Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(548 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(49 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(276 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(273 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3936 produtos de "Ciclo celular/Ponto de verificação"
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Firategrast
CAS:Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFórmula:C27H27F2NO6Pureza:99.67%Cor e Forma:SolidPeso molecular:499.5Ref: TM-TQ0291
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg133,00€25mg268,00€50mg439,00€100mg708,00€200mg964,00€Cytembena
CAS:Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.Fórmula:C11H8BrNaO4Pureza:99.7%Cor e Forma:White PowderPeso molecular:307.07Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Fórmula:C20H24N4SPureza:99.8%Cor e Forma:SolidPeso molecular:352.5Ref: TM-T12721
1mg71,00€1mL*10mM (DMSO)105,00€5mg138,00€10mg205,00€25mg358,00€50mg502,00€100mg665,00€200mg893,00€AzddMeC
CAS:AzddMeC (Az-Dcme) is an HIV-1 reverse transcriptase and HIV-1 replication inhibitor with antiretroviral activity.AzddMeC is used in the study of HIV-1 infectionFórmula:C10H14N6O3Pureza:97.14% - 99.62%Cor e Forma:SolidPeso molecular:266.26YK-2-69
CAS:YK-2-69 selectively blocks DYRK2 at Lys-231 and Lys-234, outperforming enzalutamide in prostate cancer treatment.Fórmula:C25H27FN8OSPureza:98.61% - 99.64%Cor e Forma:SolidPeso molecular:506.6ITX3
CAS:ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM.Fórmula:C22H17N3OSPureza:97.28%Cor e Forma:SolidPeso molecular:371.45CD532
CAS:CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Fórmula:C26H25F3N8OPureza:99.99%Cor e Forma:SolidPeso molecular:522.52AS 1892802
CAS:AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.Fórmula:C20H19N3O2Pureza:99.86%Cor e Forma:SolidPeso molecular:333.38Ref: TM-T22037
1mg49,00€5mg92,00€1mL*10mM (DMSO)109,00€10mg166,00€25mg358,00€50mg530,00€100mg758,00€200mg1.044,00€AS-0141
CAS:AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。Fórmula:C21H22F3N5O4Pureza:99.97%Cor e Forma:SolidPeso molecular:465.439-Isopropylolomoucine
CAS:9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.Fórmula:C17H22N6OPureza:99.82%Cor e Forma:SolidPeso molecular:326.4Ref: TM-T23589
1mg315,00€1mL*10mM (DMSO)607,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€(S)-PF-06873600
CAS:(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.Fórmula:C20H27F2N5O4SPureza:98.59%Cor e Forma:SolidPeso molecular:471.52DS18561882
CAS:DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.Fórmula:C28H31F3N4O6SPureza:98.19% - >99.99%Cor e Forma:SolidPeso molecular:608.63Ref: TM-T11103
1mg109,00€5mg260,00€1mL*10mM (DMSO)358,00€10mg409,00€25mg737,00€50mg1.198,00€100mg1.611,00€INDY
CAS:INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.Fórmula:C12H13NO2SPureza:99.26%Cor e Forma:SolidPeso molecular:235.3NSC16168
CAS:NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.Fórmula:C17H15NO9S3Pureza:99.88%Cor e Forma:SolidPeso molecular:473.5Ref: TM-T16351
1mg60,00€5mg130,00€1mL*10mM (DMSO)135,00€10mg200,00€25mg338,00€50mg497,00€100mg708,00€200mg964,00€5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
CAS:5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].Fórmula:C49H54N7O8PCor e Forma:SolidPeso molecular:899.97WEE1-IN-4
CAS:Wee1 Inhibitor I is an ATP-binding site-targeting Wee1 inhibitor.Fórmula:C20H11ClN2O3Cor e Forma:SolidPeso molecular:362.77CCT251455
CAS:CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.Fórmula:C26H26ClN7O2Pureza:99.1% - 99.79%Cor e Forma:SolidPeso molecular:503.98Ref: TM-T14906
1mg154,00€5mg371,00€1mL*10mM (DMSO)413,00€10mg620,00€25mg1.341,00€50mg2.142,00€100mg2.790,00€WRN inhibitor 5
CAS:WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).Fórmula:C23H20N2O6SCor e Forma:SolidPeso molecular:452.48GSK2163632A
CAS:GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.Fórmula:C27H32N8O3SCor e Forma:SolidPeso molecular:548.66LDC3140
CAS:LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).Fórmula:C23H33N7OPureza:98%Cor e Forma:SolidPeso molecular:423.555,6,7,8-Tetrahydro-8-deazahomofolic acid
CAS:5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.Fórmula:C21H26N6O6Cor e Forma:SolidPeso molecular:458.47KM05382
