Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(115 produtos)
- CDK(546 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(47 produtos)
- Dinamina(27 produtos)
- Ferroptose(227 produtos)
- HSP(180 produtos)
- Integrinas(269 produtos)
- Cinesina(87 produtos)
- LIM Quinase(20 produtos)
- Microtúbulo associado(274 produtos)
- PKC(126 produtos)
- PLK(25 produtos)
- ROCK(62 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(76 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3906 produtos de "Ciclo celular/Ponto de verificação"
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LNA-AMP
CAS:LNA-AMP is a nucleotide analog used in the synthesis of oligonucleotides.Fórmula:C11H14N5O7PCor e Forma:SolidPeso molecular:359.23Eprociclovir Na
CAS:Eprociclovir Na (A-5021) is 15x stronger than acyclovir at inhibiting herpesviruses, showing promise for EHV1 and herpetic keratitis treatment.Fórmula:C11H14N5NaO3Cor e Forma:SolidPeso molecular:287.25CHK-IN-1
CAS:CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Fórmula:C18H19ClFN5OSPureza:>99.99%Cor e Forma:SolidPeso molecular:407.89isoGTP lithium
CAS:isoGTP (Isoguanosine-5'-triphosphate) lithium is a GTP analog.Fórmula:C10H12Li4N5O14P3Cor e Forma:SolidPeso molecular:546.91BAY-364
CAS:BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+Fórmula:C23H19N3O4Cor e Forma:SolidPeso molecular:401.418-Azakinetin riboside
CAS:8-Azakinetin riboside, a structural analog of kinetin riboside, exhibits cytotoxic activity [1].Fórmula:C14H16N6O5Cor e Forma:SolidPeso molecular:348.31Methyl 3-oxodecanoate
CAS:Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.Fórmula:C11H20O3Cor e Forma:SolidPeso molecular:200.2755-Methylcytosine hydrochloride
CAS:5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.Fórmula:C5H8ClN3OCor e Forma:SolidPeso molecular:161.59CDK9 autophagic degrader 1
CAS:CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.Fórmula:C34H39N7O4S2Cor e Forma:SolidPeso molecular:673.848MtTMPK-IN-2
CAS:MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).Fórmula:C23H24ClN3O3Cor e Forma:SolidPeso molecular:425.915'-DMT-5-F-2'-dU Phosphoramidite
CAS:5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.Fórmula:C39H46FN4O8PCor e Forma:SolidPeso molecular:748.777CYP2C19-IN-1
CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.Fórmula:C26H26N2O6SCor e Forma:SolidPeso molecular:494.56CDK2 degrader 6
CAS:CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.Fórmula:C23H22F5N5O3Cor e Forma:SolidPeso molecular:511.44Zeltociclib
CAS:Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.Fórmula:C18H20F3N4O2PCor e Forma:SolidPeso molecular:412.346SF0166
CAS:SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Fórmula:C23H27F2N5O4Cor e Forma:SolidPeso molecular:475.496-N-Hydroxylaminopurine
CAS:6-N-Hydroxylaminopurine is a base analog with mutagenic activity.Fórmula:C5H5N5OPeso molecular:151.13USP7-IN-10
CAS:USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Fórmula:C26H29ClN4O3SCor e Forma:SolidPeso molecular:513.05WRN inhibitor 13
CAS:WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.Fórmula:C16H20N2O5SCor e Forma:SolidPeso molecular:352.405RNase L ligand 3
CAS:RNase L ligand 3 is an RNase L ligand employed in the synthesis of F3-PEG8-RiboTAC.Fórmula:C27H27N3OSCor e Forma:SolidPeso molecular:441.59AGH-107
CAS:AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.Fórmula:C13H12IN3Cor e Forma:SolidPeso molecular:337.162'-(2-Nitrobenzyl)-ATP
CAS:2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.Fórmula:C17H21N6O15P3Cor e Forma:SolidPeso molecular:642.30LNA-CTP
CAS:LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.
