Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2677 produtos para "Cromatina/Epigenética".
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Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Cor e Forma:Odour SolidRef: TM-L1600
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarTyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
CAS:Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.Fórmula:C88H138N20O34P2Pureza:98%Cor e Forma:SolidPeso molecular:2082.1CC-90005
CAS:CC-90005 is a potent, selective oral PKC-θ inhibitor with an IC50 of 8 nM, preferential over PKC-δ, and inhibits T cell activation.Fórmula:C21H27F2N7O2Cor e Forma:SolidPeso molecular:447.48Sulfo SMCC R-phycoerythrin
SulfoSMCCR-phycoerythrin is a conjugate composed of the protein crosslinker SMCC and R-PE (R-Phycoerythrin), designed for labeling proteins to carry red fluorescence. SMCC functions to bind antigen-coupled spleen cells, thereby inducing antigen-specific immune responses.Cor e Forma:Odour SolidPROTAC BRD4 Degrader-9
CAS:PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.Fórmula:C59H71F2N9O15S4Cor e Forma:SolidPeso molecular:1312.5ZXH-3-26
CAS:ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.Fórmula:C38H37ClN8O7SPureza:98.90% - 98.90%Cor e Forma:SolidPeso molecular:785.27PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]Fórmula:C39H42FN9O7Cor e Forma:SolidPeso molecular:767.81PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.Fórmula:C27H30F3N7O6S2Pureza:98%Cor e Forma:SolidPeso molecular:669.7MZP-54
CAS:MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Fórmula:C55H66ClN7O9SPureza:98%Cor e Forma:SolidPeso molecular:1036.67Lys-CoA TFA
Lys-CoA TFA: p300 HAT inhibitor, IC50 50-500 nM, >100x selective vs PCAF, inhibits p300-dependent transcription.Fórmula:C33H54F3N10O21P3SCor e Forma:SolidPeso molecular:1108.82MOCPAC
CAS:MOCPAC is an HDAC1 specific substrate [1] .Fórmula:C27H31N3O6Cor e Forma:SolidPeso molecular:493.55TAT-cyclo-CLLFVY
CAS:Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Fórmula:C111H188N42O24S2Pureza:98%Cor e Forma:SolidPeso molecular:2559.1GSK973
CAS:GSK973 is a selective oral BET inhibitor, 1600x more for BRD4 BD2 (pIC50 7.8, pKd 8.7) than BD1, effective against other BD2s.Fórmula:C23H23FN2O4Cor e Forma:SolidPeso molecular:410.445ZMF-23
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis andFórmula:C22H23Cl2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:476.36DB008
DB008 is a selective PARP16 inhibitor with IC50 of 0.27 μM, has acrylamide, and is membrane-permeable.Fórmula:C25H21FN4O3Cor e Forma:SolidPeso molecular:444.46BRD4-IN-2
CAS:BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC 50 value of 9.9 nM.Fórmula:C43H48N8O11Cor e Forma:SolidPeso molecular:852.902FDA-Approved Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Cor e Forma:LiquidRef: TM-L1610
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarCEM114
CAS:CEM114 is a potent chemical compound known as a chemical epigenetic modifier (CEM).Fórmula:C84H122FN9O19SCor e Forma:SolidPeso molecular:1613.0JPS014
CAS:JPS014: A potent benzamide-based VHL E3-ligase PROTAC that degrades HDAC1/2, altering gene expression and inducing apoptosis in HCT116 cells.Fórmula:C46H59N7O7SCor e Forma:SolidPeso molecular:854.07HSP90-IN-30
HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.Fórmula:C20H39B12N4O2Cor e Forma:SolidPeso molecular:499.41897
