Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(548 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(49 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(276 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(274 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3937 produtos de "Ciclo celular/Ponto de verificação"
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SB-747651A Dihydrochloride
CAS:SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.Fórmula:C16H24Cl2N8OPureza:98.05%Cor e Forma:SolidPeso molecular:415.32Ref: TM-T9652
500mgA consultar1mg70,00€5mg146,00€1mL*10mM (DMSO)160,00€10mg207,00€25mg349,00€50mg497,00€100mg675,00€CF-1743
CAS:CF-1743 is an anti-varicella zoster virus nucleoside and inhibits VZV replication.Fórmula:C22H26N2O5Pureza:99.6% - 99.79%Cor e Forma:SolidPeso molecular:398.45NR2F6 modulator-1
CAS:NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.Fórmula:C23H17NO5SPureza:98.31%Cor e Forma:SolidPeso molecular:419.45Ref: TM-T62204
1mg87,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg268,00€25mg502,00€50mg703,00€100mg982,00€CHD1Li 6.11
CAS:CHD1Li 6.11 inhibits CHD1L protein (IC50: 3.3 µM), shrinks CRC tumors in vivo, and is orally active.Fórmula:C21H22BrN5OSPureza:99.04%Cor e Forma:SolidPeso molecular:472.4Ref: TM-T63049
1mg96,00€5mg205,00€1mL*10mM (DMSO)215,00€10mg334,00€25mg567,00€50mg807,00€100mg1.099,00€500mg2.205,00€DENV-IN-5
CAS:Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.Fórmula:C23H25ClF2N4OSPureza:99.42%Cor e Forma:SolidPeso molecular:478.99Ref: TM-T63143
1mg424,00€1mL*10mM (DMSO)898,00€5mg964,00€10mg1.288,00€25mg1.890,00€50mg2.322,00€100mg3.060,00€L82
CAS:L82: A selective, non-competitive DNA Lig1 inhibitor with anti-proliferative effects on breast cancer cells. IC50=12 μM.Fórmula:C11H8ClN5O4Pureza:98.06% - 98.91%Cor e Forma:SolidPeso molecular:309.67Ref: TM-T60753
5mg70,00€1mL*10mM (DMSO)77,00€10mg103,00€25mg187,00€50mg298,00€100mg472,00€500mg1.026,00€P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Fórmula:C12H9NO3S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:279.33Ref: TM-T28284
1mg137,00€1mL*10mM (DMSO)239,00€5mg314,00€10mg427,00€25mg600,00€50mg798,00€100mg1.099,00€200mg1.468,00€GKI-1
CAS:GKI-1, a GWL kinase inhibitor: IC50 - 4.9 µM for hGWLFL, 2.5 µM for hGWL-KinDom, 11 µM for ROCK1; weak on PKA.Fórmula:C15H12ClN3Pureza:99.96%Cor e Forma:SolidPeso molecular:269.73Ref: TM-T11402
1mg93,00€5mg200,00€1mL*10mM (DMSO)215,00€10mg299,00€25mg485,00€50mg658,00€100mg892,00€ProINDY
CAS:ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.Fórmula:C14H15NO3SPureza:97.19%Cor e Forma:SolidPeso molecular:277.346-Hydroxy-DOPA
CAS:6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
Fórmula:C9H11NO5Pureza:97.78% - 97.95%Cor e Forma:SolidPeso molecular:213.19CDK-IN-2
CAS:CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Fórmula:C18H19ClFN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:363.81Ref: TM-TQ0078
1mg38,00€2mg51,00€1mL*10mM (DMSO)92,00€5mg96,00€10mg138,00€25mg258,00€50mg376,00€100mg532,00€500mg1.063,00€hSMG-1 inhibitor 11e
CAS:hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.Fórmula:C26H27N7O3SPureza:99.89%Cor e Forma:SolidPeso molecular:517.6SMN-C2
CAS:SMN-C2, a SMN2 gene splicing regulator, is an RNA-binding ligand that regulates pre-mRNA splicing and has potential for studying spinal muscular atrophy.Fórmula:C24H27N5O2Pureza:99.14%Cor e Forma:SolidPeso molecular:417.5Ref: TM-T73475
1mg105,00€5mg250,00€1mL*10mM (DMSO)268,00€10mg401,00€25mg795,00€50mg982,00€100mg1.324,00€USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Fórmula:C17H16N6O2SPureza:98.84% - 99.59%Cor e Forma:SolidPeso molecular:368.41DS18561882
CAS:DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.Fórmula:C28H31F3N4O6SPureza:98.19% - >99.99%Cor e Forma:SolidPeso molecular:608.63Ref: TM-T11103
1mg109,00€5mg260,00€1mL*10mM (DMSO)358,00€10mg409,00€25mg737,00€50mg1.198,00€100mg1.611,00€3-Cyanovinylcarbazole phosphoramidite
CAS:3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.Fórmula:C50H53N4O6PCor e Forma:SolidPeso molecular:836.95DDD85646
CAS:DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.Fórmula:C21H24Cl2N6O2SPureza:97.8% - 99.76%Cor e Forma:SolidPeso molecular:495.43Ref: TM-T27135
1mg90,00€5mg253,00€1mL*10mM (DMSO)275,00€10mg379,00€25mg640,00€50mg892,00€100mg1.224,00€G4/HDAC-IN-1
G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.Fórmula:C36H49ClFN7O4Cor e Forma:SolidPeso molecular:698.27SHP2/CDK4-IN-1
CAS:SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.Fórmula:C33H35ClF2N10OSCor e Forma:SolidPeso molecular:693.21Lotrafiban
CAS:Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.Fórmula:C23H32N4O4Cor e Forma:SolidPeso molecular:428.52CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Fórmula:C23H25ClFN5Pureza:99%Cor e Forma:SolidPeso molecular:425.93Ref: TM-T14918
