Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(547 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(276 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(273 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
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Foram encontrados 3935 produtos de "Ciclo celular/Ponto de verificação"
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Antiviral agent 34
CAS:Antiviral Agent 34 is an antiviral compound that inhibits influenza virus and inhibits the proliferation of influenza virus by modulating RNA polymerase.Fórmula:C29H33N3O2SPureza:99.51%Cor e Forma:SoildPeso molecular:487.66AZD4573
CAS:AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.Fórmula:C22H28ClN5O2Pureza:99% - 99.51%Cor e Forma:SolidPeso molecular:429.94(R)-Simurosertib
CAS:(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.Fórmula:C17H19N5OSPureza:99.89%Cor e Forma:SolidPeso molecular:341.43Thymectacin
CAS:Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.Fórmula:C21H25BrN3O9PPureza:97.05% - 99.49%Cor e Forma:SolidPeso molecular:574.32LY3295668
CAS:LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Fórmula:C24H26ClF2N5O2Pureza:99.68%Cor e Forma:SolidPeso molecular:489.95LNA-Adenosine
CAS:LNA-Adenosine (LNA-A) is a nucleoside analogue that acts as a ligand for adenosine A3 receptors.Fórmula:C11H13N5O4Pureza:99.15%Cor e Forma:SolidPeso molecular:279.25Plogosertib
CAS:Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.Fórmula:C34H48N8O3Pureza:99.22% - 99.85%Cor e Forma:SolidPeso molecular:616.797Ref: TM-T71399
1mg205,00€5mg537,00€1mL*10mM (DMSO)712,00€10mg802,00€25mg1.395,00€50mg1.935,00€100mg2.502,00€Gossypolone
CAS:Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.Fórmula:C30H26O10Pureza:99.15%Cor e Forma:SolidPeso molecular:546.52Ref: TM-T31987
1mg175,00€5mg404,00€1mL*10mM (DMSO)507,00€10mg593,00€25mg888,00€50mg1.251,00€100mg1.693,00€500mg3.402,00€GNE-375
CAS:GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.Fórmula:C25H29N3O5Pureza:98.99%Cor e Forma:SolidPeso molecular:451.51Ref: TM-T27423
1mg111,00€5mg264,00€1mL*10mM (DMSO)299,00€10mg409,00€25mg670,00€50mg964,00€100mg1.414,00€Filibuvir
CAS:Filibuvir (PF-00868554) inhibits HCV polymerase genotypes 1a/1b, EC50s 59 nM.Fórmula:C29H37N5O3Pureza:99.28% - >99.99%Cor e Forma:SolidPeso molecular:503.64CFI-402257
CAS:CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.Fórmula:C28H30N6O3Pureza:96.66% - 99.51%Cor e Forma:SolidPeso molecular:498.58Cdk1/2 Inhibitor III
CAS:Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.Fórmula:C15H13F2N7O2S2Pureza:99.92%Cor e Forma:SolidPeso molecular:425.44B I09
CAS:B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.Fórmula:C16H17NO5Pureza:99.64%Cor e Forma:SolidPeso molecular:303.31CCT129202
CAS:CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Fórmula:C23H25ClN8OSPureza:98.14%Cor e Forma:SolidPeso molecular:497.02αvβ1 integrin-IN-1
CAS:αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.Fórmula:C26H34N6O6SPureza:99.39% - 99.69%Cor e Forma:SolidPeso molecular:558.65Ref: TM-T13473
1mg109,00€5mg260,00€1mL*10mM (DMSO)319,00€10mg409,00€25mg660,00€50mg888,00€100mg1.224,00€200mg1.648,00€DHX9-IN-2
CAS:DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.Fórmula:C18H16ClN3O3S2Pureza:98%Cor e Forma:SolidPeso molecular:421.92Ref: TM-T82568
1mg92,00€5mg230,00€1mL*10mM (DMSO)251,00€10mg356,00€25mg510,00€50mg663,00€100mg858,00€Roxifiban acetate
CAS:Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFórmula:C23H33N5O8Pureza:97.91% - 98.36%Cor e Forma:SolidPeso molecular:507.54Sorivudine
CAS:Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.Fórmula:C11H13BrN2O6Pureza:99.74%Cor e Forma:SolidPeso molecular:349.13Lomibuvir
CAS:Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.Fórmula:C25H35NO4SPureza:99.83%Cor e Forma:SolidPeso molecular:445.61CeMMEC1
CAS:CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).Fórmula:C19H16N2O4Pureza:98.9% - 99.92%Cor e Forma:SolidPeso molecular:336.34CDK2-IN-40
CAS:CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.Fórmula:C16H21N7O2Cor e Forma:SolidPeso molecular:343.3845-Methylcytosine hydrochloride
CAS:5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.Fórmula:C5H8ClN3OCor e Forma:SolidPeso molecular:161.59Dyrk1A/α-synuclein-IN-1
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).Fórmula:C20H21N5O3SCor e Forma:SolidPeso molecular:411.48Zorubicin
