Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2490 produtos de "Cromatina/Epigenética"
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EXQ-2d
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.Fórmula:C18H17N3O3Cor e Forma:SolidPeso molecular:323.35HD-TAC7
CAS:HD-TAC7 is a PROTAC HDAC degrader; IC50s: HDAC1 (3.6μM), HDAC2 (4.2μM), HDAC3 (1.1μM); reduces NF-κB p65; researched for asthma, COPD.Fórmula:C33H32FN7O7Cor e Forma:SolidPeso molecular:657.65(R)-SKBG-1
CAS:(R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNAFórmula:C22H26ClN3O6SPureza:97.25%Cor e Forma:SolidPeso molecular:495.98Ep300/CREBBP-IN-3
CAS:Ep300/CREBBP-IN-3 inhibits Ep300 & CREBBP (IC50: 0.056 & 0.095 μM respectively); potential for cancer research.Fórmula:C26H25F4N5O3Cor e Forma:SolidPeso molecular:531.50PROTAC BET degrader-2
CAS:PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).Fórmula:C41H42N10O6Pureza:98%Cor e Forma:SolidPeso molecular:770.84Ref: TM-T12559
5mg379,00€10mg600,00€25mg1.111,00€50mgA consultar100mgA consultar1mL*10mM (DMSO)605,00€BRD4-IN-4
CAS:BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line andFórmula:C17H18N2O3SPureza:99.97%Cor e Forma:SolidPeso molecular:330.4PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Cor e Forma:Odour SolidHDAC6-IN-42
HDAC6-IN-42 (compound 2b) is an HDAC6 inhibitor with an IC50 of 0.009 μM, demonstrating significant anti-leukemia activity and synergistic effects with Decitabine, indicating its potential use in the research of Acute Myeloid Leukemia (AML).Fórmula:C24H28FN3O4Peso molecular:441.20638PAD2-IN-2 TFA
PAD2-IN-2 (cis-isomer of 1) TFA is an inhibitor of protein arginine deiminase 2 (PAD2). This molecule features an azobenzene photoswitch, enabling the optical regulation of PAD activity. Additionally, PAD2-IN-2 TFA inhibits the citrullination of histone H3.Fórmula:C28H27ClF3N7O3Cor e Forma:SolidPeso molecular:602.01UNC10142
UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.Fórmula:C33H52N6O3Cor e Forma:SolidPeso molecular:580.8MAK683-CH2CH2COOH hydrochloride
MAK683-CH2CH2COOH, an EED binder, was key in crafting PROTAC EED degrader-1 and -2 targeting VHL-E3 ligase.Fórmula:C23H22ClFN6O3Cor e Forma:SolidPeso molecular:484.91(rel)-Tranylcypromine D5 hydrochloride
CAS:(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.Fórmula:C9H12ClNPureza:98%Cor e Forma:SolidPeso molecular:174.682SJ46420
SJ46420, a potent and selective precursor variant of SJ46421, functions as a BRD3 PROTAC degrader through a KLHDC2-dependent mechanism. This compound specifically degrades BRD3, which concurrently results in the partial reduction of BRD2 or BRD4 levels.Fórmula:C43H43ClN8O5S2Cor e Forma:SolidPeso molecular:851.44mUNO
CAS:mUNO is a tumor-homing peptide (mUNO, sequence: "CSPGAK") that specifically binds to murine CD206, targeting tumor-associated macrophages that express CD206/MRC1. Additionally, mUNO can interact with human recombinant CD206.Fórmula:C22H39N7O8SCor e Forma:SolidPeso molecular:561.652MRS2698
CAS:MRS2698: potent P2Y2 agonist, EC50 8 nM, >300x selectivity over P2Y4/P2Y6.Fórmula:C9H16N3O13P3SPureza:98%Cor e Forma:SolidPeso molecular:499.22HDAC1/2-IN-3
CAS:HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively.Fórmula:C24H25N5OSCor e Forma:SolidPeso molecular:431.56TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Fórmula:C23H21FN4O2Cor e Forma:SolidPeso molecular:404.16485UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Fórmula:C47H70N6O8Pureza:98%Cor e Forma:SolidPeso molecular:847.09HDAC/CD13-IN-1
HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μMFórmula:C27H41Cl2N5O4Pureza:98%Cor e Forma:SolidPeso molecular:570.55Flindersine
CAS:Flindersine is a useful organic compound for research related to life sciences. The catalog number is T124718 and the CAS number is 523-64-8.Fórmula:C14H13NO2Cor e Forma:SolidPeso molecular:227.263
