Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(547 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(276 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(273 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3935 produtos de "Ciclo celular/Ponto de verificação"
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CDK4/6-IN-17
CAS:CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Fórmula:C27H28F4N8Pureza:98%Cor e Forma:SolidPeso molecular:540.56MU-380
CAS:MU-380 is an effective and selective inhibitor of CHK1.Fórmula:C15H15BrF3N7Cor e Forma:SolidPeso molecular:430.23Bisindolylmaleimide X hydrochloride
CAS:Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).Fórmula:C26H25ClN4O2Pureza:99.23%Cor e Forma:SolidPeso molecular:460.96COH1
CAS:COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1].Fórmula:C11H10N2O3SPureza:98%Cor e Forma:SolidPeso molecular:250.27CDK7-IN-22
CAS:CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Fórmula:C22H25F3N6Pureza:98%Cor e Forma:SolidPeso molecular:430.47CDK9-IN-29
CAS:CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.Fórmula:C29H33F2N5O4Pureza:98%Cor e Forma:SolidPeso molecular:553.6NITD008
CAS:NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.Fórmula:C13H14N4O4Pureza:98.04%Cor e Forma:SolidPeso molecular:290.27ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Fórmula:C17H17N3O2SPureza:98%Cor e Forma:SolidPeso molecular:327.4Mevociclib
CAS:Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Fórmula:C31H35ClN8O2Pureza:98.02% - 98.02%Cor e Forma:SolidPeso molecular:587.11DNA polymerase-IN-1
CAS:DNA polymerase-IN-1 exhibits antiproliferative activity against tumor cells and inhibits Taq DNA polymerase as a DNA polymerase inhibitor.Fórmula:C10H7ClO4Pureza:99.16%Cor e Forma:SolidPeso molecular:226.61XL413 hydrochloride
CAS:XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.Fórmula:C14H13Cl2N3O2Pureza:98.81% - 99.8%Cor e Forma:SolidPeso molecular:326.18Ref: TM-T6735
1mg50,00€5mg109,00€10mg152,00€25mg268,00€50mg447,00€100mg672,00€200mg888,00€500mg1.369,00€2'-Deoxypseudoisocytidine
CAS:2'-Deoxypseudoisocytidine is a nucleoside analogue.Fórmula:C9H13N3O4Pureza:98%Cor e Forma:SolidPeso molecular:227.22WRN inhibitor 3
CAS:WRN Inhibitor 3 (example 110), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).Fórmula:C20H20N2O5SCor e Forma:SolidPeso molecular:400.45hDHODH-IN-1
CAS:hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.Fórmula:C17H14N2O2Pureza:99.97%Cor e Forma:SolidPeso molecular:278.31Ref: TM-T11546
1mg34,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg103,00€25mg200,00€50mg290,00€100mg404,00€200mg545,00€GGTI 2147
CAS:GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.Fórmula:C28H30N4O3Pureza:98.24%Cor e Forma:SolidPeso molecular:470.56MS-444
CAS:MS-444 (BE-34776) is an MLCK and HuR inhibitor with antitumor activity that can be used to study triple-negative breast cancer and colorectal cancer.Fórmula:C13H10O4Pureza:99.45% - 99.45%Cor e Forma:SolidPeso molecular:230.22Chroman 1
CAS:Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Fórmula:C24H28N4O4Pureza:99.67% - 99.84%Cor e Forma:SolidPeso molecular:436.5Ref: TM-T14960
1mg73,00€5mg160,00€1mL*10mM (DMSO)173,00€10mg250,00€25mg430,00€50mg645,00€100mg888,00€KM05382
CAS:KM05382 inhibits CDK9 and the transcription of GAPDH.Fórmula:C20H19ClN2O3S2Cor e Forma:SolidPeso molecular:434.963-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFórmula:C13H8O3Pureza:98%Cor e Forma:SolidPeso molecular:212.2FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Fórmula:C25H29N5OSCor e Forma:SolidPeso molecular:447.6CDK8-IN-3
CAS:CDK8-IN-3 is an inhibitor of CDK8.Fórmula:C22H23N5O2Pureza:98%Cor e Forma:SolidPeso molecular:389.45ROCK2-IN-2
CAS:ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Fórmula:C18H12N6OSPureza:99.65%Cor e Forma:SolidPeso molecular:360.39Ref: TM-T12747
1mg50,00€5mg111,00€1mL*10mM (DMSO)136,00€10mg177,00€25mg304,00€50mg447,00€100mg692,00€200mg888,00€L-Methioninamide hydrochloride
CAS:L-Methioninamide hydrochloride is a potent inhibitor of methionyl-tRNA synthetase that reduces the toxicity of CDDP.Fórmula:C5H13ClN2OSPureza:99.93%Cor e Forma:SolidPeso molecular:184.69BMT-090605