CAS:Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.Fórmula:C34H35N3O10Cor e Forma:SolidPeso molecular:645.66N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine
CAS:N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a nucleoside analog that resembles the natural nucleotide adenosine in structure. It acts as an activator of ribonucleotide reductase, facilitating the conversion of ribonucleotides into deoxyribonucleotides.Fórmula:C38H35N5O6Cor e Forma:SolidPeso molecular:657.714RNAP-σ interaction inhibitor-1
CAS:RNAP-σ interaction inhibitor-1 (compound 5d) acts as an inhibitor of the interaction between RNA polymerase and the sigma factor. It exhibits activity against Streptococci with a minimum inhibitory concentration (MIC) ranging from 1-2 µg/mL.Fórmula:C19H11Cl3N2O6S2Cor e Forma:SolidPeso molecular:533.79Ascofuranone
CAS:Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODHFórmula:C23H29ClO5Cor e Forma:SolidPeso molecular:420.93CHK1 inhibitor
CAS:CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Fórmula:C17H21BrN4OPureza:98%Cor e Forma:SolidPeso molecular:377.28UM-C162
CAS:UM-C162, a benzimidazole derivative, offers protection to nematodes from Staphylococcus aureus infections. It inhibits biofilm formation without impairing bacterial viability. Additionally, UM-C162 disrupts the production of Staphylococcus aureus hemolysins, proteases, and coagulases. This compound holds potential as an antivirulence agent for managing Staphylococcus aureus infections.Fórmula:C30H25N3O4Cor e Forma:SolidPeso molecular:491.54RAD51-IN-5
CAS:RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)Fórmula:C26H38N4O5S2Cor e Forma:SolidPeso molecular:550.732′-OMe-UMP
CAS:2′-OMe-UMP is a nucleotide analog used in the synthesis of oligonucleotides.Fórmula:C10H15N2O9PPeso molecular:338.21DS96432529
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.Fórmula:C18H26N4O3SCor e Forma:SoildPeso molecular:378.49AB25583
CAS:AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.Fórmula:C22H17ClN4O3SCor e Forma:SolidPeso molecular:452.91MtTMPK-IN-5
MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.Fórmula:C21H23N5O2Cor e Forma:SolidPeso molecular:377.44EFdA-TP tetrasodium
CAS:EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.Fórmula:C12H11FN5Na4O12P3Pureza:98%Cor e Forma:SolidPeso molecular:621.12PKMYT1-IN-7
CAS:PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.Fórmula:C17H18FN5O3Cor e Forma:SolidPeso molecular:359.3556K465
CAS:6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.Fórmula:C26H33ClFN9OPureza:99.78%Cor e Forma:SolidPeso molecular:542.05LY 254155
CAS:LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.Fórmula:C19H23N5O6SPureza:98%Cor e Forma:SolidPeso molecular:449.48FT3967385
FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.Fórmula:C21H19N5O2Cor e Forma:SolidPeso molecular:373.41c-Myc inhibitor 4
Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.Fórmula:C26H33FN6O3Cor e Forma:SolidPeso molecular:496.58Epolactaene
CAS:Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.Fórmula:C21H27NO6Cor e Forma:SolidPeso molecular:389.44KL-50
CAS:KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.Fórmula:C7H7FN6O2Cor e Forma:SolidPeso molecular:226.17CDK/HDAC-IN-1
CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.Fórmula:C20H18N4O4Cor e Forma:SolidPeso molecular:378.38Kolavenic acid analog
CAS:KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Fórmula:C25H38O4Cor e Forma:SolidPeso molecular:402.57HBV-IN-48
CAS:HBV-IN-48, an HBV inhibitor, exhibits potent antiviral activity against HBV in HepDE19 cells, demonstrated by its EC 50 value of 0.005 μM. Additionally, it effectively reduces serum HBV DNA levels in mouse models of HBV infection.Fórmula:C22H15F4N3O3Cor e Forma:SolidPeso molecular:445.37CDK7/12-IN-1
CAS:CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.Fórmula:C25H34N8OCor e Forma:SolidPeso molecular:462.59CDK7-IN-18
CAS:CDK7-IN-18 (Compound 15) is a pyrimidine-derived CDK7 inhibitor suitable for studying cancers with transcriptional dysregulation.Fórmula:C22H24F3N7OSPureza:99.28% - 99.54%Cor e Forma:SolidPeso molecular:491.53GR 83895
CAS:GR 83895 is an antagonist of prototype fibrinogen receptor.Fórmula:C29H39N9O8SPureza:98%Cor e Forma:SolidPeso molecular:673.74L-Tyrosyl-L-glutamic acid
CAS:L-Tyrosyl-L-glutamic acid acts as an inhibitor of the amino acid permease GAP1.Fórmula:C14H18N2O6Cor e Forma:SolidPeso molecular:310.3ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Fórmula:C19H22N4O3SCor e Forma:SolidPeso molecular:386.47
