ROCK
Os inibidores da quinase associada a Rho (ROCK) têm como alvo as quinases ROCK, que estão envolvidas na regulação do citoesqueleto, forma e motilidade celular. ROCK desempenha um papel significativo no controle da divisão celular, particularmente em processos como a citocinese. Inibir a ROCK pode levar a mudanças na dinâmica do ciclo celular, na motilidade celular e na apoptose, tornando esses inibidores valiosos na pesquisa do câncer, neurobiologia e estudos cardiovasculares. Na CymitQuimica, oferecemos uma seleção de inibidores ROCK de alta qualidade para apoiar sua pesquisa em biologia celular, dinâmica do citoesqueleto e mecanismos de doenças.
Foram encontrados 61 produtos de "ROCK"
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ROCK inhibitor-2
CAS:ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Fórmula:C21H20N2O2Pureza:99.85%Cor e Forma:SolidPeso molecular:332.4Ref: TM-T12746
1mg66,00€1mL*10mM (DMSO)106,00€5mg144,00€10mg216,00€25mg432,00€50mg645,00€100mg905,00€CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Fórmula:C24H21F3N6OPureza:99.01% - 99.04%Cor e Forma:SolidPeso molecular:466.46Netarsudil Dihydrochloride
CAS:Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Fórmula:C28H29Cl2N3O3Pureza:99.94% - 99.98%Cor e Forma:SolidPeso molecular:526.45Y-33075 dihydrochloride
CAS:Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Fórmula:C16H18Cl2N4OPureza:98.88% - 99.89%Cor e Forma:SolidPeso molecular:353.25Ref: TM-T13384L
1mg34,00€5mg66,00€1mL*10mM (DMSO)78,00€10mg102,00€25mg192,00€50mg341,00€100mg510,00€200mg732,00€GKI-1 HCl
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.Fórmula:C15H13Cl2N3Pureza:98.1%Cor e Forma:SoildPeso molecular:306.19Ref: TM-T11402L
1mg71,00€5mg154,00€1mL*10mM (DMSO)167,00€10mg221,00€25mg354,00€50mg497,00€100mg705,00€200mg928,00€Ripasudil free base
CAS:Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.Fórmula:C15H18FN3O2SPureza:98%Cor e Forma:SolidPeso molecular:323.39Ref: TM-T7492
1mg75,00€5mg150,00€1mL*10mM (DMSO)166,00€10mg238,00€25mg530,00€50mg873,00€100mg1.459,00€Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Cor e Forma:SolidPeso molecular:291.37WAY-656935
CAS:WAY-656935 inhibits ROCK.Fórmula:C20H28ClN3O3SPureza:97%Cor e Forma:SolidPeso molecular:425.97ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Fórmula:C28H30N8O2Cor e Forma:SolidPeso molecular:510.59Verosudil
CAS:Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.Fórmula:C17H17N3O2SPureza:99.68%Cor e Forma:SolidPeso molecular:327.4Ref: TM-T60924
1mg55,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg231,00€25mg370,00€50mg522,00€100mg692,00€Belumosudil mesylate
CAS:Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.Fórmula:C27H28N6O5SPureza:98.73%Cor e Forma:SolidPeso molecular:548.61Ref: TM-T39555
1mg34,00€2mg46,00€5mg71,00€1mL*10mM (DMSO)85,00€10mg96,00€25mg155,00€50mg230,00€100mg353,00€200mg517,00€Cotosudil
CAS:Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Fórmula:C16H21N3O2SPureza:98.41%Cor e Forma:SolidPeso molecular:319.42GSK269962A hydrochloride
CAS:GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.Fórmula:C29H31ClN8O5Cor e Forma:SolidPeso molecular:607.06ZINC00881524
CAS:ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
Fórmula:C21H20N2O3SPureza:99.48%Cor e Forma:SolidPeso molecular:380.46Narciclasine
CAS:Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Fórmula:C14H13NO7Pureza:98.16% - 99.58%Cor e Forma:SolidPeso molecular:307.26SAR407899
CAS:SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Fórmula:C14H16N2O2Pureza:99.42%Cor e Forma:SolidPeso molecular:244.29Ref: TM-T7391
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg128,00€50mg200,00€100mg319,00€200mg474,00€RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFórmula:C17H16N4O2SPureza:99.53% - ≥95%Cor e Forma:SolidPeso molecular:340.4Ref: TM-T2011
500µg50,00€1mg66,00€5mg135,00€1mL*10mM (DMSO)152,00€10mg197,00€25mg349,00€50mg512,00€100mg730,00€SAR407899 hydrochloride
CAS:SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFórmula:C14H17ClN2O2Pureza:99.15%Cor e Forma:SolidPeso molecular:280.75SR-3677
CAS:SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).Fórmula:C22H24N4O4Pureza:98.46%Cor e Forma:SolidPeso molecular:408.45Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Fórmula:C14H18ClN3O3SPureza:98.05%Cor e Forma:SolidPeso molecular:343.83
