Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(548 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(49 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(278 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(274 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3939 produtos de "Ciclo celular/Ponto de verificação"
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CDK7-IN-10
CAS:CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)Fórmula:C29H35N7O3Cor e Forma:SolidPeso molecular:529.63SEC inhibitor KL-2
CAS:KL-2: potent SEC inhibitor, selectively disrupts AFF4-CCNT1, dose-dependent, Ki: 1.50 μM.Fórmula:C17H13ClFNO3Pureza:99.86%Cor e Forma:SolidPeso molecular:333.74αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Fórmula:C28H35F3N6O8SPureza:98%Cor e Forma:SolidPeso molecular:672.67BPKDi
CAS:BPKDi is a potent and selective inhibitor of PKD (protein kinase D).Fórmula:C21H28N6OPureza:98%Cor e Forma:SolidPeso molecular:380.49UIAA-II-232
CAS:UIAA-II-232 (compound 19b) is a potent inhibitor of DNA gyrase catalytic (IC 50= 3.5 μM).Fórmula:C20H24FN5O3Cor e Forma:SolidPeso molecular:401.43SLK/STK10-IN-1
CAS:SLK/STK10-IN-1 is a selective and potent inhibitor of SLK and STK10 with potential antitumor activity.Fórmula:C17H13ClN2O3Pureza:99.34%Cor e Forma:SolidPeso molecular:328.75Chrysotobibenzyl
CAS:Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.Fórmula:C19H24O5Cor e Forma:SolidPeso molecular:332.398RK64
CAS:8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .Fórmula:C14H16N8O2SCor e Forma:SolidPeso molecular:360.4DDD100097
CAS:DDD100097 is a N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.Fórmula:C22H30Cl2F2N4O2SPureza:98.89%Cor e Forma:SolidPeso molecular:523.475,10-Dideazafolic acid
CAS:5,10-Dideazafolic acid is an antileukemic drug.Fórmula:C21H21N5O6Cor e Forma:SolidPeso molecular:439.42Aloisine A
CAS:Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.Fórmula:C16H17N3OPureza:98%Cor e Forma:SolidPeso molecular:267.33MMV688844
CAS:MMV688844 inhibits M. abscessus DNA cyclooxygenase (IC50: 2μM) and has MIC50 of 12μM on strain bamboo; useful in antimicrobial studies.Fórmula:C23H25ClN4O2Cor e Forma:SolidPeso molecular:424.92CDK7-IN-13
CAS:CDK7-IN-13 (compound 1) is an effective CDK7 inhibitor for investigating cancers associated with transcriptional dysregulation.Fórmula:C20H23F3N6OSPureza:99.22%Cor e Forma:SolidPeso molecular:452.5TP1287
CAS:TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.Fórmula:C21H21ClNO8PCor e Forma:SolidPeso molecular:481.82AS-136A
CAS:AS-136A is an orally active MV RdRp inhibitor with antiviral activity that inhibits measles virus and blocks viral RNA synthesis.Fórmula:C17H19F3N4O3SPureza:98.52%Cor e Forma:SolidPeso molecular:416.42Ref: TM-T62160
1mg215,00€5mg537,00€1mL*10mM (DMSO)590,00€10mg802,00€25mg1.369,00€50mg1.783,00€100mg2.395,00€Indirubin-3'-monoxime-5-sulphonic acid
CAS:Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.Fórmula:C16H11N3O5SPureza:98%Cor e Forma:SolidPeso molecular:357.34Braco-19 trihydrochloride
CAS:BRACO19 3HCl inhibits telomerase, blocking its capping function, and prevents HAdV viral replication.Fórmula:C35H46Cl3N7O2Pureza:98.74%Cor e Forma:SolidPeso molecular:703.14CH-1504
CAS:CH-1504, dihydrofolate reductase (DHFR) inhibitor, is used potentially for the treatment of rheumatoid arthritis.Fórmula:C23H23N5O5Cor e Forma:SolidPeso molecular:449.46Antibacterial agent 89
CAS:Antibacterial agent 89 blocks bacterial transcription and clostridial cytotoxins, inhibiting β'CH-σ interactions.Fórmula:C21H10Cl2F3NO5SCor e Forma:SolidPeso molecular:516.27R-82913
CAS:R-82913 blocks RNA-polymerase, lowers mouse DOI-head-shakes, halts 13 HIV-1 strains with 0.15µM IC50, beats AZT-TP by 20x; ineffective on HIV-2.Fórmula:C16H20ClN3SCor e Forma:SolidPeso molecular:321.87UCK2 Inhibitor-1
CAS:UCK2 Inhibitor-1 is a non-competitive UCK2 inhibitor with an IC 50 of 4.7 µM .Fórmula:C27H21N3O4SCor e Forma:SolidPeso molecular:483.54RTC14
CAS:RTC14 induces PTC readthrough, restoring dystrophin and aiding muscle function in Duchenne model mice.Fórmula:C17H18N2O3Cor e Forma:SolidPeso molecular:298.34Epiroprim
CAS:Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor with antibacterial activity, inhibiting Staphylococcus and Streptococcus.Fórmula:C19H23N5O2Pureza:99.68% - >99.99%Cor e Forma:SolidPeso molecular:353.4212(S)-HpETE
CAS:12(S)-HpETE activates human blood leukocyte 5-LOE and mediates induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction.Fórmula:C20H32O4Cor e Forma:SolidPeso molecular:336.47AM-TS23
