Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(548 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(49 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(276 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(274 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3937 produtos de "Ciclo celular/Ponto de verificação"
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RHI002-Me
CAS:RHI002-Me is a methylated derivative of RHI002, a selective inhibitor of human RNaseH2.Fórmula:C18H19N3O2S2Pureza:98%Cor e Forma:SolidPeso molecular:373.49FLDP-5
CAS:FLDP-5: BBB-penetrant curcuminoid, induces ROS, DNA damage, S phase arrest, suppresses tumors in LN-18 cells.Fórmula:C21H21NO5Cor e Forma:SolidPeso molecular:367.4CDK7-IN-2
CAS:CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.Fórmula:C26H39N7O3Cor e Forma:SolidPeso molecular:497.63MFH290
CAS:MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.Fórmula:C26H31N5O3S2Cor e Forma:SolidPeso molecular:525.69A 65281
CAS:A 65281: antibacterial isothiazoloquinolone, inhibits P4-unknotting, induces DNA breakage via topoisomerase II.Fórmula:C17H16F2N4O2SPureza:98%Cor e Forma:SolidPeso molecular:378.4CB10-277
CAS:CB10-277 is a synthetic anti-cancer drug related to dacarbazine that alkylates DNA, inhibits DNA replication and repair, and may block DNA synthesis.Fórmula:C9H11N3O2Cor e Forma:SolidPeso molecular:193.2Capzimin
CAS:Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.Fórmula:C30H24N6O2S4Pureza:98.31% - 99.32%Cor e Forma:SolidPeso molecular:628.81Ref: TM-T10672
2mgA consultar1mg48,00€5mg95,00€1mL*10mM (DMSO)131,00€10mg150,00€25mg300,00€50mg515,00€Edatrexate
CAS:Edatrexate (CGP 30694), a Methotrexate analog, combats MTX-resistant tumors and researches various cancers.Fórmula:C22H25N7O5Cor e Forma:SolidPeso molecular:467.48M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Fórmula:C31H30F3N7O2Pureza:98.95%Cor e Forma:SolidPeso molecular:589.61(E/Z)-BIO-acetoxime
CAS:(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.Fórmula:C18H12BrN3O3Cor e Forma:SolidPeso molecular:398.21BI8622
CAS:BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.Fórmula:C25H26N6OPureza:98.28% - 98.28%Cor e Forma:SolidPeso molecular:426.51IRE1α kinase-IN-9
CAS:IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM.Fórmula:C24H24N2O6Pureza:98%Cor e Forma:SolidPeso molecular:436.46Zaurategrast ethyl ester
CAS:Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.Fórmula:C28H29BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:549.46Thiarabine
CAS:Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.Fórmula:C9H13N3O4SPureza:98%Cor e Forma:SolidPeso molecular:259.28IRE1α kinase-IN-8
CAS:IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α.Fórmula:C23H22N2O5Pureza:98%Cor e Forma:SolidPeso molecular:406.43Dihydro-5-azacytidine acetate
CAS:Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Fórmula:C10H18N4O7Pureza:98%Cor e Forma:SolidPeso molecular:306.27HBV-IN-21
CAS:HBV-IN-21 inhibits HBV DNA replication (IC50: 2.2 μM) and binds HBV capsid protein well (KD: 60.0 μM).Fórmula:C17H17FN4OS2Cor e Forma:SolidPeso molecular:376.47CDK4/6-IN-7
CAS:CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.Fórmula:C18H18ClN5O3Cor e Forma:SolidPeso molecular:387.82Enocitabine
CAS:Enocitabine is a nucleoside analog.Fórmula:C31H55N3O6Pureza:97.22%Cor e Forma:SolidPeso molecular:565.78BRD9185
