Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2624 produtos de "Cromatina/Epigenética"
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MTDH-SND1 blocker 1
CAS:MTDH-SND1 Blocker 1 (Compound C26-A6) serves as an inhibitor targeting the MTDH-SND1 protein, effectively suppressing cancer metastasis [1].Fórmula:C14H13ClN4O3SCor e Forma:SolidPeso molecular:352.8F-Amidine TFA
CAS:F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.Fórmula:C14H19FN4O2CF3COOHCor e Forma:SolidPeso molecular:408.4Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Fórmula:C42H70O12Pureza:98.46% - 99.13%Cor e Forma:SolidPeso molecular:767.00Ampkinone
CAS:Ampkinone is an indirect AMPK activator.Fórmula:C31H23NO6Pureza:98%Cor e Forma:SolidPeso molecular:505.52CW 008
CAS:CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.Fórmula:C21H14F2N6O2Pureza:97.39%Cor e Forma:SolidPeso molecular:420.37NMS-P953
CAS:NMS-P953: JAK2 inhibitor, reduces tumor growth in SET-2 model, confirmed in vivo action, good pharmacokinetics and safety.Fórmula:C16H11ClF3N5OCor e Forma:SolidPeso molecular:381.74JBI-589
CAS:JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.Fórmula:C29H28FN5OCor e Forma:SolidPeso molecular:481.56JAK-IN-1
CAS:JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.Fórmula:C20H24N6O2Pureza:98%Cor e Forma:SolidPeso molecular:380.44CAY10398
CAS:CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).Fórmula:C15H23N3O3Cor e Forma:SolidPeso molecular:293.367dBRD4-BD1
CAS:dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.Fórmula:C50H53F3N8O9Cor e Forma:SolidPeso molecular:967Tubulin/JAK2-IN-1
CAS:Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significantFórmula:C22H20N6O3Cor e Forma:SolidPeso molecular:416.43GW814408X
CAS:GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Fórmula:C19H16N6OPeso molecular:344.37BY27
CAS:BY27 is a BET BD2 inhibitor with anticancer activity that inhibits BRD2, BRD3 and BRD4 and suppresses tumor growth.Fórmula:C22H21ClN6Pureza:99.4% - 99.68%Cor e Forma:SolidPeso molecular:404.891,2-Didecanoyl-sn-glycerol
CAS:GNN14490, a substrate for human pancreatic lipase, is utilized to create monomolecular films for enzyme assay studies.Fórmula:C23H44O5Cor e Forma:SolidPeso molecular:400.6GSK-2807 free base
CAS:GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.Fórmula:C19H32N8O5Cor e Forma:SolidPeso molecular:452.51Lin281632
CAS:Lin281632 is an inhibitor of RNA binding protein Lin28 and bromodomain. Lin281632 promotes mESC differentiation.Fórmula:C15H15N5OPureza:99.84%Cor e Forma:SolidPeso molecular:281.31Ref: TM-T27835
1mg34,00€5mg71,00€1mL*10mM (DMSO)79,00€10mg101,00€25mg212,00€50mg340,00€100mg535,00€500mg1.144,00€BRCA1-IN-2
CAS:BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.Fórmula:C26H33N4O7PPureza:98.04%Cor e Forma:SolidPeso molecular:544.54ZL0420
CAS:ZL0420: Potent, selective BRD4 inhibitor, IC50 27 nM BD1 & 32 nM BD2.Fórmula:C16H16N4O2Pureza:99.38%Cor e Forma:SolidPeso molecular:296.32ZLN024
CAS:ZLN024 is an activator of AMPK allosteric.Fórmula:C13H13BrN2OSPureza:99.751%Cor e Forma:SolidPeso molecular:325.22Ref: TM-T13411
1mg93,00€5mg177,00€1mL*10mM (DMSO)178,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€TNKS1/2-IN-1
CAS:TNKS1/2-IN-1: potent inhibitor for cancer, fibrosis research; pIC50 7.1-8.2.Fórmula:C26H23F4N3O4Cor e Forma:SolidPeso molecular:517.47
