Microtúbulo associado
Os inibidores de proteínas associadas aos microtúbulos têm como alvo as proteínas que interagem com os microtúbulos, os componentes estruturais do citoesqueleto da célula que são essenciais para a divisão celular. Essas proteínas regulam a estabilidade e a dinâmica dos microtúbulos durante a mitose. A inibição de proteínas associadas aos microtúbulos pode interromper a função dos microtúbulos, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas de rápida divisão. Esses inibidores são amplamente utilizados na pesquisa do câncer e no desenvolvimento de medicamentos. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteínas associadas aos microtúbulos de alta qualidade para apoiar sua pesquisa em divisão celular, dinâmica do citoesqueleto e terapia do câncer.
Foram encontrados 262 produtos de "Microtúbulo associado"
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PBB3
CAS:<p>PBB3 is a tau-specific PET tracer.</p>Fórmula:C17H15N3OSCor e Forma:SolidPeso molecular:309.39Oxaline
CAS:<p>Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].</p>Fórmula:C24H25N5O4Cor e Forma:SolidPeso molecular:447.49AMXI-5001 hydrochloride
<p>AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.</p>Fórmula:C25H21ClFN5O3Cor e Forma:SolidPeso molecular:493.92Lisavanbulin
CAS:<p>Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.</p>Fórmula:C26H29N9O3Cor e Forma:SolidPeso molecular:515.57EX05
CAS:<p>EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.</p>Fórmula:C26H30F2N4O5SCor e Forma:SolidPeso molecular:548.60AM-9022
CAS:<p>AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].</p>Fórmula:C27H36F2N6O4SCor e Forma:SolidPeso molecular:578.67TACC3 inhibitor 2
CAS:<p>TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.</p>Fórmula:C20H22FN5O2Cor e Forma:SolidPeso molecular:383.419Tubulin polymerization-IN-77
CAS:<p>Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.</p>Fórmula:C22H19BrF3NO7Cor e Forma:SolidPeso molecular:546.288Tubulin polymerization-IN-63
CAS:<p>Tubulin polymerization-IN-63 (compound 6) is an inhibitor of tubulin polymerization. It exhibits an IC50 value of 0.29 μM against MES-SA cells, making it suitable for use in cancer research.</p>Fórmula:C20H24ClCuN5O2SCor e Forma:SolidPeso molecular:497.5TPI-287
CAS:<p>TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.</p>Fórmula:C46H63NO15Cor e Forma:SolidPeso molecular:869.99Monomethyl auristatin E intermediate-17
CAS:<p>MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).</p>Fórmula:C27H35NO7SPeso molecular:517.63Tubulin polymerization-IN-75
CAS:<p>Tubulin polymerization-IN-75 (Compound 6) is an inhibitor of tubulin polymerization, with an IC50 value of 30 μM. It effectively suppresses the proliferation of cancer cells Huh7 and 293T, demonstrating IC50 values of 14.3 μM and 13.8 μM, respectively.</p>Fórmula:C14H11NOCor e Forma:SolidPeso molecular:209.243Tubulin polymerization-IN-33
<p>Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.</p>Fórmula:C27H28N2O6Cor e Forma:SolidPeso molecular:476.52Tubulin inhibitor 16
<p>Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].</p>Fórmula:C16H12FNO2Cor e Forma:SolidPeso molecular:269.27Tasidotin hydrochloride
CAS:<p>Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.</p>Fórmula:C32H59ClN6O5Pureza:98%Cor e Forma:SolidPeso molecular:643.30Icafolin-methyl
CAS:<p>Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.</p>Fórmula:C18H18F2N2O5Cor e Forma:SolidPeso molecular:380.343Tubulin polymerization-IN-32
<p>Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.</p>Fórmula:C29H30N2O7Cor e Forma:SolidPeso molecular:518.56Tubulin polymerization-IN-74
CAS:<p>Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.</p>Fórmula:C14H11NSCor e Forma:SolidPeso molecular:225.309JC168
CAS:<p>JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.</p>Fórmula:C26H40O7Cor e Forma:SolidPeso molecular:464.592Myoseverin B
CAS:<p>Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.</p>Fórmula:C27H32N6O2Cor e Forma:SolidPeso molecular:472.582