CAS:BMT-090605: AAK1 inhibitor (IC50=0.6 nM), also affects BIKE (45 nM) and GAK (60 nM), has antinociceptive properties.Fórmula:C21H24N4O2Pureza:98%Cor e Forma:SolidPeso molecular:364.44USP1-IN-6
CAS:USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Fórmula:C29H27F3N8OCor e Forma:SolidPeso molecular:560.57TNH
CAS:TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].Fórmula:C39H57ClN6O13Cor e Forma:SolidPeso molecular:853.36L-739758
CAS:L-739758 is a glycoprotein IIb/IIIa inhibitor.Fórmula:C22H26N4O5S3Cor e Forma:SolidPeso molecular:522.66GRK2 Inhibitor 2
CAS:GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Fórmula:C19H16N4O2Cor e Forma:SolidPeso molecular:332.365,6,7,8-Tetrahydro-8-deazahomofolic acid
CAS:5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.Fórmula:C21H26N6O6Cor e Forma:SolidPeso molecular:458.47CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Fórmula:C23H27FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:442.48(S)-Cdc7-IN-18
CAS:'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'Fórmula:C19H21N5OSCor e Forma:SolidPeso molecular:367.47Carotegrast
CAS:Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.Fórmula:C27H24Cl2N4O5Cor e Forma:SolidPeso molecular:555.41HQ005
CAS:HQ005, a potent CCNK degrader, exhibits an impressive DC50 value of 0.041 µM and functions as a molecular-glue degrader.Fórmula:C15H15N5O2S2Cor e Forma:SolidPeso molecular:361.44GSK2646264
CAS:GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.Fórmula:C24H26N2O2Cor e Forma:SolidPeso molecular:374.48PF-6808472
CAS:PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.Fórmula:C25H27FN8O3SPureza:99.02%Cor e Forma:SolidPeso molecular:538.6ML-099
CAS:ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.Fórmula:C14H13NO2SPureza:99.73%Cor e Forma:SolidPeso molecular:259.32Ref: TM-T22991
1mg46,00€2mg60,00€1mL*10mM (DMSO)88,00€5mg90,00€10mg144,00€25mg289,00€50mg462,00€100mg672,00€ROCK-IN-9
CAS:ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Fórmula:C20H20FN5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.4Alatrofloxacin
CAS:Alatrofloxacin is a prodrug of trovafloxacin.Fórmula:C26H25F3N6O5Cor e Forma:SolidPeso molecular:558.51G-5758
CAS:G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.Fórmula:C27H24F4N6O3SCor e Forma:SolidPeso molecular:588.58Brodimoprim
CAS:Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR).Fórmula:C13H15BrN4O2Pureza:98% - 99.71%Cor e Forma:SolidPeso molecular:339.19LDC3140
CAS:LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).Fórmula:C23H33N7OPureza:98%Cor e Forma:SolidPeso molecular:423.55Gly-Arg-Gly-Asp-Ser TFA
CAS:Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.Fórmula:C19H31F3N8O11Cor e Forma:SolidPeso molecular:604.49SB-743921 free base
CAS:SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).Fórmula:C31H33ClN2O3Pureza:98%Cor e Forma:SolidPeso molecular:517.06H-1152 dihydrochloride
CAS:H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Fórmula:C16H23Cl2N3O2SPureza:99.85%Cor e Forma:SolidPeso molecular:392.34Ref: TM-T35328
1mg60,00€5mg135,00€1mL*10mM (DMSO)147,00€10mg215,00€25mg415,00€50mg655,00€100mg888,00€CF53
CAS:CF53: potent, selective oral BET inhibitor; Ki <1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.Fórmula:C24H25N7O2Pureza:99.72%Cor e Forma:SolidPeso molecular:443.5Ref: TM-T10773
1mg92,00€5mg200,00€1mL*10mM (DMSO)215,00€10mg299,00€25mg484,00€50mg658,00€100mg892,00€BDP9066
CAS:BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.Fórmula:C20H24N6Pureza:98.18%Cor e Forma:SolidPeso molecular:348.44Ref: TM-T14521
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg178,00€25mg409,00€50mg708,00€100mg1.224,00€500mg2.448,00€XY028-140
CAS:XY028-140 is a selective CDK4/6 inhibitor and degrader, acting via PROTAC with ligands for Cereblon and CDK in cancer cells.Fórmula:C39H40N10O7Pureza:98.59%Cor e Forma:SolidPeso molecular:760.8IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Fórmula:C23H19N5OPureza:99.3%Cor e Forma:SolidPeso molecular:381.43SMN-C3
CAS:SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).Fórmula:C24H28N6OPureza:99.01% - 99.05%Cor e Forma:SolidPeso molecular:416.52Debio-0123
CAS:Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.Fórmula:C26H28Cl2N6OPureza:99.93%Cor e Forma:SolidPeso molecular:511.45
