Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(548 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(49 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(276 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(273 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3936 produtos de "Ciclo celular/Ponto de verificação"
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OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Fórmula:C22H16ClFN2O4Pureza:98.59%Cor e Forma:SoildPeso molecular:426.83CDK9-IN-10
CAS:CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.Fórmula:C22H16O5Pureza:99.8%Cor e Forma:SolidPeso molecular:360.36Eprociclovir
CAS:Eprociclovir (A-5021) is a novel acyclovir analog that is a potent inhibitor of EHV1 replication and may be used for the treatment and/or prevention ofFórmula:C11H15N5O3Pureza:98.50% - 99.86%Cor e Forma:SolidPeso molecular:265.27CRT-0105950
CAS:CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C21H16ClN3OSPureza:99.78% - 99.86%Cor e Forma:SolidPeso molecular:393.89Ref: TM-T23917
1mg62,00€5mg133,00€1mL*10mM (DMSO)147,00€10mg205,00€25mg416,00€50mg670,00€100mg1.071,00€ZIM
CAS:ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.Fórmula:C20H19N3O3Pureza:99.85%Cor e Forma:SolidPeso molecular:349.38CHD1Li 6.11
CAS:CHD1Li 6.11 inhibits CHD1L protein (IC50: 3.3 µM), shrinks CRC tumors in vivo, and is orally active.Fórmula:C21H22BrN5OSPureza:99.04%Cor e Forma:SolidPeso molecular:472.4Ref: TM-T63049
1mg96,00€5mg205,00€1mL*10mM (DMSO)215,00€10mg334,00€25mg567,00€50mg807,00€100mg1.099,00€500mg2.205,00€NR2F6 modulator-1
CAS:NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.Fórmula:C23H17NO5SPureza:98.31%Cor e Forma:SolidPeso molecular:419.45Ref: TM-T62204
1mg87,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg268,00€25mg502,00€50mg703,00€100mg982,00€hDHODH-IN-7
CAS:hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.Fórmula:C21H23FN4OPureza:99.87%Cor e Forma:SolidPeso molecular:366.43Ref: TM-T11031
1mg115,00€2mg172,00€5mg255,00€1mL*10mM (DMSO)266,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€DENV-IN-5
CAS:Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.Fórmula:C23H25ClF2N4OSPureza:99.42%Cor e Forma:SolidPeso molecular:478.99Ref: TM-T63143
1mg424,00€1mL*10mM (DMSO)898,00€5mg964,00€10mg1.288,00€25mg1.890,00€50mg2.322,00€100mg3.060,00€DSS30
CAS:DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.Fórmula:C16H14ClNO3S2Pureza:99.19% - 99.4%Cor e Forma:SolidPeso molecular:367.87CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Fórmula:C20H23N9OPureza:98.78%Cor e Forma:SolidPeso molecular:405.46Ref: TM-T10791
1mg168,00€2mg231,00€5mg371,00€1mL*10mM (DMSO)423,00€10mg558,00€25mg868,00€50mg1.153,00€100mg1.575,00€200mg2.125,00€Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Fórmula:C27H21N3O3Pureza:99.22%Cor e Forma:SolidPeso molecular:435.47Ref: TM-T35570
1mg66,00€5mg144,00€1mL*10mM (DMSO)157,00€10mg245,00€25mg492,00€50mg710,00€100mg973,00€Peldesine
CAS:Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.Fórmula:C12H11N5OPureza:99.27% - 99.9%Cor e Forma:SolidPeso molecular:241.25Ref: TM-T12399
1mg108,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg416,00€25mg690,00€50mg964,00€100mg1.305,00€500mg2.592,00€SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFórmula:C16H8N2O3Pureza:99.72%Cor e Forma:SolidPeso molecular:276.25Ref: TM-T12926
