CymitQuimica logo
Cromatina/Epigenética

Cromatina/Epigenética

Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.

Subcategorias de "Cromatina/Epigenética"

Foram encontrados 2486 produtos de "Cromatina/Epigenética"

Ordenar por

Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
produtos por página.
  • Tubulin/HDAC-IN-3


    Tubulin/HDAC-IN-3 (compound 12a) serves as a potent dual inhibitor of tubulin polymerization and HDAC1/8, exhibiting IC50 values of 5.4 μM for tubulin
    Fórmula:C28H28N2O10
    Cor e Forma:Solid
    Peso molecular:552.53

    Ref: TM-T78880

    5mg
    A consultar
    50mg
    A consultar
  • JPS014

    CAS:
    JPS014: A potent benzamide-based VHL E3-ligase PROTAC that degrades HDAC1/2, altering gene expression and inducing apoptosis in HCT116 cells.
    Fórmula:C46H59N7O7S
    Cor e Forma:Solid
    Peso molecular:854.07

    Ref: TM-T74453

    5mg
    A consultar
    50mg
    A consultar
  • HD-TAC7

    CAS:
    HD-TAC7 is a PROTAC HDAC degrader; IC50s: HDAC1 (3.6μM), HDAC2 (4.2μM), HDAC3 (1.1μM); reduces NF-κB p65; researched for asthma, COPD.
    Fórmula:C33H32FN7O7
    Cor e Forma:Solid
    Peso molecular:657.65

    Ref: TM-T74514

    5mg
    A consultar
    50mg
    A consultar
  • EXQ-2d


    EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.
    Fórmula:C18H17N3O3
    Cor e Forma:Solid
    Peso molecular:323.35

    Ref: TM-T205739

    10mg
    A consultar
    50mg
    A consultar
  • INCB059872

    CAS:
    INCB059872: potent, oral, selective LSD1 inhibitor for myeloid leukemia research.
    Fórmula:C23H34N2O3
    Cor e Forma:Solid
    Peso molecular:386.536

    Ref: TM-T39226

    5mg
    922,00€
  • PROTAC TYK2 degrader-1

    CAS:
    PROTAC TYK2 degrader-1 (CPD-155) functions as a selective degrader of TYK2, demonstrating a degradation maximum (D max) greater than 60%. This compound effectively targets TYK2 for degradation, utilizing a linker to connect the TYK2 ligand with the VHL ligand Thalidomide, each color-coded for identification.
    Fórmula:C40H41N13O7
    Peso molecular:815.84

    Ref: TM-T87269

    10mg
    A consultar
    50mg
    A consultar
  • UNC10142


    UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.
    Fórmula:C33H52N6O3
    Cor e Forma:Solid
    Peso molecular:580.8

    Ref: TM-T203332

    10mg
    A consultar
    50mg
    A consultar
  • MRS2698

    CAS:
    MRS2698: potent P2Y2 agonist, EC50 8 nM, >300x selectivity over P2Y4/P2Y6.
    Fórmula:C9H16N3O13P3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:499.22

    Ref: TM-T16139

    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • PROTAC BET degrader-2

    CAS:
    PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).
    Fórmula:C41H42N10O6
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:770.84

    Ref: TM-T12559

    5mg
    379,00€
    10mg
    600,00€
    25mg
    1.111,00€
    50mg
    A consultar
    100mg
    A consultar
    1mL*10mM (DMSO)
    605,00€
  • Pim-1 kinase inhibitor 11


    <p>Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.</p>
    Cor e Forma:Odour Solid

    Ref: TM-T200676

    10mg
    A consultar
    50mg
    A consultar
  • (R)-SKBG-1

    CAS:
    (R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNA
    Fórmula:C22H26ClN3O6S
    Pureza:97.25%
    Cor e Forma:Solid
    Peso molecular:495.98

    Ref: TM-T79156

    1mg
    79,00€
    5mg
    150,00€
    10mg
    268,00€
    25mg
    590,00€
    1mL*10mM (DMSO)
    164,00€
  • GNE-987

    CAS:
    GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.
    Fórmula:C56H67F2N9O8S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1096.31

    Ref: TM-T11441

    1mg
    444,00€
    5mg
    1.009,00€
    10mg
    1.603,00€
  • Protein kinase C α peptide TFA

    CAS:
    Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.
    Fórmula:C68H115F3N24O26S
    Cor e Forma:Solid
    Peso molecular:1773.85

    Ref: TM-T76388

    5mg
    A consultar
    50mg
    A consultar
  • Cath-L-dBET1


    Cath-L-dBET1 is a PROTAC degrader targeting BRD4. It has an IC50 value of 2.8 μM in MDA-MB-231 cells. Activated by cathepsin L (Cath-L), Cath-L-dBET1 recruits E3 ubiquitin ligase to degrade BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable for antitumor research.
    Cor e Forma:Odour Solid

    Ref: TM-T206243

    10mg
    A consultar
    50mg
    A consultar
  • PF-3166


    PF-3166 (compound PF-3166) is a cell-active inhibitor of PAD2.
    Cor e Forma:Odour Solid

    Ref: TM-T200686

    10mg
    A consultar
    50mg
    A consultar
  • Povorcitinib phosphate

    CAS:
    Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.
    Fórmula:C23H25F5N7O5P
    Pureza:99.57%
    Cor e Forma:Solid
    Peso molecular:605.45

    Ref: TM-T39113L

    1mg
    48,00€
    5mg
    101,00€
    10mg
    154,00€
    25mg
    250,00€
    50mg
    359,00€
    100mg
    487,00€
    200mg
    655,00€
    1mL*10mM (DMSO)
    A consultar
  • PROTAC SMARCA2 degrader-26

    CAS:
    PROTAC SMARCA2 degrader-26 (compound 45) is an effective degrader of SMARCA2 using the PROTAC technology. It induces degradation of SMARCA2 and SMARCA4 in VCaP cells, with degradation percentages of 94% and 57%, respectively. Additionally, PROTAC SMARCA2 degrader-26 demonstrates antiproliferative activity.
    Fórmula:C46H54N8O5S
    Cor e Forma:Solid
    Peso molecular:831.04

    Ref: TM-T201143

    10mg
    A consultar
    50mg
    A consultar
  • TYK2 activator-1


    TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.
    Fórmula:C23H21FN4O2
    Cor e Forma:Solid
    Peso molecular:404.16485

    Ref: TM-T207637

    10mg
    A consultar
    50mg
    A consultar
  • UNC4976


    UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.
    Fórmula:C47H70N6O8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:847.09

    Ref: TM-T13255

    100mg
    A consultar
    500mg
    A consultar
  • PARPi-FL

    CAS:
    PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.
    Fórmula:C34H32BF3N6O3
    Pureza:99.73%
    Cor e Forma:Solid
    Peso molecular:640.46

    Ref: TM-T24597

    1mg
    202,00€
    5mg
    512,00€
    10mg
    753,00€
    25mg
    1.415,00€
    50mg
    2.118,00€