CAS:KM05382 inhibits CDK9 and the transcription of GAPDH.Fórmula:C20H19ClN2O3S2Cor e Forma:SolidPeso molecular:434.96CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFórmula:C25H29N5O2SCor e Forma:SolidPeso molecular:463.6Methotrexate-γ-aspartate
CAS:Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.Fórmula:C24H27N9O8Pureza:98%Cor e Forma:SolidPeso molecular:569.53Antifolate C1
CAS:Antifolate C1 blocks purine creation, favors uptake via folate receptors/PCFT over RFC.Fórmula:C19H21N5O6SCor e Forma:SolidPeso molecular:447.465-DACTHF
CAS:5,11-methenyltetrahydrohomofolate blocks GAR & AIR transformylase; used as an anti-purine drug.Fórmula:C19H24N6O6Pureza:98%Cor e Forma:SolidPeso molecular:432.43Diazoketone methotrexate
CAS:Diazoketone methotrexate is an analog of methotrexate with potential antitumor activity.Fórmula:C21H22N10O4Cor e Forma:SolidPeso molecular:478.46IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Fórmula:C23H21Cl2NO5Pureza:98%Cor e Forma:SolidPeso molecular:462.32TAS-114
CAS:TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.Fórmula:C21H29N3O6SPureza:99.76%Cor e Forma:SolidPeso molecular:451.54Spirofylline
CAS:Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.Fórmula:C24H28N6O5Pureza:98%Cor e Forma:SolidPeso molecular:480.52BVDU 5′-Triphosphate
CAS:BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.Fórmula:C11H16BrN2O14P3Pureza:98%Cor e Forma:SolidPeso molecular:573.08Zaurategrast
CAS:Zaurategrast (CDP323) is an oral α4-integrin antagonist that blocks VCAM-1 interactions and is used to study immune cell trafficking.Fórmula:C26H25BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:521.41ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Fórmula:C17H17N3O2SPureza:98%Cor e Forma:SolidPeso molecular:327.4DNA polymerase-IN-1
CAS:DNA polymerase-IN-1 exhibits antiproliferative activity against tumor cells and inhibits Taq DNA polymerase as a DNA polymerase inhibitor.Fórmula:C10H7ClO4Pureza:99.16%Cor e Forma:SolidPeso molecular:226.61Lamifiban
CAS:Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.Fórmula:C24H28N4O6Pureza:98%Cor e Forma:SolidPeso molecular:468.5ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Fórmula:C26H22ClF2N7OPureza:98%Cor e Forma:SolidPeso molecular:521.95NVS-SM2
CAS:NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.Fórmula:C23H30N6OCor e Forma:SolidPeso molecular:406.52PLK1/p38γ-IN-1
CAS:PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellularFórmula:C21H26ClN3O2Pureza:98%Cor e Forma:SolidPeso molecular:387.9NTRC 0066-0
CAS:NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.Fórmula:C33H39N7O2Pureza:98.30%Cor e Forma:SolidPeso molecular:565.71SC-52012
CAS:SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.Fórmula:C25H30N4O6Pureza:97.20%Cor e Forma:SolidPeso molecular:482.53Chroman 1
CAS:Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Fórmula:C24H28N4O4Pureza:99.67% - 99.84%Cor e Forma:SolidPeso molecular:436.5Ref: TM-T14960
1mg73,00€5mg160,00€1mL*10mM (DMSO)173,00€10mg250,00€25mg430,00€50mg645,00€100mg888,00€UNC-2170
CAS:UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.Fórmula:C14H21BrN2OPureza:97.44%Cor e Forma:SolidPeso molecular:313.23Ref: TM-T24925
5mg46,00€1mL*10mM (DMSO)57,00€10mg71,00€25mg138,00€50mg200,00€100mg284,00€200mg391,00€SB-267268
CAS:SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Fórmula:C22H24F3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:451.445'-ODMT cEt m5U Phosphoramidite (Amidite)
CAS:5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].Fórmula:C42H51N4O9PCor e Forma:SolidPeso molecular:786.85m-Se3
CAS:m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].Fórmula:C29H23IN2SePureza:98%Cor e Forma:SolidPeso molecular:605.37Fosfluridine tidoxil
CAS:Fosfluridine tidoxil, a thymidylate synthase inhibitor, is used potentially for the treatment of colorectal cancer, and breast cancer.Fórmula:C34H62FN2O10PSCor e Forma:SolidPeso molecular:740.9DCB-3503
CAS:DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.Fórmula:C24H27NO5Cor e Forma:SolidPeso molecular:409.473-Cyanovinylcarbazole phosphoramidite
CAS:3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.Fórmula:C50H53N4O6PCor e Forma:SolidPeso molecular:836.95L 738167
CAS:L 738167 is a potent antagonist of the long-acting fibrinogen receptor.Fórmula:C25H34N6O6SCor e Forma:SolidPeso molecular:546.64JNJ-26076713
CAS:JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.Fórmula:C29H38N4O3Pureza:98%Cor e Forma:SolidPeso molecular:490.64
