Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2677 produtos para "Cromatina/Epigenética".
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HDAC8-IN-6
HDAC8-IN-6 (compound 3) is a potent inhibitor of HDAC8 with an IC50 of 5.1 μM and exhibits cytotoxicity.Fórmula:C19H18IN3O2Cor e Forma:SolidPeso molecular:447.04437PROTAC BRD4 Degrader-13
CAS:PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Fórmula:C68H85F2N11O17P2S2Cor e Forma:SolidPeso molecular:1492.55HSP90-IN-30
HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.Fórmula:C20H39B12N4O2Cor e Forma:SolidPeso molecular:499.41897Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Fórmula:C22H28ClN3O4Pureza:99.86%Cor e Forma:White SolidPeso molecular:433.93MJ-26
MJ-26 is an inhibitor targeting Menin, characterized by a high binding affinity (Ki: 0.56 μM) and significant antiproliferative activity. It functions by inhibiting Menin-MLL interaction and promoting the degradation of Menin protein. MJ-26 demonstrates notable antitumor effects against acute myeloid leukemia (AML) and is applicable for AML research.SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Fórmula:C14H16N2OPureza:99.58%Cor e Forma:SolidPeso molecular:228.29Ref: TM-T9648
1mg92,00€5mg192,00€1mL*10mM (DMSO)195,00€10mg295,00€25mg505,00€50mg708,00€100mg964,00€200mg1.288,00€MRTX9768 hydrochloride
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.Cor e Forma:SolidCD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Cor e Forma:SolidMS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Fórmula:C15H26Cl2N2OPureza:99.9%Cor e Forma:SolidPeso molecular:321.28PKC β pseudosubstrate
CAS:Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Fórmula:C177H294N62O38S3Pureza:98%Cor e Forma:SolidPeso molecular:3994.84MS8535
MS8535 is a selective SPIN1 inhibitor with an IC50 value of 0.2 μM.Fórmula:C28H38N6O2Cor e Forma:SolidPeso molecular:490.30562BAY-184
CAS:BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.Fórmula:C23H20N2O4SPureza:98.87%Cor e Forma:SolidPeso molecular:420.48E67-2
CAS:E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Fórmula:C21H36N6O2Cor e Forma:SolidPeso molecular:404.559Mz325
CAS:Mz325 is an effective dual inhibitor of HDAC6 and SIRT2, IC50=0.043 μM and 0.32 μM respectively, and can be used for the study of tubulin deacetylation.Fórmula:C38H45N9O5S2Pureza:98.71%Cor e Forma:White SolidPeso molecular:771.95ATF3 inducer 1
CAS:ATF3 inducer 1 is an ATF3 inducer with lipid-lowering activity, alleviating glucose intolerance and insulin resistance induced by high-fat diet (HFD).Fórmula:C12H10N2O3Pureza:99.04%Cor e Forma:SolidPeso molecular:230.22pTH-Related Protein (1-40) (human, mouse, rat)
CAS:pTH-Related Protein (1-40) boosts rat calcium absorption via PTHR1 and PKCα/β. It up-regulates PTHR1, TRPV6, CaBP-D9k, NCX1, and PMCA1.Fórmula:C207H334N66O58Peso molecular:4675.27Casdatifan
CAS:Casdaitifan (AB521) is an orally active hypoxia inducible factor 2 alpha (HIF-2 alpha) inhibitor. Casdaitifan exhibits significant anti-tumor effects in the clear cell renal cell carcinoma (ccRCC) model.Fórmula:C21H17F4NO3SPeso molecular:439.42Thalidomide-NH-CBP/p300 ligand 2
CAS:Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).Fórmula:C48H57F2N11O6Cor e Forma:SolidPeso molecular:922.052PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.Fórmula:C53H64N12O9SPureza:98%Cor e Forma:SolidPeso molecular:1045.22RK 286D
CAS:RK 286D is an indolocarbazole antibiotic.Fórmula:C26H23N3O4Cor e Forma:SolidPeso molecular:441.48
