e Forma:SolidPeso molecular:595.96MtTMPK-IN-6
CAS:MtTMPK-IN-6 inhibits M. tuberculosis thymidylate kinase with IC50 of 29 μM, promising for TB research.Fórmula:C23H25N3O3Cor e Forma:SolidPeso molecular:391.46ERCC1-XPF-IN-1
CAS:ERCC1-XPF-IN-1: potent ERCC1-XPF inhibitor (IC50: 0.49 μM), hampers CPD removal, boosts UV toxicity, hinders DNA repair.Fórmula:C28H32ClN5O2Cor e Forma:SolidPeso molecular:506.04RET-IN-19
CAS:RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.Fórmula:C28H28N6O4SCor e Forma:SolidPeso molecular:544.62ML372
CAS:ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration.Fórmula:C18H20N2O4SCor e Forma:SolidPeso molecular:360.43Teloxantrone HCl
CAS:Teloxantrone, a DNA topoisomerase II inhibitor, is used potentially for the treatment of solid tumors.Fórmula:C21H28ClN5O5Cor e Forma:SolidPeso molecular:465.94(R)-Filanesib
CAS:(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).Fórmula:C20H22F2N4O2SCor e Forma:SolidPeso molecular:420.48Nexinhib20
CAS:Nexinhib20 is an inhibitor of exosome synthesis and transport with anti-inflammatory activity, inhibits RAB27A and neutral sphingomyelinase 2 (nSMase2) nsMase2.Fórmula:C15H16N4O3Pureza:99.89%Cor e Forma:SolidPeso molecular:300.31CDK4/6-IN-8
CAS:CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).Fórmula:C18H18N6O5Cor e Forma:SolidPeso molecular:398.37IMB-10
CAS:IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.Fórmula:C19H15NOS2Cor e Forma:SolidPeso molecular:337.46BMS-587101
CAS:BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.Fórmula:C26H20Cl2N4O4SCor e Forma:SolidPeso molecular:555.43Aminopterin sodium
CAS:Aminopterin sodium is an immunosuppressive anticancer drug, blocking folate synthesis by inhibiting dihydrofolate reductase.Fórmula:C19H20N8NaO5Cor e Forma:SolidPeso molecular:463.41SMAPP1
CAS:SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.Fórmula:C27H25N5O5S2Pureza:98%Cor e Forma:SolidPeso molecular:563.65c-Myc inhibitor 9
CAS:c-Myc inhibitor 9 (compound 332) with logEC50 ≥6, suppresses tumors in mice, useful for cancer research.Fórmula:C27H31N5OSCor e Forma:SolidPeso molecular:473.63Tenofovir exalidex
CAS:Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistantFórmula:C28H52N5O5PPureza:99.83%Cor e Forma:SolidPeso molecular:569.72DHX9-IN-1
CAS:DHX9-IN-1 is a potent ATP-dependent RNA helicase A (DHX9) inhibitor, exhibiting an IC50 of 9.45 nM and demonstrating antitumor activity [1].Fórmula:C21H21F2N5O3SCor e Forma:SolidPeso molecular:461.49Ref: TM-T82569
1mg205,00€5mg528,00€1mL*10mM (DMSO)537,00€10mg782,00€25mg1.161,00€50mg1.558,00€100mg2.322,00€Yoshi-864
CAS:Yoshi-864, an alkyl sulfonate, alkylates DNA to hinder replication; potential anti-cancer agent.Fórmula:C8H20ClNO6S2Cor e Forma:SolidPeso molecular:325.83CDK7-IN-20
CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.Fórmula:C30H26N6O3Cor e Forma:SolidPeso molecular:518.57BPIC
CAS:BPIC is an agent of anti-tumor that acts by inhibiting inflammation and scavenging free radicals.Fórmula:C27H20N2O5Cor e Forma:SolidPeso molecular:452.46CDK7-IN-16
CAS:CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.Fórmula:C19H21F3N6O2SCor e Forma:SolidPeso molecular:454.47Integrin modulator 1
CAS:Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.Fórmula:C13H14N2O4Pureza:99.61%Cor e Forma:SolidPeso molecular:262.26L 703014
CAS:L 703014 is an antagonist of the fibrinogen receptor.Fórmula:C24H34N4O4Pureza:98%Cor e Forma:SolidPeso molecular:442.55CLK1-IN-2
CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.Fórmula:C16H12Cl2N2O2SCor e Forma:SolidPeso molecular:367.25TDRL-X80
CAS:TDRL-X80 inhibits XPA DNA binding; effective on single, double, and cisplatin-damaged DNA; IC50: 18-29 μM (FP), 21-39 μM (ELISA).Fórmula:C23H15ClN2O6Cor e Forma:SolidPeso molecular:450.83
