Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2624 produtos de "Cromatina/Epigenética"
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SP-2-225
CAS:SP-2-225, a selective inhibitor of HDAC6, augments the production of cancer-associated antigens and enhances macrophage antigen cross-presentation to T cells,Fórmula:C28H34N2O3Pureza:98%Cor e Forma:SolidPeso molecular:446.58MARK-IN-2
CAS:MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Fórmula:C18H18ClF2N5OSPureza:98%Cor e Forma:SolidPeso molecular:425.88TC-AC28
CAS:TC-AC28 is a novel potent and selective Brd2(2) ligand.Fórmula:C23H21N5O3Pureza:98%Cor e Forma:SolidPeso molecular:415.44GSK4028
CAS:GSK4028 is the enantiomeric negative control of GSK4027, a PCAF/GCN5 bromodomain chemical probe, with a pIC50 of 4.9 in a TR-FRET assay.Fórmula:C17H21BrN4OCor e Forma:SolidPeso molecular:377.28JH-131e-153
CAS:JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈Fórmula:C22H38O5Cor e Forma:SolidPeso molecular:382.53Bavarostat
CAS:Bavarostat: brain-penetrant HDAC6 inhibitor; IC50=60nM; >80x selective for HDAC6; modulates tubulin over histone acetylation.Fórmula:C20H27FN2O2Cor e Forma:SolidPeso molecular:346.44GSK2646264
CAS:GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.Fórmula:C24H26N2O2Cor e Forma:SolidPeso molecular:374.48Lepzacitinib
CAS:Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Fórmula:C18H21N5O3Pureza:99.85%Cor e Forma:SolidPeso molecular:355.39Ref: TM-T78207
1mg50,00€5mg104,00€1mL*10mM (DMSO)114,00€10mg167,00€25mg340,00€50mg505,00€100mg712,00€200mg1.009,00€INCB059872 tosylate
CAS:INCB059872: potent, selective oral LSD1 inhibitor, increasing tumor-suppressor gene expression by promoting H3K4 and H3K9 methylation.Fórmula:C37H50N2O9S2Cor e Forma:SolidPeso molecular:730.932PARP-2-IN-1
CAS:PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).Fórmula:C21H19F4N5O3Pureza:98%Cor e Forma:SolidPeso molecular:465.4T-448 free base
CAS:T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).Fórmula:C17H20N4OSPureza:98%Cor e Forma:SolidPeso molecular:328.43KAT modulator-1
CAS:KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].Fórmula:C20H36O2Pureza:98%Cor e Forma:SolidPeso molecular:308.5Compound SA91-0178
CAS:SA91-0178 (3-{[(1-methyl-2-oxo-1'-phenyl-1,2-dihydrospiro[indole-3,4'-piperidine]-5-carbonyl)amino]methyl}benzoic acid) is a specific METTL1 inhibitor and effectively alleviated tissue injury during septic inflammation.Fórmula:C28H27N3O4Peso molecular:469.54GSK3368715 hydrochloride
CAS:GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.Fórmula:C20H38N4O2·HClCor e Forma:SolidPeso molecular:403PI3K/HDAC-IN-2
CAS:PI3K/HDAC-IN-2: dual inhibitor with IC50s - PI3Kα: 226nM, β: 279nM, γ: 467nM, δ: 29nM; HDAC1: 1.3nM. Selective to PI3Kδ/class I/IIb HDAC, anticancer.Fórmula:C23H23N7O4Cor e Forma:SolidPeso molecular:461.47ARTD3/PARP3-IN-1
CAS:ARTD3/PARP3-IN-1 is a non-selective inhibitor targeting diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3)/PARP3 [1].Fórmula:C17H16N4O2Cor e Forma:SolidPeso molecular:308.33GRK2 Inhibitor 2
CAS:GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Fórmula:C19H16N4O2Cor e Forma:SolidPeso molecular:332.36TRC160334 sodium
CAS:TRC160334 is a HIF hydroxylases inhibitor.Fórmula:C14H15N3O5SCor e Forma:SolidPeso molecular:337.35UNC7145
CAS:UNC6934 Negative Control (Axon 3591) is a chemically related compound that serves as a negative control for UNC6934, a potent and selective chemical probe that specifically targets the N-terminal PWWP (PWWP1) domain of NSD2.Fórmula:C24H23N5O4Cor e Forma:SolidPeso molecular:445.4705
