Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2599 produtos para "Cromatina/Epigenética".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
PROTAC BRD4 Degrader-10
CAS:Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.Fórmula:C59H71F2N9O15S4Cor e Forma:SolidPeso molecular:1312.5GSK973
CAS:GSK973 is a selective oral BET inhibitor, 1600x more for BRD4 BD2 (pIC50 7.8, pKd 8.7) than BD1, effective against other BD2s.Fórmula:C23H23FN2O4Cor e Forma:SolidPeso molecular:410.445VPC-70063
CAS:VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Fórmula:C16H12F6N2SPureza:99.98%Cor e Forma:White SolidPeso molecular:378.34Ref: TM-T60019
1mg49,00€5mg101,00€1mL*10mM (DMSO)130,00€10mg152,00€25mg268,00€50mg385,00€100mg560,00€200mg790,00€INCB059872
CAS:INCB059872: potent, oral, selective LSD1 inhibitor for myeloid leukemia research.Fórmula:C23H34N2O3Cor e Forma:SolidPeso molecular:386.536CARM1/HDAC2-IN-1
CARM1/HDAC2-IN-1 (Compound CH-1) is a dual inhibitor targeting CARM1 and HDAC2, with IC50 values of 3.71 nM and 4.07 nM, respectively. This compound exhibits antitumor activity.Fórmula:C35H42N8O3Cor e Forma:SolidPeso molecular:622.33799PROTAC BRD4 Degrader-13
CAS:PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Fórmula:C68H85F2N11O17P2S2Cor e Forma:SolidPeso molecular:1492.55SJ1008030
CAS:SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.Fórmula:C42H43N13O7SCor e Forma:SolidPeso molecular:873.94TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Fórmula:C23H21FN4O2Cor e Forma:SolidPeso molecular:404.16485MJ-26
MJ-26 is an inhibitor targeting Menin, characterized by a high binding affinity (Ki: 0.56 μM) and significant antiproliferative activity. It functions by inhibiting Menin-MLL interaction and promoting the degradation of Menin protein. MJ-26 demonstrates notable antitumor effects against acute myeloid leukemia (AML) and is applicable for AML research.SAMS
CAS:SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).Fórmula:C74H131N29O18S2Pureza:98%Cor e Forma:SolidPeso molecular:1779.15HDAC6-IN-53
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.Cor e Forma:Odour SolidMS-8709
CAS:MS-8709 is a potent and selective G9a/GLP PROTAC Degrader with a DC50(G9a) of 274 nM and a DC50(GLP) of 260 nM. It induces G9a/GLP protein degradation in a concentration-dependent and time-dependent manner via the ubiquitin-proteasome system, without affecting mRNA expression levels. MS-8709 demonstrates superior cell growth inhibition compared to the parent compound UNC0642 in prostate cancer, leukemia, and lung cancer cell models, and exhibits mouse pharmacokinetic characteristics suitable for in vivo efficacy studies.Fórmula:C64H95F2N11O7SPureza:99.98%Peso molecular:1200.57MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Fórmula:C15H26Cl2N2OPureza:99.9%Cor e Forma:SolidPeso molecular:321.28PKC β pseudosubstrate
CAS:Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Fórmula:C177H294N62O38S3Pureza:98%Cor e Forma:SolidPeso molecular:3994.84SMARCA2-IN-10
CAS:SMARCA2-IN-10 is a selective SMARCA2 ATPase inhibitor (IC50=17.676 μM), induces death in SMARCA4-deficient tumor cells, for NSCLC and melanoma research.Fórmula:C28H20N2O7Pureza:99.99%Peso molecular:496.47BAY-184
CAS:BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.Fórmula:C23H20N2O4SPureza:98.87%Cor e Forma:SolidPeso molecular:420.48MS8535
MS8535 is a selective SPIN1 inhibitor with an IC50 value of 0.2 μM.Fórmula:C28H38N6O2Cor e Forma:SolidPeso molecular:490.30562Mz325
CAS:Mz325 is an effective dual inhibitor of HDAC6 and SIRT2, IC50=0.043 μM and 0.32 μM respectively, and can be used for the study of tubulin deacetylation.Fórmula:C38H45N9O5S2Pureza:98.71%Cor e Forma:White SolidPeso molecular:771.95pTH-Related Protein (1-40) (human, mouse, rat)
CAS:pTH-Related Protein (1-40) boosts rat calcium absorption via PTHR1 and PKCα/β. It up-regulates PTHR1, TRPV6, CaBP-D9k, NCX1, and PMCA1.Fórmula:C207H334N66O58Peso molecular:4675.27Axltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Fórmula:C63H107N19O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1514.77