1mg77,00€2mg101,00€5mg168,00€10mg253,00€25mg416,00€50mg580,00€100mg783,00€200mg1.054,00€Galocitabine
CAS:Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.Fórmula:C19H22FN3O8Pureza:99.89%Cor e Forma:SolidPeso molecular:439.39Elarofiban
CAS:Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Fórmula:C22H32N4O4Pureza:98.76%Cor e Forma:SolidPeso molecular:416.51L82
CAS:L82: A selective, non-competitive DNA Lig1 inhibitor with anti-proliferative effects on breast cancer cells. IC50=12 μM.Fórmula:C11H8ClN5O4Pureza:98.06% - 98.91%Cor e Forma:SolidPeso molecular:309.67Ref: TM-T60753
5mg70,00€1mL*10mM (DMSO)77,00€10mg103,00€25mg187,00€50mg298,00€100mg472,00€500mg1.026,00€ProINDY
CAS:ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.Fórmula:C14H15NO3SPureza:97.19%Cor e Forma:SolidPeso molecular:277.34DDRI-18
CAS:DDRI-18 is an inhibitor that regulates the DNA damage response, has anticancer activity, and inhibits non-homologous end-joining (NHEJ) DNA repair.Fórmula:C26H20N6Pureza:98%Cor e Forma:SolidPeso molecular:416.48Cdk2 Inhibitor II
CAS:Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.Fórmula:C14H11BrN4O3SPureza:97.27%Cor e Forma:SolidPeso molecular:395.23SEL120-34A
CAS:SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Fórmula:C15H18Br2N4Pureza:99.764% - 99.84%Cor e Forma:SolidPeso molecular:414.14Ref: TM-T10744
1mg612,00€5mg1.529,00€1mL*10mM (DMSO)1.835,00€10mg1.880,00€25mg2.178,00€50mg2.862,00€100mg3.870,00€SMN-C2
CAS:SMN-C2, a SMN2 gene splicing regulator, is an RNA-binding ligand that regulates pre-mRNA splicing and has potential for studying spinal muscular atrophy.Fórmula:C24H27N5O2Pureza:99.14%Cor e Forma:SolidPeso molecular:417.5Ref: TM-T73475
1mg105,00€5mg250,00€1mL*10mM (DMSO)268,00€10mg401,00€25mg795,00€50mg982,00€100mg1.324,00€BioE-1115
CAS:BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).Fórmula:C19H18FN3O2Pureza:97.54%Cor e Forma:SolidPeso molecular:339.36BML-259
CAS:BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Fórmula:C14H16N2OSPureza:99.84%Cor e Forma:SolidPeso molecular:260.35Ref: TM-T36964
5mg48,00€1mL*10mM (DMSO)50,00€10mg80,00€25mg160,00€50mg264,00€100mg462,00€500mg982,00€PCSK9-IN-10
CAS:PCSK9-IN-10: potent oral PCSK9 inhibitor (IC50 = 6.4 µM), upregulates LDLR, curbs atherosclerosis, for hyperlipidemia research.Fórmula:C18H23N5O4Pureza:99.06%Cor e Forma:SoildPeso molecular:373.41Ref: TM-T72025
2mg39,00€5mg60,00€1mL*10mM (DMSO)62,00€10mg96,00€25mg170,00€50mg266,00€100mg391,00€200mg555,00€Haspin-IN-3
CAS:Haspin-IN-3 is a potent haspin inhibitor with an IC50 of 14 nM.Haspin-IN-3 has anticancer activity.
Fórmula:C16H10N2O3Pureza:98.78%Cor e Forma:SolidPeso molecular:278.2610-Formylfolic acid
CAS:10-Formylfolic acid is a novel and potent inhibitor of dihydrofolate reductase, which can be used in leukemia research.Fórmula:C20H19N7O7Pureza:99.97%Cor e Forma:SolidPeso molecular:469.41USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Fórmula:C17H16N6O2SPureza:98.84% - 99.59%Cor e Forma:SolidPeso molecular:368.41CQ211
CAS:CQ211 is a potent selective RIOK2 inhibitor, Kd 6.1 nM, effectively inhibits cancer cell line proliferation.Fórmula:C26H22F3N7O2Pureza:97.01% - 98.31%Cor e Forma:SolidPeso molecular:521.49Talotrexin ammonium
CAS:Talotrexin ammonium, a non-polyglutamic antifolate, inhibits cancer by targeting DHFR.
