Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(547 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(276 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(273 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
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Foram encontrados 3935 produtos de "Ciclo celular/Ponto de verificação"
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Cdc7-IN-7
CAS:Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.
Fórmula:C21H22N4O5Pureza:98.78%Cor e Forma:SolidPeso molecular:410.42RIOK2-IN-1
CAS:RIOK2-IN-1 (com 4) is a selective RIOK2 inhibitor with a Kd of 150 nM, though it demonstrates low cellular activity with an IC50 of 14,600 nM.Fórmula:C18H16N2OCor e Forma:SolidPeso molecular:276.33Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.18%Cor e Forma:SolidPeso molecular:512.46KSP-IA
CAS:KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.Fórmula:C21H22F2N2OPureza:98%Cor e Forma:SolidPeso molecular:356.41Senexin A hydrochloride
CAS:Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].Fórmula:C17H15ClN4Cor e Forma:SolidPeso molecular:310.78LX7101 hydrochloride
CAS:LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Fórmula:C23H29N7O3HClCor e Forma:SolidPeso molecular:488Bexotegrast HCl
CAS:Bexotegrast (PLN-74809) inhibits αVβ1/αVβ6 integrins, preventing TGF-β1 activation to treat IPF and PSC.Fórmula:C27H38Cl2N6O3Cor e Forma:SolidPeso molecular:565.54Nε-(1-Carboxyethyl)-L-lysine
CAS:Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.Fórmula:C9H18N2O4Cor e Forma:SolidPeso molecular:218.25ROCK2-IN-7
CAS:ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.Fórmula:C26H28FN5OPureza:98%Cor e Forma:SolidPeso molecular:445.53αvβ6 integrin inhibitor 2
CAS:αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.Fórmula:C21H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:386.49BMT-090605 hydrochloride
CAS:BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.Fórmula:C21H25ClN4O2Cor e Forma:SolidPeso molecular:400.91Inixaciclib
CAS:Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.Fórmula:C26H30F2N6OCor e Forma:SolidPeso molecular:480.55Thymidine-5'-O-(α,β-methylene)diphosphate sodium
CAS:Thymidine-5’-O-(α,β-methylene)diphosphate (TMP-CP), a hydrolytically stable derivative of TDP, functions as an inhibitor of thymidine kinase (Ki = 23 µM).Fórmula:C11H15N2O10P2·3NaCor e Forma:SolidPeso molecular:466.16Tirofiban HCl
CAS:Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.
Fórmula:C22H37ClN2O5SPureza:98%Cor e Forma:SolidPeso molecular:477.06Diazoketone methotrexate
CAS:Diazoketone methotrexate is an analog of methotrexate with potential antitumor activity.Fórmula:C21H22N10O4Cor e Forma:SolidPeso molecular:478.46SB-267268
CAS:SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Fórmula:C22H24F3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:451.44Homouridine
CAS:Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).Fórmula:C10H14N2O6Pureza:98%Cor e Forma:SolidPeso molecular:258.23DUB-IN-7
CAS:DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Fórmula:C17H19N5OCor e Forma:SolidPeso molecular:309.37DHODH-IN-14
CAS:DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.Fórmula:C15H7F4N3O3Pureza:99.81%Cor e Forma:SolidPeso molecular:353.23Ref: TM-T11023
500mgA consultar1mg109,00€2mg163,00€5mg243,00€1mL*10mM (DMSO)250,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€pppApG
CAS:pppApG serves as an initial substrate for the synthesis of vRNA (viral RNA) and cRNA (complementary RNA), with applications in influenza virus research [1].Fórmula:C20H28N10O20P4Cor e Forma:SolidPeso molecular:852.39GSPT1 degrader-2
CAS:GSPT1 degrader-2 is a potent degrader of GSPT1 [1].Fórmula:C22H20ClN3O5Cor e Forma:SolidPeso molecular:441.86MOMA-341
CAS:MOMA-341, ATP-competitive WRN allosteric inhibitor (Cys727 site), induces DNA damage and tumor regression in dMMR/MSI-H models, for solid tumors.Fórmula:C28H26F4N6O3Cor e Forma:SolidPeso molecular:570.545-DACTHF
CAS:5,11-methenyltetrahydrohomofolate blocks GAR & AIR transformylase; used as an anti-purine drug.Fórmula:C19H24N6O6Pureza:98%Cor e Forma:SolidPeso molecular:432.43Lotrafiban hydrochloride
CAS:Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.Fórmula:C23H33ClN4O4Cor e Forma:SolidPeso molecular:464.99PTC258
