Microtúbulo associado
Os inibidores de proteínas associadas aos microtúbulos têm como alvo as proteínas que interagem com os microtúbulos, os componentes estruturais do citoesqueleto da célula que são essenciais para a divisão celular. Essas proteínas regulam a estabilidade e a dinâmica dos microtúbulos durante a mitose. A inibição de proteínas associadas aos microtúbulos pode interromper a função dos microtúbulos, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas de rápida divisão. Esses inibidores são amplamente utilizados na pesquisa do câncer e no desenvolvimento de medicamentos. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteínas associadas aos microtúbulos de alta qualidade para apoiar sua pesquisa em divisão celular, dinâmica do citoesqueleto e terapia do câncer.
Foram encontrados 273 produtos de "Microtúbulo associado"
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N-Deacetylcolchicine
CAS:Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK/SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming) for ease of communication.Fórmula:C20H23NO5Cor e Forma:SolidPeso molecular:357.4ASN90
CAS:ASN90 is a specific, orally active inhibitor of the O-GlcNAcase (OGA) enzyme, demonstrating an IC50 of 10.2 nM.Fórmula:C17H21N5O3SCor e Forma:SolidPeso molecular:375.45Dolastatinol
CAS:Dolastatinol, a synthetic analog of Dolastatin 10, serves as a potent low-nanomolar inhibitor of tubulin polymerization.Fórmula:C43H70N6O7SCor e Forma:SolidPeso molecular:815.12MK-6240
CAS:MK-6240: A tau PET tracer with high specificity for NFTs binding.Fórmula:C16H11FN4Pureza:98%Cor e Forma:SolidPeso molecular:278.283,4',5-Trismethoxybenzophenone
CAS:3,4',5-Trismethoxybenzophenone (compound 16a) is an effective inhibitor of tubulin assembly, demonstrating a half-maximal inhibitory concentration (IC 50) of 2.6 µM [1].Fórmula:C16H16O4Cor e Forma:SolidPeso molecular:272.3Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2
CAS:Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau inFórmula:C38H65N11O9Cor e Forma:SolidPeso molecular:819.99CNS-11
CAS:CNS-11, a compound that disaggregates tau fibrils, is utilized in Alzheimer's disease (AD) research [1].Fórmula:C25H21N3O2Cor e Forma:SolidPeso molecular:395.45THK-5105
CAS:THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.Fórmula:C20H21FN2O2Cor e Forma:SolidPeso molecular:340.39Oxaline
CAS:Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].Fórmula:C24H25N5O4Cor e Forma:SolidPeso molecular:447.49Antitumor agent-67
CAS:Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells.Fórmula:C45H47NO13Cor e Forma:SolidPeso molecular:809.85Tubulin polymerization-IN-74
CAS:Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.Fórmula:C14H11NSCor e Forma:SolidPeso molecular:225.309TTBK1/2-IN-3
CAS:TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).Fórmula:C21H22N4OCor e Forma:SolidPeso molecular:346.426Myoseverin B
CAS:Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.Fórmula:C27H32N6O2Cor e Forma:SolidPeso molecular:472.582Tasidotin hydrochloride
CAS:Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Fórmula:C32H59ClN6O5Pureza:98%Cor e Forma:SolidPeso molecular:643.30Icafolin-methyl
CAS:Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.Fórmula:C18H18F2N2O5Cor e Forma:SolidPeso molecular:380.343PROTAC α-synuclein degrader 6
CAS:PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.Fórmula:C37H39N5O9SPeso molecular:729.80PM-060184
CAS:PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.Fórmula:C31H45N3O7Pureza:98%Cor e Forma:SolidPeso molecular:571.7Tubulin inhibitor 16
Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].Fórmula:C16H12FNO2Cor e Forma:SolidPeso molecular:269.27