CAS:BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.Fórmula:C23H21F6N3O2Pureza:98%Cor e Forma:SolidPeso molecular:485.42DHODH-IN-1
CAS:DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.Fórmula:C21H20F3N3O2Pureza:99.76%Cor e Forma:SolidPeso molecular:403.4Aurora A/PKC-IN-1
CAS:Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.Fórmula:C16H14N6OSe2Cor e Forma:SolidPeso molecular:464.24Cdc7-IN-5
CAS:Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.Fórmula:C25H23N3O5Pureza:98.4%Cor e Forma:SolidPeso molecular:445.47Ref: TM-T10727
1mg90,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg356,00€25mg587,00€50mg802,00€100mg1.108,00€CAY10760
CAS:CAY10760 inhibits RAD51-BRCA2 interaction (EC50=19 μM), reduces homologous recombination by 54%, and hinders BxPC-3/Capan-1 cancer cell proliferation.Fórmula:C28H24ClN3O3Cor e Forma:SolidPeso molecular:485.96DHODH-IN-19
CAS:DHODH-IN-19, a strong DHODH blocker, may help treat cancer and inflammation. (Patent WO2021238881A1)Fórmula:C22H18ClF6N3O3Cor e Forma:SolidPeso molecular:521.84UMK57
CAS:UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,Fórmula:C17H17N3SPureza:99.86%Cor e Forma:SolidPeso molecular:295.4GRK6-IN-1
CAS:GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Fórmula:C22H23ClN6O2Pureza:99.37%Cor e Forma:SolidPeso molecular:438.91Ref: TM-T62518
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg178,00€25mg409,00€50mg708,00€100mg1.153,00€Peldesine
CAS:Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.Fórmula:C12H11N5OPureza:99.27% - 99.9%Cor e Forma:SolidPeso molecular:241.25Ref: TM-T12399
1mg108,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg416,00€25mg690,00€50mg964,00€100mg1.305,00€500mg2.592,00€DIF-3
CAS:DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Fórmula:C13H17ClO4Pureza:99.57%Cor e Forma:SolidPeso molecular:272.72Ref: TM-T60485
1mg96,00€1mL*10mM (DMSO)205,00€5mg222,00€10mg333,00€25mg557,00€50mg795,00€100mg1.071,00€500mg2.187,00€HA-1004
CAS:HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.Fórmula:C12H15N5O2SPureza:99.56% - 99.63%Cor e Forma:SolidPeso molecular:293.34SB 328437
CAS:SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).Fórmula:C21H18N2O5Pureza:99.54%Cor e Forma:SolidPeso molecular:378.38Ref: TM-T23321
1mg39,00€1mL*10mM (DMSO)69,00€5mg82,00€10mg123,00€25mg250,00€50mg394,00€100mg618,00€200mg874,00€Anticancer agent 73
CAS:Anticancer agent 73 inhibits TRBP, disrupting TRBP-Dicer, and hinders HCC growth and spread by altering HCC miRNA and protein expression.Fórmula:C14H15NO4Pureza:99.56%Cor e Forma:SolidPeso molecular:261.27Talotrexin ammonium
CAS:Talotrexin ammonium, a non-polyglutamic antifolate, inhibits cancer by targeting DHFR.
Fórmula:C27H30N10O6Pureza:97.49%Cor e Forma:SolidPeso molecular:590.59Ref: TM-T64295
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€PCSK9-IN-10
CAS:PCSK9-IN-10: potent oral PCSK9 inhibitor (IC50 = 6.4 µM), upregulates LDLR, curbs atherosclerosis, for hyperlipidemia research.Fórmula:C18H23N5O4Pureza:99.06%Cor e Forma:SoildPeso molecular:373.41Ref: TM-T72025
2mg39,00€5mg60,00€1mL*10mM (DMSO)62,00€10mg96,00€25mg170,00€50mg266,00€100mg391,00€200mg555,00€Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Fórmula:C20H24N4SPureza:99.8%Cor e Forma:SolidPeso molecular:352.5Ref: TM-T12721
1mg71,00€1mL*10mM (DMSO)105,00€5mg138,00€10mg205,00€25mg358,00€50mg502,00€100mg665,00€200mg893,00€GS-6620 PM