CAS:PTC258 is a specific, orally active modulator of the splicing of the Elongator complex protein 1 gene (ELP1), enhancing its expression both in vitro and in vivoFórmula:C16H18ClN3S2Cor e Forma:SolidPeso molecular:351.92TAK 029
CAS:TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.Fórmula:C19H23N5O7Cor e Forma:SolidPeso molecular:433.42ROCK-IN-8
CAS:ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,Fórmula:C30H25FN4O4SPureza:98%Cor e Forma:SolidPeso molecular:556.61Zaurategrast
CAS:Zaurategrast (CDP323) is an oral α4-integrin antagonist that blocks VCAM-1 interactions and is used to study immune cell trafficking.Fórmula:C26H25BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:521.41BVDU 5′-Triphosphate
CAS:BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.Fórmula:C11H16BrN2O14P3Pureza:98%Cor e Forma:SolidPeso molecular:573.08ON 108600
CAS:ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.Fórmula:C22H14Cl2N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:537.39Riviciclib
CAS:Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.Fórmula:C21H20ClNO5Pureza:98%Cor e Forma:SolidPeso molecular:401.84Votoplam
CAS:Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1].Fórmula:C21H25N9OPureza:98%Cor e Forma:SolidPeso molecular:419.48ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Fórmula:C26H22ClF2N7OPureza:98%Cor e Forma:SolidPeso molecular:521.95Cdk4 Inhibitor
CAS:PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.Fórmula:C20H10BrN3O2Cor e Forma:SolidPeso molecular:404.2Spirofylline
CAS:Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.Fórmula:C24H28N6O5Pureza:98%Cor e Forma:SolidPeso molecular:480.52AR-13503
CAS:AR-13503, a Netarsudil metabolite, is a ROCK inhibitor, potentially treating glaucoma and lowering eye pressure.Fórmula:C19H19N3O2Cor e Forma:SolidPeso molecular:321.37Mps1-IN-10
CAS:Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects onFórmula:C24H27N7O2Cor e Forma:SolidPeso molecular:445.52DAM-IN-1
CAS:DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.Fórmula:C16H17NO4Pureza:98%Cor e Forma:SolidPeso molecular:287.31Phototrexate
CAS:Phototrexate, a photochromic Methotrexate analog, is a UVA-activated, reversible DHFR inhibitor with antifolate properties (IC50: 6 nM cis vs. 34 μM trans).Fórmula:C20H19N7O5Cor e Forma:SolidPeso molecular:437.41USP1-IN-5
CAS:USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFórmula:C27H23F3N8OCor e Forma:SolidPeso molecular:532.52ROCK-IN-10
CAS:ROCK-IN-10 (compound 50) serves as a powerful inhibitor of ROCK, exhibiting IC50 values of 6 nM for ROCK1 and 4 nM for ROCK2, respectively. It demonstrates over 100-fold selectivity towards ROCK1 and ROCK2 when compared to other kinases [1].Fórmula:C25H25N5O3Cor e Forma:SolidPeso molecular:443.507Methotrexate-γ-aspartate
CAS:Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.Fórmula:C24H27N9O8Pureza:98%Cor e Forma:SolidPeso molecular:569.53CDK9-IN-8
CAS:CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).Fórmula:C31H32FN7O3Pureza:99.54%Cor e Forma:SolidPeso molecular:569.63Cytarabine 5′-monophosphate
CAS:Cytarabine 5′-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase α, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.Fórmula:C9H14N3O8PCor e Forma:SolidPeso molecular:323.198CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFórmula:C25H29N5O2SCor e Forma:SolidPeso molecular:463.6NVS-SM2
CAS:NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.Fórmula:C23H30N6OCor e Forma:SolidPeso molecular:406.52Pencitabine
CAS:Pen is an oral cancer drug that blocks DNA synthesis by inhibiting key enzymes and integrating into DNA.Fórmula:C15H20F3N3O6Cor e Forma:SolidPeso molecular:395.335′-Guanylyl methylenediphosphonate sodium
CAS:5′-Guanylyl methylenediphosphonate (sodium) serves as a GTP analogue and acts as a specific, competitive inhibitor of the GTP reaction in protein synthesis [1].Fórmula:C11H15N5Na3O13P3Cor e Forma:SolidPeso molecular:587.15AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Fórmula:C21H13Cl2N3O2SPureza:97.05%Cor e Forma:SolidPeso molecular:442.32Ref: TM-T10215
1mg54,00€5mg118,00€1mL*10mM (DMSO)131,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€Sapacitabine
CAS:Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.Fórmula:C26H42N4O5Pureza:98.82%Cor e Forma:SolidPeso molecular:490.64