Fórmula:C10H16N3O14P3Cor e Forma:SolidPeso molecular:495.172′-F-UDP
CAS:2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.Fórmula:C9H13FN2O11P2Cor e Forma:SolidPeso molecular:406.15Ladirubicin
CAS:Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.Fórmula:C29H31NO11SCor e Forma:SolidPeso molecular:601.62CDK9-IN-11
CAS:CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].Fórmula:C20H25N3O4Pureza:98%Cor e Forma:SolidPeso molecular:371.43MtTMPK-IN-1
MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.Fórmula:C22H24N4O3Cor e Forma:SolidPeso molecular:392.45CHK1-IN-4
CAS:CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.Fórmula:C18H18BrN7O2Pureza:98%Cor e Forma:SolidPeso molecular:444.29Dyrk1A-IN-4
CAS:Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.Fórmula:C14H13F3N6Cor e Forma:SolidPeso molecular:322.297-Methylguanosine 5′-monophosphate
CAS:7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.Fórmula:C11H16N5O8PCor e Forma:SolidPeso molecular:377.25CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Fórmula:C21H22N4OCor e Forma:SolidPeso molecular:346.433-deoxy-3-fluoro-β-D-Ribofuranose 25
CAS:Compound 25, β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate), exhibits strong activity in inhibiting the growth of tumor cells [1].Fórmula:C17H19FO7Cor e Forma:SolidPeso molecular:354.33CDK9-IN-34
CAS:CDK9-IN-34 (Compound 1b) is an inhibitor of CDK9 with an IC50 of 0.25 μM. It exhibits cytotoxicity against cancer cell lines HCT116, MCF7, and K652, with IC50 values of 1.43 μM, 3.01 μM, and 50.27 μM, respectively. Additionally, CDK9-IN-34 demonstrates antiviral activity against coronavirus 229E with an IC50 of 145.92 μM.Fórmula:C18H20N4Cor e Forma:SolidPeso molecular:292.38IRE1α kinase-IN-4
CAS:IRE1α kinase-IN-4 (compound 6) is a potent inhibitor of IRE1α, exhibiting a Ki value of 140 nM. It acts as an ATP-competitive ligand for IRE1α [1].Fórmula:C29H31N7O2Cor e Forma:SolidPeso molecular:509.6MtTMPK-IN-3
CAS:MtTMPK-IN-3 inhibits Mycobacterium tuberculosis kinase with IC50 0.12μM, MIC 12.5μM on Mtb, cytotoxic EC50 12.5μM on MRC-5 cells.Fórmula:C23H23Cl2N3O3Cor e Forma:SolidPeso molecular:460.35L-2'-Fd4C
CAS:L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].Fórmula:C9H10FN3O3Cor e Forma:SolidPeso molecular:227.19L 734217
CAS:L 734217 is an antagonist of the fibrinogen receptor.Fórmula:C18H31N3O4Pureza:98%Cor e Forma:SolidPeso molecular:353.46p38α inhibitor 9
CAS:p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.Fórmula:C27H24FN3O3Cor e Forma:SolidPeso molecular:457.49612(S)-HETE
CAS:Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.
Fórmula:C20H32O3Cor e Forma:SolidPeso molecular:320.47Pol I-IN-1
Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibitionFórmula:C23H22N4O2Cor e Forma:SolidPeso molecular:386.45UMPK ligand 1
CAS:UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).
Fórmula:C15H22N4O5SCor e Forma:SolidPeso molecular:370.424TMX-3013
CAS:TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Fórmula:C17H14BrFN6O3SCor e Forma:SolidPeso molecular:481.3WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Fórmula:C30H31N5O3Cor e Forma:SolidPeso molecular:509.6CDK2-IN-8
CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.Fórmula:C22H25N5O3Cor e Forma:SolidPeso molecular:407.47SR121566A
CAS:SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).Fórmula:C20H25N5O4SPureza:98%Cor e Forma:SolidPeso molecular:431.51Dyrk1A-IN-11
CAS:Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.Fórmula:C23H23F5N8OCor e Forma:SolidPeso molecular:522.47CHK1-IN-2
CAS:CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Fórmula:C20H22N4OSPureza:98%Cor e Forma:SolidPeso molecular:366.48LNA-GTP
CAS:LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.Fórmula:C11H16N5O14P3Cor e Forma:SolidPeso molecular:535.19DNA gyrase B-IN-1
DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.Fórmula:C23H18ClF3N6O4SCor e Forma:SolidPeso molecular:566.942'-Deoxycytidine hydrate
CAS:2'-Deoxycytidine (Deoxycytidine) hydrate is a component of nucleic acids.Fórmula:C9H15N3O5Cor e Forma:SolidPeso molecular:245.23Metesind Glucuronate
CAS:Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.Fórmula:C29H34N4O10SCor e Forma:SolidPeso molecular:630.67