CAS:GS-6620 PM, oral Hep C polymerase inhibitor prodrug, is a potent GS-6620 derivative with limited activity against other viruses.Fórmula:C13H15N5O4Pureza:98.52% - 98.7%Cor e Forma:SolidPeso molecular:305.29Abemaciclib metabolite M20
CAS:Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。Fórmula:C27H32F2N8OPureza:98.1% - 99.08%Cor e Forma:SolidPeso molecular:522.59NSC16168
CAS:NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.Fórmula:C17H15NO9S3Pureza:99.88%Cor e Forma:SolidPeso molecular:473.5Ref: TM-T16351
1mg60,00€5mg130,00€1mL*10mM (DMSO)135,00€10mg200,00€25mg338,00€50mg497,00€100mg708,00€200mg964,00€SEL120-34A
CAS:SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Fórmula:C15H18Br2N4Pureza:99.764% - 99.84%Cor e Forma:SolidPeso molecular:414.14Ref: TM-T10744
1mg612,00€5mg1.529,00€1mL*10mM (DMSO)1.835,00€10mg1.880,00€25mg2.178,00€50mg2.862,00€100mg3.870,00€CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Fórmula:C20H23N9OPureza:98.78%Cor e Forma:SolidPeso molecular:405.46Ref: TM-T10791
1mg168,00€2mg231,00€5mg371,00€1mL*10mM (DMSO)423,00€10mg558,00€25mg868,00€50mg1.153,00€100mg1.575,00€200mg2.125,00€Eprociclovir
CAS:Eprociclovir (A-5021) is a novel acyclovir analog that is a potent inhibitor of EHV1 replication and may be used for the treatment and/or prevention ofFórmula:C11H15N5O3Pureza:98.50% - 99.86%Cor e Forma:SolidPeso molecular:265.27AGX51
CAS:AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.Fórmula:C27H29NO4Pureza:97.65%Cor e Forma:OilPeso molecular:431.52Ref: TM-T10268
1mg96,00€5mg205,00€1mL*10mM (DMSO)227,00€10mg334,00€25mg652,00€50mg858,00€100mg1.108,00€200mg1.504,00€CRT-0105950
CAS:CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C21H16ClN3OSPureza:99.78% - 99.86%Cor e Forma:SolidPeso molecular:393.89Ref: TM-T23917
1mg62,00€5mg133,00€1mL*10mM (DMSO)147,00€10mg205,00€25mg416,00€50mg670,00€100mg1.071,00€SRX3177
CAS:SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.Fórmula:C31H32N6O4SPureza:99.16%Cor e Forma:SolidPeso molecular:584.69Ref: TM-T69742
1mg70,00€5mg150,00€1mL*10mM (DMSO)178,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€CRT0066854 hydrochloride
CAS:CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Fórmula:C24H27Cl2N5SPureza:99.63%Cor e Forma:SolidPeso molecular:488.48Ref: TM-T10888
1mg57,00€5mg122,00€1mL*10mM (DMSO)146,00€10mg192,00€25mg324,00€50mg459,00€100mg642,00€200mg888,00€SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFórmula:C16H8N2O3Pureza:99.72%Cor e Forma:SolidPeso molecular:276.25Ref: TM-T12926
1mg77,00€2mg101,00€5mg168,00€10mg253,00€25mg416,00€50mg580,00€100mg783,00€200mg1.054,00€TTP-8307
CAS:TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses and is used in the study of viral infections.Fórmula:C27H21FN4OPureza:98.95%Cor e Forma:SolidPeso molecular:436.48Ref: TM-T13221
1mg100,00€5mg236,00€1mL*10mM (DMSO)286,00€10mg380,00€25mg740,00€50mg1.108,00€100mg1.791,00€200mg2.412,00€BioE-1115
CAS:BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).Fórmula:C19H18FN3O2Pureza:97.54%Cor e Forma:SolidPeso molecular:339.36YK-2-69
CAS:YK-2-69 selectively blocks DYRK2 at Lys-231 and Lys-234, outperforming enzalutamide in prostate cancer treatment.Fórmula:C25H27FN8OSPureza:98.61% - 99.64%Cor e Forma:SolidPeso molecular:506.6Elarofiban
CAS:Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Fórmula:C22H32N4O4Pureza:98.76%Cor e Forma:SolidPeso molecular:416.51