CAS:AM-TS23 is used as a DNA polymerase lambda and beta inhibitor.Fórmula:C17H12N2O3S3Pureza:98%Cor e Forma:SolidPeso molecular:388.48ML366
CAS:ML366 is a Vibrio cholerae Quorum Sensing inhibitor Acting via the LuxO response regulator.Fórmula:C17H19N3O4Pureza:98%Cor e Forma:SolidPeso molecular:329.35P1788
CAS:P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor that can induce DNA damage [1].Fórmula:C15H17NO3Cor e Forma:SolidPeso molecular:259.3ProTAME
CAS:ProTAME inhibits APC/CFzr & APC/CCdc20, enhances cell death with doxorubicin/etoposide in primary/MM cells, especially after TOPIIα upregulation.Fórmula:C34H38N4O12SPureza:98%Cor e Forma:SolidPeso molecular:726.75Werner syndrome RecQ helicase-IN-4
CAS:Werner syndrome RecQ helicase-IN-4 is a WRN inhibitor with anticancer and anti-proliferative activity, used in colorectal and gastric cancer research.Fórmula:C32H33F3N8O5Pureza:98.27%Cor e Forma:SolidPeso molecular:666.65β-catenin-IN-3
CAS:β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces theFórmula:C19H20Br2N2OSCor e Forma:SolidPeso molecular:484.25HBX28258
CAS:HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.Fórmula:C26H30ClN3OPureza:98%Cor e Forma:SolidPeso molecular:435.99Nitracrine
CAS:Nitracrine: a 1-nitroacridine, hypoxia-selective, anti-tumor agent; inhibits RNA synthesis, binds DNA reversibly and forms covalent adducts.Fórmula:C18H20N4O2Pureza:98%Cor e Forma:SolidPeso molecular:324.38JNJ-9676
CAS:JNJ-9676 is an orally active inhibitor of the coronavirus membrane protein, thereby blocking viral assembly and release.coronavirus and SARS-CoV.Fórmula:C28H21F2N5O2Pureza:99.83%Cor e Forma:SoildPeso molecular:497.5Ref: TM-T205924
1mg137,00€5mg330,00€1mL*10mM (DMSO)354,00€10mg532,00€25mg1.108,00€50mg1.738,00€100mg2.592,00€Synucleozid
CAS:Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.Fórmula:C22H20N6Pureza:98%Cor e Forma:SolidPeso molecular:368.43DENV-IN-7
CAS:DENV-IN-7, a flavone analog, inhibits dengue virus at 70 nM EC50 with low toxicity to normal cells.Fórmula:C24H22O8Cor e Forma:SolidPeso molecular:438.43PF-4950834
CAS:PF-4950834, a ATP-competitive, selective Rho kinase inhibitor, provides therapeutic benefits in chronic inflammatory diseases.Fórmula:C21H19N3O2Pureza:98%Cor e Forma:SolidPeso molecular:345.39BSJ-01-175
CAS:BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.Fórmula:C30H33ClN6O2Cor e Forma:SolidPeso molecular:545.08PV-1115
CAS:PV-1115 is an effective and highly selective inhibitor of the Chk2.Fórmula:C20H19N7O3Pureza:98%Cor e Forma:SolidPeso molecular:405.41HIV-1 inhibitor-43
CAS:HIV-1 Inhibitor-43 suppresses HIV-1, with EC50: 21.3 nM (Y188L), 6.2 nM (K103N-Y181C), <0.7 nM (K103N/Y181C), and lowers HIV RNA/p24 protein.Fórmula:C24H21ClN2O4SCor e Forma:SolidPeso molecular:468.95DNA Gyrase-IN-5
CAS:DNA Gyrase-IN-5 is a potent inhibitor of DNA gyrase (IC50: 0.10 μM) and has an antibacterial effect on both wild-type and drug-resistant strains.Fórmula:C25H15BrClN5Cor e Forma:SolidPeso molecular:500.78Syntelin
CAS:Syntelin: a selective CENP-E inhibitor with an IC50 of 160 nM; distinct from GSK923295, effective on resistant mutants.Fórmula:C21H20N6O2S3Cor e Forma:SolidPeso molecular:484.62Zalunfiban
CAS:RUC-4 is an aIIb 3 antagonist. It is also used for prehospital therapy of myocardial infarction.Fórmula:C16H18N8O2SCor e Forma:SolidPeso molecular:386.43MDK6204
CAS:MDK6204 is a selective inhibitor of CLK1 and CLK2.Fórmula:C20H20N6OPureza:98%Cor e Forma:SolidPeso molecular:360.41CCT245737(S)
CAS:CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.Fórmula:C16H16F3N7OCor e Forma:SolidPeso molecular:379.34Photoregulin3
CAS:Photoregulin3 is a inhibitor of rod photoreceptor gene expression, potentially though Nr2e3 modulation.Fórmula:C22H23N3O3Cor e Forma:SolidPeso molecular:377.44Cylindrospermopsin
CAS:Cylindrospermopsin: a toxic cyanobacterial uracil derivative, disrupts protein/glutathione synthesis in hepatocytes, and is genotoxic.Fórmula:C15H21N5O7SCor e Forma:SolidPeso molecular:415.42Beaucage reagent
CAS:Beaucage reagent, which is found to be effective in causing DNA cleavage.Fórmula:C7H4O3S2Pureza:98.50%Cor e Forma:White To Off-White PowderPeso molecular:200.23(Rac)-Managlinat dialanetil
CAS:Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.Fórmula:C21H33N4O6PSPureza:98.52%Cor e Forma:SolidPeso molecular:500.55DHODH-IN-12
CAS:DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.Fórmula:C10H9N3O2Pureza:99.53%Cor e Forma:SolidPeso molecular:203.2Ref: TM-T11021
1mg73,00€1mL*10mM (DMSO)122,00€5mg149,00€10mg213,00€25mg319,00€50mg447,00€100mg610,00€200mg823,00€