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg266,00€25mg460,00€50mg668,00€100mg945,00€Fosfluridine tidoxil
CAS:Fosfluridine tidoxil, a thymidylate synthase inhibitor, is used potentially for the treatment of colorectal cancer, and breast cancer.Fórmula:C34H62FN2O10PSCor e Forma:SolidPeso molecular:740.9CDK7-IN-25
CAS:CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].Fórmula:C33H32N6O3Pureza:98%Cor e Forma:SolidPeso molecular:560.65NITD008
CAS:NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.Fórmula:C13H14N4O4Pureza:98.04%Cor e Forma:SolidPeso molecular:290.27m-Se3
CAS:m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].Fórmula:C29H23IN2SePureza:98%Cor e Forma:SolidPeso molecular:605.375'-ODMT cEt m5U Phosphoramidite (Amidite)
CAS:5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].Fórmula:C42H51N4O9PCor e Forma:SolidPeso molecular:786.85Lotrafiban hydrochloride
CAS:Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.Fórmula:C23H33ClN4O4Cor e Forma:SolidPeso molecular:464.99SB-267268
CAS:SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Fórmula:C22H24F3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:451.44UNC-2170
CAS:UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.Fórmula:C14H21BrN2OPureza:97.44%Cor e Forma:SolidPeso molecular:313.23Ref: TM-T24925
5mg46,00€1mL*10mM (DMSO)57,00€10mg71,00€25mg138,00€50mg200,00€100mg284,00€200mg391,00€AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Fórmula:C21H13Cl2N3O2SPureza:97.05%Cor e Forma:SolidPeso molecular:442.32Ref: TM-T10215
1mg54,00€5mg118,00€1mL*10mM (DMSO)131,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€SC-52012
CAS:SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.Fórmula:C25H30N4O6Pureza:97.20%Cor e Forma:SolidPeso molecular:482.53NTRC 0066-0
CAS:NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.Fórmula:C33H39N7O2Pureza:98.30%Cor e Forma:SolidPeso molecular:565.71PLK1-IN-7
CAS:PLK1-IN-7 (compound 30e) is a potent inhibitor exhibiting an IC50 value of 0.66 nM and demonstrates significant antiproliferative and antitumor activities [1].Fórmula:C24H24F4N8O2Cor e Forma:SolidPeso molecular:532.49Sovesudil
CAS:Sovesudil (PHP-201) is a potent ROCK inhibitor with IC50 of 3.7 nM/2.3 nM for ROCK-I/II; lowers IOP without hyperemia.Fórmula:C23H22FN3O3Cor e Forma:SolidPeso molecular:407.44PLK1/p38γ-IN-1
CAS:PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellularFórmula:C21H26ClN3O2Pureza:98%Cor e Forma:SolidPeso molecular:387.9PTC258
CAS:PTC258 is a specific, orally active modulator of the splicing of the Elongator complex protein 1 gene (ELP1), enhancing its expression both in vitro and in vivoFórmula:C16H18ClN3S2Cor e Forma:SolidPeso molecular:351.92XL413 hydrochloride
CAS:XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.Fórmula:C14H13Cl2N3O2Pureza:98.81% - 99.8%Cor e Forma:SolidPeso molecular:326.18Ref: TM-T6735
1mg50,00€5mg109,00€10mg152,00€25mg268,00€50mg447,00€100mg672,00€200mg888,00€500mg1.369,00€CDK4/6-IN-15
CAS:CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.Fórmula:C21H27FN8SCor e Forma:SolidPeso molecular:442.56UNC2170 maleate
CAS:53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.Fórmula:C14H21BrN2OC4H4O4Cor e Forma:SolidPeso molecular:429.31Lerociclib
CAS:Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.Fórmula:C26H34N8OPureza:99%Cor e Forma:SolidPeso molecular:474.6CDK7-IN-22
CAS:CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Fórmula:C22H25F3N6Pureza:98%Cor e Forma:SolidPeso molecular:430.47Alatrofloxacin
CAS:Alatrofloxacin is a prodrug of trovafloxacin.Fórmula:C26H25F3N6O5Cor e Forma:SolidPeso molecular:558.51ICAM-1-IN-1
CAS:ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.Fórmula:C15H11BrN2O2SPureza:99.67%Cor e Forma:SolidPeso molecular:363.23Ref: TM-T13147
1mg175,00€5mg371,00€1mL*10mM (DMSO)409,00€10mg557,00€25mg887,00€50mg1.198,00€100mg1.611,00€500mg3.232,00€NVS-SM2
CAS:NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.Fórmula:C23H30N6OCor e Forma:SolidPeso molecular:406.52CI 972 anhydrous
CAS:CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.Fórmula:C11H12ClN5OSPureza:98%Cor e Forma:SolidPeso molecular:297.76Lamifiban
CAS:Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.Fórmula:C24H28N4O6Pureza:98%Cor e Forma:SolidPeso molecular:468.55'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
CAS:5'-ODMT cEt N-Bzm5 C Phosphoramidite is a strong modified nucleic acid analog for antisense oligos.Fórmula:C49H56N5O9PCor e Forma:SolidPeso molecular:889.97Myt1-IN-3
CAS:Myt1-IN-3 is a potent inhibitor of Myt1 (IC50 <10 nM) [1].Fórmula:C18H19N5O2Cor e Forma:SolidPeso molecular:337.38DNA gyrase B-IN-3
CAS:DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against GramFórmula:C14H9Cl2N3O4SPureza:98%Cor e Forma:SolidPeso molecular:386.21FT671
CAS:FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Fórmula:C24H23F4N7O3Pureza:99.76%Cor e Forma:SolidPeso molecular:533.48