Fórmula:C27H30N10O6Pureza:97.49%Cor e Forma:SolidPeso molecular:590.59Ref: TM-T64295
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€GRK6-IN-1
CAS:GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Fórmula:C22H23ClN6O2Pureza:99.37%Cor e Forma:SolidPeso molecular:438.91Ref: TM-T62518
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg178,00€25mg409,00€50mg708,00€100mg1.153,00€Antiviral agent 17
CAS:Antiviral agent 17, EC50 0.015 μM in human assay, effective against murine norovirus, may aid infectious/malignant disease research.Fórmula:C11H14N4O4Pureza:99.89%Cor e Forma:SolidPeso molecular:266.25HA-1004
CAS:HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.Fórmula:C12H15N5O2SPureza:99.56% - 99.63%Cor e Forma:SolidPeso molecular:293.34CMX-521
CAS:CMX521: an antiviral for norovirus, effective against rotavirus; inhibits viral RNA polymerase.Fórmula:C13H17N5O5Pureza:99.57%Cor e Forma:SolidPeso molecular:323.3Rhodblock 6
CAS:Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Fórmula:C12H13N3OPureza:99.87%Cor e Forma:SolidPeso molecular:215.25CLK-IN-T3
CAS:CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.Fórmula:C28H30N6O2Pureza:99.61%Cor e Forma:SolidPeso molecular:482.58Ref: TM-T14980
1mg47,00€2mg62,00€5mg92,00€10mg160,00€25mg289,00€50mg505,00€100mg787,00€200mg1.063,00€CRT0066854 hydrochloride
CAS:CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Fórmula:C24H27Cl2N5SPureza:99.63%Cor e Forma:SolidPeso molecular:488.48Ref: TM-T10888
1mg57,00€5mg122,00€1mL*10mM (DMSO)146,00€10mg192,00€25mg324,00€50mg459,00€100mg642,00€200mg888,00€EHT 1610
CAS:EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.Fórmula:C18H14FN5O2SPureza:98.43%Cor e Forma:SolidPeso molecular:383.4DIF-3
CAS:DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Fórmula:C13H17ClO4Pureza:99.57%Cor e Forma:SolidPeso molecular:272.72Ref: TM-T60485
1mg96,00€1mL*10mM (DMSO)205,00€5mg222,00€10mg333,00€25mg557,00€50mg795,00€100mg1.071,00€500mg2.187,00€GKI-1
CAS:GKI-1, a GWL kinase inhibitor: IC50 - 4.9 µM for hGWLFL, 2.5 µM for hGWL-KinDom, 11 µM for ROCK1; weak on PKA.Fórmula:C15H12ClN3Pureza:99.96%Cor e Forma:SolidPeso molecular:269.73Ref: TM-T11402
1mg93,00€5mg200,00€1mL*10mM (DMSO)215,00€10mg299,00€25mg485,00€50mg658,00€100mg892,00€116-9e
CAS:116-9e (MAL2-11B) is an Hsp70 chaperone DNAJA1 inhibitor with antiviral properties, inhibits SV40 replication, and can be used to study cancer drug resistance.Fórmula:C31H32N2O5Pureza:99.55%Cor e Forma:SolidPeso molecular:512.6Ref: TM-T25770
1mL*10mM (DMSO)34,00€1mg50,00€5mg105,00€10mg170,00€25mg355,00€50mg595,00€100mg862,00€200mg1.153,00€P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Fórmula:C12H9NO3S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:279.33Ref: TM-T28284
1mg137,00€1mL*10mM (DMSO)239,00€5mg314,00€10mg427,00€25mg600,00€50mg798,00€100mg1.099,00€200mg1.468,00€dCeMM2
CAS:dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.Fórmula:C16H11ClN6OSPureza:99.68%Cor e Forma:SolidPeso molecular:370.82Ref: TM-T61477
1mg34,00€5mg74,00€1mL*10mM (DMSO)104,00€10mg113,00€25mg236,00€50mg404,00€100mg600,00€500mg1.279,00€Caracemide
CAS:Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.Fórmula:C6H11N3O4Pureza:99.8%Cor e Forma:SolidPeso molecular:189.17CDK-IN-2
CAS:CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Fórmula:C18H19ClFN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:363.81Ref: TM-TQ0078
1mg38,00€2mg51,00€1mL*10mM (DMSO)92,00€5mg96,00€10mg138,00€25mg258,00€50mg376,00€100mg532,00€500mg1.063,00€PS423
CAS:PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.Fórmula:C25H23F3O9Pureza:98.81% - 99.26%Cor e Forma:SolidPeso molecular:524.44CF-1743
CAS:CF-1743 is an anti-varicella zoster virus nucleoside and inhibits VZV replication.Fórmula:C22H26N2O5Pureza:99.6% - 99.79%Cor e Forma:SolidPeso molecular:398.45hSMG-1 inhibitor 11e
CAS:hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.Fórmula:C26H27N7O3SPureza:99.89%Cor e Forma:SolidPeso molecular:517.6SB-747651A Dihydrochloride
CAS:SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.Fórmula:C16H24Cl2N8OPureza:98.05%Cor e Forma:SolidPeso molecular:415.32Ref: TM-T9652
500mgA consultar1mg70,00€5mg146,00€1mL*10mM (DMSO)160,00€10mg207,00€25mg349,00€50mg497,00€100mg675,00€RP-6685
CAS:RP-6685 is a potent, selective DNA Polθ inhibitor with strong oral efficacy, an IC50 of 5.8 nM, and marked antitumor effects in mice.Fórmula:C22H14F7N5OPureza:99.65%Cor e Forma:SoildPeso molecular:497.37Ref: TM-T60187
1mg84,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg219,00€25mg358,00€50mg510,00€100mg715,00€
