Ferroptose
A ferroptose é uma forma de morte celular regulada caracterizada pelo acúmulo de peróxidos lipídicos e estresse oxidativo dependente de ferro. Ao contrário da apoptose, a ferroptose não é impulsionada por caspases, mas pelo fracasso das defesas antioxidantes celulares, levando à morte celular. Inibidores e indutores de ferroptose são críticos para estudar essa via única de morte celular, que está implicada em várias doenças, incluindo câncer, neurodegeneração e lesão por isquemia-reperfusão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de ferroptose de alta qualidade para apoiar sua pesquisa em mecanismos de morte celular, estresse oxidativo e patologia de doenças.
Foram encontrados 226 produtos de "Ferroptose"
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ZX703
ZX703 is a protein hydrolysis-targeting chimera (PROTAC) that mediates the degradation of GPX4 through the ubiquitin-proteasome and autophagy-lysosome pathways, with a DC50 of 0.315 µM. It induces the accumulation of lipid reactive oxygen species (ROS), thereby promoting ferroptosis in cancer cells.Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
CAS:Iron(III) compound induces ferroptosis in NB1 cells at 3μM, not apoptosis/necroptosis; inhibits various cancers, effective against drug-resistant NALM-6.Fórmula:C20H14ClFeN2O2Cor e Forma:SolidPeso molecular:405.64CQ-ER
<p>CQ-ER is a Coumarin-quinazolinone-based photosensitizer targeting the endoplasmic reticulum (ER). It induces ferroptosis, thereby enhancing photodynamic therapy (PDT).</p>Fórmula:C33H33N7O6SCor e Forma:SolidPeso molecular:655.72W1131 TFA
W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.Fórmula:C25H20F3N5O6Pureza:98.1%Cor e Forma:SolidPeso molecular:543.4584-B10
CAS:84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.Fórmula:C25H22F3NO5Pureza:99.76%Cor e Forma:SolidPeso molecular:473.44Ferroptosis-IN-3
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM).Pureza:98%Cor e Forma:Odour SolidGPX4-IN-7
<p>GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment.</p>Fórmula:C25H23ClN4O4Pureza:98%Cor e Forma:SolidPeso molecular:478.93Ferroptosis-IN-1
Ferroptosis-IN-1, a diterpene derived from A.Fórmula:C22H34O5Pureza:98%Cor e Forma:SolidPeso molecular:378.5Idebenone
CAS:Fórmula:C19H30O5Pureza:>98.0%(T)(HPLC)Cor e Forma:Light yellow to Brown powder to crystalPeso molecular:338.44Cerivastatin sodium
CAS:Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.Fórmula:C26H33FNNaO5Pureza:98.50% - 99.67%Cor e Forma:SolidPeso molecular:481.53CuATSP
CAS:CuATSP is a potent free radical trapping antioxidant (RTA) and ferroptosis inhibitor inhibit lipid peroxidation, for (ALS) and Parkinson's disease.Fórmula:C18H18CuN6S2Pureza:97.09%Cor e Forma:SolidPeso molecular:446.05CuATSM
CAS:Cu/Zn-SOD1 enzyme scavenges radicals; mutations cause ALS. Cu-ATSM, crossing blood-brain barrier, targets hypoxic tissue, may aid ALS mice.Fórmula:C8H14CuN6S2Cor e Forma:SolidPeso molecular:321.92CCW16
CAS:CCW16 is a covalent E3 ubiquitin ligase RNF4 ligand, cysteine reactivity, inducing ferroptosis in AML cells by activating ROS signalling.Fórmula:C22H20ClNO3Pureza:97%Cor e Forma:SolidPeso molecular:381.85BAY 87-2243
CAS:BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Fórmula:C26H26F3N7O2Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:525.53UAMC-3203 hydrochloride
CAS:UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.Fórmula:C25H38ClN5O2SPureza:99.62%Cor e Forma:SolidPeso molecular:508.12Baicalein monohydrate
CAS:Baicalein monohydrate blocks 12-lipoxygenase, curbs leukotrienes, lysosomal enzymes, Ca2+ dynamics, and fights arthritis.Fórmula:C15H12O6Cor e Forma:SolidPeso molecular:288.25TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Fórmula:C10H14O2Pureza:99.17% - 99.53%Cor e Forma:White Solid PowderPeso molecular:166.22Ferrostatin-1
CAS:Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death, potently inhibits Erastin-induced iron death in HT-1080 cells. High-Quality, Low-Cost!Fórmula:C15H22N2O2Pureza:96.1% - 99.68%Cor e Forma:SolidPeso molecular:262.35NADPH tetrasodium salt
CAS:NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety ofFórmula:C21H26N7Na4O17P3Pureza:97.15% - >99.99%Cor e Forma:SolidPeso molecular:833.35L-Glutamic acid monosodium salt
CAS:L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.Fórmula:C5H8NO4·NaPureza:99.93%Cor e Forma:White Solid CrystallinePeso molecular:169.11
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